iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094568

UUCD1 version

UUC-PeM-00523

Ensembl Protein ID

ENSPMAP00000010553.1

UniProt Accession

S4RZB2; S4RZB2_PETMA

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000009598.1	ENSPMAT00000010599.1	ENSPMAP00000010553.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.40e-61	207.1	1	236

Active Site

Position(s)	Description	Evidence
63	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
139	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 26   gvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedk 114
           g+k+  qvee+ysL++e+++++ +pv+gl++lFk++  +e +          ++v ++  +t+ffakq + N+Cat+Allsvlln ++ 
   Q: 1    GCKGA-QVEEIYSLEEESFSKL-KPVHGLIFLFKWTAGEEMEG---------SIVRDSRNDTLFFAKQPVRNACATQALLSVLLNVTHS 78
           79999.****************.*****************999.........778999999**************************** PP
   S: 115  lldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldl 203
            + lG+tl  ++++t ++++ +k+lal+n++ ++++hns+ar+++++ + r +++    +++afhfv++v+ +grlyeldgl+  P+dl
   Q: 79   DVTLGHTLTSFRDFTSGFDSAMKGLALSNSDTIRQVHNSFARQQMFEWDGRAAGK----DEDAFHFVAFVPKQGRLYELDGLRDGPIDL 163
           *************************************************999887....69**************************** PP
   S: 204  gkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid..................ke 261
           g+ +++e++ + ++ v+    ri+ ++++eirf+l+a+v+drr+i++ r+  l+                     e
   Q: 164  GA-CDQEDWVKSVRPVI--ERRIQRYTEGEIRFSLMAVVSDRRMIYERRIAELQAGltqgearegggarslaetSE 236
           *9.899***********..9*****************************965554445555555555555554444 PP

Organism

Petromyzon marinus

Protein Sequence
(Fasta)

GCKGAQVEEI YSLEEESFSK LKPVHGLIFL FKWTAGEEME GSIVRDSRND TLFFAKQPVR 60
NACATQALLS VLLNVTHSDV TLGHTLTSFR DFTSGFDSAM KGLALSNSDT IRQVHNSFAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGTGCATG CAGGCTGTAA AGGGGCGCAG GTGGAGGAGA TTTACAGCCT GGAGGAGGAG 60
AGCTTCAGCA AACTCAAGTG AGTTCTGCGC ACGCGGTCCC TCCGGGCACG GCGCAAACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0378--Hydrolase
KW-0645--Protease
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	40.71	1.00e-62	231.00
IUUC-Aml-001866	Ailuropoda melanoleuca	61.11	4.00e-107	379.00
IUUC-Atr-002966	Amborella trichopoda	39.63	7.00e-58	216.00
IUUC-Apl-003306	Anas platyrhynchos	55.72	1.00e-106	377.00
IUUC-Aca-004763	Anolis carolinensis	61.11	6.00e-108	382.00
IUUC-Aly-005581	Arabidopsis lyrata	50.72	9.00e-55	205.00
IUUC-Ath-007283	Arabidopsis thaliana	51.67	1.00e-58	218.00
IUUC-Ago-007999	Ashbya gossypii	36.87	1.00e-25	108.00
IUUC-Acl-008231	Aspergillus clavatus	44.75	3.00e-48	184.00
IUUC-Afl-008557	Aspergillus flavus	44.95	4.00e-48	183.00
IUUC-Afu-008988	Aspergillus fumigatus	44.95	7.00e-49	186.00
IUUC-Ani-009420	Aspergillus nidulans	42.57	9.00e-47	179.00
IUUC-Ang-009859	Aspergillus niger	42.60	1.00e-45	175.00
IUUC-Aor-010145	Aspergillus oryzae	44.95	4.00e-48	183.00
IUUC-Ate-010347	Aspergillus terreus	43.16	9.00e-47	179.00
IUUC-Ame-010791	Astyanax mexicanus	62.83	1.00e-114	404.00
IUUC-Bgr-012298	Blumeria graminis	42.18	4.00e-40	156.00
IUUC-Bta-013251	Bos taurus	62.02	2.00e-107	380.00
IUUC-Bci-013786	Botrytis cinerea	46.23	2.00e-48	184.00
IUUC-Bdi-014132	Brachypodium distachyon	47.39	7.00e-63	232.00
IUUC-Bol-015611	Brassica oleracea	41.37	4.00e-57	213.00
IUUC-Bra-017769	Brassica rapa	42.35	2.00e-57	214.00
IUUC-Cel-018604	Caenorhabditis elegans	39.46	3.00e-59	220.00
IUUC-Cja-019768	Callithrix jacchus	55.70	4.00e-101	359.00
IUUC-Cfa-020207	Canis familiaris	61.11	4.00e-107	379.00
IUUC-Cpo-021925	Cavia porcellus	57.29	7.00e-98	348.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	48.79	1.00e-52	198.00
IUUC-Csa-023958	Chlorocebus sabaeus	61.67	1.00e-105	375.00
IUUC-Cho-024928	Choloepus hoffmanni	67.53	7.00e-29	119.00
IUUC-Cin-025771	Ciona intestinalis	46.20	1.00e-73	268.00
IUUC-Csv-026149	Ciona savignyi	47.37	3.00e-77	280.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	38.01	2.00e-47	181.00
IUUC-Cne-026955	Cryptococcus neoformans	39.25	1.00e-39	155.00
IUUC-Cme-027104	Cyanidioschyzon merolae	36.25	2.00e-32	131.00
IUUC-Dre-027409	Danio rerio	61.51	2.00e-112	397.00
IUUC-Dno-028921	Dasypus novemcinctus	60.76	3.00e-106	376.00
IUUC-Dse-031170	Dothistroma septosporum	43.84	1.00e-44	171.00
IUUC-Dme-031677	Drosophila melanogaster	48.67	1.00e-79	288.00
IUUC-Ete-032707	Echinops telfairi	53.69	2.00e-58	217.00
IUUC-Eca-033776	Equus caballus	61.46	7.00e-108	381.00
IUUC-Eeu-035305	Erinaceus europaeus	57.06	3.00e-50	190.00
IUUC-Fca-035846	Felis catus	55.87	5.00e-102	362.00
IUUC-Fal-037597	Ficedula albicollis	60.76	6.00e-104	369.00
IUUC-Fox-037670	Fusarium oxysporum	47.39	9.00e-45	172.00
IUUC-Fso-038243	Fusarium solani	46.45	5.00e-43	166.00
IUUC-Gmo-038499	Gadus morhua	58.33	2.00e-100	357.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.78	2.00e-39	154.00
IUUC-Gga-040904	Gallus gallus	60.86	6.00e-113	398.00
IUUC-Gac-042058	Gasterosteus aculeatus	61.46	8.00e-108	381.00
IUUC-Gma-043030	Glycine max	39.56	6.00e-58	216.00
IUUC-Ggo-044699	Gorilla gorilla	65.25	2.00e-103	367.00
IUUC-Hsa-046227	Homo sapiens	61.46	3.00e-107	379.00
IUUC-Hvu-047359	Hordeum vulgare	40.78	2.00e-62	231.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	55.49	9.00e-102	361.00
IUUC-Kpa-049123	Komagataella pastoris	30.30	6.00e-16	75.90
IUUC-Lch-049829	Latimeria chalumnae	61.81	8.00e-108	381.00
IUUC-Lpe-050899	Leersia perrieri	52.38	9.00e-65	238.00
IUUC-Loc-052264	Lepisosteus oculatus	61.94	2.00e-106	377.00
IUUC-Lma-053110	Leptosphaeria maculans	44.39	3.00e-40	157.00
IUUC-Laf-053639	Loxodonta africana	61.11	4.00e-107	379.00
IUUC-Mcc-055506	Macaca mulatta	61.67	1.00e-105	375.00
IUUC-Mor-057001	Magnaporthe oryzae	47.56	3.00e-49	187.00
IUUC-Mpo-057608	Magnaporthe poae	43.27	1.00e-26	111.00
IUUC-Mtr-057731	Medicago truncatula	51.14	3.00e-64	237.00
IUUC-Mla-059016	Melampsora laricipopulina	39.44	1.00e-34	137.00
IUUC-Mga-060178	Meleagris gallopavo	60.53	4.00e-113	399.00
IUUC-Mvi-060353	Microbotryum violaceum	38.36	8.00e-41	159.00
IUUC-Mmr-060738	Microcebus murinus	61.46	1.00e-107	380.00
IUUC-Mdo-062266	Monodelphis domestica	72.97	5.00e-84	301.00
IUUC-Mmu-063619	Mus musculus	61.11	6.00e-106	375.00
IUUC-Mac-065301	Musa acuminata	41.61	1.00e-63	234.00
IUUC-Mpu-066058	Mustela putorius furo	61.11	6.00e-107	379.00
IUUC-Mlu-067292	Myotis lucifugus	61.67	2.00e-106	376.00
IUUC-Nfi-068275	Neosartorya fischeri	45.87	7.00e-50	189.00
IUUC-Ncr-068713	Neurospora crassa	45.95	3.00e-49	187.00
IUUC-Nle-069013	Nomascus leucogenys	61.67	1.00e-105	374.00
IUUC-Opr-070628	Ochotona princeps	55.10	1.00e-99	354.00
IUUC-Ont-072688	Oreochromis niloticus	61.72	2.00e-107	380.00
IUUC-Oan-073004	Ornithorhynchus anatinus	71.95	4.00e-100	355.00
IUUC-Ocu-074303	Oryctolagus cuniculus	61.11	9.00e-106	375.00
IUUC-Oba-075002	Oryza barthii	51.61	4.00e-65	239.00
IUUC-Obr-076392	Oryza brachyantha	50.92	3.00e-65	240.00
IUUC-Ogl-077271	Oryza glaberrima	51.61	4.00e-65	239.00
IUUC-Ogu-078493	Oryza glumaepatula	51.83	4.00e-66	243.00
IUUC-Oin-080084	Oryza indica	51.83	4.00e-66	243.00
IUUC-Olo-080803	Oryza longistaminata	51.83	4.00e-66	243.00
IUUC-Ome-081146	Oryza meridionalis	51.83	1.00e-65	241.00
IUUC-Oni-082146	Oryza nivara	51.83	4.00e-66	243.00
IUUC-Opu-083633	Oryza punctata	51.83	2.00e-65	240.00
IUUC-Oru-084789	Oryza rufipogon	51.83	4.00e-66	243.00
IUUC-Osa-086196	Oryza sativa	51.83	4.00e-66	243.00
IUUC-Ola-087126	Oryzias latipes	61.46	5.00e-108	382.00
IUUC-Olu-087665	Ostreococcus lucimarinus	44.95	2.00e-53	201.00
IUUC-Oga-089140	Otolemur garnettii	56.19	2.00e-102	364.00
IUUC-Oar-090296	Ovis aries	61.46	2.00e-107	380.00
IUUC-Ptr-090566	Pan troglodytes	61.46	3.00e-107	379.00
IUUC-Pan-092052	Papio anubis	61.67	1.00e-105	374.00
IUUC-Psi-093723	Pelodiscus sinensis	60.07	9.00e-108	381.00
IUUC-Pno-095120	Phaeosphaeria nodorum	44.39	6.00e-41	159.00
IUUC-Ppa-095761	Physcomitrella patens	49.77	4.00e-56	209.00
IUUC-Pfo-096210	Poecilia formosa	61.46	8.00e-108	381.00
IUUC-Pab-098463	Pongo abelii	61.46	3.00e-106	376.00
IUUC-Pop-099109	Populus trichocarpa	37.07	9.00e-57	212.00
IUUC-Pca-100108	Procavia capensis	71.04	1.00e-96	344.00
IUUC-Ppe-101176	Prunus persica	38.36	9.00e-56	208.00
IUUC-Pva-102629	Pteropus vampyrus	70.80	4.00e-98	349.00
IUUC-Pgr-103419	Puccinia graminis	41.55	8.00e-46	176.00
IUUC-Pte-104207	Pyrenophora teres	41.22	2.00e-24	103.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	42.86	2.00e-44	171.00
IUUC-Rno-105579	Rattus norvegicus	54.66	5.00e-101	358.00
IUUC-Sha-106894	Sarcophilus harrisii	59.26	4.00e-98	349.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	43.81	2.00e-46	177.00
IUUC-Spo-108371	Schizosaccharomyces pombe	37.04	7.00e-48	182.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	44.55	4.00e-43	166.00
IUUC-Smo-109396	Selaginella moellendorffii	40.39	7.00e-57	212.00
IUUC-Sit-110630	Setaria italica	50.23	2.00e-64	238.00
IUUC-Sly-110972	Solanum lycopersicum	41.59	8.00e-64	235.00
IUUC-Stu-112185	Solanum tuberosum	41.59	5.00e-64	236.00
IUUC-Sar-113294	Sorex araneus	51.11	8.00e-88	315.00
IUUC-Sbi-113951	Sorghum bicolor	51.61	2.00e-65	240.00
IUUC-Ssc-115501	Sus scrofa	61.11	3.00e-107	379.00
IUUC-Tgu-117152	Taeniopygia guttata	61.11	6.00e-104	369.00
IUUC-Tru-118388	Takifugu rubripes	62.15	1.00e-108	384.00
IUUC-Tsy-119109	Tarsius syrichta	61.46	6.00e-107	379.00
IUUC-Tni-120048	Tetraodon nigroviridis	62.15	4.00e-109	385.00
IUUC-Tca-121750	Theobroma cacao	39.62	3.00e-62	230.00
IUUC-Tre-122130	Trichoderma reesei	45.75	3.00e-45	173.00
IUUC-Tvi-122284	Trichoderma virens	44.34	8.00e-43	166.00
IUUC-Tae-124082	Triticum aestivum	41.10	3.00e-62	230.00
IUUC-Tur-126366	Triticum urartu	41.51	2.00e-49	187.00
IUUC-Tme-127187	Tuber melanosporum	45.65	5.00e-50	189.00
IUUC-Tbe-127619	Tupaia belangeri	52.61	2.00e-81	294.00
IUUC-Ttr-128867	Tursiops truncatus	64.49	3.00e-94	336.00
IUUC-Vda-129912	Verticillium dahliae	40.76	4.00e-41	160.00
IUUC-Vpa-130552	Vicugna pacos	73.37	5.00e-84	303.00
IUUC-Vvi-130881	Vitis vinifera	40.89	1.00e-57	215.00
IUUC-Xtr-131934	Xenopus tropicalis	57.57	1.00e-105	374.00
IUUC-Xma-133312	Xiphophorus maculatus	61.46	8.00e-108	381.00
IUUC-Yli-134487	Yarrowia lipolytica	38.68	3.00e-41	160.00
IUUC-Zma-135639	Zea mays	51.01	2.00e-58	218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence