iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064357

UUCD1 version

UUC-MuM-01069

Ensembl Protein ID

ENSMUSP00000099807.4

UniProt Accession

Q9Z1F9; Q3TQN3; Q3U819; Q3U9J5; Q8BVX9; SAE2_MOUSE

Genbank Protein ID

AAD10338.1; BAC36068.1; BAE27536.1; BAE30671.1; BAE31200.1; BAE37349.1; BAE37935.1; BAE38590.1; BAE40523.1; BAE40947.1; AAH54768.1

Protein Name

SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2

Genbank Nucleotide ID

U35833; AK075938; AK146925; AK151765; AK152415; AK163451; AK164826; AK166133; AK168673; AK169168; BC054768

Gene Name

Uba2; Sae2; Uble1b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000052997.15	ENSMUST00000102746.10	ENSMUSP00000099807.4
ENSMUSG00000052997.15	ENSMUST00000152037.2	ENSMUSP00000135078.1
ENSMUSG00000052997.15	ENSMUST00000175991.7	ENSMUSP00000135885.1
ENSMUSG00000052997.15	ENSMUST00000134856.8	ENSMUSP00000135841.1
ENSMUSG00000052997.15	ENSMUST00000156253.1	ENSMUSP00000116605.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	miRTarBase	microRNA
TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	11481243; 20682785

Classification

Family	E-value	Score	Start	End
E1	1.10e-139	467.3	10	419

Active Site

Position(s)	Description	Evidence
173	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 11   eaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesite 99
           e  e+++  +vl+vGagg+GcEllKnLvl+G+++i ++D dt++vsnlnrqFLf++++vg+sKA+va+e++ +++p+ n+eah++si++
   Q: 10   ELAEAVSGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFHPQANIEAHHDSIMN 98
           6679999********************************************************************************** PP
   S: 100  leeeivFfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtie 188
           ++++++Ff++f +V++aldnr+ar++vnr+cl+a+vpliesgt G+lGqv++i kg+tecy+c+++p+q+t+P+ct+++tp+++ h+i+
   Q: 99   PDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIV 187
           ***************************************************************************************** PP
   S: 189  wa.vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv. 274
           wa +lfn+l++ee++++ev++  d++++e++++++++e+++++++++ ++++i++k++ak+t ++ +k ++k f++di++  ++++++ 
   Q: 188  WAkYLFNQLFGEEDADQEVSP--DRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDpVKLFTKLFKDDIRYLLTMDKLWr 274
           *********************..799*************************************************************** PP
   S: 275  ...............sfcsnaealqvpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlr 343
                          + + na+++++p+ ++kd++v++++++     +++++++++++ek +g    el ++kdd+ a+d+vt+aanlr
   Q: 275  krkppvpldwaevqsQGEANADQQNEPQLGLKDQQVLDVKSYaslfsKSIETLRVHLAEKGDGA---ELIWDKDDPPAMDFVTSAANLR 360
           ****************************************************************...68******************** PP
   S: 344  aeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfda 403
           ++ +++++  ++++ik++agniipaiattnav++Gl+++E +K++sgk ++++++fl+++
   Q: 361  MHIFSMNM-KSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQ 419
           ********.***********************************************9965 PP

Organism

Mus musculus

Functional Description
(View)

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).

Protein Sequence
(Fasta)

MALSRGLPRE LAEAVSGGRV LVVGAGGIGC ELLKNLVLTG FSHIDLIDLD TIDVSNLNRQ 60
FLFQKKHVGR SKAQVAKESV LQFHPQANIE AHHDSIMNPD YNVEFFRQFI LVMNALDNRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAGGCTGGG GGGAAGGGCA CACTAGCCTC CACATGTAGT GTGTGTACAT GTGGCAGACA 60
CACAGGAAAC AGTCTCATAA CTGATGCTGA CTGTACCGGA GTCAGCGTGA ATCAGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR016040--NAD(P)-bd_dom
IPR030661--SAE2/Uba2
IPR000594--ThiF_NAD_FAD-bd
IPR028077--UAE_UbL_dom
IPR032426--UBA2_C
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF00899--ThiF
PF14732--UAE_UbL
PF16195--UBA2_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0031510--C:SUMO activating enzyme complex
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0046982--F:protein heterodimerization activity
GO:0019948--F:SUMO activating enzyme activity
GO:0008134--F:transcription factor binding
GO:0016925--P:protein sumoylation

KEGG

mmu:50995

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000112	Aegilops tauschii	40.44	2.00e-106	379.00
IUUC-Aml-001662	Ailuropoda melanoleuca	93.29	0.00e+00	1188.00
IUUC-Atr-002636	Amborella trichopoda	39.84	7.00e-113	401.00
IUUC-Apl-003369	Anas platyrhynchos	88.01	0.00e+00	1009.00
IUUC-Aca-004490	Anolis carolinensis	82.69	0.00e+00	914.00
IUUC-Aly-006359	Arabidopsis lyrata	41.47	9.00e-103	367.00
IUUC-Ath-007667	Arabidopsis thaliana	42.20	1.00e-106	380.00
IUUC-Ago-007844	Ashbya gossypii	37.45	1.00e-81	297.00
IUUC-Acl-008270	Aspergillus clavatus	42.65	3.00e-106	379.00
IUUC-Afl-008674	Aspergillus flavus	43.39	7.00e-111	394.00
IUUC-Afu-008883	Aspergillus fumigatus	42.62	3.00e-107	382.00
IUUC-Ani-009500	Aspergillus nidulans	45.53	9.00e-118	417.00
IUUC-Ang-009535	Aspergillus niger	44.02	5.00e-112	398.00
IUUC-Aor-010223	Aspergillus oryzae	43.46	2.00e-112	399.00
IUUC-Ate-010282	Aspergillus terreus	43.69	2.00e-89	323.00
IUUC-Ame-011736	Astyanax mexicanus	77.69	0.00e+00	979.00
IUUC-Bgr-012166	Blumeria graminis	41.94	7.00e-98	351.00
IUUC-Bta-012589	Bos taurus	93.59	0.00e+00	1199.00
IUUC-Bci-013802	Botrytis cinerea	42.50	1.00e-101	363.00
IUUC-Bdi-014697	Brachypodium distachyon	41.03	9.00e-109	387.00
IUUC-Bol-016315	Brassica oleracea	39.20	3.00e-109	389.00
IUUC-Bra-017009	Brassica rapa	39.51	6.00e-110	391.00
IUUC-Cel-018708	Caenorhabditis elegans	44.66	3.00e-132	465.00
IUUC-Cja-019120	Callithrix jacchus	94.06	0.00e+00	1153.00
IUUC-Cfa-021061	Canis familiaris	93.59	0.00e+00	1194.00
IUUC-Cpo-021842	Cavia porcellus	93.28	0.00e+00	1151.00
IUUC-Csa-024104	Chlorocebus sabaeus	93.92	0.00e+00	1126.00
IUUC-Cho-024332	Choloepus hoffmanni	84.46	0.00e+00	842.00
IUUC-Cin-025363	Ciona intestinalis	61.91	0.00e+00	684.00
IUUC-Cgl-026419	Colletotrichum gloeosporioides	42.61	6.00e-97	348.00
IUUC-Cne-026888	Cryptococcus neoformans	51.97	1.00e-73	270.00
IUUC-Cme-027315	Cyanidioschyzon merolae	33.98	4.00e-58	219.00
IUUC-Dre-028420	Danio rerio	75.56	0.00e+00	920.00
IUUC-Dno-030041	Dasypus novemcinctus	93.60	0.00e+00	1152.00
IUUC-Dor-031039	Dipodomys ordii	78.96	7.00e-177	613.00
IUUC-Dse-031504	Dothistroma septosporum	38.23	1.00e-96	347.00
IUUC-Dme-031771	Drosophila melanogaster	48.70	2.00e-147	516.00
IUUC-Ete-033037	Echinops telfairi	88.28	0.00e+00	1040.00
IUUC-Eca-033774	Equus caballus	93.43	0.00e+00	1147.00
IUUC-Eeu-035074	Erinaceus europaeus	93.43	0.00e+00	927.00
IUUC-Fca-036508	Felis catus	93.60	0.00e+00	1148.00
IUUC-Fal-036813	Ficedula albicollis	85.98	0.00e+00	1002.00
IUUC-Fox-038056	Fusarium oxysporum	44.59	4.00e-107	382.00
IUUC-Fso-038223	Fusarium solani	43.04	2.00e-104	373.00
IUUC-Gmo-038526	Gadus morhua	78.91	0.00e+00	900.00
IUUC-Ggr-039767	Gaeumannomyces graminis	43.82	7.00e-101	361.00
IUUC-Gga-040981	Gallus gallus	86.79	0.00e+00	1031.00
IUUC-Gac-041437	Gasterosteus aculeatus	76.10	0.00e+00	922.00
IUUC-Gma-044072	Glycine max	37.90	5.00e-115	408.00
IUUC-Ggo-045358	Gorilla gorilla	90.70	0.00e+00	1075.00
IUUC-Hsa-046068	Homo sapiens	94.06	0.00e+00	1131.00
IUUC-Hvu-047646	Hordeum vulgare	36.96	2.00e-106	379.00
IUUC-Itr-047887	Ictidomys tridecemlineatus	93.76	0.00e+00	1150.00
IUUC-Lch-049565	Latimeria chalumnae	81.75	0.00e+00	1040.00
IUUC-Lpe-050884	Leersia perrieri	40.64	6.00e-107	381.00
IUUC-Loc-052493	Lepisosteus oculatus	81.21	0.00e+00	1021.00
IUUC-Lma-053117	Leptosphaeria maculans	44.25	3.00e-101	362.00
IUUC-Laf-054518	Loxodonta africana	90.33	0.00e+00	1125.00
IUUC-Mcc-055334	Macaca mulatta	94.38	0.00e+00	1129.00
IUUC-Mor-057137	Magnaporthe oryzae	43.53	6.00e-96	345.00
IUUC-Mpo-057449	Magnaporthe poae	42.16	2.00e-101	363.00
IUUC-Mtr-058045	Medicago truncatula	38.36	2.00e-115	409.00
IUUC-Mla-058864	Melampsora laricipopulina	45.51	2.00e-95	343.00
IUUC-Mga-059422	Meleagris gallopavo	81.86	0.00e+00	909.00
IUUC-Mvi-060536	Microbotryum violaceum	42.62	5.00e-88	318.00
IUUC-Mmr-061161	Microcebus murinus	92.18	0.00e+00	1147.00
IUUC-Mdo-061802	Monodelphis domestica	90.61	0.00e+00	1108.00
IUUC-Mac-065475	Musa acuminata	38.03	7.00e-109	388.00
IUUC-Mpu-066895	Mustela putorius furo	93.75	0.00e+00	1194.00
IUUC-Mlu-067862	Myotis lucifugus	93.45	0.00e+00	1194.00
IUUC-Nfi-068385	Neosartorya fischeri	44.38	3.00e-111	395.00
IUUC-Ncr-068885	Neurospora crassa	41.48	8.00e-106	377.00
IUUC-Nle-069524	Nomascus leucogenys	93.75	0.00e+00	1115.00
IUUC-Opr-071038	Ochotona princeps	93.91	0.00e+00	1195.00
IUUC-Ont-071719	Oreochromis niloticus	76.35	0.00e+00	979.00
IUUC-Oan-072877	Ornithorhynchus anatinus	89.19	0.00e+00	972.00
IUUC-Ocu-074080	Oryctolagus cuniculus	93.59	0.00e+00	1149.00
IUUC-Oba-075936	Oryza barthii	39.38	1.00e-105	377.00
IUUC-Obr-076841	Oryza brachyantha	39.96	1.00e-107	383.00
IUUC-Ogl-077686	Oryza glaberrima	39.42	3.00e-107	382.00
IUUC-Ogu-078597	Oryza glumaepatula	38.32	1.00e-102	367.00
IUUC-Oin-079791	Oryza indica	39.38	1.00e-105	377.00
IUUC-Olo-081009	Oryza longistaminata	39.38	1.00e-105	377.00
IUUC-Ome-081327	Oryza meridionalis	36.44	3.00e-99	355.00
IUUC-Oni-082334	Oryza nivara	38.53	5.00e-103	368.00
IUUC-Opu-083447	Oryza punctata	39.56	1.00e-106	380.00
IUUC-Oru-084977	Oryza rufipogon	39.38	1.00e-105	377.00
IUUC-Osa-086160	Oryza sativa	43.24	2.00e-93	335.00
IUUC-Ola-087415	Oryzias latipes	75.96	0.00e+00	930.00
IUUC-Olu-087850	Ostreococcus lucimarinus	39.15	2.00e-98	353.00
IUUC-Oga-088434	Otolemur garnettii	93.28	0.00e+00	1150.00
IUUC-Oar-089872	Ovis aries	93.11	0.00e+00	1144.00
IUUC-Ptr-091212	Pan troglodytes	94.06	0.00e+00	1131.00
IUUC-Pan-092708	Papio anubis	97.68	4.00e-130	458.00
IUUC-Psi-093703	Pelodiscus sinensis	89.19	0.00e+00	1026.00
IUUC-Pno-094953	Phaeosphaeria nodorum	45.58	2.00e-105	376.00
IUUC-Ppa-095963	Physcomitrella patens	44.06	3.00e-107	382.00
IUUC-Pfo-097515	Poecilia formosa	74.92	0.00e+00	924.00
IUUC-Pab-097951	Pongo abelii	93.75	0.00e+00	982.00
IUUC-Pop-099703	Populus trichocarpa	35.05	1.00e-96	347.00
IUUC-Pca-100426	Procavia capensis	91.88	0.00e+00	1173.00
IUUC-Ppe-101152	Prunus persica	38.95	1.00e-111	397.00
IUUC-Pva-102792	Pteropus vampyrus	89.31	0.00e+00	1108.00
IUUC-Pgr-103592	Puccinia graminis	43.75	4.00e-100	359.00
IUUC-Ptt-103805	Puccinia triticina	41.27	1.00e-84	307.00
IUUC-Pte-104215	Pyrenophora teres	44.12	2.00e-110	393.00
IUUC-Pyt-104634	Pyrenophora triticirepentis	45.64	2.00e-109	389.00
IUUC-Rno-106117	Rattus norvegicus	97.81	0.00e+00	1244.00
IUUC-Sce-106177	Saccharomyces cerevisiae	34.06	2.00e-75	276.00
IUUC-Sha-107006	Sarcophilus harrisii	90.95	0.00e+00	1114.00
IUUC-Sja-107967	Schizosaccharomyces japonicus	43.71	6.00e-94	338.00
IUUC-Spo-108020	Schizosaccharomyces pombe	44.77	7.00e-96	344.00
IUUC-Ssl-108509	Sclerotinia sclerotiorum	43.43	2.00e-103	369.00
IUUC-Smo-109264	Selaginella moellendorffii	40.84	3.00e-103	369.00
IUUC-Sit-110581	Setaria italica	41.21	2.00e-107	383.00
IUUC-Sly-111870	Solanum lycopersicum	39.08	8.00e-111	394.00
IUUC-Stu-112283	Solanum tuberosum	39.21	2.00e-108	386.00
IUUC-Sar-113432	Sorex araneus	69.27	0.00e+00	762.00
IUUC-Sbi-114075	Sorghum bicolor	37.66	3.00e-107	382.00
IUUC-Sre-114926	Sporisorium reilianum	38.82	1.00e-104	374.00
IUUC-Ssc-116281	Sus scrofa	96.79	1.00e-115	408.00
IUUC-Tgu-117247	Taeniopygia guttata	84.49	0.00e+00	1000.00
IUUC-Tru-118075	Takifugu rubripes	71.25	0.00e+00	890.00
IUUC-Tsy-119398	Tarsius syrichta	77.50	0.00e+00	876.00
IUUC-Tni-120771	Tetraodon nigroviridis	66.31	0.00e+00	806.00
IUUC-Tca-121651	Theobroma cacao	39.11	2.00e-109	389.00
IUUC-Tre-122224	Trichoderma reesei	43.31	2.00e-96	346.00
IUUC-Tvi-122634	Trichoderma virens	43.23	9.00e-96	344.00
IUUC-Tae-123607	Triticum aestivum	40.26	7.00e-107	381.00
IUUC-Tur-126417	Triticum urartu	39.96	8.00e-107	380.00
IUUC-Tme-127016	Tuber melanosporum	44.86	3.00e-96	345.00
IUUC-Tbe-127678	Tupaia belangeri	77.28	3.00e-166	578.00
IUUC-Ttr-128598	Tursiops truncatus	90.16	0.00e+00	1140.00
IUUC-Uma-129612	Ustilago maydis	42.07	5.00e-96	345.00
IUUC-Vda-129811	Verticillium dahliae	40.50	2.00e-102	366.00
IUUC-Vpa-130732	Vicugna pacos	79.38	0.00e+00	972.00
IUUC-Vvi-130832	Vitis vinifera	40.88	1.00e-106	380.00
IUUC-Xtr-132823	Xenopus tropicalis	75.29	0.00e+00	907.00
IUUC-Xma-133552	Xiphophorus maculatus	74.76	0.00e+00	923.00
IUUC-Yli-134666	Yarrowia lipolytica	38.46	2.00e-76	280.00
IUUC-Zma-135547	Zea mays	40.55	1.00e-105	377.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence