iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046076

UUCD1 version

UUC-HoS-01104

Ensembl Protein ID

ENSP00000449861.1

UniProt Accession

Q504Q3; O75189; Q76E12; Q8IVE1; PAN2_HUMAN

Genbank Protein ID

BAD02263.1; BAA31685.2; AAH24043.1; AAH94885.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AB107585; AB014610; BC024043; BC094885

Gene Name

PAN2; KIAA0710; USP52

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000135473.14	ENST00000440411.7	ENSP00000388231.3
ENSG00000135473.14	ENST00000257931.9	ENSP00000257931.5
ENSG00000135473.14	ENST00000548043.5	ENSP00000449861.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.00e-19	69.5	525	911

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs..............g 86
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e                 g
   Q: 525  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGNNFLRAFRTIPEASAlgliladsdeasgkG 607
           56*********************...55654......57*************99***************99998866777777777776666 PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +     q   +f+l ql++++++       e      ++      ++  ++++s+i +lF  ++++   c +c+++++r ++ l ++l+ p+
   Q: 608  NLARLIQRWNRFILTQLHQDMQE------LEIP----QAYRGAGGSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLFTLSYPD 688
           77777778888999999999933......1111....12333467889*****************99999.8*******************8 PP
   S: 179  keetkkeslqdcLesftkeee.legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.. 267
            ++++k+  +  +++  k+   l+++ + +c++c+k+q + ++  +++lP++L+++    s +e+     +++ +v f+  + ++++  +  
   Q: 689  GSKSDKTGKNYDFAQVLKRSIcLDQNTQAWCDTCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFW--RMQAEVAFK--MAVKKHGGEis 776
           8888887655556665555542677778*****************************99977666555..588888887..56666665533 PP
   S: 268  ......peekqke..............................................................kkkYeLiavvvHsG.sl 290
                                                                                       + Y+L+a vvH   s 
   Q: 777  knkefaL-----AdwkelgspegvlvcpsieelknvwlpfsirmkmtknkgldvcnwtdgdemqwgparaeeehgVYVYDLMATVVHILdSR 863
           3444440.....0555555555555555555555555555555555555566666666666666666666666669*************9** PP
   S: 291  ssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
            +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 864  TGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 911
           ***********999988877777888************9999888654 PP

Organism

Homo sapiens

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCCCGAG CCCTTCTTGA TTGGAAGAAG CGCCTCGGAC CCCGGTCCTT GGCGCCGTAG 60
TGGTTAGGTT GAGCCCTAGG CGTGGGGGAG AACTGGGGAA ACTGGAATTT CCCGCGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0000175--F:3'-5'-exoribonuclease activity
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

hsa:9924

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	98.17	0.00e+00	2357.00
IUUC-Apl-003500	Anas platyrhynchos	85.52	0.00e+00	1884.00
IUUC-Aca-004930	Anolis carolinensis	83.95	0.00e+00	2016.00
IUUC-Acl-008214	Aspergillus clavatus	31.25	1.00e-156	547.00
IUUC-Afu-009112	Aspergillus fumigatus	31.26	4.00e-147	516.00
IUUC-Ang-009531	Aspergillus niger	30.92	2.00e-149	523.00
IUUC-Ame-011259	Astyanax mexicanus	76.36	0.00e+00	1837.00
IUUC-Bta-012371	Bos taurus	97.67	0.00e+00	2343.00
IUUC-Bci-013684	Botrytis cinerea	31.31	6.00e-134	472.00
IUUC-Cja-019297	Callithrix jacchus	95.41	0.00e+00	2314.00
IUUC-Cfa-020489	Canis familiaris	97.25	0.00e+00	2325.00
IUUC-Cpo-022392	Cavia porcellus	96.51	0.00e+00	2343.00
IUUC-Csa-023220	Chlorocebus sabaeus	99.08	0.00e+00	2376.00
IUUC-Csv-025841	Ciona savignyi	45.34	0.00e+00	899.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.64	9.00e-163	568.00
IUUC-Cne-026932	Cryptococcus neoformans	42.94	6.00e-73	270.00
IUUC-Dre-028482	Danio rerio	74.17	0.00e+00	1784.00
IUUC-Dno-029398	Dasypus novemcinctus	97.00	0.00e+00	2315.00
IUUC-Dor-030307	Dipodomys ordii	90.27	0.00e+00	1320.00
IUUC-Dme-032111	Drosophila melanogaster	41.31	0.00e+00	882.00
IUUC-Eca-033985	Equus caballus	98.09	0.00e+00	2352.00
IUUC-Eeu-034928	Erinaceus europaeus	84.41	0.00e+00	777.00
IUUC-Fca-035587	Felis catus	98.17	0.00e+00	2360.00
IUUC-Fal-037587	Ficedula albicollis	84.32	0.00e+00	1982.00
IUUC-Fso-038133	Fusarium solani	29.31	4.00e-131	462.00
IUUC-Gmo-039076	Gadus morhua	73.72	0.00e+00	1746.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.20	1.00e-140	494.00
IUUC-Gga-040948	Gallus gallus	85.54	0.00e+00	2064.00
IUUC-Gac-042396	Gasterosteus aculeatus	74.32	0.00e+00	1798.00
IUUC-Ggo-045412	Gorilla gorilla	99.83	0.00e+00	2388.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	90.34	0.00e+00	2116.00
IUUC-Kpa-049178	Komagataella pastoris	40.48	1.00e-66	248.00
IUUC-Lch-050279	Latimeria chalumnae	72.18	0.00e+00	1704.00
IUUC-Loc-052872	Lepisosteus oculatus	76.54	0.00e+00	1840.00
IUUC-Lma-052986	Leptosphaeria maculans	32.35	3.00e-157	549.00
IUUC-Laf-054181	Loxodonta africana	95.45	0.00e+00	2305.00
IUUC-Mcc-054812	Macaca mulatta	99.00	0.00e+00	2365.00
IUUC-Meu-056325	Macropus eugenii	92.35	0.00e+00	2217.00
IUUC-Mor-057246	Magnaporthe oryzae	29.26	8.00e-125	442.00
IUUC-Mpo-057464	Magnaporthe poae	31.78	3.00e-143	503.00
IUUC-Mla-058911	Melampsora laricipopulina	32.74	1.00e-100	361.00
IUUC-Mga-059335	Meleagris gallopavo	85.89	0.00e+00	2015.00
IUUC-Mvi-060461	Microbotryum violaceum	34.32	1.00e-144	508.00
IUUC-Mmr-060636	Microcebus murinus	98.59	0.00e+00	2358.00
IUUC-Mmu-063503	Mus musculus	95.53	0.00e+00	2277.00
IUUC-Mpu-066670	Mustela putorius furo	98.09	0.00e+00	2350.00
IUUC-Mlu-068119	Myotis lucifugus	96.76	0.00e+00	2358.00
IUUC-Nfi-068398	Neosartorya fischeri	31.93	2.00e-156	546.00
IUUC-Ncr-068927	Neurospora crassa	29.92	2.00e-129	457.00
IUUC-Nle-069651	Nomascus leucogenys	95.43	0.00e+00	2284.00
IUUC-Opr-070614	Ochotona princeps	96.68	0.00e+00	2300.00
IUUC-Ont-072433	Oreochromis niloticus	74.65	0.00e+00	1851.00
IUUC-Oan-073283	Ornithorhynchus anatinus	73.83	0.00e+00	1422.00
IUUC-Ocu-074401	Oryctolagus cuniculus	96.45	0.00e+00	2320.00
IUUC-Ola-087522	Oryzias latipes	74.30	0.00e+00	1796.00
IUUC-Oga-088226	Otolemur garnettii	97.03	0.00e+00	2340.00
IUUC-Oar-089241	Ovis aries	97.84	0.00e+00	2379.00
IUUC-Pan-092297	Papio anubis	99.06	0.00e+00	2116.00
IUUC-Psi-094043	Pelodiscus sinensis	82.32	0.00e+00	1929.00
IUUC-Pma-094394	Petromyzon marinus	69.34	0.00e+00	1563.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.80	3.00e-148	519.00
IUUC-Ppa-095188	Physcomitrella patens	32.46	3.00e-157	549.00
IUUC-Pfo-097517	Poecilia formosa	75.45	0.00e+00	1855.00
IUUC-Pca-100471	Procavia capensis	97.19	0.00e+00	2199.00
IUUC-Pva-102805	Pteropus vampyrus	93.60	0.00e+00	1854.00
IUUC-Pte-104021	Pyrenophora teres	31.89	2.00e-159	556.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	31.71	3.00e-158	553.00
IUUC-Rno-105471	Rattus norvegicus	95.59	0.00e+00	2278.00
IUUC-Sce-106235	Saccharomyces cerevisiae	37.76	4.00e-60	227.00
IUUC-Sha-106883	Sarcophilus harrisii	91.41	0.00e+00	2043.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.08	2.00e-142	500.00
IUUC-Sar-113323	Sorex araneus	95.64	0.00e+00	1721.00
IUUC-Sre-115075	Sporisorium reilianum	29.49	7.00e-69	256.00
IUUC-Ssc-116363	Sus scrofa	96.69	0.00e+00	2349.00
IUUC-Tru-118427	Takifugu rubripes	74.84	0.00e+00	1869.00
IUUC-Tni-120218	Tetraodon nigroviridis	75.10	0.00e+00	1863.00
IUUC-Tre-122177	Trichoderma reesei	31.61	1.00e-150	527.00
IUUC-Tme-127176	Tuber melanosporum	32.36	1.00e-139	490.00
IUUC-Tbe-127641	Tupaia belangeri	88.64	0.00e+00	807.00
IUUC-Ttr-128888	Tursiops truncatus	96.80	0.00e+00	1489.00
IUUC-Uma-129361	Ustilago maydis	38.42	2.00e-63	238.00
IUUC-Xtr-132811	Xenopus tropicalis	79.00	0.00e+00	1897.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence