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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046560
Ensembl Protein ID ENSP00000371859.2
UniProt Accession Q9NRL2; Q9NZ15; Q9P065; Q9UIG1; Q9Y3V3; BAZ1A_HUMAN
Genbank Protein ID AAF70601.1; AAF32366.1; BAA89209.1; EAW65900.1; AAF28995.1; CAB43261.1
Protein Name Bromodomain adjacent to zinc finger domain protein 1A; ATP-dependent chromatin-remodeling protein; ATP-utilizing chromatin assembly and remodeling factor 1; CHRAC subunit ACF1; Williams syndrome transcription factor-related chromatin-remodeling factor 180; hWALp1
Genbank Nucleotide ID AF213467; AF221130; AB032252; AL121603; AF161435; AL050089
Gene Name BAZ1A; ACF1; WCRF180; HSPC317
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198604.10 ENST00000358716.8 ENSP00000351555.4
ENSG00000198604.10 ENST00000382422.6 ENSP00000371859.2
ENSG00000198604.10 ENST00000555331.1 ENSP00000450902.1
ENSG00000198604.10 ENST00000554865.1 ENSP00000450923.1
ENSG00000198604.10 ENST00000556314.2 ENSP00000480380.1
ENSG00000198604.10 ENST00000553573.1 ENSP00000451896.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRecordsRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.00e-08 36.9 1149 1197
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           + C++C+++g+ e ++v C+ C++  H  C+ ++  +++p+ + w+Cp+Cr 
   Q: 1149 ARCKICRKKGDAE-NMVLCDGCDRGHHTYCVRPK-LKTVPEGD-WFCPECRP 1197
           57*********98.6*******************.*******7.******96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC. Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes.
 Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC. Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes.
Protein Sequence
(Fasta)
MPLLHRKPFV RQKPPADLRP DEEVFYCKVT NEIFRHYDDF FERTILCNSL VWSCAVTGRP 60
GLTYQEALES EKKARQNLQS FPEPLIIPVL YLTSLTHRSR LHEICDDIFA YVKDRYFVEE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046560|E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTTTCCCAT CGTGTAGTCA AGAGTCTGTG CCAGACTTGA AGGCTTTACT TTGTTAGCCA 60
TGTGTTTATG AACCCCCAGC GCTTTCCCTA GATCTTTTGG CTGATAATCT CAAACATGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046560|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR018501--DDT_dom
IPR032675--L_dom-like
IPR028942--WHIM1_dom
IPR028941--WHIM2_dom
IPR013136--WSTF_Acf1_Cbp146
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50827--DDT
PS51136--WAC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00439--Bromodomain
PF02791--DDT
PF00628--PHD
PF10537--WAC_Acf1_DNA_bd
PF15612--WHIM1
PF15613--WSD
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM00571--DDT
SM00249--PHD
Gene Ontology

GO:0016590--C:ACF complex
GO:0008623--C:CHRAC
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0006261--P:DNA-dependent DNA replication
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:11177
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002389 Ailuropoda melanoleuca 93.76 0.00e+00 1914.00
IUUC-Apl-004078 Anas platyrhynchos 73.46 0.00e+00 1984.00
IUUC-Aca-004951 Anolis carolinensis 72.37 0.00e+00 1405.00
IUUC-Bta-012850 Bos taurus 94.93 0.00e+00 1412.00
IUUC-Cel-018523 Caenorhabditis elegans 46.38 4.00e-16 81.30
IUUC-Cja-018999 Callithrix jacchus 94.73 0.00e+00 1925.00
IUUC-Cfa-020916 Canis familiaris 96.29 0.00e+00 1418.00
IUUC-Cpo-022146 Cavia porcellus 82.60 0.00e+00 2197.00
IUUC-Csa-024039 Chlorocebus sabaeus 97.95 0.00e+00 2634.00
IUUC-Cho-024914 Choloepus hoffmanni 83.61 0.00e+00 1322.00
IUUC-Cin-025450 Ciona intestinalis 42.92 6.00e-41 161.00
IUUC-Csv-026068 Ciona savignyi 54.55 5.00e-39 153.00
IUUC-Dre-027413 Danio rerio 57.93 0.00e+00 727.00
IUUC-Dno-029438 Dasypus novemcinctus 93.51 0.00e+00 1848.00
IUUC-Dor-030774 Dipodomys ordii 80.15 2.00e-163 570.00
IUUC-Dme-031772 Drosophila melanogaster 30.18 6.00e-35 144.00
IUUC-Ete-033052 Echinops telfairi 84.63 0.00e+00 1627.00
IUUC-Eca-034262 Equus caballus 94.02 0.00e+00 1835.00
IUUC-Eeu-034704 Erinaceus europaeus 72.56 0.00e+00 689.00
IUUC-Fca-036207 Felis catus 94.25 0.00e+00 926.00
IUUC-Fal-036702 Ficedula albicollis 74.76 0.00e+00 1658.00
IUUC-Gmo-039218 Gadus morhua 47.57 4.00e-93 337.00
IUUC-Gga-040776 Gallus gallus 77.96 0.00e+00 1428.00
IUUC-Gac-042358 Gasterosteus aculeatus 53.56 0.00e+00 703.00
IUUC-Itr-048135 Ictidomys tridecemlineatus 95.19 0.00e+00 1362.00
IUUC-Laf-054049 Loxodonta africana 92.91 0.00e+00 1915.00
IUUC-Mga-059382 Meleagris gallopavo 77.65 0.00e+00 1904.00
IUUC-Mmr-061301 Microcebus murinus 94.68 0.00e+00 1398.00
IUUC-Mdo-062889 Monodelphis domestica 81.19 0.00e+00 1569.00
IUUC-Mmu-064057 Mus musculus 87.16 0.00e+00 2273.00
IUUC-Mpu-066668 Mustela putorius furo 93.08 0.00e+00 1912.00
IUUC-Mlu-068089 Myotis lucifugus 95.17 0.00e+00 1382.00
IUUC-Nle-069936 Nomascus leucogenys 98.29 0.00e+00 2560.00
IUUC-Oan-073582 Ornithorhynchus anatinus 82.89 0.00e+00 1613.00
IUUC-Ocu-074115 Oryctolagus cuniculus 88.24 0.00e+00 2477.00
IUUC-Ogu-078790 Oryza glumaepatula 46.43 2.00e-13 70.10
IUUC-Ome-081195 Oryza meridionalis 50.98 2.00e-13 70.10
IUUC-Oru-084688 Oryza rufipogon 42.86 2.00e-13 70.50
IUUC-Ola-086709 Oryzias latipes 53.16 0.00e+00 949.00
IUUC-Oga-088100 Otolemur garnettii 90.47 0.00e+00 1301.00
IUUC-Oar-089208 Ovis aries 94.07 0.00e+00 1894.00
IUUC-Ptr-090630 Pan troglodytes 99.58 0.00e+00 2103.00
IUUC-Pan-092146 Papio anubis 95.27 0.00e+00 1438.00
IUUC-Psi-092932 Pelodiscus sinensis 77.71 0.00e+00 1475.00
IUUC-Pfo-096572 Poecilia formosa 55.39 0.00e+00 736.00
IUUC-Pva-102893 Pteropus vampyrus 95.25 0.00e+00 1939.00
IUUC-Rno-105098 Rattus norvegicus 86.95 0.00e+00 2204.00
IUUC-Sha-106513 Sarcophilus harrisii 80.58 0.00e+00 1567.00
IUUC-Sar-113192 Sorex araneus 98.47 3.00e-109 390.00
IUUC-Ssc-116407 Sus scrofa 95.76 0.00e+00 1375.00
IUUC-Tgu-117403 Taeniopygia guttata 76.90 0.00e+00 1963.00
IUUC-Tru-118124 Takifugu rubripes 54.08 0.00e+00 694.00
IUUC-Tsy-119386 Tarsius syrichta 92.72 0.00e+00 1389.00
IUUC-Vpa-130046 Vicugna pacos 91.50 0.00e+00 2255.00
IUUC-Xtr-132132 Xenopus tropicalis 61.50 0.00e+00 1091.00
Created Date 25-Jun-2017

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