iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023334

Ensembl Protein ID

ENSCSAP00000008004.1

UniProt Accession

A0A0D9RHB5; A0A0D9RHB5_CHLSB

Genbank Protein ID

ENSCSAP00000008004

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01115941

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000011809.1	ENSCSAT00000009898.1	ENSCSAP00000008004.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-135	452.2	568	897

Active Site

Position(s)	Description	Evidence
867	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 568  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 656
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv+++r
   Q: 657  IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWR 740
           *********************************99...6666..7******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy++++++iqwFw+++ +++se+r ++LqFvTg
   Q: 741  FVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTG 829
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 830  TSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 897
           *******************************************************************8 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MATCAVEVFG LLEDEENSRI VRVKVIAGIG LAKKDILGAS DPYVRVTLYD PMNGVLTSVQ 60
TKTIKKSLNP KWNEEILFRV HPQQHRLLFE VFDENRLTRD DFLGQVDVPL YPLPTENPRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCTCCACA GTTGCCTGCC CTGGGCGGGG GCGAGCGTGT CCGGTTTGTT GGAAGCGTTC 60
GGAAATGGCA ACTTGCGCGG TGGAGGTGTT CGGGCTCCTG GAGGACGAGG TGCGGGGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	95.14	0.00e+00	1529.00
IUUC-Apl-003886	Anas platyrhynchos	75.89	0.00e+00	1396.00
IUUC-Ame-011138	Astyanax mexicanus	83.96	0.00e+00	844.00
IUUC-Bgr-012148	Blumeria graminis	46.92	7.00e-152	531.00
IUUC-Bta-012453	Bos taurus	92.34	0.00e+00	1429.00
IUUC-Cel-018564	Caenorhabditis elegans	53.38	5.00e-180	624.00
IUUC-Cja-019034	Callithrix jacchus	96.39	0.00e+00	1419.00
IUUC-Cfa-020258	Canis familiaris	95.39	0.00e+00	1469.00
IUUC-Cpo-021648	Cavia porcellus	90.68	0.00e+00	1615.00
IUUC-Cin-025157	Ciona intestinalis	67.08	0.00e+00	786.00
IUUC-Dre-027924	Danio rerio	67.89	0.00e+00	1030.00
IUUC-Dno-029159	Dasypus novemcinctus	90.08	0.00e+00	1310.00
IUUC-Dme-032166	Drosophila melanogaster	67.99	0.00e+00	706.00
IUUC-Ete-032409	Echinops telfairi	86.63	0.00e+00	1179.00
IUUC-Eca-033441	Equus caballus	95.23	0.00e+00	1614.00
IUUC-Eeu-034546	Erinaceus europaeus	75.19	0.00e+00	1164.00
IUUC-Fca-036384	Felis catus	94.66	0.00e+00	1505.00
IUUC-Fal-037547	Ficedula albicollis	81.76	0.00e+00	1419.00
IUUC-Gmo-039679	Gadus morhua	68.40	0.00e+00	1230.00
IUUC-Gga-040524	Gallus gallus	82.61	0.00e+00	1440.00
IUUC-Gac-042607	Gasterosteus aculeatus	66.99	0.00e+00	1225.00
IUUC-Hsa-046479	Homo sapiens	98.88	0.00e+00	1559.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	83.80	0.00e+00	1177.00
IUUC-Lch-050445	Latimeria chalumnae	74.20	0.00e+00	1199.00
IUUC-Loc-052645	Lepisosteus oculatus	73.77	0.00e+00	1326.00
IUUC-Laf-053638	Loxodonta africana	83.92	0.00e+00	1335.00
IUUC-Mcc-055585	Macaca mulatta	99.75	0.00e+00	1527.00
IUUC-Meu-056897	Macropus eugenii	95.47	6.00e-170	591.00
IUUC-Mga-059362	Meleagris gallopavo	76.00	0.00e+00	1391.00
IUUC-Mvi-060395	Microbotryum violaceum	53.51	1.00e-148	520.00
IUUC-Mmr-061061	Microcebus murinus	94.78	0.00e+00	1510.00
IUUC-Mmu-063318	Mus musculus	80.79	0.00e+00	1379.00
IUUC-Mpu-066567	Mustela putorius furo	95.13	0.00e+00	1698.00
IUUC-Mlu-068148	Myotis lucifugus	94.53	0.00e+00	1483.00
IUUC-Ncr-068918	Neurospora crassa	47.66	1.00e-154	540.00
IUUC-Nle-069225	Nomascus leucogenys	98.51	0.00e+00	1569.00
IUUC-Oan-073019	Ornithorhynchus anatinus	85.50	0.00e+00	1463.00
IUUC-Ocu-074409	Oryctolagus cuniculus	93.66	0.00e+00	1504.00
IUUC-Oga-088241	Otolemur garnettii	87.22	0.00e+00	1337.00
IUUC-Oar-089797	Ovis aries	95.29	0.00e+00	1557.00
IUUC-Ptr-091629	Pan troglodytes	97.06	0.00e+00	1393.00
IUUC-Pan-092285	Papio anubis	99.69	0.00e+00	1188.00
IUUC-Psi-093618	Pelodiscus sinensis	82.86	0.00e+00	1295.00
IUUC-Pfo-097145	Poecilia formosa	69.68	0.00e+00	1201.00
IUUC-Pab-098394	Pongo abelii	97.44	0.00e+00	1677.00
IUUC-Pca-100568	Procavia capensis	78.44	0.00e+00	1119.00
IUUC-Pgr-103620	Puccinia graminis	52.60	5.00e-146	511.00
IUUC-Ptt-103806	Puccinia triticina	51.82	1.00e-119	424.00
IUUC-Pte-104016	Pyrenophora teres	48.28	2.00e-159	555.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	48.28	2.00e-159	555.00
IUUC-Rno-106095	Rattus norvegicus	81.02	0.00e+00	1404.00
IUUC-Sha-107370	Sarcophilus harrisii	79.63	0.00e+00	1313.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.99	3.00e-156	545.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.99	2.00e-155	543.00
IUUC-Sre-114929	Sporisorium reilianum	47.01	1.00e-153	537.00
IUUC-Tgu-117474	Taeniopygia guttata	81.84	0.00e+00	1441.00
IUUC-Tru-117675	Takifugu rubripes	64.85	0.00e+00	1188.00
IUUC-Tni-119993	Tetraodon nigroviridis	64.19	0.00e+00	1159.00
IUUC-Tvi-122595	Trichoderma virens	46.46	3.00e-152	532.00
IUUC-Tme-126897	Tuber melanosporum	49.10	7.00e-146	511.00
IUUC-Tbe-127408	Tupaia belangeri	86.53	0.00e+00	1144.00
IUUC-Ttr-128437	Tursiops truncatus	85.12	0.00e+00	1167.00
IUUC-Vpa-130503	Vicugna pacos	88.89	0.00e+00	1274.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence