iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117160

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ABQF01015672

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000008455.1	ENSTGUT00000008804.1	ENSTGUP00000008711.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-98	329.2	250	651

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp............................................ 42
           tGl+NlgNtCYmNSvLQ+Ls++  +re++l+   ++++      +                                            
   Q: 250  TGLRNLGNTCYMNSVLQVLSHLLIFRECFLKldlNQTQ------Ellatatngktrssskhlsiaastlhvnesqekvkgsysvrrpsf 332
           7******************************5552222......222345577888888999999999999999999999999999999 PP
   S: 43   ...............kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpke 116
                          ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         
   Q: 333  ggasksmeliqprepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQQEL--------- 412
           99999999999999999999************************************************************......... PP
   S: 117  eeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdcLesftke 197
           e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +         l+++L++ft++
   Q: 413  ETTGTRYPALIPASQRKLIKQVLNVVNNIFHGQLLSQVTCLTCDNKSNTVEPFWDLSLEFPERYHCNGKemssqypcLLTEMLAKFTET 501
           77888888999999***********************************************9999887789999999************ PP
   S: 198  eelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke. 274
           e leg+  y c++c+ k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v+f + L+++p+c++++ k+   
   Q: 502  EALEGKI-YACDQCNTKRRkfsskpvilteAQKQLMVCRLPQVLRLHLKRFRWSGR-NHREKIGVHVSFDQILNMEPYCCRESLKSLLp 588
           ****965.*******999999999999999***********************997.8889********************88776546 PP
   S: 275  .kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + +++eev++   ++aY+lfY +
   Q: 589  dCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLNMCTMEEVCK---AQAYILFYSQ 651
           69***************************9999********************...********87 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MDKCKHVGRL RLAQDHSILN PQKWHCMDCN TTESVWACLS CSHVACGRYI EEHALKHFQE 60
SSHPVALEVN ELYVFCYLCD DYVLNDNATG DLKLLRSTLS AIKSQNYDCT TRSGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAAGT GTAAGCACGT AGGACGTCTG CGACTGGCCC AAGATCACTC CATTCTCAAT 60
CCTCAGAAAT GGCATTGCAT GGACTGCAAT ACTACGGAAT CTGTGTGGGC GTGCCTCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	74.85	0.00e+00	1015.00
IUUC-Apl-003673	Anas platyrhynchos	87.17	0.00e+00	1158.00
IUUC-Aca-004434	Anolis carolinensis	83.02	0.00e+00	1103.00
IUUC-Ame-010986	Astyanax mexicanus	67.76	0.00e+00	908.00
IUUC-Bta-012774	Bos taurus	73.61	0.00e+00	1018.00
IUUC-Cja-019619	Callithrix jacchus	73.58	0.00e+00	1006.00
IUUC-Cfa-020957	Canis familiaris	73.83	0.00e+00	1013.00
IUUC-Csa-023177	Chlorocebus sabaeus	73.14	0.00e+00	1005.00
IUUC-Cho-024877	Choloepus hoffmanni	67.85	2.00e-178	618.00
IUUC-Cin-025587	Ciona intestinalis	48.19	6.00e-110	391.00
IUUC-Csv-025814	Ciona savignyi	43.66	9.00e-151	526.00
IUUC-Dre-027878	Danio rerio	67.86	0.00e+00	876.00
IUUC-Dno-029832	Dasypus novemcinctus	74.38	0.00e+00	1022.00
IUUC-Ete-032627	Echinops telfairi	72.74	0.00e+00	1013.00
IUUC-Eca-033863	Equus caballus	75.26	0.00e+00	999.00
IUUC-Eeu-035225	Erinaceus europaeus	69.69	0.00e+00	949.00
IUUC-Fca-036288	Felis catus	73.54	0.00e+00	1003.00
IUUC-Fal-037207	Ficedula albicollis	92.69	0.00e+00	1204.00
IUUC-Gmo-039249	Gadus morhua	72.78	3.00e-138	485.00
IUUC-Gga-040457	Gallus gallus	85.42	0.00e+00	1108.00
IUUC-Ggo-044926	Gorilla gorilla	73.72	0.00e+00	1004.00
IUUC-Hsa-046079	Homo sapiens	73.72	0.00e+00	1004.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	73.14	0.00e+00	1001.00
IUUC-Lch-050260	Latimeria chalumnae	73.77	0.00e+00	976.00
IUUC-Loc-051981	Lepisosteus oculatus	81.52	0.00e+00	701.00
IUUC-Laf-054491	Loxodonta africana	74.19	0.00e+00	1011.00
IUUC-Mcc-055694	Macaca mulatta	73.28	0.00e+00	1006.00
IUUC-Mga-059523	Meleagris gallopavo	86.01	0.00e+00	1132.00
IUUC-Mmr-060885	Microcebus murinus	74.89	0.00e+00	1031.00
IUUC-Mdo-063018	Monodelphis domestica	81.78	0.00e+00	1102.00
IUUC-Mmu-064012	Mus musculus	66.76	0.00e+00	890.00
IUUC-Mpu-066207	Mustela putorius furo	74.12	0.00e+00	1018.00
IUUC-Mlu-066929	Myotis lucifugus	72.60	0.00e+00	968.00
IUUC-Opr-070375	Ochotona princeps	68.71	0.00e+00	922.00
IUUC-Ont-071637	Oreochromis niloticus	67.72	0.00e+00	904.00
IUUC-Oan-073030	Ornithorhynchus anatinus	80.27	0.00e+00	883.00
IUUC-Ocu-074836	Oryctolagus cuniculus	72.12	0.00e+00	965.00
IUUC-Oga-088367	Otolemur garnettii	74.01	0.00e+00	998.00
IUUC-Oar-089953	Ovis aries	73.75	0.00e+00	1026.00
IUUC-Ptr-090980	Pan troglodytes	73.72	0.00e+00	1004.00
IUUC-Pan-092748	Papio anubis	73.83	0.00e+00	1016.00
IUUC-Psi-094078	Pelodiscus sinensis	83.71	0.00e+00	917.00
IUUC-Pab-098514	Pongo abelii	74.89	0.00e+00	1019.00
IUUC-Pva-102984	Pteropus vampyrus	75.00	0.00e+00	1026.00
IUUC-Rno-106019	Rattus norvegicus	67.10	0.00e+00	926.00
IUUC-Sha-106965	Sarcophilus harrisii	82.02	0.00e+00	1096.00
IUUC-Ssc-115299	Sus scrofa	74.05	0.00e+00	1030.00
IUUC-Tru-118156	Takifugu rubripes	64.75	0.00e+00	858.00
IUUC-Tni-119733	Tetraodon nigroviridis	64.82	0.00e+00	877.00
IUUC-Tbe-128084	Tupaia belangeri	70.66	0.00e+00	962.00
IUUC-Ttr-128928	Tursiops truncatus	75.15	0.00e+00	1033.00
IUUC-Vpa-130706	Vicugna pacos	73.94	0.00e+00	1018.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence