iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000047056.14	ENST00000358220.5	ENSP00000350954.1
ENSG00000047056.14	ENST00000436154.1	ENSP00000404346.1
ENSG00000047056.14	ENST00000620998.4	ENSP00000478057.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-23	82.6	365	396
UBD/Beta-Prp	2.50e-44	153.3	278	486

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlr 31
           gHtd vt+  f  ++ +vsGsdD t+kvWDl+
   Q: 365  GHTDTVTSAVFtVGDNVVSGSDDRTVKVWDLK 396
           8*******99*733669*************96 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkc..vhtlkgheds 96
           ++h++v+ + ++  ++++ +t+s+d+t  ++dv+t  l++sl gh++e t ++ +p++ + vt+s+D t ++wd++++++  v +++gh+d+
   Q: 278  KSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDT 369
           456666666888889999**********************************************************665422889******* PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkllrtltgghtdsvys 185
           v+s  f   gd +vsGs+drt++vwdl++     +t +  + ++n ++v   +++++  +++r+vrl+d+   + ++l r  ++gh ++v +
   Q: 370  VTSAVFTV-GDNVVSGSDDRTVKVWDLKNMRSPIATIRTDS-AINRINVCVGQKIIALPHDNRQVRLFDMsgvRLARLPRSSRQGHRRMVCC 459
           ***99999.********************988874555555.55555555559*****************555555555555777******* PP
   S: 186  lsfdsng..kelvsgsldgtvklwdlq 210
            +++++     l +++ d++ + w++ 
   Q: 460  SAWSEDHpvCNLFTCGFDRQAIGWNIN 486
           ******9888899***********986 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MPTESASCST ARQTKQKRKS HSLSIRRTNS SEQERTGLPR DMLEGQDSKL PSSVRSTLLE 60
LFGQIEREFE NLYIENLELR REIDTLNERL AAEGQAIDGA ELSKGQLKTK ASHSTSQLSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAACGATGG CCTTTCTGCG GTGTCTGCGA CCGGGACCAA GGCGGAGCAA AGTCGCCGGG 60
GGTGTGGGGT GTTCCACGCT ATGTTGGGAG TGTTCGCTTT CGAGGTACAT GACTACGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0000460--P:maturation of 5.8S rRNA
GO:0000470--P:maturation of LSU-rRNA

KEGG

hsa:22884

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001249	Ailuropoda melanoleuca	95.36	0.00e+00	953.00
IUUC-Apl-003647	Anas platyrhynchos	94.14	0.00e+00	936.00
IUUC-Aca-004759	Anolis carolinensis	93.13	0.00e+00	942.00
IUUC-Ame-011103	Astyanax mexicanus	56.21	2.00e-143	502.00
IUUC-Bta-012718	Bos taurus	94.96	0.00e+00	946.00
IUUC-Cel-018499	Caenorhabditis elegans	43.14	1.00e-95	343.00
IUUC-Cja-019492	Callithrix jacchus	98.38	0.00e+00	1005.00
IUUC-Cfa-020199	Canis familiaris	94.96	0.00e+00	981.00
IUUC-Cpo-022500	Cavia porcellus	90.52	0.00e+00	934.00
IUUC-Csa-023567	Chlorocebus sabaeus	99.19	0.00e+00	1012.00
IUUC-Cho-025071	Choloepus hoffmanni	68.62	0.00e+00	647.00
IUUC-Cin-025460	Ciona intestinalis	45.14	1.00e-103	370.00
IUUC-Csv-026042	Ciona savignyi	46.41	6.00e-108	384.00
IUUC-Dre-028214	Danio rerio	84.01	0.00e+00	862.00
IUUC-Dno-029826	Dasypus novemcinctus	95.66	0.00e+00	818.00
IUUC-Dor-030967	Dipodomys ordii	97.34	0.00e+00	901.00
IUUC-Dme-031936	Drosophila melanogaster	49.26	3.00e-118	418.00
IUUC-Ete-032452	Echinops telfairi	93.52	0.00e+00	955.00
IUUC-Eca-033278	Equus caballus	95.77	0.00e+00	985.00
IUUC-Eeu-034592	Erinaceus europaeus	84.21	0.00e+00	837.00
IUUC-Fca-036431	Felis catus	95.98	0.00e+00	986.00
IUUC-Fal-037149	Ficedula albicollis	92.93	0.00e+00	931.00
IUUC-Gmo-038476	Gadus morhua	79.16	0.00e+00	776.00
IUUC-Gga-041099	Gallus gallus	93.74	0.00e+00	936.00
IUUC-Gac-042374	Gasterosteus aculeatus	83.00	0.00e+00	817.00
IUUC-Ggo-044683	Gorilla gorilla	91.90	0.00e+00	928.00
IUUC-Itr-048870	Ictidomys tridecemlineatus	97.58	0.00e+00	924.00
IUUC-Lch-050571	Latimeria chalumnae	84.03	0.00e+00	877.00
IUUC-Loc-052652	Lepisosteus oculatus	81.80	0.00e+00	864.00
IUUC-Laf-053712	Loxodonta africana	94.59	0.00e+00	970.00
IUUC-Mcc-055521	Macaca mulatta	99.19	0.00e+00	1012.00
IUUC-Meu-056324	Macropus eugenii	90.08	0.00e+00	894.00
IUUC-Mga-060114	Meleagris gallopavo	93.55	0.00e+00	936.00
IUUC-Mmr-061176	Microcebus murinus	96.97	0.00e+00	993.00
IUUC-Mdo-061888	Monodelphis domestica	94.15	0.00e+00	922.00
IUUC-Mmu-063977	Mus musculus	96.57	0.00e+00	995.00
IUUC-Mpu-066220	Mustela putorius furo	82.35	3.00e-179	620.00
IUUC-Mlu-068155	Myotis lucifugus	95.97	0.00e+00	989.00
IUUC-Nle-069964	Nomascus leucogenys	99.39	0.00e+00	1013.00
IUUC-Opr-070925	Ochotona princeps	95.99	8.00e-153	533.00
IUUC-Ont-071317	Oreochromis niloticus	85.48	0.00e+00	836.00
IUUC-Oan-072952	Ornithorhynchus anatinus	94.35	0.00e+00	944.00
IUUC-Ocu-073913	Oryctolagus cuniculus	96.77	0.00e+00	997.00
IUUC-Ola-087024	Oryzias latipes	84.31	0.00e+00	878.00
IUUC-Oga-087945	Otolemur garnettii	96.98	0.00e+00	998.00
IUUC-Oar-089854	Ovis aries	95.36	0.00e+00	939.00
IUUC-Ptr-091486	Pan troglodytes	99.80	0.00e+00	1019.00
IUUC-Pan-091738	Papio anubis	99.19	0.00e+00	1012.00
IUUC-Psi-093953	Pelodiscus sinensis	92.94	0.00e+00	931.00
IUUC-Pma-094560	Petromyzon marinus	74.06	0.00e+00	772.00
IUUC-Pfo-097222	Poecilia formosa	84.62	0.00e+00	834.00
IUUC-Pab-098778	Pongo abelii	94.53	0.00e+00	950.00
IUUC-Pca-100852	Procavia capensis	92.71	0.00e+00	938.00
IUUC-Pva-103130	Pteropus vampyrus	94.63	1.00e-133	469.00
IUUC-Rno-105848	Rattus norvegicus	87.50	0.00e+00	878.00
IUUC-Sha-106750	Sarcophilus harrisii	94.35	0.00e+00	949.00
IUUC-Sar-113749	Sorex araneus	87.85	0.00e+00	885.00
IUUC-Ssc-115691	Sus scrofa	93.54	0.00e+00	930.00
IUUC-Tgu-117365	Taeniopygia guttata	92.32	0.00e+00	885.00
IUUC-Tru-117595	Takifugu rubripes	83.06	0.00e+00	828.00
IUUC-Tsy-118973	Tarsius syrichta	77.35	2.00e-156	545.00
IUUC-Tni-120545	Tetraodon nigroviridis	83.13	0.00e+00	862.00
IUUC-Tbe-127976	Tupaia belangeri	71.66	0.00e+00	695.00
IUUC-Ttr-128472	Tursiops truncatus	93.52	0.00e+00	951.00
IUUC-Xtr-132621	Xenopus tropicalis	91.31	0.00e+00	900.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence