iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093604

Ensembl Protein ID

ENSPSIP00000017951.1

UniProt Accession

K7GCE0; K7GCE0_PELSI

Genbank Protein ID

ENSPSIP00000017951

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Genbank Nucleotide ID

AGCU01098983

Gene Name

RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000015970.1	ENSPSIT00000018034.1	ENSPSIP00000017951.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.40e-07	31.2	16	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e f + p++lpC+H+ + +C+q       +++ + +CP Cr
   Q: 16   CQICMEIFVE-PVTLPCNHTLCNSCFQST-----VEKASLYCPFCR 55
           9********9.9**************544.....5**********8 PP

Organism

Pelodiscus sinensis

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MSKKAEAPLS LTDCLCQICM EIFVEPVTLP CNHTLCNSCF QSTVEKASLY CPFCRRRVSS 60
WARYNARKNT LINWELWERI QKNYPEECQC RVNGQDLEED LCISQPLHQL SKPGELRQEY 120

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Nucleotide Sequence
(Fasta)

ATTCAAAATG TCGAAGAAAG CTGAGGCTCC GCTTTCCTTA ACTGACTGTC TTTGCCAAAT 60
CTGCATGGAA ATTTTTGTGG AGCCAGTGAC CCTGCCATGC AACCACACTC TCTGTAATTC 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0031491--F:nucleosome binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0035518--P:histone H2A monoubiquitination
GO:0036351--P:histone H2A-K13 ubiquitination
GO:0036352--P:histone H2A-K15 ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pss:102450880

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001573	Ailuropoda melanoleuca	43.68	5.00e-87	314.00
IUUC-Atr-002992	Amborella trichopoda	37.65	3.00e-10	58.90
IUUC-Apl-003963	Anas platyrhynchos	54.13	2.00e-120	425.00
IUUC-Aca-004420	Anolis carolinensis	49.19	1.00e-104	373.00
IUUC-Ame-011521	Astyanax mexicanus	57.94	7.00e-42	164.00
IUUC-Bta-013002	Bos taurus	44.35	6.00e-87	314.00
IUUC-Cja-019945	Callithrix jacchus	42.23	5.00e-83	301.00
IUUC-Cfa-020533	Canis familiaris	43.25	1.00e-85	310.00
IUUC-Cpo-021643	Cavia porcellus	40.84	7.00e-65	241.00
IUUC-Csa-023638	Chlorocebus sabaeus	42.13	1.00e-87	317.00
IUUC-Cho-024319	Choloepus hoffmanni	42.46	6.00e-77	281.00
IUUC-Cin-025679	Ciona intestinalis	38.52	9.00e-24	103.00
IUUC-Csv-026052	Ciona savignyi	39.10	5.00e-23	100.00
IUUC-Dre-028519	Danio rerio	45.53	1.00e-37	150.00
IUUC-Dno-029294	Dasypus novemcinctus	42.12	7.00e-84	304.00
IUUC-Ete-032714	Echinops telfairi	64.96	3.00e-41	162.00
IUUC-Eca-033343	Equus caballus	44.37	4.00e-90	325.00
IUUC-Eeu-034633	Erinaceus europaeus	36.76	1.00e-09	57.00
IUUC-Fca-036251	Felis catus	43.02	2.00e-89	322.00
IUUC-Fal-037048	Ficedula albicollis	53.39	1.00e-141	496.00
IUUC-Gmo-039400	Gadus morhua	49.57	4.00e-33	132.00
IUUC-Gga-040444	Gallus gallus	53.30	1.00e-141	496.00
IUUC-Gac-041735	Gasterosteus aculeatus	54.68	2.00e-39	155.00
IUUC-Gma-044332	Glycine max	40.79	3.00e-12	65.90
IUUC-Ggo-044940	Gorilla gorilla	46.35	2.00e-30	126.00
IUUC-Hsa-046424	Homo sapiens	51.48	5.00e-55	208.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	42.51	7.00e-74	271.00
IUUC-Lch-050649	Latimeria chalumnae	39.82	3.00e-62	232.00
IUUC-Loc-051847	Lepisosteus oculatus	34.99	8.00e-52	197.00
IUUC-Laf-053938	Loxodonta africana	40.84	1.00e-92	333.00
IUUC-Mcc-055360	Macaca mulatta	42.62	4.00e-82	298.00
IUUC-Meu-056684	Macropus eugenii	40.81	1.00e-75	276.00
IUUC-Mtr-058007	Medicago truncatula	40.79	6.00e-12	65.10
IUUC-Mga-059699	Meleagris gallopavo	52.85	4.00e-132	464.00
IUUC-Mmr-060779	Microcebus murinus	43.04	5.00e-91	328.00
IUUC-Mdo-062225	Monodelphis domestica	43.82	1.00e-86	313.00
IUUC-Mmu-064239	Mus musculus	42.23	4.00e-68	251.00
IUUC-Mpu-066141	Mustela putorius furo	43.02	9.00e-95	340.00
IUUC-Mlu-067945	Myotis lucifugus	43.06	2.00e-90	325.00
IUUC-Nle-069769	Nomascus leucogenys	41.57	1.00e-85	310.00
IUUC-Opr-070905	Ochotona princeps	37.81	1.00e-72	267.00
IUUC-Ont-071477	Oreochromis niloticus	50.99	4.00e-38	152.00
IUUC-Oan-073587	Ornithorhynchus anatinus	72.44	2.00e-52	197.00
IUUC-Ocu-073832	Oryctolagus cuniculus	41.61	3.00e-81	295.00
IUUC-Ola-086478	Oryzias latipes	50.00	2.00e-36	144.00
IUUC-Oga-088318	Otolemur garnettii	43.86	1.00e-85	310.00
IUUC-Oar-089647	Ovis aries	43.39	1.00e-85	310.00
IUUC-Ptr-090516	Pan troglodytes	51.15	9.00e-58	217.00
IUUC-Pan-092302	Papio anubis	42.06	3.00e-82	298.00
IUUC-Pfo-096441	Poecilia formosa	56.43	2.00e-44	172.00
IUUC-Pab-097729	Pongo abelii	51.15	2.00e-55	209.00
IUUC-Pca-100552	Procavia capensis	68.69	2.00e-39	157.00
IUUC-Pva-102780	Pteropus vampyrus	42.23	4.00e-89	321.00
IUUC-Rno-105461	Rattus norvegicus	40.29	6.00e-75	274.00
IUUC-Sha-106809	Sarcophilus harrisii	46.02	3.00e-98	352.00
IUUC-Sly-110934	Solanum lycopersicum	40.24	5.00e-13	68.20
IUUC-Stu-112446	Solanum tuberosum	40.24	5.00e-13	68.20
IUUC-Sar-113579	Sorex araneus	37.09	9.00e-66	244.00
IUUC-Sbi-113834	Sorghum bicolor	40.79	3.00e-11	62.40
IUUC-Tgu-117187	Taeniopygia guttata	75.93	1.00e-78	285.00
IUUC-Tru-118182	Takifugu rubripes	41.13	2.00e-35	142.00
IUUC-Tni-120205	Tetraodon nigroviridis	50.34	2.00e-42	166.00
IUUC-Tca-121416	Theobroma cacao	40.79	3.00e-12	65.50
IUUC-Tre-121992	Trichoderma reesei	37.97	2.00e-08	53.90
IUUC-Tbe-127622	Tupaia belangeri	43.96	4.00e-97	348.00
IUUC-Ttr-128988	Tursiops truncatus	44.68	3.00e-89	322.00
IUUC-Vpa-130302	Vicugna pacos	65.87	9.00e-47	181.00
IUUC-Vvi-131424	Vitis vinifera	39.47	2.00e-10	59.70
IUUC-Xtr-132196	Xenopus tropicalis	47.65	4.00e-50	192.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence