iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074657

UUCD1 version

UUC-OrC-00181

Ensembl Protein ID

ENSOCUP00000004160.2

UniProt Accession

G1SMK5; G1SMK5_RABIT

Protein Name

Uncharacterized protein

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000004808.2	ENSOCUT00000004808.2	ENSOCUP00000004160.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.00e-07	31.5	317	356

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 317  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 356
           99********.******************....5.555555****8 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

QVVRLCQNPK LALKNSPPYI LDLLPDTYQH LRTVLSRYEG KMETLGENEY FRVFMENLMK 60
KTKQTISLFK EGKERMYEEN SQPRRNLTKL SLIFSHMLAE LKGIFPSGLF QGDTFRITKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTGGTGC GGTTGTGTCA GAACCCAAAG CTGGCGCTAA AGAACAGCCC ACCCTATATC 60
TTAGACCTGC TGCCAGACAC CTACCAGCAT CTCCGGACTG TCTTGTCAAG ATATGAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	92.44	0.00e+00	1480.00
IUUC-Apl-004041	Anas platyrhynchos	84.68	0.00e+00	1381.00
IUUC-Aca-004899	Anolis carolinensis	82.00	0.00e+00	1272.00
IUUC-Ame-010746	Astyanax mexicanus	59.35	6.00e-179	620.00
IUUC-Bta-012759	Bos taurus	92.25	0.00e+00	1486.00
IUUC-Cja-019207	Callithrix jacchus	92.24	0.00e+00	1493.00
IUUC-Cfa-020897	Canis familiaris	92.47	0.00e+00	1466.00
IUUC-Cpo-021453	Cavia porcellus	91.20	0.00e+00	1521.00
IUUC-Csa-023136	Chlorocebus sabaeus	91.65	0.00e+00	1477.00
IUUC-Cho-024282	Choloepus hoffmanni	83.55	0.00e+00	1182.00
IUUC-Csv-025938	Ciona savignyi	69.21	1.00e-166	579.00
IUUC-Dre-027644	Danio rerio	68.51	0.00e+00	994.00
IUUC-Dno-030025	Dasypus novemcinctus	93.08	0.00e+00	1488.00
IUUC-Ete-033118	Echinops telfairi	79.02	0.00e+00	819.00
IUUC-Eca-033900	Equus caballus	94.13	0.00e+00	1503.00
IUUC-Eeu-035142	Erinaceus europaeus	86.08	0.00e+00	957.00
IUUC-Fca-035455	Felis catus	91.29	0.00e+00	1444.00
IUUC-Fal-037182	Ficedula albicollis	96.19	0.00e+00	867.00
IUUC-Gmo-038698	Gadus morhua	86.44	0.00e+00	835.00
IUUC-Gga-040438	Gallus gallus	84.09	0.00e+00	1368.00
IUUC-Gac-042166	Gasterosteus aculeatus	77.78	0.00e+00	844.00
IUUC-Ggo-045618	Gorilla gorilla	92.35	0.00e+00	1495.00
IUUC-Hsa-046177	Homo sapiens	91.88	0.00e+00	1481.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	96.47	0.00e+00	1011.00
IUUC-Lch-050095	Latimeria chalumnae	74.71	0.00e+00	1153.00
IUUC-Loc-052570	Lepisosteus oculatus	72.04	0.00e+00	1088.00
IUUC-Laf-054008	Loxodonta africana	91.02	0.00e+00	1471.00
IUUC-Mcc-054676	Macaca mulatta	91.53	0.00e+00	1474.00
IUUC-Mga-059239	Meleagris gallopavo	83.51	0.00e+00	1366.00
IUUC-Mmr-060907	Microcebus murinus	89.94	0.00e+00	1437.00
IUUC-Mdo-062595	Monodelphis domestica	88.72	0.00e+00	1419.00
IUUC-Mmu-063725	Mus musculus	92.25	0.00e+00	1531.00
IUUC-Mpu-066771	Mustela putorius furo	91.40	0.00e+00	1471.00
IUUC-Mlu-067206	Myotis lucifugus	78.26	0.00e+00	1101.00
IUUC-Nle-069285	Nomascus leucogenys	88.63	0.00e+00	1382.00
IUUC-Opr-071026	Ochotona princeps	93.07	0.00e+00	1514.00
IUUC-Ont-071954	Oreochromis niloticus	68.76	0.00e+00	997.00
IUUC-Ola-087165	Oryzias latipes	67.67	0.00e+00	1011.00
IUUC-Oga-088198	Otolemur garnettii	80.26	0.00e+00	1265.00
IUUC-Oar-090258	Ovis aries	92.24	0.00e+00	1459.00
IUUC-Ptr-090710	Pan troglodytes	91.88	0.00e+00	1481.00
IUUC-Pan-092785	Papio anubis	91.53	0.00e+00	1475.00
IUUC-Pfo-096990	Poecilia formosa	89.55	0.00e+00	783.00
IUUC-Pab-098526	Pongo abelii	92.00	0.00e+00	1481.00
IUUC-Pca-100984	Procavia capensis	75.60	9.00e-161	560.00
IUUC-Pva-102352	Pteropus vampyrus	98.31	0.00e+00	843.00
IUUC-Rno-105876	Rattus norvegicus	91.20	0.00e+00	1499.00
IUUC-Sha-107588	Sarcophilus harrisii	87.58	0.00e+00	1238.00
IUUC-Sar-112959	Sorex araneus	88.67	0.00e+00	1432.00
IUUC-Ssc-115261	Sus scrofa	92.13	0.00e+00	1476.00
IUUC-Tgu-116580	Taeniopygia guttata	80.99	0.00e+00	1275.00
IUUC-Tru-118731	Takifugu rubripes	67.52	0.00e+00	988.00
IUUC-Tsy-118982	Tarsius syrichta	83.51	0.00e+00	1017.00
IUUC-Tni-120725	Tetraodon nigroviridis	67.64	0.00e+00	990.00
IUUC-Tbe-128018	Tupaia belangeri	95.60	0.00e+00	1157.00
IUUC-Ttr-128927	Tursiops truncatus	93.16	0.00e+00	1510.00
IUUC-Vpa-130369	Vicugna pacos	92.56	0.00e+00	1424.00
IUUC-Xtr-132474	Xenopus tropicalis	73.46	0.00e+00	1092.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence