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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045813
UUCD1 version UUC-HoS-00749
Ensembl Protein ID ENSP00000326531.8
UniProt Accession Q86W42; B2RA85; Q8NBR1; Q9BTV9; THOC6_HUMAN
Genbank Protein ID BAC11552.1; BAG36782.1; AAH03118.1; AAH50674.1
Protein Name THO complex subunit 6 homolog; Functional spliceosome-associated protein 35; WD repeat-containing protein 58
Genbank Nucleotide ID AK075330; AK314086; BC003118; BC050674
Gene Name THOC6; WDR58; PSEC0006
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000131652.13 ENST00000326266.12 ENSP00000326531.8
ENSG00000131652.13 ENST00000253952.9 ENSP00000253952.9
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.70e-13 51.2 166 205
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllks 38
           gHtd ++cla+   ++ ++sG+ Dg +++WDlrt + +++
   Q: 166  GHTDYIHCLALreRSPEVLSGGEDGAVRLWDLRTAKEVQT 205
           8**********98559******************998875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.
 Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.
Protein Sequence
(Fasta)
MERAVPLAVP LGQTEVFQAL QRLHMTIFSQ SVSPCGKFLA AGNNYGQIAI FSLSSALSSE 60
AKEESKKPVV TFQAHDGPVY SMVSTDRHLL SAGDGEVKAW LWAEMLKKGC KELWRRQPPY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045813|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGGCGGGCAC AGCCGCGAGG TTCTGCGCGG GCGCGGAAGA CGGGCGGCGC GTGGCGGAAG 60
GCAGGCTTGC TCCTCGGGGT GGGGGAGGGT ATCCGGCTTA AGGGGGCTGC GGTGGACACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045813|E3,WD_repeat|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0509--mRNA transport
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000347--C:THO complex
GO:0000445--C:THO complex part of transcription export complex
GO:0000346--C:transcription export complex
GO:0003723--F:RNA binding
GO:0006915--P:apoptotic process
GO:0007417--P:central nervous system development
GO:0031124--P:mRNA 3'-end processing
GO:0006406--P:mRNA export from nucleus
GO:0043066--P:negative regulation of apoptotic process
GO:0006405--P:RNA export from nucleus
GO:0008380--P:RNA splicing
GO:0006369--P:termination of RNA polymerase II transcription
GO:0046784--P:viral mRNA export from host cell nucleus
KEGG hsa:79228
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001101 Aegilops tauschii 30.24 6.00e-30 125.00
IUUC-Aml-001693 Ailuropoda melanoleuca 96.77 1.00e-180 625.00
IUUC-Atr-002699 Amborella trichopoda 29.20 3.00e-23 102.00
IUUC-Aca-004231 Anolis carolinensis 70.34 2.00e-126 445.00
IUUC-Aly-006385 Arabidopsis lyrata 31.45 6.00e-28 118.00
IUUC-Ath-006723 Arabidopsis thaliana 31.45 7.00e-28 118.00
IUUC-Ame-010813 Astyanax mexicanus 65.12 7.00e-85 306.00
IUUC-Bta-013458 Bos taurus 95.89 1.00e-178 619.00
IUUC-Bdi-014935 Brachypodium distachyon 29.84 6.00e-30 125.00
IUUC-Bol-015442 Brassica oleracea 30.71 4.00e-28 119.00
IUUC-Bra-017807 Brassica rapa 31.32 4.00e-28 119.00
IUUC-Cja-019061 Callithrix jacchus 98.25 0.00e+00 630.00
IUUC-Cfa-021146 Canis familiaris 97.36 0.00e+00 629.00
IUUC-Cpo-022512 Cavia porcellus 96.19 1.00e-180 625.00
IUUC-Csa-023055 Chlorocebus sabaeus 98.24 0.00e+00 639.00
IUUC-Cho-024693 Choloepus hoffmanni 95.88 4.00e-99 353.00
IUUC-Cin-025181 Ciona intestinalis 36.34 2.00e-55 209.00
IUUC-Csv-025852 Ciona savignyi 34.33 6.00e-47 181.00
IUUC-Dre-028221 Danio rerio 59.94 2.00e-114 405.00
IUUC-Dno-029200 Dasypus novemcinctus 91.01 3.00e-88 317.00
IUUC-Dor-030863 Dipodomys ordii 95.31 3.00e-178 617.00
IUUC-Dme-032016 Drosophila melanogaster 29.28 3.00e-36 145.00
IUUC-Eca-034363 Equus caballus 97.07 0.00e+00 629.00
IUUC-Fca-036546 Felis catus 96.77 0.00e+00 627.00
IUUC-Gmo-038513 Gadus morhua 56.76 6.00e-105 374.00
IUUC-Gac-042606 Gasterosteus aculeatus 57.45 7.00e-108 383.00
IUUC-Gma-043171 Glycine max 29.17 5.00e-32 132.00
IUUC-Ggo-044877 Gorilla gorilla 99.41 0.00e+00 643.00
IUUC-Hvu-047782 Hordeum vulgare 31.08 2.00e-20 92.40
IUUC-Itr-047876 Ictidomys tridecemlineatus 97.07 0.00e+00 629.00
IUUC-Lch-049506 Latimeria chalumnae 64.13 2.00e-119 422.00
IUUC-Lpe-051203 Leersia perrieri 29.83 1.00e-24 107.00
IUUC-Loc-052451 Lepisosteus oculatus 51.53 2.00e-85 308.00
IUUC-Laf-053864 Loxodonta africana 95.31 1.00e-177 615.00
IUUC-Mcc-055705 Macaca mulatta 90.72 5.00e-157 546.00
IUUC-Meu-055926 Macropus eugenii 90.83 1.00e-156 545.00
IUUC-Mtr-058556 Medicago truncatula 30.56 5.00e-32 132.00
IUUC-Mmr-060836 Microcebus murinus 97.36 0.00e+00 631.00
IUUC-Mdo-062534 Monodelphis domestica 90.83 1.00e-155 542.00
IUUC-Mmu-063560 Mus musculus 95.31 4.00e-178 617.00
IUUC-Mac-065134 Musa acuminata 28.23 2.00e-26 113.00
IUUC-Mpu-066031 Mustela putorius furo 97.95 0.00e+00 633.00
IUUC-Mlu-068051 Myotis lucifugus 92.96 6.00e-171 593.00
IUUC-Nle-069080 Nomascus leucogenys 98.83 0.00e+00 638.00
IUUC-Opr-070787 Ochotona princeps 91.79 2.00e-168 584.00
IUUC-Ont-071952 Oreochromis niloticus 56.21 1.00e-106 380.00
IUUC-Oan-073334 Ornithorhynchus anatinus 86.15 2.00e-118 418.00
IUUC-Oba-075175 Oryza barthii 30.39 1.00e-25 110.00
IUUC-Obr-076393 Oryza brachyantha 30.94 2.00e-25 110.00
IUUC-Ogl-077603 Oryza glaberrima 35.59 8.00e-19 87.40
IUUC-Ogu-078211 Oryza glumaepatula 30.39 1.00e-25 110.00
IUUC-Oin-079554 Oryza indica 30.39 7.00e-26 110.00
IUUC-Olo-080922 Oryza longistaminata 32.48 3.00e-23 102.00
IUUC-Ome-081127 Oryza meridionalis 23.76 2.00e-12 67.40
IUUC-Oni-082376 Oryza nivara 30.39 1.00e-25 110.00
IUUC-Opu-083163 Oryza punctata 29.83 4.00e-25 108.00
IUUC-Oru-084311 Oryza rufipogon 30.39 2.00e-25 110.00
IUUC-Osa-085762 Oryza sativa 35.59 1.00e-18 87.00
IUUC-Oga-088804 Otolemur garnettii 95.60 2.00e-179 621.00
IUUC-Oar-090095 Ovis aries 95.31 5.00e-178 616.00
IUUC-Ptr-090731 Pan troglodytes 99.71 0.00e+00 643.00
IUUC-Pan-092595 Papio anubis 98.83 0.00e+00 637.00
IUUC-Psi-093866 Pelodiscus sinensis 70.20 4.00e-117 414.00
IUUC-Pma-094236 Petromyzon marinus 59.88 2.00e-113 402.00
IUUC-Pfo-096095 Poecilia formosa 56.21 3.00e-106 378.00
IUUC-Pab-098385 Pongo abelii 98.83 0.00e+00 641.00
IUUC-Pop-099433 Populus trichocarpa 27.71 1.00e-28 120.00
IUUC-Pca-101119 Procavia capensis 96.35 4.00e-117 414.00
IUUC-Ppe-101677 Prunus persica 28.63 5.00e-27 115.00
IUUC-Pva-102726 Pteropus vampyrus 96.48 2.00e-180 625.00
IUUC-Rno-105576 Rattus norvegicus 95.89 3.00e-179 620.00
IUUC-Sha-106774 Sarcophilus harrisii 91.44 1.00e-157 548.00
IUUC-Sit-109988 Setaria italica 28.12 7.00e-28 118.00
IUUC-Sly-110864 Solanum lycopersicum 29.23 1.00e-27 117.00
IUUC-Sar-113060 Sorex araneus 88.19 9.00e-126 442.00
IUUC-Sbi-114699 Sorghum bicolor 29.44 3.00e-28 119.00
IUUC-Ssc-116445 Sus scrofa 97.07 0.00e+00 630.00
IUUC-Tru-117834 Takifugu rubripes 56.97 4.00e-111 394.00
IUUC-Tni-119651 Tetraodon nigroviridis 57.45 1.00e-109 389.00
IUUC-Tca-121318 Theobroma cacao 27.42 5.00e-28 118.00
IUUC-Tae-124184 Triticum aestivum 30.24 6.00e-30 125.00
IUUC-Tur-126226 Triticum urartu 30.39 1.00e-26 113.00
IUUC-Tbe-128079 Tupaia belangeri 81.27 9.00e-107 379.00
IUUC-Ttr-128391 Tursiops truncatus 91.81 6.00e-169 586.00
IUUC-Vvi-131148 Vitis vinifera 27.02 8.00e-25 107.00
IUUC-Xtr-132743 Xenopus tropicalis 62.02 7.00e-117 413.00
IUUC-Xma-133722 Xiphophorus maculatus 56.52 4.00e-107 380.00
Created Date 25-Jun-2017

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