iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-69	235.6	1243	1588

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           +Gl+Nlg+tCY+ S++Q+L++ipe r+++++ k++e++       ++++ l +lqk+f+ l++s+ ka++pr + k+  + ++ +++
   Q: 1243 VGLTNLGATCYLASTIQQLYMIPEARQAVFTaKYSEDM-------KHKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNT 1322
           6******************************3444444.......4568899*********************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            eq+D  Ef++ l+ ++ee                               + k++++ lF+g ++++++ l+c++vs++ e+f+++ 
   Q: 1323 GEQKDMTEFFTDLITKVEEMS----------------------------PELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVR 1381
           *****************9977............................567899******************************** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           ++v + +     ++ ++L++ t +++leg+n+y c++c kk++aek+  +kklP++L+++ +R++f+  ++++ek+n++++fpl+Ld
   Q: 1382 CQVADMK-----NIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLD 1463
           *******.....9************************************************************************** PP
   S: 261  lspfcts................peekqkekkkYeLiavvvHsGslssGHYvayvkn.......ekgkWllfdDskVtevkeeevle 324
           ++p++++                + +k++e+++Y+Li+v vH+G++++GHY++++++       +++kW+lf+D +V++ + ++  +
   Q: 1464 MTPYTEDflmgksdrkegfkdvgDHSKDTESYEYDLIGVTVHTGTADGGHYYSFIRDivnphayKNNKWYLFNDAEVKPFDSAQLAS 1550
           **********99999999999996677777***************************99999988999******************9 PP
   S: 325  etg........................staYvlfYkrr 338
           e+                         ++aY+lfYkr+
   Q: 1551 ECFggemttktydsvtdkfmdfsfektHSAYMLFYKRM 1588
           7779********************************96 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

PRRGRVGGAG KDLVFNTEPL PSVDNRIRML DACAHSEDPE HDISGEMSSA HIAQGSQESC 60
ITRSGDFLGE TIGNELFNCR QFIGPQHHHH HHHHHHHHHH HHHHHHHHHD GHMVDDMLSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTTAAAGAA GAGGAAGAGT AGGCGGAGCA GGAAAGGACC TGGTGTTTAA CACTGAGCCC 60
TTGCCGTCCG TGGATAACCG AATACGAATG CTAGATGCCT GTGCTCACTC TGAAGACCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002257	Ailuropoda melanoleuca	96.37	0.00e+00	5553.00
IUUC-Apl-003284	Anas platyrhynchos	93.45	0.00e+00	5406.00
IUUC-Aca-004415	Anolis carolinensis	92.66	0.00e+00	5324.00
IUUC-Acl-008140	Aspergillus clavatus	28.62	7.00e-64	240.00
IUUC-Afl-008381	Aspergillus flavus	27.36	2.00e-64	242.00
IUUC-Afu-008857	Aspergillus fumigatus	26.41	2.00e-63	239.00
IUUC-Ani-009257	Aspergillus nidulans	28.68	3.00e-56	215.00
IUUC-Ang-009759	Aspergillus niger	26.98	1.00e-63	239.00
IUUC-Aor-009931	Aspergillus oryzae	27.36	3.00e-64	241.00
IUUC-Ate-010246	Aspergillus terreus	27.77	6.00e-53	204.00
IUUC-Ame-011219	Astyanax mexicanus	64.44	0.00e+00	2458.00
IUUC-Bgr-012195	Blumeria graminis	26.81	7.00e-65	244.00
IUUC-Bta-012989	Bos taurus	96.58	0.00e+00	5515.00
IUUC-Bci-013798	Botrytis cinerea	32.68	4.00e-58	221.00
IUUC-Cja-018974	Callithrix jacchus	90.80	0.00e+00	769.00
IUUC-Cfa-021214	Canis familiaris	96.61	0.00e+00	5559.00
IUUC-Cpo-021912	Cavia porcellus	96.67	0.00e+00	3526.00
IUUC-Csa-023658	Chlorocebus sabaeus	96.34	0.00e+00	5543.00
IUUC-Cho-024971	Choloepus hoffmanni	81.81	0.00e+00	3130.00
IUUC-Cgl-026466	Colletotrichum gloeosporioides	27.99	7.00e-64	240.00
IUUC-Dre-027428	Danio rerio	84.07	0.00e+00	4599.00
IUUC-Dno-029690	Dasypus novemcinctus	95.73	0.00e+00	5488.00
IUUC-Dor-030817	Dipodomys ordii	86.86	0.00e+00	2105.00
IUUC-Dse-031423	Dothistroma septosporum	25.97	3.00e-36	148.00
IUUC-Dme-032102	Drosophila melanogaster	53.73	0.00e+00	841.00
IUUC-Ete-032552	Echinops telfairi	92.18	0.00e+00	2944.00
IUUC-Eca-033457	Equus caballus	96.44	0.00e+00	5541.00
IUUC-Eeu-035118	Erinaceus europaeus	92.53	0.00e+00	3021.00
IUUC-Fca-036213	Felis catus	94.54	0.00e+00	4982.00
IUUC-Fal-037643	Ficedula albicollis	91.41	0.00e+00	5301.00
IUUC-Fox-037971	Fusarium oxysporum	27.39	1.00e-62	236.00
IUUC-Fso-038108	Fusarium solani	27.10	1.00e-59	226.00
IUUC-Ggr-040075	Gaeumannomyces graminis	32.63	4.00e-62	234.00
IUUC-Gga-040511	Gallus gallus	91.21	0.00e+00	5311.00
IUUC-Gac-042024	Gasterosteus aculeatus	89.40	0.00e+00	4262.00
IUUC-Ggo-044924	Gorilla gorilla	91.73	0.00e+00	5319.00
IUUC-Hsa-046913	Homo sapiens	96.34	0.00e+00	5544.00
IUUC-Itr-048626	Ictidomys tridecemlineatus	96.68	0.00e+00	5560.00
IUUC-Lch-049675	Latimeria chalumnae	85.73	0.00e+00	3844.00
IUUC-Loc-052832	Lepisosteus oculatus	87.44	0.00e+00	4991.00
IUUC-Lma-053130	Leptosphaeria maculans	27.66	1.00e-60	229.00
IUUC-Laf-054169	Loxodonta africana	95.30	0.00e+00	5506.00
IUUC-Mcc-055847	Macaca mulatta	95.30	0.00e+00	5460.00
IUUC-Meu-056327	Macropus eugenii	84.42	0.00e+00	1549.00
IUUC-Mor-057152	Magnaporthe oryzae	35.41	1.00e-61	233.00
IUUC-Mpo-057310	Magnaporthe poae	26.87	5.00e-60	228.00
IUUC-Mmr-060780	Microcebus murinus	96.68	0.00e+00	5558.00
IUUC-Mdo-062308	Monodelphis domestica	92.20	0.00e+00	5366.00
IUUC-Mmu-063457	Mus musculus	98.17	0.00e+00	5608.00
IUUC-Mpu-066917	Mustela putorius furo	93.61	0.00e+00	5329.00
IUUC-Mlu-067696	Myotis lucifugus	96.37	0.00e+00	5529.00
IUUC-Nfi-068259	Neosartorya fischeri	27.05	5.00e-64	241.00
IUUC-Ncr-068911	Neurospora crassa	26.08	2.00e-59	226.00
IUUC-Nle-069586	Nomascus leucogenys	96.20	0.00e+00	5536.00
IUUC-Opr-070447	Ochotona princeps	92.36	0.00e+00	2840.00
IUUC-Ont-072396	Oreochromis niloticus	86.16	0.00e+00	4618.00
IUUC-Oan-073147	Ornithorhynchus anatinus	93.37	0.00e+00	5408.00
IUUC-Ocu-074324	Oryctolagus cuniculus	96.27	0.00e+00	5527.00
IUUC-Ola-086312	Oryzias latipes	84.81	0.00e+00	4681.00
IUUC-Oga-088878	Otolemur garnettii	96.58	0.00e+00	5557.00
IUUC-Oar-089919	Ovis aries	96.37	0.00e+00	5500.00
IUUC-Ptr-090713	Pan troglodytes	96.74	0.00e+00	5021.00
IUUC-Pan-091957	Papio anubis	96.99	0.00e+00	5036.00
IUUC-Psi-093240	Pelodiscus sinensis	92.79	0.00e+00	5374.00
IUUC-Pma-094469	Petromyzon marinus	72.83	0.00e+00	4078.00
IUUC-Pno-095059	Phaeosphaeria nodorum	29.57	2.00e-57	219.00
IUUC-Pfo-097159	Poecilia formosa	84.96	0.00e+00	4677.00
IUUC-Pab-098003	Pongo abelii	96.06	0.00e+00	5529.00
IUUC-Pca-100799	Procavia capensis	91.08	0.00e+00	1943.00
IUUC-Pva-103226	Pteropus vampyrus	91.40	0.00e+00	5191.00
IUUC-Pte-104235	Pyrenophora teres	26.71	3.00e-59	225.00
IUUC-Pyt-104803	Pyrenophora triticirepentis	27.06	7.00e-61	229.00
IUUC-Sha-106979	Sarcophilus harrisii	93.76	0.00e+00	5386.00
IUUC-Sar-113444	Sorex araneus	88.36	0.00e+00	4964.00
IUUC-Ssc-115815	Sus scrofa	96.69	0.00e+00	4434.00
IUUC-Tgu-117470	Taeniopygia guttata	92.83	0.00e+00	5326.00
IUUC-Tru-118543	Takifugu rubripes	82.10	0.00e+00	4641.00
IUUC-Tsy-119081	Tarsius syrichta	87.18	0.00e+00	4808.00
IUUC-Tre-122057	Trichoderma reesei	29.13	3.00e-62	235.00
IUUC-Tvi-122570	Trichoderma virens	35.62	3.00e-59	225.00
IUUC-Tme-127154	Tuber melanosporum	27.61	7.00e-60	226.00
IUUC-Tbe-127801	Tupaia belangeri	85.18	0.00e+00	3258.00
IUUC-Ttr-129262	Tursiops truncatus	91.99	0.00e+00	5240.00
IUUC-Vda-129686	Verticillium dahliae	28.53	4.00e-62	234.00
IUUC-Vpa-130484	Vicugna pacos	94.29	0.00e+00	5205.00
IUUC-Xtr-131769	Xenopus tropicalis	86.02	0.00e+00	5003.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence