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Tag Content
UUCD2 ID IUUC-Dre-027901
UUCD1 version UUC-DaR-00944
Ensembl Protein ID ENSDARP00000072590.3
UniProt Accession F1R4B5; F1R4B5_DANRE
Genbank Protein ID ENSDARP00000072590
Protein Name Ubiquitin protein ligase E3A
Genbank Nucleotide ID CR388007
Gene Name ube3a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000055737.4 ENSDART00000078128.3 ENSDARP00000072590.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.20e-104 351.3 530 856
Active Site
Position(s) Description Evidence
825 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e++  F+++G++lg+a++++ +ld+
   Q: 530  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ENEGQFTLIGIVLGLAIYNNCILDV 613
           689******************************************998888876.89888....6899********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p l++slk + e+ e ++ee  + +tf++s++  +g+   ++Lk++G++ipVtneN++++v l++
   Q: 614  HFPMVIYRKLMGKKGTFRDLADSHPVLFQSLKDLMEY-EGNVEED-MMITFQISQTDlFGNPLMYDLKESGDKIPVTNENRKDFVALYA 700
           *************************************.6678775.9999996554449****************************** PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           ey l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l++ t+y+ggy++ds+ i+ Fwe++++f++e+++ fLq
   Q: 701  EYMLNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEESTEYDGGYNKDSRIIRDFWETVHSFEQEKKRLFLQ 789
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d drlP+s+TCfn+L LPeYs+ e+lke+Ll Ai+++kgF++
   Q: 790  FTTGTDRAPVGGLGKLK---MIIAKNGPDsDRLPTSHTCFNVLLLPEYSTVEKLKERLLKAITYAKGFGM 856
           *****************...8888877777**************************************97 PP
   
Organism Danio rerio
Protein Sequence
(Fasta)
MKRAAAKHLI ERYYHQLTEG CGNEACTNEA CGSSPGFQRM DNNAAAIKAL ELYKNNAKLC 60
DPHPSKKGAS SAFPENSAKG AHNFSACSNG KMNHKDLPPT REDFRDLNFL TEDKVYEILS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-027901|E3,HECT|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGATCGCTCT CCGTGTTTGC CTCAGTTGAT CAAGATGGCC GCGAATATTT TGTGGAGGGG 60
TTGGAGTTGA ATACACGCCG CACTAGAAGC GATTGTGATG TTGAGAGACC AGATTCATTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-027901|E3,HECT|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A
PROSITE

PS50237--HECT
Pfam

PF16558--AZUL
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002214 Ailuropoda melanoleuca 85.75 0.00e+00 1432.00
IUUC-Atr-003144 Amborella trichopoda 44.55 2.00e-92 333.00
IUUC-Apl-003742 Anas platyrhynchos 85.93 0.00e+00 1449.00
IUUC-Aca-004873 Anolis carolinensis 84.95 0.00e+00 1447.00
IUUC-Ame-011166 Astyanax mexicanus 94.64 0.00e+00 1600.00
IUUC-Bta-013286 Bos taurus 85.18 0.00e+00 1401.00
IUUC-Cja-019707 Callithrix jacchus 86.23 0.00e+00 1434.00
IUUC-Cfa-020154 Canis familiaris 85.53 0.00e+00 1426.00
IUUC-Cpo-021292 Cavia porcellus 85.51 0.00e+00 1419.00
IUUC-Cre-022790 Chlamydomonas reinhardtii 50.00 8.00e-83 300.00
IUUC-Csa-023378 Chlorocebus sabaeus 86.23 0.00e+00 1433.00
IUUC-Cho-025059 Choloepus hoffmanni 81.80 0.00e+00 1351.00
IUUC-Cin-025643 Ciona intestinalis 43.01 0.00e+00 696.00
IUUC-Csv-026282 Ciona savignyi 43.38 0.00e+00 652.00
IUUC-Cme-027151 Cyanidioschyzon merolae 43.12 5.00e-98 352.00
IUUC-Dno-029320 Dasypus novemcinctus 85.18 0.00e+00 1429.00
IUUC-Dor-030756 Dipodomys ordii 91.67 0.00e+00 639.00
IUUC-Dme-032035 Drosophila melanogaster 50.08 1.00e-164 573.00
IUUC-Eca-033843 Equus caballus 85.28 0.00e+00 1405.00
IUUC-Eeu-035109 Erinaceus europaeus 84.11 0.00e+00 1385.00
IUUC-Fca-036344 Felis catus 85.31 0.00e+00 1428.00
IUUC-Fal-036747 Ficedula albicollis 85.81 0.00e+00 1448.00
IUUC-Gmo-038840 Gadus morhua 63.40 0.00e+00 1098.00
IUUC-Gga-040399 Gallus gallus 85.93 0.00e+00 1450.00
IUUC-Gac-041933 Gasterosteus aculeatus 85.33 0.00e+00 1390.00
IUUC-Ggo-044804 Gorilla gorilla 86.23 0.00e+00 1432.00
IUUC-Hsa-045727 Homo sapiens 86.23 0.00e+00 1432.00
IUUC-Itr-048289 Ictidomys tridecemlineatus 81.89 0.00e+00 1336.00
IUUC-Lch-050197 Latimeria chalumnae 84.25 0.00e+00 1432.00
IUUC-Loc-052743 Lepisosteus oculatus 86.98 0.00e+00 1469.00
IUUC-Lma-053245 Leptosphaeria maculans 35.54 2.00e-57 218.00
IUUC-Laf-053615 Loxodonta africana 85.63 0.00e+00 1439.00
IUUC-Mcc-054934 Macaca mulatta 86.23 0.00e+00 1432.00
IUUC-Meu-056061 Macropus eugenii 87.23 0.00e+00 1248.00
IUUC-Mga-059271 Meleagris gallopavo 85.80 0.00e+00 1443.00
IUUC-Mmr-061288 Microcebus murinus 86.23 0.00e+00 1437.00
IUUC-Mdo-062975 Monodelphis domestica 85.90 0.00e+00 1447.00
IUUC-Mmu-063674 Mus musculus 84.60 0.00e+00 1392.00
IUUC-Mpu-066568 Mustela putorius furo 85.88 0.00e+00 1436.00
IUUC-Mlu-067522 Myotis lucifugus 81.58 0.00e+00 1357.00
IUUC-Nle-069505 Nomascus leucogenys 86.23 0.00e+00 1432.00
IUUC-Opr-070570 Ochotona princeps 78.89 0.00e+00 1301.00
IUUC-Ont-071527 Oreochromis niloticus 85.68 0.00e+00 1466.00
IUUC-Oan-073446 Ornithorhynchus anatinus 80.83 0.00e+00 911.00
IUUC-Ocu-074922 Oryctolagus cuniculus 84.49 0.00e+00 1422.00
IUUC-Ola-086996 Oryzias latipes 83.96 0.00e+00 1437.00
IUUC-Oga-088261 Otolemur garnettii 85.86 0.00e+00 1431.00
IUUC-Oar-090024 Ovis aries 85.18 0.00e+00 1401.00
IUUC-Ptr-090455 Pan troglodytes 86.23 0.00e+00 1432.00
IUUC-Pan-092509 Papio anubis 85.83 0.00e+00 1286.00
IUUC-Psi-092974 Pelodiscus sinensis 85.33 0.00e+00 1420.00
IUUC-Pma-094643 Petromyzon marinus 71.95 0.00e+00 1256.00
IUUC-Pno-094886 Phaeosphaeria nodorum 36.10 2.00e-58 221.00
IUUC-Pfo-096905 Poecilia formosa 85.66 0.00e+00 1456.00
IUUC-Pab-097840 Pongo abelii 83.90 0.00e+00 1389.00
IUUC-Pca-100869 Procavia capensis 84.83 0.00e+00 1424.00
IUUC-Pva-103040 Pteropus vampyrus 90.48 0.00e+00 634.00
IUUC-Rno-105453 Rattus norvegicus 84.60 0.00e+00 1392.00
IUUC-Sha-107651 Sarcophilus harrisii 85.90 0.00e+00 1447.00
IUUC-Smo-108858 Selaginella moellendorffii 48.70 8.00e-113 401.00
IUUC-Sar-113293 Sorex araneus 85.65 0.00e+00 1433.00
IUUC-Ssc-115979 Sus scrofa 85.16 0.00e+00 1425.00
IUUC-Tgu-116901 Taeniopygia guttata 85.81 0.00e+00 1448.00
IUUC-Tru-118368 Takifugu rubripes 86.35 0.00e+00 1464.00
IUUC-Tsy-119516 Tarsius syrichta 81.78 0.00e+00 1319.00
IUUC-Tni-120143 Tetraodon nigroviridis 85.78 0.00e+00 1450.00
IUUC-Tbe-127484 Tupaia belangeri 79.43 0.00e+00 953.00
IUUC-Ttr-129078 Tursiops truncatus 85.06 0.00e+00 1413.00
IUUC-Vpa-130312 Vicugna pacos 77.94 0.00e+00 1201.00
IUUC-Xtr-132881 Xenopus tropicalis 84.71 0.00e+00 1432.00
Created Date 25-Jun-2017

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