iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050646

Ensembl Protein ID

ENSLACP00000004089.1

UniProt Accession

H3A368; H3A368_LATCH

Genbank Protein ID

ENSLACP00000004089

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01167254

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000003633.1	ENSLACT00000004125.1	ENSLACP00000004089.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.10e-32	108.8	368	398
UBD/Beta-Prp	4.40e-54	183.9	284	545

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           Htd+v +++f ++ +++vsGs+Dgt ++W +
   Q: 368  HTDKVDSIQFcNTgNRFVSGSRDGTARIWQF 398
           ***********777***************86 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl.....lrslsgheae...........vtavkfspdgkilvtgseDrtikvw..dlstgkcvht 89
           s +k++l ++++dg i  w+++  +l                            + +fs  g +l+tgs+D++i+v+     +++ ++ 
   Q: 284  SGSKRFLSSTGADGIICFWQWDARTLkfshrP--------SkfterprpgvqMICSSFSAGGMFLATGSTDHIIRVYffGSGQPEKISE 364
           56788999999*******99999666444442........23455556665555677888888**************777779999*** PP
   S: 90   lkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvr 162
           l+ h+d+v s++f+ +g+++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t++
   Q: 365  LECHTDKVDSIQFCNTGNRFVSGSRDGTARIWQFKRQEWRSIlldmatrpsghnpqglEDKITKLKVTMVAWDRHDNTVITAVNNLTLK 453
           ***********************************99999889**************889999999*********************** PP
   S: 163  lWdlktgkllrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssD 243
           +W++ tg+l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g+ +r++ +         v + +  p++++++++ s+
   Q: 454  VWNSYTGQLIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGTKIRSYFNMIegqghGAVFDCKCAPDGQHFACTDSH 539
           **************9.*********999999..89********************9999875423333334444444777777777777 PP
   S: 244  gsiriW 249
           g + i+
   Q: 540  GHLLIF 545
           777665 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MSCDSKHIKE LKSELYFLIA RFLEDGPCQQ AAEVLIREVE EKQLLPKRTD WMGKEHPRTY 60
ENLLMQKVKC YRHIAPDHLL RICQRVEPLL EREIPPSVPG VQSLLGAGRQ SLLRTNKSCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTGTG ACAGTAAACA CATCAAAGAA TTGAAATCTG GTAAGTACAC AGCTGCAGGA 60
AAGCATATAC AGTCTGAAAT TCCACCCAGA GTCGCAGCAA CCATTGCACA ACTAATAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0008286--P:insulin receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001881	Ailuropoda melanoleuca	60.64	0.00e+00	1811.00
IUUC-Apl-004016	Anas platyrhynchos	62.05	0.00e+00	1743.00
IUUC-Aca-004474	Anolis carolinensis	75.46	0.00e+00	2581.00
IUUC-Aly-006406	Arabidopsis lyrata	31.30	1.00e-66	249.00
IUUC-Ame-010602	Astyanax mexicanus	60.16	0.00e+00	1674.00
IUUC-Bta-013125	Bos taurus	85.20	0.00e+00	1395.00
IUUC-Bdi-014797	Brachypodium distachyon	32.73	3.00e-54	207.00
IUUC-Cja-018868	Callithrix jacchus	76.55	0.00e+00	2684.00
IUUC-Cfa-020963	Canis familiaris	60.64	0.00e+00	1804.00
IUUC-Cpo-022077	Cavia porcellus	74.00	0.00e+00	2479.00
IUUC-Csa-023618	Chlorocebus sabaeus	84.50	0.00e+00	1524.00
IUUC-Cho-024794	Choloepus hoffmanni	80.77	0.00e+00	776.00
IUUC-Dre-028508	Danio rerio	59.12	0.00e+00	1661.00
IUUC-Dno-030048	Dasypus novemcinctus	82.92	0.00e+00	1447.00
IUUC-Dor-030195	Dipodomys ordii	77.15	0.00e+00	1251.00
IUUC-Ete-032650	Echinops telfairi	60.60	0.00e+00	1189.00
IUUC-Eca-034274	Equus caballus	85.07	0.00e+00	1384.00
IUUC-Eeu-034688	Erinaceus europaeus	84.20	0.00e+00	1172.00
IUUC-Fca-036099	Felis catus	61.44	0.00e+00	1794.00
IUUC-Fal-037307	Ficedula albicollis	60.23	0.00e+00	1740.00
IUUC-Gmo-039451	Gadus morhua	69.37	0.00e+00	719.00
IUUC-Gga-041097	Gallus gallus	63.56	0.00e+00	1831.00
IUUC-Gac-042435	Gasterosteus aculeatus	55.37	0.00e+00	1592.00
IUUC-Ggo-045347	Gorilla gorilla	84.56	0.00e+00	1431.00
IUUC-Hsa-046757	Homo sapiens	84.16	0.00e+00	1498.00
IUUC-Hvu-047706	Hordeum vulgare	31.58	2.00e-36	145.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	65.96	0.00e+00	805.00
IUUC-Lpe-051619	Leersia perrieri	30.10	2.00e-68	254.00
IUUC-Loc-052672	Lepisosteus oculatus	73.30	0.00e+00	2533.00
IUUC-Laf-054140	Loxodonta africana	77.77	0.00e+00	2606.00
IUUC-Mcc-055061	Macaca mulatta	84.04	0.00e+00	1510.00
IUUC-Mga-060063	Meleagris gallopavo	62.51	0.00e+00	1779.00
IUUC-Mmr-060837	Microcebus murinus	83.37	0.00e+00	1442.00
IUUC-Mdo-061903	Monodelphis domestica	78.68	0.00e+00	2707.00
IUUC-Mmu-063772	Mus musculus	83.93	0.00e+00	1500.00
IUUC-Mpu-066628	Mustela putorius furo	60.57	0.00e+00	1810.00
IUUC-Mlu-067928	Myotis lucifugus	84.43	0.00e+00	1420.00
IUUC-Nle-070094	Nomascus leucogenys	82.09	0.00e+00	1448.00
IUUC-Opr-070971	Ochotona princeps	73.31	0.00e+00	711.00
IUUC-Ont-071589	Oreochromis niloticus	57.82	0.00e+00	1565.00
IUUC-Oan-073185	Ornithorhynchus anatinus	76.25	0.00e+00	2519.00
IUUC-Ocu-074033	Oryctolagus cuniculus	78.62	0.00e+00	2375.00
IUUC-Ogl-077493	Oryza glaberrima	26.18	3.00e-28	121.00
IUUC-Ogu-078641	Oryza glumaepatula	26.18	5.00e-28	120.00
IUUC-Oin-079669	Oryza indica	31.34	8.00e-52	198.00
IUUC-Olo-080755	Oryza longistaminata	31.43	2.00e-53	205.00
IUUC-Oni-082991	Oryza nivara	26.18	3.00e-28	121.00
IUUC-Ola-086648	Oryzias latipes	77.09	0.00e+00	1348.00
IUUC-Oga-088578	Otolemur garnettii	85.09	0.00e+00	1391.00
IUUC-Oar-090247	Ovis aries	84.95	0.00e+00	1393.00
IUUC-Ptr-091266	Pan troglodytes	83.94	0.00e+00	1407.00
IUUC-Pan-092734	Papio anubis	84.50	0.00e+00	1522.00
IUUC-Psi-093408	Pelodiscus sinensis	61.93	0.00e+00	1783.00
IUUC-Pma-094427	Petromyzon marinus	64.86	1.00e-129	455.00
IUUC-Pfo-096191	Poecilia formosa	73.87	0.00e+00	2123.00
IUUC-Pab-098402	Pongo abelii	84.16	0.00e+00	1498.00
IUUC-Pop-099185	Populus trichocarpa	36.29	2.00e-69	258.00
IUUC-Pca-101128	Procavia capensis	88.24	0.00e+00	1306.00
IUUC-Ppe-101849	Prunus persica	31.70	2.00e-73	271.00
IUUC-Pva-102512	Pteropus vampyrus	62.75	0.00e+00	1555.00
IUUC-Rno-106013	Rattus norvegicus	82.71	0.00e+00	1365.00
IUUC-Sha-107061	Sarcophilus harrisii	58.70	0.00e+00	1620.00
IUUC-Sit-110017	Setaria italica	31.24	4.00e-55	210.00
IUUC-Sar-113520	Sorex araneus	71.09	0.00e+00	1158.00
IUUC-Sbi-114195	Sorghum bicolor	29.17	7.00e-59	221.00
IUUC-Ssc-115461	Sus scrofa	75.14	0.00e+00	2533.00
IUUC-Tgu-116513	Taeniopygia guttata	60.40	0.00e+00	1739.00
IUUC-Tru-118186	Takifugu rubripes	57.24	0.00e+00	1558.00
IUUC-Tsy-119132	Tarsius syrichta	76.68	0.00e+00	1163.00
IUUC-Tni-120110	Tetraodon nigroviridis	56.88	0.00e+00	1554.00
IUUC-Tbe-127479	Tupaia belangeri	73.01	0.00e+00	1123.00
IUUC-Ttr-129265	Tursiops truncatus	61.39	0.00e+00	1746.00
IUUC-Vpa-130160	Vicugna pacos	75.45	0.00e+00	2457.00
IUUC-Xtr-132717	Xenopus tropicalis	70.87	0.00e+00	2452.00
IUUC-Xma-134159	Xiphophorus maculatus	56.99	0.00e+00	1528.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence