iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118388

UUCD1 version

UUC-TaR-01109

Ensembl Protein ID

ENSTRUP00000007458.1

UniProt Accession

H2S4Y6; H2S4Y6_TAKRU

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

uchl5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000003181.1	ENSTRUT00000007505.1	ENSTRUP00000007458.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	5.90e-95	319.8	1	316

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m + + ew+ +esdPg+ft+l++ fg+k+  qvee++s++pen++ + +pv+gl++lFk+++ +e +          ++v+++ +++if
   Q: 1    MAGSAGEWCLMESDPGVFTELIKGFGCKGA-QVEEIWSMEPENFDNL-KPVHGLIFLFKWQPGEEPAG---------SIVQDSRLDQIF 78
           667789************************.****************.*******************9.........8899******** PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc +  + lG+tl +++e+++++++ +k+lal+n++v++++hn +ar+++++ + + +++    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCFHSDMSLGDTLTEFREFSQSFDAAMKGLALSNSEVIRQVHNGFARQQMFEFDAKSSAK----DEDAF 163
           **************************************************************************998777....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg  ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i++ ++  l+++        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGV-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYERKIAELQTQltqdepmd 249
           **************************9.78999*********..******************************999998889999998 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveet 325
             +   +l+ i+se++k++  +++e++k k++k+++irR++ny  fi++++k+la++++l  lve+ 
   Q: 250  tDQSSTFLSSIQSEIAKYQLLIEEENQKLKRYKVENIRRKHNYLPFIMELLKTLAEHQQLMPLVEKA 316
           8667789*********************************************************984 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MAGSAGEWCL MESDPGVFTE LIKGFGCKGA QVEEIWSMEP ENFDNLKPVH GLIFLFKWQP 60
GEEPAGSIVQ DSRLDQIFFA KQVINNACAT QAIVSVLLNC FHSDMSLGDT LTEFREFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGGAA GCGCAGGAGA GTGGTGTCTC ATGGAAAGTG ACCCCGGTGT CTTCACAGAA 60
CTGATCAAAG GGTTCGGTGA GTGAGCCTGC CGTTAGCCGA CCCATTCAGT GTAACGTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031011--C:Ino80 complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

tru:101075260

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.95	3.00e-82	298.00
IUUC-Aml-001866	Ailuropoda melanoleuca	88.50	8.00e-171	592.00
IUUC-Atr-002966	Amborella trichopoda	46.26	9.00e-81	293.00
IUUC-Apl-003306	Anas platyrhynchos	81.28	2.00e-169	588.00
IUUC-Aca-004763	Anolis carolinensis	91.03	6.00e-175	606.00
IUUC-Aly-005581	Arabidopsis lyrata	47.11	5.00e-79	287.00
IUUC-Ath-007283	Arabidopsis thaliana	47.42	4.00e-81	294.00
IUUC-Ago-007999	Ashbya gossypii	33.44	5.00e-32	131.00
IUUC-Acl-008231	Aspergillus clavatus	43.10	8.00e-52	197.00
IUUC-Afl-008557	Aspergillus flavus	37.70	2.00e-54	205.00
IUUC-Afu-008988	Aspergillus fumigatus	44.35	5.00e-53	201.00
IUUC-Ani-009420	Aspergillus nidulans	38.75	1.00e-52	200.00
IUUC-Ang-009859	Aspergillus niger	41.80	6.00e-49	187.00
IUUC-Aor-010145	Aspergillus oryzae	37.70	2.00e-54	205.00
IUUC-Ate-010347	Aspergillus terreus	41.11	1.00e-51	196.00
IUUC-Ame-010791	Astyanax mexicanus	92.40	0.00e+00	641.00
IUUC-Bgr-012298	Blumeria graminis	37.70	4.00e-49	188.00
IUUC-Bta-013251	Bos taurus	88.50	2.00e-169	588.00
IUUC-Bci-013786	Botrytis cinerea	37.17	5.00e-56	211.00
IUUC-Bdi-014132	Brachypodium distachyon	46.93	5.00e-80	290.00
IUUC-Bol-015611	Brassica oleracea	48.77	7.00e-83	300.00
IUUC-Bra-017769	Brassica rapa	48.77	6.00e-83	300.00
IUUC-Cel-018604	Caenorhabditis elegans	46.42	1.00e-80	293.00
IUUC-Cja-019768	Callithrix jacchus	80.35	3.00e-164	570.00
IUUC-Cfa-020207	Canis familiaris	88.50	8.00e-171	592.00
IUUC-Cpo-021925	Cavia porcellus	84.35	2.00e-161	561.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	46.11	1.00e-73	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	88.18	2.00e-168	585.00
IUUC-Cho-024928	Choloepus hoffmanni	88.31	7.00e-38	150.00
IUUC-Cin-025771	Ciona intestinalis	54.97	7.00e-101	360.00
IUUC-Csv-026149	Ciona savignyi	57.37	3.00e-103	367.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	38.24	2.00e-52	199.00
IUUC-Cne-026955	Cryptococcus neoformans	36.09	6.00e-52	197.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.24	6.00e-49	187.00
IUUC-Dre-027409	Danio rerio	93.62	0.00e+00	645.00
IUUC-Dno-028921	Dasypus novemcinctus	88.50	1.00e-170	592.00
IUUC-Dse-031170	Dothistroma septosporum	37.97	2.00e-54	205.00
IUUC-Dme-031677	Drosophila melanogaster	60.94	3.00e-114	404.00
IUUC-Ete-032707	Echinops telfairi	62.38	2.00e-108	385.00
IUUC-Eca-033776	Equus caballus	88.54	8.00e-156	542.00
IUUC-Eeu-035305	Erinaceus europaeus	70.74	3.00e-75	275.00
IUUC-Fca-035846	Felis catus	81.47	9.00e-166	575.00
IUUC-Fal-037597	Ficedula albicollis	89.93	2.00e-153	535.00
IUUC-Fox-037670	Fusarium oxysporum	47.62	5.00e-52	197.00
IUUC-Fso-038243	Fusarium solani	47.62	2.00e-51	196.00
IUUC-Gmo-038499	Gadus morhua	92.65	5.00e-175	606.00
IUUC-Ggr-039975	Gaeumannomyces graminis	39.84	6.00e-46	177.00
IUUC-Gga-040904	Gallus gallus	90.03	0.00e+00	627.00
IUUC-Gac-042058	Gasterosteus aculeatus	97.12	0.00e+00	639.00
IUUC-Gma-043030	Glycine max	48.96	2.00e-85	308.00
IUUC-Ggo-044699	Gorilla gorilla	82.41	1.00e-153	535.00
IUUC-Hsa-046227	Homo sapiens	88.18	1.00e-170	592.00
IUUC-Hvu-047359	Hordeum vulgare	45.59	3.00e-81	295.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	80.52	3.00e-165	574.00
IUUC-Lch-049829	Latimeria chalumnae	91.05	5.00e-174	603.00
IUUC-Lpe-050899	Leersia perrieri	47.00	7.00e-77	280.00
IUUC-Loc-052264	Lepisosteus oculatus	93.31	3.00e-177	613.00
IUUC-Lma-053110	Leptosphaeria maculans	37.42	2.00e-46	179.00
IUUC-Laf-053639	Loxodonta africana	88.50	8.00e-171	592.00
IUUC-Mcc-055506	Macaca mulatta	88.18	2.00e-168	585.00
IUUC-Mor-057001	Magnaporthe oryzae	44.73	1.00e-52	199.00
IUUC-Mpo-057608	Magnaporthe poae	41.18	6.00e-32	130.00
IUUC-Mtr-057731	Medicago truncatula	48.66	2.00e-85	309.00
IUUC-Mla-059016	Melampsora laricipopulina	42.29	2.00e-42	165.00
IUUC-Mga-060178	Meleagris gallopavo	90.13	3.00e-167	580.00
IUUC-Mvi-060353	Microbotryum violaceum	39.10	1.00e-55	209.00
IUUC-Mmr-060738	Microcebus murinus	88.50	4.00e-171	593.00
IUUC-Mdo-062266	Monodelphis domestica	90.20	6.00e-113	399.00
IUUC-Mmu-063619	Mus musculus	86.90	2.00e-168	584.00
IUUC-Mac-065301	Musa acuminata	50.79	4.00e-89	320.00
IUUC-Mpu-066058	Mustela putorius furo	88.82	3.00e-171	594.00
IUUC-Mlu-067292	Myotis lucifugus	87.54	3.00e-167	580.00
IUUC-Nfi-068275	Neosartorya fischeri	37.94	1.00e-54	206.00
IUUC-Ncr-068713	Neurospora crassa	38.68	4.00e-57	214.00
IUUC-Nle-069013	Nomascus leucogenys	87.86	6.00e-168	583.00
IUUC-Opr-070628	Ochotona princeps	77.35	2.00e-154	538.00
IUUC-Ont-072688	Oreochromis niloticus	94.60	8.00e-180	622.00
IUUC-Oan-073004	Ornithorhynchus anatinus	88.21	2.00e-131	461.00
IUUC-Ocu-074303	Oryctolagus cuniculus	88.82	2.00e-171	595.00
IUUC-Oba-075002	Oryza barthii	47.59	2.00e-81	295.00
IUUC-Obr-076392	Oryza brachyantha	48.26	5.00e-79	287.00
IUUC-Ogl-077271	Oryza glaberrima	47.59	2.00e-81	295.00
IUUC-Ogu-078493	Oryza glumaepatula	47.59	5.00e-82	297.00
IUUC-Oin-080084	Oryza indica	47.59	5.00e-82	297.00
IUUC-Olo-080803	Oryza longistaminata	47.29	1.00e-81	296.00
IUUC-Ome-081146	Oryza meridionalis	47.29	2.00e-81	295.00
IUUC-Oni-082146	Oryza nivara	47.59	5.00e-82	297.00
IUUC-Opu-083633	Oryza punctata	47.95	1.00e-77	283.00
IUUC-Oru-084789	Oryza rufipogon	47.59	5.00e-82	297.00
IUUC-Osa-086196	Oryza sativa	47.59	5.00e-82	297.00
IUUC-Ola-087126	Oryzias latipes	94.57	1.00e-174	605.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.28	8.00e-67	246.00
IUUC-Oga-089140	Otolemur garnettii	80.88	2.00e-165	574.00
IUUC-Oar-090296	Ovis aries	87.86	3.00e-169	587.00
IUUC-Ptr-090566	Pan troglodytes	88.18	1.00e-170	592.00
IUUC-Pan-092052	Papio anubis	88.18	2.00e-168	585.00
IUUC-Psi-093723	Pelodiscus sinensis	90.62	3.00e-160	557.00
IUUC-Pma-094568	Petromyzon marinus	62.15	3.00e-108	384.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.70	1.00e-47	183.00
IUUC-Ppa-095761	Physcomitrella patens	46.49	3.00e-83	301.00
IUUC-Pfo-096210	Poecilia formosa	93.61	2.00e-179	620.00
IUUC-Pab-098463	Pongo abelii	88.18	4.00e-170	590.00
IUUC-Pop-099423	Populus trichocarpa	48.37	3.00e-84	305.00
IUUC-Pca-100108	Procavia capensis	87.80	1.00e-130	459.00
IUUC-Ppe-101176	Prunus persica	49.40	6.00e-84	303.00
IUUC-Pva-102629	Pteropus vampyrus	85.88	3.00e-135	474.00
IUUC-Pgr-103419	Puccinia graminis	39.02	3.00e-54	205.00
IUUC-Pte-104207	Pyrenophora teres	41.42	3.00e-30	124.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	37.70	2.00e-53	202.00
IUUC-Rno-105579	Rattus norvegicus	78.02	1.00e-148	518.00
IUUC-Sha-106894	Sarcophilus harrisii	86.96	8.00e-146	509.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	39.87	1.00e-58	219.00
IUUC-Spo-108371	Schizosaccharomyces pombe	39.81	3.00e-60	225.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	37.68	1.00e-46	179.00
IUUC-Smo-109396	Selaginella moellendorffii	51.08	2.00e-88	319.00
IUUC-Sit-110630	Setaria italica	48.62	2.00e-85	308.00
IUUC-Sly-110972	Solanum lycopersicum	47.92	8.00e-80	290.00
IUUC-Stu-112185	Solanum tuberosum	47.90	1.00e-88	319.00
IUUC-Sar-113294	Sorex araneus	72.80	1.00e-148	519.00
IUUC-Sbi-113951	Sorghum bicolor	48.93	1.00e-85	309.00
IUUC-Ssc-115501	Sus scrofa	87.54	4.00e-159	553.00
IUUC-Tgu-117152	Taeniopygia guttata	90.28	2.00e-153	535.00
IUUC-Tsy-119109	Tarsius syrichta	88.50	5.00e-171	593.00
IUUC-Tni-120048	Tetraodon nigroviridis	99.68	0.00e+00	651.00
IUUC-Tca-121750	Theobroma cacao	49.70	9.00e-90	323.00
IUUC-Tre-122130	Trichoderma reesei	39.33	9.00e-55	206.00
IUUC-Tvi-122284	Trichoderma virens	38.54	1.00e-50	193.00
IUUC-Tae-124082	Triticum aestivum	45.57	7.00e-81	293.00
IUUC-Tur-126366	Triticum urartu	42.69	1.00e-66	246.00
IUUC-Tme-127187	Tuber melanosporum	40.59	7.00e-60	223.00
IUUC-Tbe-127619	Tupaia belangeri	79.79	7.00e-130	456.00
IUUC-Ttr-128867	Tursiops truncatus	80.00	3.00e-114	404.00
IUUC-Vda-129912	Verticillium dahliae	37.50	3.00e-53	201.00
IUUC-Vpa-130552	Vicugna pacos	90.43	2.00e-116	412.00
IUUC-Vvi-130881	Vitis vinifera	48.66	2.00e-83	302.00
IUUC-Xtr-131934	Xenopus tropicalis	83.28	1.00e-170	591.00
IUUC-Xma-133312	Xiphophorus maculatus	93.29	3.00e-178	617.00
IUUC-Yli-134487	Yarrowia lipolytica	32.63	8.00e-46	177.00
IUUC-Zma-135462	Zea mays	43.69	1.00e-72	266.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence