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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046144
UUCD1 version UUC-HoS-00112
Ensembl Protein ID ENSP00000263464.3
UniProt Accession Q13489; Q16628; Q9HC27; Q9UP46; BIRC3_HUMAN
Genbank Protein ID AAC41943.1; AAC50371.1; AAC50507.1; AAC83232.1; AAU88144.1; AAH37420.1; AAG09369.1
Protein Name Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; Cellular inhibitor of apoptosis 2; IAP homolog C; Inhibitor of apoptosis protein 1; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF-signaling complex protein 1
Genbank Nucleotide ID L49432; U45878; U37546; AF070674; AY764389; BC037420; AF178945
Gene Name BIRC3; API2; MIHC; RNF49
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000023445.13 ENST00000263464.7 ENSP00000263464.3
ENSG00000023445.13 ENST00000527309.1 ENSP00000431718.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19279678; 19854138; 18997792; 20097753; 18997792; 16235027
UBD/Alpha-Helix/UBA UBA 18939944
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 2.80e-05 25.7 376 419
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 1    sededkleqlveMGFdreealqaLra....annnleaAveyLld 40
           ++++++++ +veMGF+r++++q  ++    ++ n+  + +++ld
   Q: 376  MMNTPVINAAVEMGFSRSLVKQTVQRkilaTGENYRLVNDLVLD 419
           789**************************66*******999986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
 Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Protein Sequence
(Fasta)
MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV 60
NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS 120
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Protein Fasta Sequence


>IUUC-Hsa-046144|E3,RING;UBD,UBA|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCATTTAAAA GACAGCGTGA GACTCGCGCC CTCCGGCACG GAAAAGGCCA GGCGACAGGT 60
GTCGCTTGAA AAGACTGGGC TTGTCCTTGC TGGTGCATGC GTCGTCGGCC TCTGGGCAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046144|E3,RING;UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001370--BIR_rpt
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01282--BIR_REPEAT_1
PS50143--BIR_REPEAT_2
PS50209--CARD
PS50089--ZF_RING_2
Pfam

PF00653--BIR
PF00619--CARD
SMART

SM00238--BIR
SM00114--CARD
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0016740--F:transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0060546--P:negative regulation of necroptotic process
GO:0038061--P:NIK/NF-kappaB signaling
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0051291--P:protein heterooligomerization
GO:0042981--P:regulation of apoptotic process
GO:2000116--P:regulation of cysteine-type endopeptidase activity
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0060544--P:regulation of necroptotic process
GO:0070424--P:regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:0039535--P:regulation of RIG-I signaling pathway
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0007283--P:spermatogenesis
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
KEGG hsa:330
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002499 Amborella trichopoda 48.21 4.00e-13 68.90
IUUC-Apl-003549 Anas platyrhynchos 70.72 0.00e+00 832.00
IUUC-Acl-008330 Aspergillus clavatus 29.89 7.00e-14 72.80
IUUC-Afu-008813 Aspergillus fumigatus 30.82 1.00e-13 72.40
IUUC-Ani-009424 Aspergillus nidulans 27.12 1.00e-14 75.50
IUUC-Ate-010501 Aspergillus terreus 30.86 1.00e-15 79.00
IUUC-Bta-013105 Bos taurus 78.97 0.00e+00 890.00
IUUC-Cel-018418 Caenorhabditis elegans 44.07 2.00e-09 57.00
IUUC-Cfa-020667 Canis familiaris 74.50 0.00e+00 871.00
IUUC-Csa-024159 Chlorocebus sabaeus 86.75 0.00e+00 1013.00
IUUC-Cho-024929 Choloepus hoffmanni 80.63 0.00e+00 914.00
IUUC-Csv-026182 Ciona savignyi 31.40 2.00e-67 250.00
IUUC-Cgl-026472 Colletotrichum gloeosporioides 36.53 7.00e-20 93.20
IUUC-Cne-027029 Cryptococcus neoformans 31.18 1.00e-12 68.60
IUUC-Eca-034417 Equus caballus 86.26 0.00e+00 989.00
IUUC-Fal-037656 Ficedula albicollis 70.54 0.00e+00 834.00
IUUC-Fox-037889 Fusarium oxysporum 32.10 1.00e-14 75.90
IUUC-Fso-038452 Fusarium solani 32.30 4.00e-13 70.50
IUUC-Ggr-039891 Gaeumannomyces graminis 31.98 7.00e-17 82.80
IUUC-Ggo-044605 Gorilla gorilla 99.01 0.00e+00 1114.00
IUUC-Itr-048379 Ictidomys tridecemlineatus 86.92 0.00e+00 1002.00
IUUC-Kpa-049324 Komagataella pastoris 30.00 2.00e-12 69.30
IUUC-Lma-052958 Leptosphaeria maculans 33.33 1.00e-12 68.90
IUUC-Laf-053720 Loxodonta africana 84.00 0.00e+00 942.00
IUUC-Mcc-055282 Macaca mulatta 86.59 0.00e+00 1014.00
IUUC-Mor-057252 Magnaporthe oryzae 32.60 3.00e-17 84.30
IUUC-Mpo-057489 Magnaporthe poae 31.98 1.00e-16 82.00
IUUC-Mtr-057913 Medicago truncatula 29.29 4.00e-09 54.70
IUUC-Mvi-060388 Microbotryum violaceum 26.63 1.00e-06 48.50
IUUC-Mmr-060719 Microcebus murinus 88.41 0.00e+00 1014.00
IUUC-Mmu-063340 Mus musculus 74.01 0.00e+00 875.00
IUUC-Mac-065489 Musa acuminata 27.72 1.00e-09 57.00
IUUC-Mpu-066740 Mustela putorius furo 71.69 0.00e+00 852.00
IUUC-Mlu-067988 Myotis lucifugus 82.28 0.00e+00 922.00
IUUC-Ncr-068787 Neurospora crassa 32.50 5.00e-14 73.20
IUUC-Nle-069942 Nomascus leucogenys 97.35 0.00e+00 1102.00
IUUC-Opr-070597 Ochotona princeps 83.11 0.00e+00 956.00
IUUC-Ocu-074698 Oryctolagus cuniculus 86.92 0.00e+00 1009.00
IUUC-Osa-085816 Oryza sativa 40.43 2.00e-08 52.80
IUUC-Oga-089080 Otolemur garnettii 80.83 0.00e+00 950.00
IUUC-Oar-089496 Ovis aries 85.64 0.00e+00 959.00
IUUC-Ptr-091203 Pan troglodytes 99.01 0.00e+00 1116.00
IUUC-Pno-094971 Phaeosphaeria nodorum 35.14 5.00e-14 73.20
IUUC-Ppa-095167 Physcomitrella patens 42.86 7.00e-12 65.10
IUUC-Pte-104098 Pyrenophora teres 35.00 3.00e-16 79.70
IUUC-Pyt-104561 Pyrenophora triticirepentis 34.59 3.00e-16 79.70
IUUC-Rno-105292 Rattus norvegicus 74.01 0.00e+00 881.00
IUUC-Spo-108317 Schizosaccharomyces pombe 27.17 3.00e-16 81.30
IUUC-Smo-109461 Selaginella moellendorffii 42.59 4.00e-11 61.60
IUUC-Sly-110837 Solanum lycopersicum 50.00 3.00e-09 56.20
IUUC-Stu-112233 Solanum tuberosum 50.00 1.00e-09 57.80
IUUC-Sar-113239 Sorex araneus 76.53 0.00e+00 841.00
IUUC-Tgu-116931 Taeniopygia guttata 70.05 0.00e+00 843.00
IUUC-Tsy-118958 Tarsius syrichta 81.94 8.00e-177 613.00
IUUC-Tre-121884 Trichoderma reesei 32.52 5.00e-13 70.10
IUUC-Tvi-122552 Trichoderma virens 33.12 3.00e-13 70.90
IUUC-Ttr-128766 Tursiops truncatus 85.76 0.00e+00 996.00
Created Date 25-Jun-2017

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