iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022392

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AAKN02014840

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000014918.3	ENSCPOT00000015064.2	ENSCPOP00000013443.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.80e-20	72.7	525	910

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 525  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 604
           56*********************...55654......57*************9****************99999866777777666666 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++++        +e  +  +      ++  ++++s+i +lF  ++++   c +c+++++r+++ l +
   Q: 605  gkGNLARLIQRWNRFILTQLHQDMQE--------LEVPQ--AYRGVGGSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRTSSTLLF 682
           66666666777788888888888833........22222..3344567899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeee.legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           +l+ p+ ++++k+  +  +++  k+   le++ + +c++c+k+q + ++  +++lP++L+++    s +e+     +i+ +v f+  + 
   Q: 683  TLSYPEGSNCDKTGKNYDFAQVLKRSIcLEQNTQAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFW--RIQAEVAFK--MA 767
           *****99998888555555555554432666778******************************9977776555..588899987..67 PP
   S: 261  lspfcts.....peekqke.................................................................kkkYe 279
           ++++  +     +                                                                        + Y+
   Q: 768  IKKYGGEisknkE-----FaladrkelrspeglllcssieelknvwlpfsirmkmtknkgldvcnwtdgdevqwglakaeeergVCVYD 851
           7777777333440.....2445555555555666666666666666666666666666666666666666666666666666669**** PP
   S: 280  LiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleet 326
           L+a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++ 
   Q: 852  LMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHESVQFD 910
           *********9*************999988877777888************988777754 PP

Organism

Cavia porcellus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEYAPSIHST LDPVLDAHLN PSLLQNVELD PEGVALDALP VQESVHIMEG 60
VYSELHSVVA EVGVPVTVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACTTTG AGGGTCTGGA CCCTGGATTG GCAGAGTATG CCCCATCCAT ACATTCCACC 60
TTGGACCCTG TCCTGGATGC CCACCTGAAC CCAAGTTTGC TACAGAATGT GGAGCTGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	96.76	0.00e+00	2315.00
IUUC-Apl-003500	Anas platyrhynchos	84.99	0.00e+00	1863.00
IUUC-Aca-004930	Anolis carolinensis	83.29	0.00e+00	1998.00
IUUC-Acl-008214	Aspergillus clavatus	31.50	2.00e-157	550.00
IUUC-Afu-009112	Aspergillus fumigatus	31.67	4.00e-148	519.00
IUUC-Ang-009531	Aspergillus niger	31.18	4.00e-151	529.00
IUUC-Ame-011259	Astyanax mexicanus	76.49	0.00e+00	1837.00
IUUC-Bta-012371	Bos taurus	96.17	0.00e+00	2295.00
IUUC-Bci-013684	Botrytis cinerea	31.04	2.00e-135	477.00
IUUC-Cja-019297	Callithrix jacchus	93.78	0.00e+00	2250.00
IUUC-Cfa-020489	Canis familiaris	96.17	0.00e+00	2290.00
IUUC-Csa-023220	Chlorocebus sabaeus	96.51	0.00e+00	2315.00
IUUC-Csv-025841	Ciona savignyi	45.74	7.00e-133	468.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.64	3.00e-164	572.00
IUUC-Cne-026932	Cryptococcus neoformans	42.70	2.00e-72	267.00
IUUC-Dre-028482	Danio rerio	74.59	0.00e+00	1788.00
IUUC-Dno-029398	Dasypus novemcinctus	95.59	0.00e+00	2275.00
IUUC-Dor-030307	Dipodomys ordii	90.97	0.00e+00	1319.00
IUUC-Dme-032111	Drosophila melanogaster	41.48	0.00e+00	885.00
IUUC-Eca-033985	Equus caballus	96.76	0.00e+00	2306.00
IUUC-Eeu-034928	Erinaceus europaeus	83.20	0.00e+00	760.00
IUUC-Fca-035587	Felis catus	97.25	0.00e+00	2323.00
IUUC-Fal-037587	Ficedula albicollis	83.98	0.00e+00	1966.00
IUUC-Fso-038133	Fusarium solani	31.95	1.00e-97	351.00
IUUC-Gmo-039076	Gadus morhua	73.56	0.00e+00	1751.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.14	7.00e-139	488.00
IUUC-Gga-040948	Gallus gallus	85.12	0.00e+00	2046.00
IUUC-Gac-042396	Gasterosteus aculeatus	74.98	0.00e+00	1808.00
IUUC-Ggo-045412	Gorilla gorilla	96.67	0.00e+00	2317.00
IUUC-Hsa-046076	Homo sapiens	96.51	0.00e+00	2312.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	89.42	0.00e+00	2088.00
IUUC-Kpa-049178	Komagataella pastoris	31.34	5.00e-84	306.00
IUUC-Lch-050279	Latimeria chalumnae	72.22	0.00e+00	1699.00
IUUC-Loc-052872	Lepisosteus oculatus	76.71	0.00e+00	1841.00
IUUC-Lma-052986	Leptosphaeria maculans	32.73	6.00e-158	551.00
IUUC-Laf-054181	Loxodonta africana	94.21	0.00e+00	2260.00
IUUC-Mcc-054812	Macaca mulatta	96.34	0.00e+00	2300.00
IUUC-Meu-056325	Macropus eugenii	91.93	0.00e+00	2199.00
IUUC-Mor-057246	Magnaporthe oryzae	29.37	2.00e-121	430.00
IUUC-Mpo-057464	Magnaporthe poae	31.54	3.00e-140	493.00
IUUC-Mla-058911	Melampsora laricipopulina	40.48	1.00e-69	258.00
IUUC-Mga-059335	Meleagris gallopavo	85.28	0.00e+00	1992.00
IUUC-Mvi-060461	Microbotryum violaceum	34.12	9.00e-144	504.00
IUUC-Mmr-060636	Microcebus murinus	96.59	0.00e+00	2302.00
IUUC-Mmu-063503	Mus musculus	95.20	0.00e+00	2265.00
IUUC-Mpu-066670	Mustela putorius furo	96.92	0.00e+00	2311.00
IUUC-Mlu-068119	Myotis lucifugus	95.42	0.00e+00	2310.00
IUUC-Nfi-068398	Neosartorya fischeri	32.18	9.00e-158	551.00
IUUC-Ncr-068927	Neurospora crassa	29.98	9.00e-130	458.00
IUUC-Nle-069651	Nomascus leucogenys	92.85	0.00e+00	2219.00
IUUC-Opr-070614	Ochotona princeps	95.77	0.00e+00	2271.00
IUUC-Ont-072433	Oreochromis niloticus	75.14	0.00e+00	1858.00
IUUC-Oan-073283	Ornithorhynchus anatinus	73.73	0.00e+00	1417.00
IUUC-Ocu-074401	Oryctolagus cuniculus	95.54	0.00e+00	2287.00
IUUC-Ola-087522	Oryzias latipes	74.71	0.00e+00	1798.00
IUUC-Oga-088226	Otolemur garnettii	95.21	0.00e+00	2286.00
IUUC-Oar-089241	Ovis aries	96.34	0.00e+00	2330.00
IUUC-Pan-092297	Papio anubis	96.52	0.00e+00	2056.00
IUUC-Psi-094043	Pelodiscus sinensis	81.99	0.00e+00	1909.00
IUUC-Pma-094394	Petromyzon marinus	69.22	0.00e+00	1553.00
IUUC-Pno-095053	Phaeosphaeria nodorum	32.08	4.00e-149	522.00
IUUC-Ppa-095188	Physcomitrella patens	32.38	2.00e-157	550.00
IUUC-Pfo-097517	Poecilia formosa	75.86	0.00e+00	1864.00
IUUC-Pca-100471	Procavia capensis	96.83	0.00e+00	2177.00
IUUC-Pva-102805	Pteropus vampyrus	92.18	0.00e+00	1811.00
IUUC-Pte-104021	Pyrenophora teres	31.91	6.00e-160	558.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	31.73	2.00e-158	553.00
IUUC-Rno-105471	Rattus norvegicus	95.17	0.00e+00	2262.00
IUUC-Sce-106235	Saccharomyces cerevisiae	37.92	2.00e-59	224.00
IUUC-Sha-106883	Sarcophilus harrisii	91.04	0.00e+00	2027.00
IUUC-Spo-108169	Schizosaccharomyces pombe	31.91	5.00e-142	498.00
IUUC-Sar-113323	Sorex araneus	94.41	0.00e+00	1689.00
IUUC-Sre-115075	Sporisorium reilianum	37.61	3.00e-60	227.00
IUUC-Ssc-116363	Sus scrofa	95.45	0.00e+00	2305.00
IUUC-Tru-118427	Takifugu rubripes	75.33	0.00e+00	1877.00
IUUC-Tni-120218	Tetraodon nigroviridis	75.51	0.00e+00	1869.00
IUUC-Tre-122177	Trichoderma reesei	31.62	2.00e-151	530.00
IUUC-Tme-127176	Tuber melanosporum	32.76	2.00e-138	486.00
IUUC-Tbe-127641	Tupaia belangeri	87.22	0.00e+00	798.00
IUUC-Ttr-128888	Tursiops truncatus	95.46	0.00e+00	1452.00
IUUC-Uma-129361	Ustilago maydis	38.12	8.00e-63	236.00
IUUC-Xtr-132811	Xenopus tropicalis	78.26	0.00e+00	1876.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence