iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003493

Ensembl Protein ID

ENSAPLP00000001910.1

UniProt Accession

U3I3T9; U3I3T9_ANAPL

Genbank Protein ID

ENSAPLP00000001910

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01080048

Gene Name

HECTD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000002424.1	ENSAPLT00000002489.1	ENSAPLP00000001910.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.40e-121	403.3	2161	2622

Active Site

Position(s)	Description	Evidence
2591	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l++++  d+e++q++   glk+p                     
   Q: 2161 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDDfpDDESRQVDIGGGLKPPgyyvqrscglftapfpqdsde 2246
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2247 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsleedsk 2333
           *************************************99999999999999999999999999999999999999988888887777 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e ++p+++++lkeik++a +                                  +ie+lgl+
   Q: 2334 sefildppkpkppawFNGILTWEDFELINPHRARFLKEIKDLAIKrrqilsnkslsedekntklqelmlknpsgsgpplSIEDLGLN 2420
           7777777666666666668***********************933445555566777778889999999999*************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafr...eGfneviplellslFteeelellicGee 222
           ++f++s++++g t+++ LkpgGe++ Vt++N+eeYv+l++++++++gi++q+eafr   +Gfn+v+p+e+ls+F++ee+++++cG+ 
   Q: 2421 FQFCPSSKVYGFTAVD-LKPGGEDETVTMDNAEEYVDLMFDFCMHTGIQKQMEAFReikDGFNRVFPMEKLSSFSHEEVQMILCGN- 2505
           *************999.**************************************84446**************************. PP
   S: 223  eidvedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnT 303
             +++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nT
   Q: 2506 --QSPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNT 2590
           ..6666666665555555********************************************************************* PP
   S: 304  CfnyLkLPeYsskeilkekLlyAieetkgFels 336
           C++yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2591 CVHYLKLPEYSSEEIMRERLLAATME-KGFHLN 2622
           **************************.****86 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGATG TGGACCCAGA CACGTTGCTG GAATGGCTGC AGATGGGGCA GGGAGATGAA 60
AGGGATATGC AGCTAATAGC GCTGGAACAG CTCTGCATGC TACTTCTGAT GTCAGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	95.39	0.00e+00	4497.00
IUUC-Aca-004521	Anolis carolinensis	97.74	0.00e+00	2846.00
IUUC-Ame-011258	Astyanax mexicanus	91.29	0.00e+00	2389.00
IUUC-Bta-012835	Bos taurus	95.42	0.00e+00	4509.00
IUUC-Cel-018153	Caenorhabditis elegans	52.40	2.00e-173	603.00
IUUC-Cja-019174	Callithrix jacchus	94.52	0.00e+00	4421.00
IUUC-Cfa-021115	Canis familiaris	95.31	0.00e+00	4454.00
IUUC-Cpo-022382	Cavia porcellus	91.41	0.00e+00	4261.00
IUUC-Csa-023230	Chlorocebus sabaeus	95.58	0.00e+00	4506.00
IUUC-Cho-024711	Choloepus hoffmanni	93.62	0.00e+00	1613.00
IUUC-Cin-025342	Ciona intestinalis	53.00	0.00e+00	1380.00
IUUC-Csv-026031	Ciona savignyi	52.10	0.00e+00	1417.00
IUUC-Dre-027435	Danio rerio	87.65	0.00e+00	4126.00
IUUC-Dno-029954	Dasypus novemcinctus	95.50	0.00e+00	4477.00
IUUC-Dor-030734	Dipodomys ordii	93.37	0.00e+00	1421.00
IUUC-Dme-031739	Drosophila melanogaster	59.80	0.00e+00	1630.00
IUUC-Ete-033192	Echinops telfairi	90.30	0.00e+00	1182.00
IUUC-Eca-033434	Equus caballus	95.23	0.00e+00	4480.00
IUUC-Eeu-035031	Erinaceus europaeus	82.57	0.00e+00	1073.00
IUUC-Fca-035998	Felis catus	93.86	0.00e+00	4390.00
IUUC-Fal-037468	Ficedula albicollis	97.05	0.00e+00	2845.00
IUUC-Gmo-038495	Gadus morhua	90.95	0.00e+00	1371.00
IUUC-Gga-040736	Gallus gallus	98.93	0.00e+00	2858.00
IUUC-Gac-041777	Gasterosteus aculeatus	91.47	0.00e+00	2411.00
IUUC-Ggo-044677	Gorilla gorilla	91.21	0.00e+00	4225.00
IUUC-Hsa-045879	Homo sapiens	95.58	0.00e+00	4506.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	95.61	0.00e+00	4506.00
IUUC-Lch-050444	Latimeria chalumnae	92.20	0.00e+00	4222.00
IUUC-Loc-051986	Lepisosteus oculatus	88.54	0.00e+00	4163.00
IUUC-Laf-054230	Loxodonta africana	95.31	0.00e+00	4434.00
IUUC-Mcc-054787	Macaca mulatta	95.58	0.00e+00	4506.00
IUUC-Meu-056502	Macropus eugenii	88.02	0.00e+00	1303.00
IUUC-Mga-059409	Meleagris gallopavo	93.67	0.00e+00	2140.00
IUUC-Mmr-061667	Microcebus murinus	95.28	0.00e+00	4478.00
IUUC-Mdo-061960	Monodelphis domestica	95.74	0.00e+00	4502.00
IUUC-Mmu-063941	Mus musculus	94.74	0.00e+00	4441.00
IUUC-Mpu-065939	Mustela putorius furo	95.46	0.00e+00	4502.00
IUUC-Mlu-068112	Myotis lucifugus	95.31	0.00e+00	4469.00
IUUC-Nle-069001	Nomascus leucogenys	95.50	0.00e+00	4501.00
IUUC-Opr-071222	Ochotona princeps	93.08	0.00e+00	2086.00
IUUC-Ont-072101	Oreochromis niloticus	86.57	0.00e+00	2629.00
IUUC-Oan-072814	Ornithorhynchus anatinus	95.77	0.00e+00	4489.00
IUUC-Ocu-074011	Oryctolagus cuniculus	95.46	0.00e+00	4500.00
IUUC-Ola-086412	Oryzias latipes	91.68	0.00e+00	2421.00
IUUC-Oar-089668	Ovis aries	95.50	0.00e+00	4506.00
IUUC-Ptr-090517	Pan troglodytes	94.93	0.00e+00	4460.00
IUUC-Pan-091849	Papio anubis	92.94	0.00e+00	4333.00
IUUC-Psi-093390	Pelodiscus sinensis	95.47	0.00e+00	2756.00
IUUC-Pma-094628	Petromyzon marinus	83.20	0.00e+00	1590.00
IUUC-Pfo-097075	Poecilia formosa	84.59	0.00e+00	2631.00
IUUC-Pab-098176	Pongo abelii	95.58	0.00e+00	4506.00
IUUC-Pca-101123	Procavia capensis	88.77	0.00e+00	2341.00
IUUC-Pva-103008	Pteropus vampyrus	88.62	0.00e+00	1779.00
IUUC-Rno-105885	Rattus norvegicus	95.00	0.00e+00	4482.00
IUUC-Sha-107048	Sarcophilus harrisii	95.68	0.00e+00	4500.00
IUUC-Sar-113071	Sorex araneus	93.45	0.00e+00	1275.00
IUUC-Ssc-115963	Sus scrofa	95.16	0.00e+00	4481.00
IUUC-Tgu-117167	Taeniopygia guttata	96.08	0.00e+00	2689.00
IUUC-Tru-118626	Takifugu rubripes	92.75	0.00e+00	2486.00
IUUC-Tsy-119504	Tarsius syrichta	94.02	0.00e+00	2261.00
IUUC-Tni-119877	Tetraodon nigroviridis	91.77	0.00e+00	2422.00
IUUC-Tbe-127602	Tupaia belangeri	89.51	0.00e+00	1026.00
IUUC-Ttr-128394	Tursiops truncatus	93.29	0.00e+00	2981.00
IUUC-Vpa-130280	Vicugna pacos	94.60	0.00e+00	4274.00
IUUC-Xtr-131787	Xenopus tropicalis	86.81	0.00e+00	2627.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence