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Tag Content
UUCD2 ID IUUC-Tru-118179
UUCD1 version UUC-TaR-00603
Ensembl Protein ID ENSTRUP00000028602.1
UniProt Accession H2TV93; H2TV93_TAKRU
Protein Name Lissencephaly-1 homolog
Gene Name pafah1b1b (1 of many); LOC101072346; LIS1; PAFAH1B1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSTRUG00000011331.1 ENSTRUT00000028718.1 ENSTRUP00000028602.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.90e-57 188.1 336 374
UBD/Beta-Prp 8.40e-90 302.2 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ +++vs++dD+t+++WD++ ++ k
   Q: 336 GHDNWVRGVLFhPGgRFIVSCADDKTLRIWDYKNKRCMK 374
    8***********9989***************99998876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h +++t v f+p s+++t+s+d+tikvwd++ g++ r+l+gh++ v++++f+++gk+l+++s D+ ik+wd++ ++c++t++gh+++v
   Q: 107 HRAPVTRVIFHPVFSVMVTASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMSIKLWDFQGFECIRTMHGHDHNV 195
    6678999********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+t ++w++ tg+c++ t++gh+++v++v+ ++dg+l++s+s+D+tvr+W ++++++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTMKMWEVTTGYCVK-TFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVVASKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    ++ ++ ++l+sgs+d+t+klwd++ g c++tl gh+++v+ v f+p + ++vs+++D+++riWd++++
   Q: 283 AWAPENahstileatgseskksgkpgPFLLSGSRDKTIKLWDVSIGICLMTLVGHDNWVRGVLFHPGGRFIVSCADDKTLRIWDYKNKR 371
    *999999999999**************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372 CMKTLCAHEHFVTSLDF-HKSAPYVVTGSVDQTVKVWECR 410
    *****************.99*****************985 PP
   

Organism Takifugu rubripes
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDMN EEVDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEMT HGGPVGQKRD PKEWIPRPPE RYALSGHRAP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Tru-118179|E3,WD_repeat;UBD,Beta-Prp|Takifugu rubripes
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGATTGCGA CCGTTAGCTG GGGCCGGGCA AATGCGGAGG TACCAGAGAG GAGGAAAAAA 60
AATCTTGACC GACCGTGCCG GGTGATGCGA AAAGTCACAA TATCATACCA AAGTCAGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Tru-118179|E3,WD_repeat;UBD,Beta-Prp|Takifugu rubripes
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007281--P:germ cell development
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0022008--P:neurogenesis
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0047496--P:vesicle transport along microtubule

KEGG tru:101072346
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 91.98 0.00e+00 785.00
IUUC-Apl-004024 Anas platyrhynchos 91.95 0.00e+00 806.00
IUUC-Ago-007862 Ashbya gossypii 26.57 2.00e-39 157.00
IUUC-Afl-008502 Aspergillus flavus 45.69 1.00e-94 340.00
IUUC-Aor-009973 Aspergillus oryzae 44.44 3.00e-92 332.00
IUUC-Ate-010523 Aspergillus terreus 41.31 1.00e-88 320.00
IUUC-Bta-013106 Bos taurus 92.20 0.00e+00 807.00
IUUC-Cja-018755 Callithrix jacchus 89.76 0.00e+00 788.00
IUUC-Cfa-020749 Canis familiaris 92.20 0.00e+00 807.00
IUUC-Cpo-022371 Cavia porcellus 92.20 0.00e+00 807.00
IUUC-Csa-023524 Chlorocebus sabaeus 90.72 0.00e+00 675.00
IUUC-Cho-024764 Choloepus hoffmanni 82.21 0.00e+00 638.00
IUUC-Cne-027087 Cryptococcus neoformans 50.13 1.00e-109 389.00
IUUC-Dno-029050 Dasypus novemcinctus 91.95 0.00e+00 807.00
IUUC-Dor-030222 Dipodomys ordii 84.88 0.00e+00 729.00
IUUC-Dse-031164 Dothistroma septosporum 43.10 1.00e-100 359.00
IUUC-Dme-031745 Drosophila melanogaster 71.05 5.00e-174 603.00
IUUC-Eca-034288 Equus caballus 91.48 0.00e+00 781.00
IUUC-Eeu-034984 Erinaceus europaeus 84.63 0.00e+00 726.00
IUUC-Fca-036498 Felis catus 92.20 0.00e+00 807.00
IUUC-Fal-036920 Ficedula albicollis 91.95 0.00e+00 806.00
IUUC-Fox-037996 Fusarium oxysporum 45.32 3.00e-103 369.00
IUUC-Fso-038160 Fusarium solani 43.60 5.00e-98 351.00
IUUC-Gmo-039166 Gadus morhua 96.10 0.00e+00 832.00
IUUC-Ggr-040051 Gaeumannomyces graminis 45.58 2.00e-98 352.00
IUUC-Gga-040623 Gallus gallus 91.95 0.00e+00 806.00
IUUC-Gac-041363 Gasterosteus aculeatus 97.56 0.00e+00 841.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 92.20 0.00e+00 807.00
IUUC-Kpa-049351 Komagataella pastoris 28.81 4.00e-45 175.00
IUUC-Lma-053170 Leptosphaeria maculans 45.71 5.00e-99 354.00
IUUC-Laf-053713 Loxodonta africana 90.22 0.00e+00 788.00
IUUC-Mcc-054628 Macaca mulatta 91.71 0.00e+00 804.00
IUUC-Mpo-057583 Magnaporthe poae 45.99 3.00e-95 342.00
IUUC-Mga-059945 Meleagris gallopavo 91.71 0.00e+00 805.00
IUUC-Mmr-061289 Microcebus murinus 91.98 0.00e+00 785.00
IUUC-Mdo-061912 Monodelphis domestica 91.46 0.00e+00 800.00
IUUC-Mmu-063253 Mus musculus 92.20 0.00e+00 807.00
IUUC-Mpu-066638 Mustela putorius furo 92.20 0.00e+00 807.00
IUUC-Mlu-067267 Myotis lucifugus 90.44 0.00e+00 790.00
IUUC-Ncr-068895 Neurospora crassa 48.66 1.00e-105 376.00
IUUC-Nle-069087 Nomascus leucogenys 91.94 0.00e+00 657.00
IUUC-Opr-070579 Ochotona princeps 91.95 0.00e+00 807.00
IUUC-Ont-071905 Oreochromis niloticus 97.07 0.00e+00 837.00
IUUC-Oan-073072 Ornithorhynchus anatinus 92.20 0.00e+00 807.00
IUUC-Ocu-074180 Oryctolagus cuniculus 91.95 0.00e+00 807.00
IUUC-Ola-086815 Oryzias latipes 96.59 0.00e+00 836.00
IUUC-Oga-088219 Otolemur garnettii 89.98 0.00e+00 787.00
IUUC-Oar-090394 Ovis aries 92.20 0.00e+00 807.00
IUUC-Ptr-091517 Pan troglodytes 92.20 0.00e+00 807.00
IUUC-Pan-092421 Papio anubis 91.71 0.00e+00 804.00
IUUC-Pfo-096228 Poecilia formosa 96.10 0.00e+00 833.00
IUUC-Pab-098421 Pongo abelii 92.20 0.00e+00 807.00
IUUC-Pva-102960 Pteropus vampyrus 91.95 0.00e+00 803.00
IUUC-Rno-105123 Rattus norvegicus 92.20 0.00e+00 807.00
IUUC-Sce-106208 Saccharomyces cerevisiae 27.29 6.00e-36 145.00
IUUC-Sha-107010 Sarcophilus harrisii 91.22 0.00e+00 799.00
IUUC-Sar-113309 Sorex araneus 91.23 0.00e+00 775.00
IUUC-Sre-115003 Sporisorium reilianum 49.32 1.00e-123 436.00
IUUC-Ssc-116148 Sus scrofa 92.20 0.00e+00 807.00
IUUC-Tgu-117299 Taeniopygia guttata 91.71 0.00e+00 803.00
IUUC-Tni-120288 Tetraodon nigroviridis 99.02 0.00e+00 847.00
IUUC-Tre-121977 Trichoderma reesei 43.16 1.00e-100 360.00
IUUC-Tvi-122661 Trichoderma virens 43.87 3.00e-100 358.00
IUUC-Ttr-128929 Tursiops truncatus 92.20 0.00e+00 806.00
IUUC-Uma-129347 Ustilago maydis 47.72 5.00e-122 431.00
IUUC-Vpa-130532 Vicugna pacos 79.02 0.00e+00 626.00
IUUC-Xtr-131985 Xenopus tropicalis 92.44 0.00e+00 810.00
IUUC-Xma-133469 Xiphophorus maculatus 96.34 0.00e+00 833.00
IUUC-Yli-134403 Yarrowia lipolytica 39.29 1.00e-74 273.00
Created Date 25-Jun-2017

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