iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000170852.10	ENST00000304056.8	ENSP00000302586.4
ENSG00000170852.10	ENST00000621876.1	ENSP00000481197.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	miRcode
RAID2
Protein-protein Interaction
IID	Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.30e-19	69.8	31	98
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.20e-08	34.2	131	161

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +D++l+v+g+ef++hk vLa++Ss+F+a+f ++l+esk +  v+++ v++  ++ ++ + Ytg l +n+
   Q: 31   TDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESK-QTHVHLRNVDAATLQIIITYAYTGNLAMND 98
           79************************************.**************************9985 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           eNc+ +l+fAdl++c++Lk++a +++++ F+
   Q: 131  ENCVRLLSFADLFSCEELKQSAKRMVEHKFT 161
           9***************************996 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSTQDERQIN TEYAVSLLEQ LKLFYEQQLF TDIVLIVEGT EFPCHKMVLA TCSSYFRAMF 60
MSGLSESKQT HVHLRNVDAA TLQIIITYAY TGNLAMNDST VEQLYETACF LQVEDVLQRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCCCAGTG TTTTTCTCTT TTGTAATCTT TATAGGTGGC CAAATTACAA TTCTAGACAA 60
TGAGATGTTT GTGGAAGTCT GCTGAGTTTG GGAGATGTAG TATCCTGAGA AAGCTTTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

hsa:25948

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001980	Ailuropoda melanoleuca	99.36	0.00e+00	1234.00
IUUC-Apl-003925	Anas platyrhynchos	95.82	3.00e-175	607.00
IUUC-Aca-004617	Anolis carolinensis	92.13	0.00e+00	1139.00
IUUC-Ame-011278	Astyanax mexicanus	78.43	0.00e+00	1016.00
IUUC-Cja-019947	Callithrix jacchus	99.84	0.00e+00	1239.00
IUUC-Cfa-020881	Canis familiaris	98.57	0.00e+00	1228.00
IUUC-Cpo-022211	Cavia porcellus	98.72	0.00e+00	1229.00
IUUC-Csa-023683	Chlorocebus sabaeus	100.00	0.00e+00	1241.00
IUUC-Cho-024791	Choloepus hoffmanni	98.85	0.00e+00	1011.00
IUUC-Dre-028364	Danio rerio	78.12	0.00e+00	1022.00
IUUC-Dno-028875	Dasypus novemcinctus	99.20	0.00e+00	1271.00
IUUC-Dor-030193	Dipodomys ordii	97.01	0.00e+00	1028.00
IUUC-Dse-031236	Dothistroma septosporum	21.19	4.00e-03	37.40
IUUC-Ete-033079	Echinops telfairi	97.68	0.00e+00	996.00
IUUC-Eca-033435	Equus caballus	99.52	0.00e+00	1236.00
IUUC-Eeu-035017	Erinaceus europaeus	85.87	0.00e+00	1122.00
IUUC-Fca-036446	Felis catus	98.88	0.00e+00	1229.00
IUUC-Fal-037576	Ficedula albicollis	94.70	0.00e+00	1160.00
IUUC-Gmo-038975	Gadus morhua	78.53	0.00e+00	1054.00
IUUC-Gga-041077	Gallus gallus	94.38	0.00e+00	1186.00
IUUC-Gac-041424	Gasterosteus aculeatus	80.06	0.00e+00	1079.00
IUUC-Ggo-045425	Gorilla gorilla	91.65	0.00e+00	1123.00
IUUC-Itr-048782	Ictidomys tridecemlineatus	99.04	0.00e+00	1230.00
IUUC-Lch-049911	Latimeria chalumnae	88.28	0.00e+00	1128.00
IUUC-Loc-051799	Lepisosteus oculatus	80.96	0.00e+00	1070.00
IUUC-Laf-054074	Loxodonta africana	99.04	0.00e+00	1229.00
IUUC-Mga-059314	Meleagris gallopavo	94.22	0.00e+00	1184.00
IUUC-Mmr-061398	Microcebus murinus	99.38	0.00e+00	631.00
IUUC-Mdo-062664	Monodelphis domestica	94.86	0.00e+00	1186.00
IUUC-Mmu-064390	Mus musculus	98.56	0.00e+00	1226.00
IUUC-Mpu-065709	Mustela putorius furo	99.36	0.00e+00	1234.00
IUUC-Mlu-067793	Myotis lucifugus	97.24	0.00e+00	1182.00
IUUC-Nle-070079	Nomascus leucogenys	100.00	0.00e+00	1241.00
IUUC-Opr-070899	Ochotona princeps	99.20	0.00e+00	1234.00
IUUC-Ont-071857	Oreochromis niloticus	80.06	0.00e+00	1059.00
IUUC-Oan-073592	Ornithorhynchus anatinus	86.99	0.00e+00	1075.00
IUUC-Ocu-073873	Oryctolagus cuniculus	99.27	0.00e+00	790.00
IUUC-Ola-087086	Oryzias latipes	79.74	0.00e+00	1065.00
IUUC-Oga-088930	Otolemur garnettii	98.72	0.00e+00	1229.00
IUUC-Oar-089834	Ovis aries	98.23	0.00e+00	1228.00
IUUC-Ptr-090654	Pan troglodytes	99.84	0.00e+00	1239.00
IUUC-Pan-092621	Papio anubis	100.00	0.00e+00	1241.00
IUUC-Psi-093224	Pelodiscus sinensis	94.38	0.00e+00	1198.00
IUUC-Pfo-096292	Poecilia formosa	80.38	0.00e+00	1083.00
IUUC-Pab-098136	Pongo abelii	98.88	0.00e+00	1227.00
IUUC-Pca-100915	Procavia capensis	96.30	0.00e+00	729.00
IUUC-Pva-102336	Pteropus vampyrus	98.39	0.00e+00	1224.00
IUUC-Pyt-104602	Pyrenophora triticirepentis	20.81	3.00e-06	47.80
IUUC-Rno-106068	Rattus norvegicus	98.72	0.00e+00	1228.00
IUUC-Sha-107251	Sarcophilus harrisii	94.22	0.00e+00	1177.00
IUUC-Sar-113206	Sorex araneus	97.11	0.00e+00	1201.00
IUUC-Ssc-115475	Sus scrofa	98.72	0.00e+00	1225.00
IUUC-Tru-118290	Takifugu rubripes	79.74	0.00e+00	1050.00
IUUC-Tsy-119202	Tarsius syrichta	98.94	9.00e-151	527.00
IUUC-Tni-119756	Tetraodon nigroviridis	79.43	0.00e+00	1044.00
IUUC-Tbe-127231	Tupaia belangeri	96.15	0.00e+00	1182.00
IUUC-Ttr-128297	Tursiops truncatus	98.56	0.00e+00	1230.00
IUUC-Vpa-130190	Vicugna pacos	94.38	0.00e+00	785.00
IUUC-Xtr-132385	Xenopus tropicalis	84.91	0.00e+00	1081.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence