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Tag Content
UUCD2 ID IUUC-Mdo-063005
UUCD1 version UUC-MoD-00307
Ensembl Protein ID ENSMODP00000001283.3
UniProt Accession F7GHZ3; F7GHZ3_MONDO
Protein Name Uncharacterized protein
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMODG00000001079.3 ENSMODT00000001310.3 ENSMODP00000001283.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.60e-128 427.2 394 729
Active Site
Position(s) Description Evidence
698 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 394  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 481
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 482  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 566
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqFv
   Q: 567  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQFV 654
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 655  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 729
           ******************************99999**************************************76 PP
   
Organism Monodelphis domestica
Protein Sequence
(Fasta)
MLNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mdo-063005|E3,HECT|Monodelphis domestica
Please wait for a moment...
Nucleotide Sequence
(Fasta)
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNNN NGCTGTAGAG GATCCTTTTC CCCCGGTTGC TGGCAGGAGA TGTTGAACCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mdo-063005|E3,HECT|Monodelphis domestica
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
KEGG mdo:100015651
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 91.88 0.00e+00 1407.00
IUUC-Apl-004155 Anas platyrhynchos 94.53 0.00e+00 1459.00
IUUC-Aca-005238 Anolis carolinensis 96.45 0.00e+00 1453.00
IUUC-Ame-010901 Astyanax mexicanus 91.38 0.00e+00 1398.00
IUUC-Bta-013221 Bos taurus 90.16 0.00e+00 1347.00
IUUC-Cja-018985 Callithrix jacchus 94.85 0.00e+00 1484.00
IUUC-Cfa-020568 Canis familiaris 92.84 0.00e+00 1435.00
IUUC-Cpo-022531 Cavia porcellus 94.32 0.00e+00 1476.00
IUUC-Csa-024145 Chlorocebus sabaeus 97.81 0.00e+00 1487.00
IUUC-Cho-024963 Choloepus hoffmanni 76.34 0.00e+00 914.00
IUUC-Dre-028341 Danio rerio 91.80 0.00e+00 1408.00
IUUC-Dno-029705 Dasypus novemcinctus 92.94 0.00e+00 1420.00
IUUC-Dme-031740 Drosophila melanogaster 71.11 2.00e-175 609.00
IUUC-Eca-034125 Equus caballus 94.59 0.00e+00 1447.00
IUUC-Fca-035905 Felis catus 95.36 0.00e+00 1443.00
IUUC-Fal-037336 Ficedula albicollis 97.21 0.00e+00 1434.00
IUUC-Gmo-039486 Gadus morhua 81.06 0.00e+00 873.00
IUUC-Gga-040218 Gallus gallus 97.17 0.00e+00 1494.00
IUUC-Gac-041707 Gasterosteus aculeatus 85.09 0.00e+00 1294.00
IUUC-Ggo-045408 Gorilla gorilla 89.04 0.00e+00 1342.00
IUUC-Hsa-045878 Homo sapiens 94.98 0.00e+00 1486.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 94.58 0.00e+00 1445.00
IUUC-Loc-052628 Lepisosteus oculatus 86.02 0.00e+00 1381.00
IUUC-Laf-053644 Loxodonta africana 91.92 0.00e+00 1389.00
IUUC-Mcc-055479 Macaca mulatta 90.01 0.00e+00 1338.00
IUUC-Mga-059723 Meleagris gallopavo 93.91 0.00e+00 1416.00
IUUC-Mmu-063634 Mus musculus 97.40 0.00e+00 1468.00
IUUC-Mpu-065898 Mustela putorius furo 97.08 0.00e+00 1447.00
IUUC-Mlu-067584 Myotis lucifugus 93.70 0.00e+00 1442.00
IUUC-Nle-069033 Nomascus leucogenys 94.99 0.00e+00 1451.00
IUUC-Ont-072265 Oreochromis niloticus 83.42 0.00e+00 1304.00
IUUC-Oan-073621 Ornithorhynchus anatinus 92.51 0.00e+00 1453.00
IUUC-Ocu-073960 Oryctolagus cuniculus 93.25 0.00e+00 1414.00
IUUC-Oga-088579 Otolemur garnettii 94.98 0.00e+00 1484.00
IUUC-Oar-090396 Ovis aries 92.33 0.00e+00 1352.00
IUUC-Ptr-091624 Pan troglodytes 94.98 0.00e+00 1486.00
IUUC-Pan-092479 Papio anubis 94.86 0.00e+00 1451.00
IUUC-Psi-094074 Pelodiscus sinensis 99.46 0.00e+00 1154.00
IUUC-Pfo-097203 Poecilia formosa 85.12 0.00e+00 1303.00
IUUC-Pab-097540 Pongo abelii 94.61 0.00e+00 1414.00
IUUC-Pca-100379 Procavia capensis 72.73 0.00e+00 643.00
IUUC-Rno-105396 Rattus norvegicus 97.40 0.00e+00 1469.00
IUUC-Sha-107216 Sarcophilus harrisii 95.74 0.00e+00 1485.00
IUUC-Ssc-116413 Sus scrofa 95.20 0.00e+00 1415.00
IUUC-Tgu-116723 Taeniopygia guttata 94.33 0.00e+00 1427.00
IUUC-Tru-117843 Takifugu rubripes 82.72 0.00e+00 1281.00
IUUC-Tsy-119455 Tarsius syrichta 93.91 0.00e+00 1352.00
IUUC-Tni-120037 Tetraodon nigroviridis 81.77 0.00e+00 1227.00
IUUC-Tbe-127879 Tupaia belangeri 81.05 0.00e+00 1187.00
IUUC-Ttr-128423 Tursiops truncatus 93.09 0.00e+00 1367.00
IUUC-Xtr-132237 Xenopus tropicalis 88.08 0.00e+00 1387.00
Created Date 25-Jun-2017

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