iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090140

Ensembl Protein ID

ENSOARP00000006851.1

UniProt Accession

W5P8U4; W5P8U4_SHEEP

Genbank Protein ID

ENSOARP00000006851

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01060843

Gene Name

USP35

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000006396.1	ENSOART00000006955.1	ENSOARP00000006851.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.60e-77	260.5	442	919

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtCY+NS+LQ+L++ +++r+++l+     l e    +++++l+++lq lf+ l +s++ a+sp+++l+a +   + fs   qq
   Q: 442  GLINLGNTCYVNSILQALFMASDFRHCVLR-----LTE----HNSQPLMTKLQWLFAFLEHSQRPAISPENFLSASW--TPWFSPGTQQ 519
           9*****************************.....332....23579***************************998..677******* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           D++E+l++lld+l+ee      k+ ++ +++ k+++s + +e+++  + + ++++F+g++ ++i cl+c nvssree f+dlsl++p  
   Q: 520  DCSEYLKYLLDRLHEEE-----KTGTRICQKLKQSSSPSPPEEPPVPSATSVEKMFGGKIVTRICCLRCLNVSSREEAFTDLSLAFPPP 603
           *****************.....67888888888999999999*********************************************88 PP
   S: 180  eetkke................................................................................... 185
           e +                                                                                      
   Q: 604  ERCRRHhhhhhhrrrrlgsvllpaedagaqepgsagpqrqrkhcitggvpptildmeglgphglggqsgqekerggervgekgeeerek 692
           87766688999****************************************************************************** PP
   S: 186  .................................................................slqdcLesftkeeelegenkyyce 209
                                                                            s+ d+ + f ++e+l++en+y+ce
   Q: 693  ekveeekemeeeraaqddeeeevkevvkekvkeekekeaqekeaaagpgpgtlqsaaaasgggsrSVLDLVNYFLSPERLTSENRYHCE 781
           ***************************************************************************************** PP
   S: 210  kckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYva 297
           +c ++q+aek ++l++ P++Lil L Rfsf+ ++++r+ki +      +L l+    +        + Y+L++vvvHsG s++sGHY++
   Q: 782  SCASLQDAEKVVELSQGPRYLILTLLRFSFDLRTMRRRKILDDXL---RLPLA--GGR-------GQAYDLCSVVVHSGlSSESGHYYC 858
           **************************************9976543...23344..333.......789********************* PP
   S: 298  yvkn................ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
           y+++                 +++W+lf+D++V+ ++ e+v + t+    +taYvlfY++r
   Q: 859  YAREgaarpapaagaaerpePDNQWYLFNDTRVSFSSFESVSNVTSffpkDTAYVLFYRQR 919
           ****99999999999988888999*******************999************985 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MDKILEAVVT SSYPASVKQG LVRRVLEAAR QPLEREQCLA LLALGTRLYV SGADELPRRV 60
GCQLLHVAGR HHPEVFAEFF SARRVLRLLQ GGAGPPSARA LACVQLCLQL LPEGPGADEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGGCCACC ATGGACAAGA TCCTGGAGGC CGTGGTGACA TCATCATACC CGGCGAGCGT 60
GAAGCAAGGG CTCGTGCGGC GCGTGCTGGA GGCGGCGCGG CAGCCGCTGG AGCGCGAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001744	Ailuropoda melanoleuca	80.44	0.00e+00	989.00
IUUC-Apl-004121	Anas platyrhynchos	67.06	0.00e+00	898.00
IUUC-Aca-005070	Anolis carolinensis	64.52	9.00e-168	583.00
IUUC-Bta-012545	Bos taurus	99.24	0.00e+00	1241.00
IUUC-Cja-019731	Callithrix jacchus	91.35	0.00e+00	1162.00
IUUC-Cfa-020095	Canis familiaris	92.22	0.00e+00	1183.00
IUUC-Cpo-021961	Cavia porcellus	89.36	0.00e+00	1174.00
IUUC-Csa-023167	Chlorocebus sabaeus	90.66	0.00e+00	1152.00
IUUC-Cin-025604	Ciona intestinalis	26.92	4.00e-40	158.00
IUUC-Dno-029186	Dasypus novemcinctus	82.28	0.00e+00	840.00
IUUC-Dor-030538	Dipodomys ordii	82.67	0.00e+00	1028.00
IUUC-Dme-031871	Drosophila melanogaster	32.67	2.00e-45	177.00
IUUC-Eca-033279	Equus caballus	96.33	0.00e+00	909.00
IUUC-Eeu-035120	Erinaceus europaeus	71.13	0.00e+00	852.00
IUUC-Fca-035969	Felis catus	91.18	0.00e+00	894.00
IUUC-Fal-037625	Ficedula albicollis	67.41	0.00e+00	901.00
IUUC-Gga-040767	Gallus gallus	67.01	0.00e+00	898.00
IUUC-Ggo-045323	Gorilla gorilla	90.62	0.00e+00	915.00
IUUC-Hsa-046124	Homo sapiens	91.58	0.00e+00	1149.00
IUUC-Itr-048704	Ictidomys tridecemlineatus	93.28	0.00e+00	1175.00
IUUC-Lch-049513	Latimeria chalumnae	57.67	0.00e+00	762.00
IUUC-Laf-053999	Loxodonta africana	88.72	0.00e+00	1146.00
IUUC-Mcc-055266	Macaca mulatta	90.03	0.00e+00	1129.00
IUUC-Meu-056906	Macropus eugenii	73.72	0.00e+00	989.00
IUUC-Mga-059595	Meleagris gallopavo	70.96	0.00e+00	879.00
IUUC-Mmr-061720	Microcebus murinus	89.37	0.00e+00	701.00
IUUC-Mdo-062167	Monodelphis domestica	73.04	0.00e+00	981.00
IUUC-Mmu-063298	Mus musculus	91.02	0.00e+00	1174.00
IUUC-Mpu-066195	Mustela putorius furo	92.06	0.00e+00	1170.00
IUUC-Mlu-067583	Myotis lucifugus	87.84	0.00e+00	796.00
IUUC-Opr-070454	Ochotona princeps	89.31	3.00e-162	565.00
IUUC-Ocu-074121	Oryctolagus cuniculus	85.64	0.00e+00	967.00
IUUC-Oga-088593	Otolemur garnettii	91.30	0.00e+00	1137.00
IUUC-Pan-092168	Papio anubis	90.43	0.00e+00	1152.00
IUUC-Psi-093707	Pelodiscus sinensis	67.12	0.00e+00	899.00
IUUC-Pab-097614	Pongo abelii	90.90	0.00e+00	1142.00
IUUC-Pca-100683	Procavia capensis	86.18	0.00e+00	1132.00
IUUC-Pva-103146	Pteropus vampyrus	79.50	0.00e+00	1040.00
IUUC-Rno-105061	Rattus norvegicus	91.46	0.00e+00	1181.00
IUUC-Sha-106686	Sarcophilus harrisii	71.70	0.00e+00	961.00
IUUC-Tgu-117024	Taeniopygia guttata	69.50	0.00e+00	904.00
IUUC-Tsy-119505	Tarsius syrichta	76.89	5.00e-164	571.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence