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Tag Content
iUUCD ID IUUC-Aor-009973
Ensembl Protein ID BAE59224
UniProt Accession Q2UGU1; LIS1_ASPOR
Genbank Protein ID BAE59224.1
Protein Name Nuclear distribution protein nudF; Lissencephaly-1 homolog
Genbank Nucleotide ID AP007157
Gene Name nudF; lis1; pac1; AO090023000713
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AO090023000713 BAE59224 BAE59224
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.50e-48 157.6 181 220
UBD/Beta-Prp 2.60e-63 213.3 93 383
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH v++++f ++ +llvs+s+D+ +++WD++tg ++k+
   Q: 181 GHDHIVSAVRFiPSrNLLVSASRDNDMRIWDVTTGYCVKT 220
    79999*******888********************99875 PP
   


   UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvw.dlstgkcvhtlkghedsvlslsfsp 104
    ++h + ++cv+f+p s +a+gs+d tik+wd++ g l r+l+gh+ +v++v++ ++ +l+++s+D ik+w + +++k ++tl+gh++ v +++f p
   Q: 93 ESHRDKVNCVAFHPTFSSIASGSDDCTIKIWDWELGELERTLKGHTRAVRDVDYGGPRDnvLLASCSSDLSIKLWkPTDNYKNIRTLQGHDHIVSAVRFIP 193
    456778889*********************************************8776678**************8899********************** PP
   S: 105 sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkllrtltgghtdsvyslsfdsng.......... 192
    s++ lvs+s+d+ r+wd+ tg+c++ t +gh+++v+ v+++ dg+ l+s + D t rlWd+ ++ + rt+ g h++ +++ +f +
   Q: 194 SRNLLVSASRDNDMRIWDVTTGYCVK-TINGHTDWVRDVSISFDGRFLFSTGQDMTARLWDIstvSNIEHKRTMLG-HENFIECCAFAPPTsyqflaplag 292
    **************************.***********************************44444445567798.*********877667888888888 PP
   S: 193 ...........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlqlhnssvisvav 272
    ++++gs+d+t+k+wd +g+c++tl gh+++v+ + f+p +++l+s+s+D+++r+Wdl ++g+++ktl h+s v+s
   Q: 293 lgkrpsstngaDFMATGSRDNTIKIWDS-RGTCLMTLVGHDSWVQALVFHPGGKYLLSVSDDKTLRCWDLnQQGKCVKTLDAHESFVTSLRW 383
    8888888888999**************8.899************************************984689**********99988765 PP
   

Organism Aspergillus oryzae
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MPPLLTNRQA EELHKSMIAY LVASDLPDTA AALRREVNLS EDVFDPTTAK RYEGMLEKKW 60
TSIARLQKKA SSRLKRNQDP ASWLPSTVRY SLESHRDKVN CVAFHPTFSS IASGSDDCTI 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Aor-009973|E3,WD_repeat;UBD,Beta-Prp|Aspergillus oryzae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCCTCCCT TACTAACTAA TCGGCAAGCC GAGGAGCTGT GAGTATGTCC CATGCGAACT 60
AGTCGCTGGC GAAAGCTAAA TTCGCGTATA GACACAAGTC AATGATAGCG TACCTCGTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Aor-009973|E3,WD_repeat;UBD,Beta-Prp|Aspergillus oryzae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG aor:AOR_1_1226144
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 43.90 2.00e-89 320.00
IUUC-Apl-004024 Anas platyrhynchos 43.94 8.00e-93 332.00
IUUC-Aca-004564 Anolis carolinensis 43.43 2.00e-90 323.00
IUUC-Acl-008307 Aspergillus clavatus 64.27 1.00e-166 577.00
IUUC-Afl-008502 Aspergillus flavus 95.22 0.00e+00 830.00
IUUC-Afu-008848 Aspergillus fumigatus 58.95 2.00e-154 536.00
IUUC-Ani-009173 Aspergillus nidulans 53.81 7.00e-141 491.00
IUUC-Ang-009873 Aspergillus niger 52.54 2.00e-138 483.00
IUUC-Ate-010523 Aspergillus terreus 51.75 1.00e-137 481.00
IUUC-Ame-011154 Astyanax mexicanus 44.44 2.00e-93 333.00
IUUC-Bgr-011972 Blumeria graminis 58.84 9.00e-156 541.00
IUUC-Bta-013106 Bos taurus 43.94 8.00e-93 332.00
IUUC-Bci-013615 Botrytis cinerea 60.30 2.00e-162 563.00
IUUC-Cel-018459 Caenorhabditis elegans 41.06 2.00e-82 297.00
IUUC-Cja-018755 Callithrix jacchus 43.58 4.00e-90 322.00
IUUC-Cfa-020749 Canis familiaris 43.94 8.00e-93 332.00
IUUC-Cpo-022371 Cavia porcellus 43.94 8.00e-93 332.00
IUUC-Csa-023524 Chlorocebus sabaeus 47.19 8.00e-82 295.00
IUUC-Cho-024764 Choloepus hoffmanni 40.69 1.00e-72 264.00
IUUC-Cin-025753 Ciona intestinalis 43.18 2.00e-85 306.00
IUUC-Csv-025817 Ciona savignyi 41.92 2.00e-87 313.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 61.30 2.00e-156 543.00
IUUC-Cne-027087 Cryptococcus neoformans 46.24 8.00e-98 348.00
IUUC-Dre-028314 Danio rerio 44.44 4.00e-92 329.00
IUUC-Dno-029050 Dasypus novemcinctus 43.94 9.00e-93 331.00
IUUC-Dor-030222 Dipodomys ordii 39.24 6.00e-80 289.00
IUUC-Dse-031164 Dothistroma septosporum 54.19 9.00e-148 514.00
IUUC-Dme-031745 Drosophila melanogaster 43.61 1.00e-88 317.00
IUUC-Ete-032508 Echinops telfairi 49.04 6.00e-69 252.00
IUUC-Eca-034288 Equus caballus 43.38 1.00e-88 318.00
IUUC-Eeu-034984 Erinaceus europaeus 39.24 1.00e-79 288.00
IUUC-Fca-036498 Felis catus 43.94 8.00e-93 332.00
IUUC-Fal-036920 Ficedula albicollis 43.94 8.00e-93 332.00
IUUC-Fox-037996 Fusarium oxysporum 60.56 1.00e-162 564.00
IUUC-Fso-038160 Fusarium solani 62.95 2.00e-166 577.00
IUUC-Gmo-038983 Gadus morhua 43.94 1.00e-91 327.00
IUUC-Ggr-040051 Gaeumannomyces graminis 63.50 9.00e-166 574.00
IUUC-Gga-040623 Gallus gallus 43.94 8.00e-93 332.00
IUUC-Gac-041613 Gasterosteus aculeatus 43.69 2.00e-91 327.00
IUUC-Ggo-045410 Gorilla gorilla 43.19 5.00e-77 279.00
IUUC-Hsa-046358 Homo sapiens 43.94 1.00e-92 331.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 43.94 8.00e-93 332.00
IUUC-Kpa-049351 Komagataella pastoris 29.23 3.00e-39 154.00
IUUC-Lch-049936 Latimeria chalumnae 43.69 7.00e-92 328.00
IUUC-Loc-052476 Lepisosteus oculatus 44.04 2.00e-90 323.00
IUUC-Lma-053170 Leptosphaeria maculans 60.52 1.00e-150 524.00
IUUC-Laf-053713 Loxodonta africana 43.96 1.00e-90 324.00
IUUC-Mcc-054628 Macaca mulatta 43.94 1.00e-92 331.00
IUUC-Meu-055927 Macropus eugenii 41.76 2.00e-52 196.00
IUUC-Mor-056962 Magnaporthe oryzae 61.85 9.00e-166 574.00
IUUC-Mpo-057583 Magnaporthe poae 62.85 6.00e-157 545.00
IUUC-Mla-058819 Melampsora laricipopulina 42.27 7.00e-96 342.00
IUUC-Mga-059945 Meleagris gallopavo 43.94 1.00e-92 331.00
IUUC-Mvi-060403 Microbotryum violaceum 47.06 5.00e-110 389.00
IUUC-Mmr-061289 Microcebus murinus 43.90 1.00e-89 321.00
IUUC-Mdo-061912 Monodelphis domestica 43.69 5.00e-92 329.00
IUUC-Mmu-063253 Mus musculus 43.94 8.00e-93 332.00
IUUC-Mpu-066638 Mustela putorius furo 43.94 8.00e-93 332.00
IUUC-Mlu-067267 Myotis lucifugus 43.04 7.00e-90 322.00
IUUC-Nfi-068571 Neosartorya fischeri 61.20 3.00e-153 532.00
IUUC-Ncr-068895 Neurospora crassa 62.42 6.00e-160 555.00
IUUC-Nle-069087 Nomascus leucogenys 40.99 4.00e-72 262.00
IUUC-Opr-070579 Ochotona princeps 43.94 9.00e-93 331.00
IUUC-Ont-072432 Oreochromis niloticus 43.69 6.00e-92 328.00
IUUC-Oan-073072 Ornithorhynchus anatinus 43.94 8.00e-93 332.00
IUUC-Ocu-074180 Oryctolagus cuniculus 43.94 9.00e-93 331.00
IUUC-Ola-086815 Oryzias latipes 44.47 1.00e-92 331.00
IUUC-Oga-088219 Otolemur garnettii 43.18 1.00e-90 324.00
IUUC-Oar-090394 Ovis aries 43.94 8.00e-93 332.00
IUUC-Ptr-091517 Pan troglodytes 43.94 8.00e-93 332.00
IUUC-Pan-092421 Papio anubis 43.94 1.00e-92 331.00
IUUC-Psi-093370 Pelodiscus sinensis 43.94 2.00e-92 330.00
IUUC-Pma-094319 Petromyzon marinus 46.43 3.00e-78 283.00
IUUC-Pno-094815 Phaeosphaeria nodorum 60.22 4.00e-156 542.00
IUUC-Pfo-097089 Poecilia formosa 43.84 2.00e-92 330.00
IUUC-Pab-098421 Pongo abelii 43.94 8.00e-93 332.00
IUUC-Pca-100120 Procavia capensis 35.61 7.00e-54 202.00
IUUC-Pva-102960 Pteropus vampyrus 43.69 8.00e-92 328.00
IUUC-Pgr-103538 Puccinia graminis 44.44 4.00e-105 372.00
IUUC-Ptt-103990 Puccinia triticina 39.74 1.00e-37 149.00
IUUC-Pte-104261 Pyrenophora teres 59.91 2.00e-156 543.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 59.91 3.00e-156 542.00
IUUC-Rno-105123 Rattus norvegicus 43.94 8.00e-93 332.00
IUUC-Sce-106208 Saccharomyces cerevisiae 27.56 4.00e-34 137.00
IUUC-Sha-107010 Sarcophilus harrisii 43.94 3.00e-92 330.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 34.91 3.00e-59 220.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 61.28 2.00e-155 540.00
IUUC-Sar-113309 Sorex araneus 43.12 6.00e-87 312.00
IUUC-Sre-115003 Sporisorium reilianum 45.35 3.00e-107 380.00
IUUC-Ssc-116148 Sus scrofa 43.94 8.00e-93 332.00
IUUC-Tgu-117299 Taeniopygia guttata 43.94 8.00e-93 332.00
IUUC-Tru-118179 Takifugu rubripes 44.44 6.00e-93 332.00
IUUC-Tsy-119493 Tarsius syrichta 43.94 2.00e-91 327.00
IUUC-Tni-120288 Tetraodon nigroviridis 43.84 2.00e-90 324.00
IUUC-Tre-121977 Trichoderma reesei 58.07 2.00e-150 523.00
IUUC-Tvi-122661 Trichoderma virens 58.24 4.00e-147 512.00
IUUC-Tme-127031 Tuber melanosporum 57.49 3.00e-151 526.00
IUUC-Tbe-127492 Tupaia belangeri 41.76 8.00e-47 179.00
IUUC-Ttr-128929 Tursiops truncatus 43.94 9.00e-93 332.00
IUUC-Uma-129347 Ustilago maydis 46.15 5.00e-109 385.00
IUUC-Vda-129837 Verticillium dahliae 57.85 2.00e-145 507.00
IUUC-Vpa-130532 Vicugna pacos 36.71 8.00e-70 255.00
IUUC-Xtr-131985 Xenopus tropicalis 43.94 2.00e-92 330.00
IUUC-Xma-133314 Xiphophorus maculatus 43.94 3.00e-92 330.00
IUUC-Yli-134403 Yarrowia lipolytica 39.37 8.00e-92 328.00
Created Date 25-Jun-2017

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