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Tag Content
UUCD2 ID IUUC-Bta-012639
UUCD1 version UUC-BoT-00136
Ensembl Protein ID ENSBTAP00000037915.4
UniProt Accession Q3T139; R146B_BOVIN
Genbank Protein ID AAI02140.1
Protein Name E3 ubiquitin-protein ligase RNF146-B; RING finger protein 146-B; RING-type E3 ubiquitin transferase RNF146-B
Genbank Nucleotide ID BC102139
Gene Name RNF146B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000034531.3 ENSBTAT00000038099.4 ENSBTAP00000037915.4
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 92.76 5.00e-149 525.00 IUUC-Hsa-045790
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity).
 E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity).
Protein Sequence
(Fasta)
MMAGCGEIDH SINMLPTNRK ANESCSNTAP SLTVPECAIC LQTCVHPVSL PCKHVFCYLC 60
VKGASWLGKR CALCRQEIPE DFLDKPTLLS PEELKAASRG NGEYAWYYEG RNGWWQYDER 120
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Protein Fasta Sequence


>IUUC-Bta-012639|E3,RING|Bos taurus
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Nucleotide Sequence
(Fasta)
AGGCTCGGAG GCCGAAGAGA AAAAGACGGC GAGGGCGGCT TCGGCTGTGG CCACAGAGGT 60
GGGAGTCGGG GCGAAGCCCA CTCGAGGGGC AGGGTGAAAG TGAAGCCACT TCTGGGTCCT 120
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Nucleotide Fasta Sequence


>IUUC-Bta-012639|E3,RING|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033509--RNF146
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50918--WWE
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02825--WWE
SMART

SM00184--RING
SM00678--WWE
Gene Ontology

GO:0005829--C:cytosol
GO:0072572--F:poly-ADP-D-ribose binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG bta:767901
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002237 Ailuropoda melanoleuca 91.36 3.00e-140 491.00
IUUC-Apl-004143 Anas platyrhynchos 84.38 2.00e-129 455.00
IUUC-Aca-004557 Anolis carolinensis 80.91 2.00e-128 451.00
IUUC-Ame-011088 Astyanax mexicanus 61.48 8.00e-83 300.00
IUUC-Cel-018462 Caenorhabditis elegans 28.35 5.00e-19 87.40
IUUC-Cja-019397 Callithrix jacchus 91.92 5.00e-144 503.00
IUUC-Cfa-021140 Canis familiaris 90.53 2.00e-150 525.00
IUUC-Cpo-021387 Cavia porcellus 89.33 5.00e-155 540.00
IUUC-Csa-023503 Chlorocebus sabaeus 90.68 3.00e-140 491.00
IUUC-Cho-024895 Choloepus hoffmanni 87.83 9.00e-124 436.00
IUUC-Cin-025455 Ciona intestinalis 52.56 2.00e-43 167.00
IUUC-Dre-028824 Danio rerio 58.11 1.00e-80 293.00
IUUC-Dno-029269 Dasypus novemcinctus 89.97 2.00e-144 504.00
IUUC-Dor-030592 Dipodomys ordii 88.89 2.00e-148 518.00
IUUC-Dme-031618 Drosophila melanogaster 58.00 8.00e-56 211.00
IUUC-Ete-032478 Echinops telfairi 91.53 1.00e-152 532.00
IUUC-Eca-033389 Equus caballus 95.18 1.00e-165 575.00
IUUC-Fca-035488 Felis catus 92.39 2.00e-148 518.00
IUUC-Fal-037087 Ficedula albicollis 84.66 8.00e-142 496.00
IUUC-Gmo-039713 Gadus morhua 36.62 8.00e-08 55.10
IUUC-Gga-040401 Gallus gallus 85.51 5.00e-134 470.00
IUUC-Gac-042412 Gasterosteus aculeatus 63.67 3.00e-86 311.00
IUUC-Ggo-045417 Gorilla gorilla 94.72 1.00e-140 492.00
IUUC-Hsa-045790 Homo sapiens 91.64 2.00e-143 501.00
IUUC-Itr-048820 Ictidomys tridecemlineatus 91.55 2.00e-152 531.00
IUUC-Lch-049493 Latimeria chalumnae 70.45 2.00e-112 398.00
IUUC-Loc-052927 Lepisosteus oculatus 68.85 5.00e-97 347.00
IUUC-Laf-053904 Loxodonta africana 89.69 4.00e-146 510.00
IUUC-Mcc-055427 Macaca mulatta 87.78 8.00e-144 503.00
IUUC-Mmr-060580 Microcebus murinus 91.04 2.00e-142 498.00
IUUC-Mdo-062094 Monodelphis domestica 96.97 2.00e-78 283.00
IUUC-Mmu-063363 Mus musculus 89.14 9.00e-147 512.00
IUUC-Mpu-066816 Mustela putorius furo 93.02 5.00e-148 516.00
IUUC-Mlu-067433 Myotis lucifugus 92.20 4.00e-163 566.00
IUUC-Nle-068986 Nomascus leucogenys 91.09 6.00e-157 546.00
IUUC-Opr-071117 Ochotona princeps 39.06 8.00e-07 51.20
IUUC-Ont-072670 Oreochromis niloticus 58.39 2.00e-80 292.00
IUUC-Oan-073330 Ornithorhynchus anatinus 87.56 3.00e-107 380.00
IUUC-Ocu-074161 Oryctolagus cuniculus 93.43 2.00e-154 538.00
IUUC-Ola-086902 Oryzias latipes 68.92 2.00e-83 302.00
IUUC-Oga-089159 Otolemur garnettii 91.81 1.00e-164 572.00
IUUC-Oar-089586 Ovis aries 97.16 9.00e-150 522.00
IUUC-Ptr-090987 Pan troglodytes 91.64 2.00e-143 501.00
IUUC-Pan-091867 Papio anubis 87.74 4.00e-143 500.00
IUUC-Psi-094024 Pelodiscus sinensis 85.80 1.00e-139 489.00
IUUC-Pma-094453 Petromyzon marinus 63.91 7.00e-65 240.00
IUUC-Pfo-097108 Poecilia formosa 70.73 2.00e-83 302.00
IUUC-Pab-097997 Pongo abelii 91.85 6.00e-149 520.00
IUUC-Pca-100260 Procavia capensis 90.65 2.00e-157 548.00
IUUC-Pva-103140 Pteropus vampyrus 91.39 1.00e-151 529.00
IUUC-Rno-105795 Rattus norvegicus 85.35 2.00e-147 514.00
IUUC-Sha-107033 Sarcophilus harrisii 88.35 3.00e-145 507.00
IUUC-Ssc-116395 Sus scrofa 92.76 2.00e-164 571.00
IUUC-Tgu-116685 Taeniopygia guttata 83.14 3.00e-134 471.00
IUUC-Tru-118014 Takifugu rubripes 65.22 2.00e-85 308.00
IUUC-Tsy-119326 Tarsius syrichta 86.87 5.00e-160 556.00
IUUC-Tni-120322 Tetraodon nigroviridis 69.95 4.00e-82 298.00
IUUC-Tbe-128067 Tupaia belangeri 91.11 3.00e-151 527.00
IUUC-Ttr-128530 Tursiops truncatus 93.61 8.00e-153 532.00
IUUC-Vpa-130322 Vicugna pacos 94.15 2.00e-154 538.00
IUUC-Xtr-132606 Xenopus tropicalis 68.18 6.00e-119 420.00
Created Date 25-Jun-2017

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