iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aor-010150

Ensembl Protein ID

BAE62401

UniProt Accession

Q2U7R4; ATG3_ASPOR

Genbank Protein ID

BAE62401.1

Protein Name

Autophagy-related protein 3; Autophagy-related E2-like conjugation enzyme atg3

Genbank Nucleotide ID

AP007164

Gene Name

atg3; AO090701000734

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AO090701000734	BAE62401	BAE62401

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E2/Autophagy_C	37.13	4.00e-34	142.00	IUUC-Ath-006802
E2/Autophagy_C	53.52	1.00e-16	85.10	IUUC-Hsa-046449
E2/Autophagy_C	36.71	8.00e-51	195.00	IUUC-Sce-106172

Active Site

Position(s)	Description	Evidence
245	Glycyl thioester intermediate	{ECO:0000250}

Organism

Aspergillus oryzae

Functional Description
(View)

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8 from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8. The formation of the atg8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).

Protein Sequence
(Fasta)

MNILHSTLST WRDRLAPVSR TSTFRNTGQI TPEEFVLAGD YLVYKFPSWS WADASNPAKR 60
VSYLPPGKQF LVTRGVPCHR RLNDNFAGDA GHDDELVRDM LSGGTGGVDD DGWLRTGGGQ 120

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Nucleotide Sequence
(Fasta)

ATGAATATTC TCCATTCTAC TCTCTCCACT TGGAGAGACC GTCTTGCCCC AGTGTCCCGC 60
ACCTCCACTT TCCGCAACAC CGGCCAGATC ACTCCCGAGG AATTCGTTCT CGCAGGCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007135--Autophagy-rel_prot_3
IPR019461--Autophagy-rel_prot_3_C
IPR007134--Autophagy-rel_prot_3_N

Pfam

PF03987--Autophagy_act_C
PF10381--Autophagy_C
PF03986--Autophagy_N

Gene Ontology

GO:0005829--C:cytosol
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0044805--P:late nucleophagy
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0006612--P:protein targeting to membrane

KEGG

aor:AOR_1_1290114

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001111	Aegilops tauschii	33.98	1.00e-33	135.00
IUUC-Aml-002081	Ailuropoda melanoleuca	53.52	1.00e-18	85.10
IUUC-Atr-002712	Amborella trichopoda	42.50	8.00e-14	68.90
IUUC-Apl-003956	Anas platyrhynchos	49.09	1.00e-11	61.60
IUUC-Aca-004578	Anolis carolinensis	52.11	9.00e-18	82.00
IUUC-Aly-005823	Arabidopsis lyrata	34.64	2.00e-36	144.00
IUUC-Ath-006802	Arabidopsis thaliana	35.87	3.00e-35	140.00
IUUC-Ago-007855	Ashbya gossypii	35.29	9.00e-54	201.00
IUUC-Acl-008147	Aspergillus clavatus	77.62	2.00e-140	489.00
IUUC-Afl-008483	Aspergillus flavus	100.00	1.00e-176	610.00
IUUC-Afu-008818	Aspergillus fumigatus	83.47	9.00e-165	570.00
IUUC-Ani-009481	Aspergillus nidulans	78.86	3.00e-142	496.00
IUUC-Ang-009800	Aspergillus niger	75.62	2.00e-133	466.00
IUUC-Ate-010545	Aspergillus terreus	83.74	8.00e-93	331.00
IUUC-Ame-011793	Astyanax mexicanus	50.00	1.00e-17	82.00
IUUC-Bgr-012167	Blumeria graminis	63.59	3.00e-107	379.00
IUUC-Bta-012695	Bos taurus	53.52	1.00e-18	85.50
IUUC-Bci-013972	Botrytis cinerea	66.58	5.00e-99	352.00
IUUC-Bdi-014756	Brachypodium distachyon	32.47	3.00e-34	136.00
IUUC-Bol-015091	Brassica oleracea	50.59	3.00e-19	87.40
IUUC-Bra-017220	Brassica rapa	34.41	7.00e-35	139.00
IUUC-Cel-018143	Caenorhabditis elegans	51.22	3.00e-21	93.60
IUUC-Cja-018991	Callithrix jacchus	36.33	1.00e-35	141.00
IUUC-Cfa-020070	Canis familiaris	53.52	1.00e-18	85.10
IUUC-Cpo-021860	Cavia porcellus	53.52	6.00e-19	86.30
IUUC-Cre-022948	Chlamydomonas reinhardtii	47.50	2.00e-17	80.90
IUUC-Csa-023881	Chlorocebus sabaeus	53.52	1.00e-18	85.50
IUUC-Cho-024852	Choloepus hoffmanni	52.11	6.00e-18	82.80
IUUC-Cin-025787	Ciona intestinalis	53.73	1.00e-18	85.10
IUUC-Csv-026369	Ciona savignyi	34.70	3.00e-35	140.00
IUUC-Cgl-026680	Colletotrichum gloeosporioides	59.83	2.00e-99	353.00
IUUC-Cne-026905	Cryptococcus neoformans	36.16	2.00e-21	95.10
IUUC-Dre-028811	Danio rerio	55.88	6.00e-18	82.80
IUUC-Dno-030081	Dasypus novemcinctus	54.17	1.00e-17	82.00
IUUC-Dor-030183	Dipodomys ordii	53.52	8.00e-19	85.50
IUUC-Dse-031539	Dothistroma septosporum	53.70	7.00e-66	242.00
IUUC-Dme-031805	Drosophila melanogaster	49.40	3.00e-19	87.00
IUUC-Ete-033171	Echinops telfairi	52.50	8.00e-19	85.50
IUUC-Eca-034083	Equus caballus	53.52	1.00e-18	85.10
IUUC-Eeu-034804	Erinaceus europaeus	54.93	7.00e-19	85.90
IUUC-Fca-036289	Felis catus	53.52	1.00e-18	85.50
IUUC-Fal-037060	Ficedula albicollis	52.11	8.00e-18	82.40
IUUC-Fox-038051	Fusarium oxysporum	62.60	4.00e-104	369.00
IUUC-Fso-038124	Fusarium solani	63.61	4.00e-91	326.00
IUUC-Gmo-039538	Gadus morhua	36.67	6.00e-35	139.00
IUUC-Ggr-039880	Gaeumannomyces graminis	61.23	2.00e-109	386.00
IUUC-Gga-041108	Gallus gallus	52.11	8.00e-18	82.40
IUUC-Gac-041558	Gasterosteus aculeatus	35.61	7.00e-34	135.00
IUUC-Gma-043969	Glycine max	32.14	2.00e-34	137.00
IUUC-Ggo-045071	Gorilla gorilla	53.52	1.00e-18	85.10
IUUC-Hsa-046449	Homo sapiens	53.52	1.00e-18	85.10
IUUC-Hvu-047451	Hordeum vulgare	32.83	1.00e-32	131.00
IUUC-Itr-048360	Ictidomys tridecemlineatus	53.52	1.00e-18	85.50
IUUC-Kpa-049096	Komagataella pastoris	38.92	6.00e-56	209.00
IUUC-Lch-049726	Latimeria chalumnae	48.19	8.00e-19	85.90
IUUC-Lpe-050734	Leersia perrieri	37.92	8.00e-37	145.00
IUUC-Loc-051983	Lepisosteus oculatus	55.88	6.00e-18	82.80
IUUC-Lma-053038	Leptosphaeria maculans	65.55	4.00e-112	395.00
IUUC-Laf-054510	Loxodonta africana	50.00	7.00e-18	82.40
IUUC-Mcc-054792	Macaca mulatta	53.52	1.00e-18	85.50
IUUC-Meu-055965	Macropus eugenii	50.00	7.00e-18	82.40
IUUC-Mor-057292	Magnaporthe oryzae	63.33	7.00e-103	365.00
IUUC-Mtr-058282	Medicago truncatula	35.51	4.00e-35	139.00
IUUC-Mla-059144	Melampsora laricipopulina	36.84	3.00e-27	114.00
IUUC-Mga-059509	Meleagris gallopavo	52.11	9.00e-18	82.40
IUUC-Mvi-060281	Microbotryum violaceum	37.91	1.00e-25	108.00
IUUC-Mmr-061788	Microcebus murinus	53.52	7.00e-19	85.90
IUUC-Mdo-062922	Monodelphis domestica	53.52	1.00e-18	85.10
IUUC-Mmu-064249	Mus musculus	52.11	8.00e-18	82.40
IUUC-Mac-064474	Musa acuminata	50.00	9.00e-18	82.00
IUUC-Mpu-065717	Mustela putorius furo	53.52	1.00e-18	85.10
IUUC-Mlu-067151	Myotis lucifugus	58.06	2.00e-17	80.50
IUUC-Nfi-068551	Neosartorya fischeri	82.35	1.00e-158	550.00
IUUC-Ncr-068846	Neurospora crassa	64.35	2.00e-106	377.00
IUUC-Nle-069790	Nomascus leucogenys	53.52	1.00e-18	85.10
IUUC-Ont-072517	Oreochromis niloticus	50.00	7.00e-18	82.40
IUUC-Oan-073285	Ornithorhynchus anatinus	50.00	1.00e-17	81.30
IUUC-Ocu-074695	Oryctolagus cuniculus	53.52	1.00e-18	85.50
IUUC-Oba-075515	Oryza barthii	36.43	6.00e-37	145.00
IUUC-Obr-076787	Oryza brachyantha	38.43	2.00e-36	144.00
IUUC-Ogl-077440	Oryza glaberrima	36.43	1.00e-36	144.00
IUUC-Ogu-078294	Oryza glumaepatula	36.43	6.00e-37	145.00
IUUC-Oin-079452	Oryza indica	36.57	5.00e-37	146.00
IUUC-Olo-080450	Oryza longistaminata	35.94	3.00e-37	146.00
IUUC-Ome-081514	Oryza meridionalis	36.43	1.00e-36	145.00
IUUC-Oni-082677	Oryza nivara	36.57	5.00e-37	146.00
IUUC-Opu-083925	Oryza punctata	37.55	4.00e-36	143.00
IUUC-Oru-084828	Oryza rufipogon	35.86	7.00e-37	145.00
IUUC-Osa-085937	Oryza sativa	36.57	5.00e-37	146.00
IUUC-Ola-086559	Oryzias latipes	50.00	3.00e-19	86.30
IUUC-Olu-087766	Ostreococcus lucimarinus	30.79	2.00e-33	134.00
IUUC-Oga-087983	Otolemur garnettii	50.00	8.00e-18	82.40
IUUC-Oar-089281	Ovis aries	53.52	1.00e-18	85.50
IUUC-Ptr-090983	Pan troglodytes	53.52	1.00e-18	85.10
IUUC-Pan-092457	Papio anubis	53.52	9.00e-19	85.50
IUUC-Psi-094046	Pelodiscus sinensis	50.00	1.00e-17	81.60
IUUC-Pno-094925	Phaeosphaeria nodorum	61.52	1.00e-103	367.00
IUUC-Ppa-095487	Physcomitrella patens	37.73	2.00e-35	140.00
IUUC-Pfo-096968	Poecilia formosa	48.19	4.00e-18	83.60
IUUC-Pab-098621	Pongo abelii	53.52	1.00e-18	85.10
IUUC-Pop-100007	Populus trichocarpa	37.77	2.00e-33	134.00
IUUC-Pca-100590	Procavia capensis	50.00	1.00e-17	82.00
IUUC-Ppe-101657	Prunus persica	34.33	3.00e-34	137.00
IUUC-Pva-102446	Pteropus vampyrus	53.52	1.00e-18	85.50
IUUC-Pgr-103604	Puccinia graminis	52.38	1.00e-20	92.00
IUUC-Ptt-103941	Puccinia triticina	37.43	3.00e-25	107.00
IUUC-Pte-104252	Pyrenophora teres	64.33	2.00e-111	393.00
IUUC-Pyt-104556	Pyrenophora triticirepentis	64.04	4.00e-110	389.00
IUUC-Rno-106025	Rattus norvegicus	53.52	1.00e-18	85.10
IUUC-Sce-106172	Saccharomyces cerevisiae	35.89	8.00e-51	192.00
IUUC-Sha-106858	Sarcophilus harrisii	53.52	1.00e-18	85.50
IUUC-Sja-107905	Schizosaccharomyces japonicus	47.50	4.00e-17	79.70
IUUC-Spo-108185	Schizosaccharomyces pombe	53.85	2.00e-19	87.00
IUUC-Smo-108883	Selaginella moellendorffii	34.19	5.00e-33	132.00
IUUC-Sit-110512	Setaria italica	43.48	3.00e-18	83.60
IUUC-Sly-111238	Solanum lycopersicum	35.74	1.00e-35	141.00
IUUC-Stu-112441	Solanum tuberosum	35.36	9.00e-35	138.00
IUUC-Sar-113039	Sorex araneus	50.00	1.00e-17	81.60
IUUC-Sbi-113776	Sorghum bicolor	34.09	3.00e-34	136.00
IUUC-Sre-115074	Sporisorium reilianum	49.40	2.00e-19	87.80
IUUC-Ssc-115262	Sus scrofa	53.52	1.00e-18	85.10
IUUC-Tgu-116790	Taeniopygia guttata	52.11	8.00e-18	82.40
IUUC-Tru-118160	Takifugu rubripes	50.00	3.00e-19	87.00
IUUC-Tsy-119145	Tarsius syrichta	56.76	4.00e-08	50.10
IUUC-Tni-119937	Tetraodon nigroviridis	32.84	2.00e-27	114.00
IUUC-Tca-121323	Theobroma cacao	35.90	4.00e-36	143.00
IUUC-Tre-121993	Trichoderma reesei	55.37	1.00e-90	324.00
IUUC-Tvi-122332	Trichoderma virens	56.55	6.00e-93	332.00
IUUC-Tae-123478	Triticum aestivum	33.58	4.00e-34	136.00
IUUC-Tur-126679	Triticum urartu	33.21	1.00e-33	134.00
IUUC-Tme-127159	Tuber melanosporum	56.32	8.00e-20	88.60
IUUC-Tbe-127590	Tupaia belangeri	24.42	2.80e-01	26.60
IUUC-Ttr-128261	Tursiops truncatus	50.00	8.00e-18	82.40
IUUC-Uma-129572	Ustilago maydis	31.60	1.00e-22	99.00
IUUC-Vda-129966	Verticillium dahliae	64.44	2.00e-107	379.00
IUUC-Vpa-130698	Vicugna pacos	50.00	1.00e-17	82.00
IUUC-Vvi-131240	Vitis vinifera	27.78	3.00e-03	33.50
IUUC-Xtr-132878	Xenopus tropicalis	50.00	2.00e-17	81.30
IUUC-Xma-134017	Xiphophorus maculatus	48.19	4.00e-18	83.60
IUUC-Yli-134373	Yarrowia lipolytica	39.33	2.00e-31	127.00
IUUC-Zma-135222	Zea mays	45.65	8.00e-19	85.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence