iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092609

Ensembl Protein ID

ENSPANP00000020748.1

UniProt Accession

A0A096P5X3; A0A096P5X3_PAPAN

Genbank Protein ID

ENSPANP00000020748

Protein Name

Breast cancer type 1 susceptibility protein homolog

Genbank Nucleotide ID

AHZZ01189586

Gene Name

BRCA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000021372.1	ENSPANT00000012331.1	ENSPANP00000020748.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	92.46	0.00e+00	3002.00	IUUC-Hsa-046086

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Papio anubis

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

Protein Sequence
(Fasta)

MLKLLNQKKG PSQCPLCKND ITKRSLQEST RFSQLVEELL KIIHAFQLDT GLQFANSYNF 60
AKKENHSPEH LKDEVSIIQS MGYRNRAKRL LQSEPENPSL QETSLSVPLS NLGIVRTLRT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGGAGTTG ATCAAGGAAC CTGTCTCCAC AAAGTGTGAC CACATATTTT GCAGGTAAGT 60
TTGAATGTGT TATGTGGCTC CATTATTAGC TTTTGTTTTT GTCCTTCATA ACCCAGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom

PROSITE

PS50172--BRCT

Pfam

PF00533--BRCT
PF12820--BRCT_assoc

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	73.03	0.00e+00	2305.00
IUUC-Apl-003252	Anas platyrhynchos	32.17	3.00e-73	271.00
IUUC-Aca-004526	Anolis carolinensis	45.76	9.00e-26	112.00
IUUC-Ame-011720	Astyanax mexicanus	52.38	4.00e-24	107.00
IUUC-Bta-013433	Bos taurus	68.79	0.00e+00	2117.00
IUUC-Cja-019149	Callithrix jacchus	86.67	0.00e+00	2772.00
IUUC-Cfa-020322	Canis familiaris	72.14	0.00e+00	2236.00
IUUC-Cpo-021583	Cavia porcellus	44.23	0.00e+00	1074.00
IUUC-Csa-024227	Chlorocebus sabaeus	98.36	0.00e+00	674.00
IUUC-Cho-024530	Choloepus hoffmanni	68.27	0.00e+00	1154.00
IUUC-Dno-029247	Dasypus novemcinctus	71.78	0.00e+00	2095.00
IUUC-Ete-032472	Echinops telfairi	54.93	0.00e+00	1497.00
IUUC-Eca-033446	Equus caballus	74.97	0.00e+00	2406.00
IUUC-Eeu-034858	Erinaceus europaeus	63.44	0.00e+00	950.00
IUUC-Fca-035991	Felis catus	73.29	0.00e+00	2324.00
IUUC-Fal-036803	Ficedula albicollis	29.58	8.00e-80	293.00
IUUC-Gmo-038782	Gadus morhua	49.28	4.00e-18	87.40
IUUC-Gga-040969	Gallus gallus	30.83	6.00e-35	144.00
IUUC-Gac-042296	Gasterosteus aculeatus	45.78	2.00e-20	94.70
IUUC-Ggo-044740	Gorilla gorilla	88.78	0.00e+00	2766.00
IUUC-Hsa-046086	Homo sapiens	92.46	0.00e+00	2882.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	72.43	0.00e+00	2333.00
IUUC-Lch-049789	Latimeria chalumnae	33.28	4.00e-49	191.00
IUUC-Loc-051952	Lepisosteus oculatus	47.42	2.00e-24	108.00
IUUC-Laf-053648	Loxodonta africana	71.81	0.00e+00	2120.00
IUUC-Mcc-055210	Macaca mulatta	97.30	0.00e+00	3202.00
IUUC-Meu-056342	Macropus eugenii	39.32	1.00e-131	465.00
IUUC-Mga-060163	Meleagris gallopavo	29.87	4.00e-76	280.00
IUUC-Mmr-061402	Microcebus murinus	77.59	0.00e+00	848.00
IUUC-Mdo-062209	Monodelphis domestica	42.92	0.00e+00	995.00
IUUC-Mmu-064003	Mus musculus	54.74	0.00e+00	1564.00
IUUC-Mpu-065825	Mustela putorius furo	74.86	3.00e-159	555.00
IUUC-Mlu-068176	Myotis lucifugus	69.91	0.00e+00	2024.00
IUUC-Nle-069178	Nomascus leucogenys	92.46	0.00e+00	2941.00
IUUC-Opr-070574	Ochotona princeps	60.51	0.00e+00	1761.00
IUUC-Ont-072380	Oreochromis niloticus	50.60	7.00e-24	106.00
IUUC-Oan-073243	Ornithorhynchus anatinus	72.97	3.00e-11	60.50
IUUC-Ocu-074424	Oryctolagus cuniculus	67.20	0.00e+00	2016.00
IUUC-Ola-086863	Oryzias latipes	53.75	2.00e-23	105.00
IUUC-Oar-089938	Ovis aries	69.01	0.00e+00	2167.00
IUUC-Ptr-090960	Pan troglodytes	93.00	0.00e+00	2933.00
IUUC-Psi-093889	Pelodiscus sinensis	31.28	1.00e-55	211.00
IUUC-Pfo-096328	Poecilia formosa	51.14	2.00e-24	108.00
IUUC-Pab-097982	Pongo abelii	93.12	0.00e+00	2972.00
IUUC-Pca-100698	Procavia capensis	63.17	3.00e-180	626.00
IUUC-Pva-102631	Pteropus vampyrus	74.12	0.00e+00	1079.00
IUUC-Rno-105879	Rattus norvegicus	54.35	0.00e+00	1517.00
IUUC-Sha-106701	Sarcophilus harrisii	39.42	0.00e+00	687.00
IUUC-Sar-113047	Sorex araneus	63.49	0.00e+00	1482.00
IUUC-Ssc-115846	Sus scrofa	71.84	0.00e+00	2274.00
IUUC-Tgu-116785	Taeniopygia guttata	29.38	3.00e-71	264.00
IUUC-Tru-117895	Takifugu rubripes	38.51	4.00e-24	107.00
IUUC-Tsy-118885	Tarsius syrichta	59.76	0.00e+00	727.00
IUUC-Tni-119654	Tetraodon nigroviridis	56.63	4.00e-25	110.00
IUUC-Tbe-127421	Tupaia belangeri	60.73	9.00e-141	495.00
IUUC-Ttr-128685	Tursiops truncatus	72.81	0.00e+00	2183.00
IUUC-Vpa-130216	Vicugna pacos	70.22	0.00e+00	852.00
IUUC-Xtr-132398	Xenopus tropicalis	58.54	5.00e-24	107.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence