iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012606

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Polycomb complex protein BMI-1; Polycomb group RING finger protein 4

Genbank Nucleotide ID

BC109871

Gene Name

BMI1; PCGF4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000015584.4	ENSBTAT00000020705.4	ENSBTAP00000020705.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.80e-06	27.9	18	57
ULD/UDP/UFD/RAWUL	1.80e-30	105.4	131	226

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C   f d + +  C H f+++C+ ++        ++ +CP+C+
   Q: 18   CVLCGGYFIDATTIIECLHSFCKTCIVRY------LETSKYCPICD 57
           ********99999****************......**********5 PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk..........lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkeg 79
           isls+e++++n+ +++ +          ++k+ylrc+a++tV+hl+kfl++k+++++++++d+++e+e+L+d++tL++i+yi++w+++g
   Q: 131  ISLSIEFFDQNRLDRKINkdkekskeevNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNG 219
           6888888888888776667777888999************************************************************* PP
   S: 80   pLvLqYr 86
           pL+L+Yr
   Q: 220  PLPLKYR 226
           ******9 PP

Organism

Bos taurus

Functional Description
(View)

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).

Protein Sequence
(Fasta)

MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV 60
HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTGCAGGA TCTTTTATCA AGCAGAAATG CATCGAACAA CCAGAATCAA GATCACTGAG 60
CTAAATCCCC ACCTAATGTG TGTTCTTTGT GGAGGGTACT TCATTGATGC CACAACCATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000792--C:heterochromatin
GO:0016604--C:nuclear body
GO:0031519--C:PcG protein complex
GO:0000151--C:ubiquitin ligase complex
GO:1990841--F:promoter-specific chromatin binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0006306--P:DNA methylation
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0016573--P:histone acetylation
GO:0016574--P:histone ubiquitination
GO:0006959--P:humoral immune response
GO:0001701--P:in utero embryonic development
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030890--P:positive regulation of B cell proliferation
GO:0033092--P:positive regulation of immature T cell proliferation in thymus
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:2000011--P:regulation of adaxial/abaxial pattern formation
GO:0021903--P:rostrocaudal neural tube patterning
GO:0048103--P:somatic stem cell division
GO:0006351--P:transcription, DNA-templated

KEGG

bta:510666

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000603	Aegilops tauschii	37.21	6.00e-12	65.50
IUUC-Aml-001498	Ailuropoda melanoleuca	98.47	9.00e-170	588.00
IUUC-Apl-004208	Anas platyrhynchos	95.49	8.00e-136	476.00
IUUC-Aca-004661	Anolis carolinensis	83.74	9.00e-140	489.00
IUUC-Aly-006155	Arabidopsis lyrata	40.00	9.00e-12	65.10
IUUC-Ath-007649	Arabidopsis thaliana	42.50	3.00e-12	66.60
IUUC-Ame-010610	Astyanax mexicanus	74.47	5.00e-138	483.00
IUUC-Bdi-015045	Brachypodium distachyon	38.55	1.00e-12	68.20
IUUC-Cja-019482	Callithrix jacchus	98.73	5.00e-180	623.00
IUUC-Cfa-020482	Canis familiaris	98.47	9.00e-170	588.00
IUUC-Cpo-022061	Cavia porcellus	98.73	4.00e-180	623.00
IUUC-Csa-024102	Chlorocebus sabaeus	99.04	0.00e+00	628.00
IUUC-Cho-025081	Choloepus hoffmanni	81.12	6.00e-112	396.00
IUUC-Cin-025612	Ciona intestinalis	49.07	3.00e-52	198.00
IUUC-Dre-027929	Danio rerio	79.45	1.00e-141	495.00
IUUC-Dno-029797	Dasypus novemcinctus	97.77	0.00e+00	644.00
IUUC-Dor-030256	Dipodomys ordii	95.54	1.00e-167	582.00
IUUC-Dme-031904	Drosophila melanogaster	45.02	3.00e-53	204.00
IUUC-Ete-033148	Echinops telfairi	64.71	6.00e-83	300.00
IUUC-Eca-033318	Equus caballus	99.08	4.00e-171	593.00
IUUC-Eeu-034547	Erinaceus europaeus	85.35	8.00e-149	519.00
IUUC-Fca-035866	Felis catus	99.08	1.00e-170	592.00
IUUC-Fal-036660	Ficedula albicollis	96.32	5.00e-161	560.00
IUUC-Gmo-039341	Gadus morhua	83.08	4.00e-126	443.00
IUUC-Gga-040611	Gallus gallus	95.86	2.00e-166	578.00
IUUC-Gac-041888	Gasterosteus aculeatus	71.89	2.00e-128	451.00
IUUC-Gma-042798	Glycine max	39.02	6.00e-12	65.10
IUUC-Ggo-045027	Gorilla gorilla	99.04	2.00e-180	624.00
IUUC-Hsa-045665	Homo sapiens	99.08	0.00e+00	628.00
IUUC-Itr-049045	Ictidomys tridecemlineatus	98.41	7.00e-178	615.00
IUUC-Lch-049714	Latimeria chalumnae	86.24	2.00e-164	571.00
IUUC-Loc-052161	Lepisosteus oculatus	81.35	1.00e-143	502.00
IUUC-Laf-054108	Loxodonta africana	96.97	9.00e-178	615.00
IUUC-Mcc-055562	Macaca mulatta	99.08	0.00e+00	628.00
IUUC-Meu-056709	Macropus eugenii	98.47	3.00e-174	603.00
IUUC-Mtr-058158	Medicago truncatula	43.42	4.00e-10	57.00
IUUC-Mga-060104	Meleagris gallopavo	93.17	1.00e-120	425.00
IUUC-Mmr-061191	Microcebus murinus	99.08	0.00e+00	629.00
IUUC-Mdo-062711	Monodelphis domestica	93.53	1.00e-153	535.00
IUUC-Mmu-064255	Mus musculus	94.27	8.00e-166	575.00
IUUC-Mpu-066466	Mustela putorius furo	98.16	8.00e-170	589.00
IUUC-Mlu-067622	Myotis lucifugus	98.41	2.00e-179	621.00
IUUC-Nle-069253	Nomascus leucogenys	99.04	0.00e+00	628.00
IUUC-Opr-070511	Ochotona princeps	98.09	3.00e-178	617.00
IUUC-Ont-072177	Oreochromis niloticus	83.52	5.00e-129	453.00
IUUC-Oan-073336	Ornithorhynchus anatinus	97.55	3.00e-171	594.00
IUUC-Ocu-074113	Oryctolagus cuniculus	98.41	1.00e-169	588.00
IUUC-Oba-075690	Oryza barthii	42.25	8.00e-12	64.70
IUUC-Ogl-077513	Oryza glaberrima	42.25	9.00e-12	65.10
IUUC-Ogu-078755	Oryza glumaepatula	42.25	1.00e-11	64.70
IUUC-Oni-082398	Oryza nivara	42.25	9.00e-12	65.10
IUUC-Oru-084965	Oryza rufipogon	42.25	9.00e-12	65.10
IUUC-Osa-086282	Oryza sativa	42.25	5.00e-12	65.50
IUUC-Ola-087057	Oryzias latipes	85.19	1.00e-123	436.00
IUUC-Oga-088346	Otolemur garnettii	99.04	2.00e-180	624.00
IUUC-Oar-089843	Ovis aries	100.00	4.00e-172	596.00
IUUC-Ptr-090486	Pan troglodytes	99.04	2.00e-180	624.00
IUUC-Pan-092667	Papio anubis	99.24	1.00e-159	555.00
IUUC-Psi-093469	Pelodiscus sinensis	95.71	4.00e-173	600.00
IUUC-Pma-094481	Petromyzon marinus	74.04	9.00e-90	322.00
IUUC-Ppa-095811	Physcomitrella patens	41.38	4.00e-10	59.30
IUUC-Pfo-097156	Poecilia formosa	79.05	1.00e-132	466.00
IUUC-Pab-097670	Pongo abelii	99.04	2.00e-180	624.00
IUUC-Pop-099100	Populus trichocarpa	37.65	2.00e-12	67.40
IUUC-Pva-102800	Pteropus vampyrus	99.04	2.00e-180	624.00
IUUC-Rno-105128	Rattus norvegicus	93.63	8.00e-169	585.00
IUUC-Sha-106747	Sarcophilus harrisii	97.85	3.00e-163	567.00
IUUC-Sar-113416	Sorex araneus	98.41	3.00e-179	620.00
IUUC-Ssc-115864	Sus scrofa	98.73	2.00e-180	624.00
IUUC-Tgu-116851	Taeniopygia guttata	95.49	2.00e-136	478.00
IUUC-Tru-117698	Takifugu rubripes	85.20	9.00e-125	439.00
IUUC-Tsy-119590	Tarsius syrichta	98.41	2.00e-179	621.00
IUUC-Tni-120170	Tetraodon nigroviridis	83.46	9.00e-129	452.00
IUUC-Tae-123760	Triticum aestivum	37.21	6.00e-12	65.50
IUUC-Tur-126396	Triticum urartu	37.21	6.00e-12	65.10
IUUC-Tbe-127790	Tupaia belangeri	98.73	4.00e-180	623.00
IUUC-Ttr-129316	Tursiops truncatus	99.08	5.00e-180	623.00
IUUC-Vpa-130669	Vicugna pacos	99.39	2.00e-171	594.00
IUUC-Xtr-131912	Xenopus tropicalis	88.07	2.00e-148	518.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence