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Tag Content
UUCD2 ID IUUC-Sha-107651
UUCD1 version UUC-SaH-00460
Ensembl Protein ID ENSSHAP00000011611.1
UniProt Accession G3W856; G3W856_SARHA
Genbank Protein ID ENSSHAP00000011611
Protein Name Uncharacterized protein
Genbank Nucleotide ID AEFK01127526
Gene Name UBE3A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSHAG00000009977.1 ENSSHAT00000011707.1 ENSSHAP00000011611.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.60e-108 363.3 551 877
Active Site
Position(s) Description Evidence
846 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 551  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 634
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l++
   Q: 635  HFPMVVYRKLMGKKGTFRDLADSHPVLYQSLKDLLEY-EGSVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVSLYA 721
           *************************************.6677775.999**9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 722  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSLIIREFWEIVHSFTDEQKRLFLQ 810
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 811  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 877
           *****************...8888866666**************************************97 PP
   
Organism Sarcophilus harrisii
Protein Sequence
(Fasta)
MATACKRSPG EPHSDDIEAS RMKRAAAKHL IERYYHQLTE GCGNEVCTNE FCASCPTFLR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGT SSAYLENNSK GAHNNSCTDR KMNKKEVQGP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sha-107651|E3,HECT|Sarcophilus harrisii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCAGGATTC TGTAAAAGCC TGATTTTAGA GTTCACAAGA TCACCTGAAG TACTAGAGAA 60
ATATGGTATG TTTGTATTTT TTACATATTC ATATAAAAAT AATGGCTTAA TATCAGCTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sha-107651|E3,HECT|Sarcophilus harrisii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A
PROSITE

PS50237--HECT
Pfam

PF16558--AZUL
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG shr:100916983
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002214 Ailuropoda melanoleuca 96.61 0.00e+00 1590.00
IUUC-Atr-003144 Amborella trichopoda 45.58 1.00e-95 343.00
IUUC-Apl-003742 Anas platyrhynchos 97.28 0.00e+00 1663.00
IUUC-Aca-004873 Anolis carolinensis 96.38 0.00e+00 1679.00
IUUC-Ame-011166 Astyanax mexicanus 87.18 0.00e+00 1483.00
IUUC-Bta-013286 Bos taurus 94.08 0.00e+00 1576.00
IUUC-Cja-019707 Callithrix jacchus 95.76 0.00e+00 1609.00
IUUC-Cfa-020154 Canis familiaris 94.84 0.00e+00 1604.00
IUUC-Cpo-021292 Cavia porcellus 94.98 0.00e+00 1569.00
IUUC-Cre-022790 Chlamydomonas reinhardtii 49.37 6.00e-83 300.00
IUUC-Csa-023378 Chlorocebus sabaeus 95.79 0.00e+00 1614.00
IUUC-Cho-025059 Choloepus hoffmanni 93.00 0.00e+00 1513.00
IUUC-Cin-025643 Ciona intestinalis 44.35 0.00e+00 711.00
IUUC-Csv-026282 Ciona savignyi 44.24 0.00e+00 667.00
IUUC-Cme-027151 Cyanidioschyzon merolae 44.47 3.00e-102 366.00
IUUC-Dre-027901 Danio rerio 85.90 0.00e+00 1454.00
IUUC-Dno-029320 Dasypus novemcinctus 96.58 0.00e+00 1638.00
IUUC-Dor-030756 Dipodomys ordii 92.03 0.00e+00 716.00
IUUC-Dme-032035 Drosophila melanogaster 42.96 6.00e-167 581.00
IUUC-Eca-033843 Equus caballus 94.28 0.00e+00 1545.00
IUUC-Eeu-035109 Erinaceus europaeus 94.04 0.00e+00 1528.00
IUUC-Fca-036344 Felis catus 95.22 0.00e+00 1619.00
IUUC-Fal-036747 Ficedula albicollis 97.16 0.00e+00 1663.00
IUUC-Gmo-038840 Gadus morhua 63.10 0.00e+00 1104.00
IUUC-Gga-040399 Gallus gallus 97.16 0.00e+00 1663.00
IUUC-Gac-041933 Gasterosteus aculeatus 85.84 0.00e+00 1425.00
IUUC-Ggo-044804 Gorilla gorilla 95.54 0.00e+00 1604.00
IUUC-Hsa-045727 Homo sapiens 95.54 0.00e+00 1604.00
IUUC-Itr-048289 Ictidomys tridecemlineatus 92.17 0.00e+00 1486.00
IUUC-Lch-050197 Latimeria chalumnae 92.66 0.00e+00 1592.00
IUUC-Loc-052743 Lepisosteus oculatus 90.96 0.00e+00 1578.00
IUUC-Lma-053245 Leptosphaeria maculans 33.87 3.00e-57 217.00
IUUC-Laf-053615 Loxodonta africana 95.05 0.00e+00 1606.00
IUUC-Mcc-054934 Macaca mulatta 95.86 0.00e+00 1599.00
IUUC-Meu-056061 Macropus eugenii 99.34 0.00e+00 1396.00
IUUC-Mga-059271 Meleagris gallopavo 95.46 0.00e+00 1619.00
IUUC-Mmr-061288 Microcebus murinus 95.63 0.00e+00 1602.00
IUUC-Mdo-062975 Monodelphis domestica 99.77 0.00e+00 1700.00
IUUC-Mmu-063674 Mus musculus 93.74 0.00e+00 1563.00
IUUC-Mpu-066568 Mustela putorius furo 96.70 0.00e+00 1638.00
IUUC-Mlu-067522 Myotis lucifugus 87.78 0.00e+00 1493.00
IUUC-Nle-069505 Nomascus leucogenys 95.54 0.00e+00 1604.00
IUUC-Opr-070570 Ochotona princeps 87.57 0.00e+00 1433.00
IUUC-Ont-071527 Oreochromis niloticus 87.02 0.00e+00 1489.00
IUUC-Oan-073446 Ornithorhynchus anatinus 92.50 0.00e+00 1103.00
IUUC-Ocu-074922 Oryctolagus cuniculus 93.90 0.00e+00 1609.00
IUUC-Ola-086996 Oryzias latipes 85.48 0.00e+00 1491.00
IUUC-Oga-088261 Otolemur garnettii 95.56 0.00e+00 1576.00
IUUC-Oar-090024 Ovis aries 94.08 0.00e+00 1576.00
IUUC-Ptr-090455 Pan troglodytes 95.54 0.00e+00 1604.00
IUUC-Pan-092509 Papio anubis 93.60 0.00e+00 1434.00
IUUC-Psi-092974 Pelodiscus sinensis 97.05 0.00e+00 1635.00
IUUC-Pma-094643 Petromyzon marinus 70.82 0.00e+00 1256.00
IUUC-Pno-094886 Phaeosphaeria nodorum 35.58 3.00e-58 220.00
IUUC-Pfo-096905 Poecilia formosa 85.76 0.00e+00 1491.00
IUUC-Pab-097840 Pongo abelii 93.70 0.00e+00 1535.00
IUUC-Pca-100869 Procavia capensis 96.03 0.00e+00 1595.00
IUUC-Pva-103040 Pteropus vampyrus 96.43 0.00e+00 665.00
IUUC-Rno-105453 Rattus norvegicus 93.51 0.00e+00 1560.00
IUUC-Smo-108858 Selaginella moellendorffii 49.88 3.00e-116 412.00
IUUC-Sar-113293 Sorex araneus 95.80 0.00e+00 1578.00
IUUC-Ssc-115979 Sus scrofa 96.03 0.00e+00 1577.00
IUUC-Tgu-116901 Taeniopygia guttata 97.16 0.00e+00 1662.00
IUUC-Tru-118368 Takifugu rubripes 85.94 0.00e+00 1486.00
IUUC-Tsy-119516 Tarsius syrichta 91.82 0.00e+00 1469.00
IUUC-Tni-120143 Tetraodon nigroviridis 86.64 0.00e+00 1486.00
IUUC-Tbe-127484 Tupaia belangeri 90.27 0.00e+00 1081.00
IUUC-Ttr-129078 Tursiops truncatus 94.05 0.00e+00 1550.00
IUUC-Vpa-130312 Vicugna pacos 86.27 0.00e+00 1325.00
IUUC-Xtr-132881 Xenopus tropicalis 93.58 0.00e+00 1604.00
Created Date 25-Jun-2017

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