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Tag Content
iUUCD ID IUUC-Uma-129347
Ensembl Protein ID KIS68592
UniProt Accession Q4P9P9; A0A0D1C4P9; LIS1_USTMA
Genbank Protein ID KIS68592.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID CM003147
Gene Name PAC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
UMAG_03164 KIS68592 KIS68592
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-48 159.1 356 395
UBD/Beta-Prp 1.80e-74 249.1 118 451
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH ++v++laf ++ + l+s sdD+t+++WDl +g+++++
   Q: 356 GHDNWVRGLAFsPNgKSLLSVSDDKTMRLWDLQSGRCTRT 395
    8***********777**********************985 PP
   


   UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsps 105
    ++ h ++t+v f+p s++a++s+d t+k+wd++tg++ r+l+gh+++v++v+f+++g++ +++s+D ikvwd + ++k + tl+gh++sv s++f p
   Q: 118 MQGHRLPVTKVSFHPVFSQIASASEDTTVKLWDWETGDFERTLKGHTKAVQDVDFDSKGNYVLSCSSDLSIKVWDANnDYKNIKTLQGHDHSVSSVRFLPG 218
    5567789999****************************************************************998689********************9 PP
   S: 106 gdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng.............. 192
    +d++vs+s+d+ti++w+ +tg c + tl+gh ++v+++ ++d++ lvs+s+D+t r+Wd+++g+ +l+g h++ v+ +f +
   Q: 219 DDYIVSASRDKTIKIWEFSTGFCTK-TLQGHAEWVRSAIPSDDAKWLVSCSTDQTARVWDVSSGETKVELRG-HEHVVEVAIFAPVAsyaairqlasldpn 317
    9************************.****************99***************************9.*********6666666667777777777 PP
   S: 193 ...........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav..lsfgdnvl 280
    +++++gs+d+t+++wd +g+c++tl+gh+++v+ ++fspn++ l+s+s+D++ r+Wdl+sg +++t++ h++ + +a ++
   Q: 318 askdasasmagQFVATGSRDKTIRIWDSISGQCLKTLTGHDNWVRGLAFSPNGKSLLSVSDDKTMRLWDLQSGRCTRTIEAHQHFATGIAWgkA-----KI 413
    79999999999************************************************************************88888877331.....22 PP
   S: 281 ..........................vlgsedskvniw 292
    ++ s d +++iw
   Q: 414 eapippaqdgeeagrkqpeartvnvvATSSVDLTIKIW 451
    23333444444444444444444442555557777777 PP
   

Organism Ustilago maydis
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs (By similarity). Required for retrograde early endosome (EE) transport from the hyphal tip.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs (By similarity). Required for retrograde early endosome (EE) transport from the hyphal tip.
Protein Sequence
(Fasta)
MSGFNGTSTS SNSILSERQK DELHKSILDY FKTNNLHESF ATLMREANQE GFVPDPRAKY 60
AGLLEKKWTS VIRLQKKIME MESRISQLQE ELSAAPSAKR SASLNDWLPA ASSARHTMQG 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Uma-129347|E3,WD_repeat;UBD,Beta-Prp|Ustilago maydis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCGGCT TCAACGGCAC ATCCACATCG AGCAACAGCA TCCTCTCGGA GCGTCAAAAG 60
GATGAGTTGC ACAAGTCCAT CCTCGACTAC TTCAAGACCA ACAATCTTCA TGAATCGTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Uma-129347|E3,WD_repeat;UBD,Beta-Prp|Ustilago maydis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG uma:UMAG_03164
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 47.20 5.00e-118 415.00
IUUC-Apl-004024 Anas platyrhynchos 47.72 1.00e-122 431.00
IUUC-Aca-004564 Anolis carolinensis 47.49 6.00e-121 425.00
IUUC-Ago-007862 Ashbya gossypii 27.59 2.00e-37 148.00
IUUC-Acl-008360 Aspergillus clavatus 53.22 8.00e-121 425.00
IUUC-Afl-008502 Aspergillus flavus 50.51 6.00e-110 389.00
IUUC-Afu-008848 Aspergillus fumigatus 51.28 2.00e-125 440.00
IUUC-Ani-009173 Aspergillus nidulans 48.79 4.00e-115 406.00
IUUC-Ang-009873 Aspergillus niger 47.59 7.00e-114 402.00
IUUC-Aor-009973 Aspergillus oryzae 49.01 3.00e-108 383.00
IUUC-Ate-010523 Aspergillus terreus 46.88 2.00e-112 397.00
IUUC-Ame-011154 Astyanax mexicanus 48.40 4.00e-125 439.00
IUUC-Bgr-011972 Blumeria graminis 50.54 2.00e-127 447.00
IUUC-Bta-013106 Bos taurus 47.72 5.00e-123 432.00
IUUC-Bci-013615 Botrytis cinerea 49.68 1.00e-124 438.00
IUUC-Cel-018459 Caenorhabditis elegans 41.88 5.00e-104 369.00
IUUC-Cja-018755 Callithrix jacchus 46.35 1.00e-118 418.00
IUUC-Cfa-020749 Canis familiaris 47.72 5.00e-123 432.00
IUUC-Cpo-022371 Cavia porcellus 47.72 5.00e-123 432.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 36.79 2.00e-51 193.00
IUUC-Csa-023524 Chlorocebus sabaeus 46.92 3.00e-102 363.00
IUUC-Cho-024764 Choloepus hoffmanni 44.53 5.00e-97 345.00
IUUC-Cin-025753 Ciona intestinalis 46.12 2.00e-113 400.00
IUUC-Csv-025817 Ciona savignyi 44.98 1.00e-113 401.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 50.00 2.00e-118 417.00
IUUC-Cne-027087 Cryptococcus neoformans 59.65 9.00e-142 494.00
IUUC-Dre-028314 Danio rerio 47.15 2.00e-121 427.00
IUUC-Dno-029050 Dasypus novemcinctus 47.72 7.00e-123 432.00
IUUC-Dor-030222 Dipodomys ordii 44.06 6.00e-109 385.00
IUUC-Dse-031164 Dothistroma septosporum 48.82 4.00e-118 416.00
IUUC-Dme-031745 Drosophila melanogaster 47.72 2.00e-112 397.00
IUUC-Ete-032508 Echinops telfairi 48.36 1.00e-84 304.00
IUUC-Eca-034288 Equus caballus 46.73 4.00e-117 412.00
IUUC-Eeu-034984 Erinaceus europaeus 43.84 7.00e-108 382.00
IUUC-Fca-036498 Felis catus 47.72 5.00e-123 432.00
IUUC-Fal-036920 Ficedula albicollis 47.72 1.00e-122 431.00
IUUC-Fox-037996 Fusarium oxysporum 48.38 2.00e-122 430.00
IUUC-Fso-038160 Fusarium solani 48.16 8.00e-117 412.00
IUUC-Gmo-038983 Gadus morhua 48.17 6.00e-124 435.00
IUUC-Ggr-040051 Gaeumannomyces graminis 49.57 3.00e-119 420.00
IUUC-Gga-040623 Gallus gallus 47.72 1.00e-122 431.00
IUUC-Gac-041613 Gasterosteus aculeatus 48.17 1.00e-123 434.00
IUUC-Ggo-045410 Gorilla gorilla 44.24 2.00e-104 370.00
IUUC-Hsa-046358 Homo sapiens 47.72 7.00e-123 431.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 47.72 5.00e-123 432.00
IUUC-Kpa-049351 Komagataella pastoris 28.00 4.00e-41 160.00
IUUC-Lch-049936 Latimeria chalumnae 47.49 1.00e-122 431.00
IUUC-Loc-052476 Lepisosteus oculatus 47.20 5.00e-118 416.00
IUUC-Lma-053170 Leptosphaeria maculans 50.00 2.00e-122 431.00
IUUC-Laf-053713 Loxodonta africana 46.58 4.00e-119 419.00
IUUC-Mcc-054628 Macaca mulatta 47.49 8.00e-123 431.00
IUUC-Meu-055927 Macropus eugenii 40.79 4.00e-65 239.00
IUUC-Mor-056962 Magnaporthe oryzae 47.63 1.00e-114 405.00
IUUC-Mpo-057583 Magnaporthe poae 49.35 2.00e-113 400.00
IUUC-Mla-058819 Melampsora laricipopulina 57.05 3.00e-151 526.00
IUUC-Mga-059945 Meleagris gallopavo 47.49 2.00e-122 430.00
IUUC-Mvi-060403 Microbotryum violaceum 63.22 1.00e-174 603.00
IUUC-Mmr-061289 Microcebus murinus 47.20 4.00e-118 416.00
IUUC-Mdo-061912 Monodelphis domestica 47.95 1.00e-123 434.00
IUUC-Mmu-063253 Mus musculus 47.72 5.00e-123 432.00
IUUC-Mpu-066638 Mustela putorius furo 47.72 5.00e-123 432.00
IUUC-Mlu-067267 Myotis lucifugus 46.68 2.00e-119 420.00
IUUC-Nfi-068571 Neosartorya fischeri 48.09 6.00e-115 405.00
IUUC-Ncr-068895 Neurospora crassa 53.41 1.00e-127 448.00
IUUC-Nle-069087 Nomascus leucogenys 50.15 4.00e-101 359.00
IUUC-Opr-070579 Ochotona princeps 47.72 7.00e-123 432.00
IUUC-Ont-072432 Oreochromis niloticus 48.63 2.00e-125 440.00
IUUC-Oan-073072 Ornithorhynchus anatinus 47.72 5.00e-123 432.00
IUUC-Ocu-074180 Oryctolagus cuniculus 47.72 7.00e-123 432.00
IUUC-Obr-076806 Oryza brachyantha 30.57 2.00e-28 119.00
IUUC-Ola-086815 Oryzias latipes 49.09 5.00e-125 439.00
IUUC-Oga-088219 Otolemur garnettii 46.91 1.00e-118 417.00
IUUC-Oar-090394 Ovis aries 47.72 5.00e-123 432.00
IUUC-Ptr-091517 Pan troglodytes 47.72 5.00e-123 432.00
IUUC-Pan-092421 Papio anubis 47.49 8.00e-123 431.00
IUUC-Psi-093370 Pelodiscus sinensis 47.72 1.00e-122 431.00
IUUC-Pma-094319 Petromyzon marinus 45.09 1.00e-98 350.00
IUUC-Pno-094815 Phaeosphaeria nodorum 50.11 7.00e-124 435.00
IUUC-Pfo-097089 Poecilia formosa 48.40 6.00e-125 438.00
IUUC-Pab-098421 Pongo abelii 47.72 5.00e-123 432.00
IUUC-Pca-100120 Procavia capensis 41.25 5.00e-71 259.00
IUUC-Pva-102960 Pteropus vampyrus 47.49 7.00e-122 428.00
IUUC-Pgr-103538 Puccinia graminis 57.65 2.00e-153 533.00
IUUC-Ptt-103990 Puccinia triticina 51.61 6.00e-60 223.00
IUUC-Pte-104261 Pyrenophora teres 50.43 1.00e-124 437.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 50.65 5.00e-125 439.00
IUUC-Rno-105123 Rattus norvegicus 47.72 5.00e-123 432.00
IUUC-Sce-106208 Saccharomyces cerevisiae 29.26 4.00e-38 150.00
IUUC-Sha-107010 Sarcophilus harrisii 47.95 8.00e-124 435.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.83 5.00e-70 256.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 52.22 1.00e-123 434.00
IUUC-Sar-113309 Sorex araneus 46.50 7.00e-116 408.00
IUUC-Sre-115003 Sporisorium reilianum 83.30 0.00e+00 770.00
IUUC-Ssc-116148 Sus scrofa 47.72 5.00e-123 432.00
IUUC-Tgu-117299 Taeniopygia guttata 47.72 2.00e-122 430.00
IUUC-Tru-118179 Takifugu rubripes 47.72 8.00e-123 431.00
IUUC-Tsy-119493 Tarsius syrichta 47.95 3.00e-122 429.00
IUUC-Tni-120355 Tetraodon nigroviridis 48.17 1.00e-122 431.00
IUUC-Tre-121977 Trichoderma reesei 47.17 1.00e-112 398.00
IUUC-Tvi-122661 Trichoderma virens 46.68 1.00e-110 391.00
IUUC-Tme-127031 Tuber melanosporum 51.66 5.00e-123 432.00
IUUC-Tbe-127492 Tupaia belangeri 45.63 2.00e-59 221.00
IUUC-Ttr-128929 Tursiops truncatus 47.72 6.00e-123 432.00
IUUC-Vda-129837 Verticillium dahliae 51.31 2.00e-115 407.00
IUUC-Vpa-130532 Vicugna pacos 42.49 4.00e-94 336.00
IUUC-Xtr-131985 Xenopus tropicalis 47.95 1.00e-123 434.00
IUUC-Xma-133314 Xiphophorus maculatus 48.63 3.00e-125 439.00
IUUC-Yli-134403 Yarrowia lipolytica 38.72 3.00e-84 303.00
Created Date 25-Jun-2017

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