iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nfi-068398

Ensembl Protein ID

CADNFIAP00006624

UniProt Accession

A1DFN6; PAN2_NEOFI

Genbank Protein ID

EAW18193.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit pan2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

DS027696

Gene Name

NFIA_081370; pan2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADNFIAG00006791	CADNFIAT00006791	CADNFIAP00006624

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-10	39.6	485	821

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs......... 85
           Gl+ + +  + N++LQ L +ip +r+l l++  +++  e      ++ll+++  lf  l k + ++ + ++ll++++++ e  +         
   Q: 485  GLETHIANSFTNALLQLLKFIPLVRNLALHHAASTCIYE------TCLLCEMGYLFDMLEKANGQNCQATNLLRTFSSYREASNlglfeenlt 571
           788888899*********************888888765......7*******************************9999877553333333 PP
   S: 86   .gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreep.....fldl 172
            ++     q + +f+l+q+                           + +    +++ +++ +    +++i+c  c+n+ +r  +      ++ 
   Q: 572  tKSLSSAIQSVNRFFLNQIAH-------------------------DFRMIVPSSDDLDQRLSTIASESIRCMFCQNEIVRPGNslaneLIYP 639
           222333333333333333333.........................44677778888889999999999999999999977554000004455 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf......sfseeqksrekinkkvefple. 258
            +++++ + +    ++++L++  ++e+ +   + +c+ c+++q+++ + +++++P vLil+           +s  ++ +e +   v+  +  
   Q: 640  AIDIKQARRNPAFRFSNILRASIERETQN---RGWCNYCRRYQQVTIRKSIHRMPLVLILNAALSnpicrrLWSIPGWLPEEVGIAVDNGQVm 729
           6788888888788************9987...59**************************965553333336777777777777777766552 PP
   S: 259  .LdlspfctspeekqkekkkYeLiavvvHsG..slssGHYvayvkn........ekgkWllfdDskVtevkeeevleetg..staYvlfYkr 337
            ++ ++  t+ ++k  + + YeL++ v+     ++++ H v++++          k++W lf+D  Vtev+++e l++++  +++ +l Y+ 
   Q: 730  cFEGDELKTQLQNKLPNLVVYELVGLVSEIDipEHQKPHLVSFINVsissreleAKNRWHLFNDFLVTEVDKDEALRFNQpwKSPCILAYQA 821
           34445677777777778**********9998889999*********888888766888*******************999999999999986 PP

Organism

Neosartorya fischeri

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pab1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MEADWDELSR IPVPPPSPHG LPTAATTIAF DDVSELLWAG NEFGRITSFY GPELQRYTSV 60
RAHPVSDGPV RQILFHERGV ISLSPKSVHM ITRRGLTQWH ISHEEMTDLY CMSLTAQLNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCCG ATTGGGACGA ATTGTCGCGC ATTCCGGTGC CTCCTCCAAG CCCGCATGGC 60
CTACCGACCG CCGCGACGAC AATAGCATTC GACGATGTGT CTGAATTACT TTGGGCCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

nfi:NFIA_081370

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.85	1.00e-152	532.00
IUUC-Apl-003500	Anas platyrhynchos	31.65	1.00e-135	476.00
IUUC-Aca-004930	Anolis carolinensis	31.96	9.00e-151	526.00
IUUC-Acl-008214	Aspergillus clavatus	93.24	0.00e+00	2217.00
IUUC-Afu-009112	Aspergillus fumigatus	97.85	0.00e+00	2316.00
IUUC-Ang-009531	Aspergillus niger	87.25	0.00e+00	2093.00
IUUC-Ame-011259	Astyanax mexicanus	30.36	2.00e-85	309.00
IUUC-Bta-012371	Bos taurus	32.20	3.00e-153	534.00
IUUC-Bci-013684	Botrytis cinerea	49.64	0.00e+00	1070.00
IUUC-Cja-019297	Callithrix jacchus	31.38	2.00e-150	525.00
IUUC-Cfa-020489	Canis familiaris	32.03	7.00e-152	530.00
IUUC-Cpo-022392	Cavia porcellus	32.00	3.00e-153	534.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.94	9.00e-152	529.00
IUUC-Csv-025841	Ciona savignyi	29.49	7.00e-121	427.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	51.37	0.00e+00	1157.00
IUUC-Cne-026932	Cryptococcus neoformans	34.61	2.00e-160	558.00
IUUC-Dre-028482	Danio rerio	28.94	1.00e-79	290.00
IUUC-Dno-029398	Dasypus novemcinctus	31.68	3.00e-153	534.00
IUUC-Dor-030307	Dipodomys ordii	31.91	2.00e-93	335.00
IUUC-Dme-032111	Drosophila melanogaster	29.65	1.00e-78	286.00
IUUC-Eca-033985	Equus caballus	32.03	4.00e-152	530.00
IUUC-Eeu-034928	Erinaceus europaeus	30.27	4.00e-40	158.00
IUUC-Fca-035587	Felis catus	31.97	2.00e-153	535.00
IUUC-Fal-037587	Ficedula albicollis	32.50	2.00e-150	525.00
IUUC-Fso-038133	Fusarium solani	48.22	1.00e-176	612.00
IUUC-Gmo-039076	Gadus morhua	28.33	1.00e-75	276.00
IUUC-Ggr-039957	Gaeumannomyces graminis	47.30	0.00e+00	1015.00
IUUC-Gga-040948	Gallus gallus	32.70	1.00e-149	522.00
IUUC-Gac-042396	Gasterosteus aculeatus	29.38	8.00e-82	297.00
IUUC-Ggo-045412	Gorilla gorilla	31.77	5.00e-152	530.00
IUUC-Hsa-046076	Homo sapiens	31.77	7.00e-152	530.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.75	6.00e-135	473.00
IUUC-Kpa-049178	Komagataella pastoris	32.78	4.00e-170	590.00
IUUC-Lch-050279	Latimeria chalumnae	39.43	7.00e-64	237.00
IUUC-Loc-052872	Lepisosteus oculatus	30.12	3.00e-81	295.00
IUUC-Lma-052986	Leptosphaeria maculans	52.66	0.00e+00	1207.00
IUUC-Laf-054181	Loxodonta africana	31.92	1.00e-150	526.00
IUUC-Mcc-054812	Macaca mulatta	32.14	4.00e-152	531.00
IUUC-Meu-056325	Macropus eugenii	32.12	3.00e-152	531.00
IUUC-Mor-057246	Magnaporthe oryzae	43.16	0.00e+00	873.00
IUUC-Mpo-057464	Magnaporthe poae	46.58	0.00e+00	1019.00
IUUC-Mla-058911	Melampsora laricipopulina	34.90	8.00e-168	582.00
IUUC-Mga-059335	Meleagris gallopavo	32.65	1.00e-149	522.00
IUUC-Mvi-060461	Microbotryum violaceum	34.95	7.00e-167	579.00
IUUC-Mmr-060636	Microcebus murinus	32.20	1.00e-150	526.00
IUUC-Mmu-063503	Mus musculus	31.82	1.00e-153	535.00
IUUC-Mpu-066670	Mustela putorius furo	31.94	7.00e-152	530.00
IUUC-Mlu-068119	Myotis lucifugus	31.81	6.00e-155	540.00
IUUC-Ncr-068927	Neurospora crassa	43.13	0.00e+00	884.00
IUUC-Nle-069651	Nomascus leucogenys	31.04	5.00e-143	500.00
IUUC-Opr-070614	Ochotona princeps	31.64	5.00e-150	523.00
IUUC-Ont-072433	Oreochromis niloticus	30.07	5.00e-84	304.00
IUUC-Oan-073283	Ornithorhynchus anatinus	40.63	3.00e-59	222.00
IUUC-Ocu-074401	Oryctolagus cuniculus	31.83	7.00e-151	526.00
IUUC-Ola-087522	Oryzias latipes	31.05	3.00e-150	524.00
IUUC-Oga-088226	Otolemur garnettii	32.01	1.00e-152	532.00
IUUC-Oar-089241	Ovis aries	32.26	9.00e-156	543.00
IUUC-Pan-092297	Papio anubis	32.01	2.00e-139	488.00
IUUC-Psi-094043	Pelodiscus sinensis	31.48	7.00e-139	486.00
IUUC-Pma-094394	Petromyzon marinus	30.54	4.00e-142	497.00
IUUC-Pno-095053	Phaeosphaeria nodorum	51.94	0.00e+00	1078.00
IUUC-Ppa-095188	Physcomitrella patens	28.64	4.00e-115	407.00
IUUC-Pfo-097517	Poecilia formosa	31.54	3.00e-151	527.00
IUUC-Pca-100471	Procavia capensis	31.96	6.00e-152	530.00
IUUC-Pva-102805	Pteropus vampyrus	30.48	5.00e-116	410.00
IUUC-Pte-104021	Pyrenophora teres	52.40	0.00e+00	1212.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	53.34	0.00e+00	1206.00
IUUC-Rno-105471	Rattus norvegicus	32.28	4.00e-155	540.00
IUUC-Sce-106235	Saccharomyces cerevisiae	31.75	5.00e-138	483.00
IUUC-Sha-106883	Sarcophilus harrisii	32.17	9.00e-147	513.00
IUUC-Spo-108169	Schizosaccharomyces pombe	36.25	0.00e+00	663.00
IUUC-Sar-113323	Sorex araneus	33.77	1.00e-123	436.00
IUUC-Sre-115075	Sporisorium reilianum	41.76	1.00e-65	243.00
IUUC-Ssc-116363	Sus scrofa	31.87	7.00e-145	506.00
IUUC-Tru-118427	Takifugu rubripes	31.30	3.00e-150	524.00
IUUC-Tni-120218	Tetraodon nigroviridis	29.62	2.00e-86	313.00
IUUC-Tre-122177	Trichoderma reesei	49.59	0.00e+00	1136.00
IUUC-Tme-127176	Tuber melanosporum	46.82	0.00e+00	934.00
IUUC-Tbe-127641	Tupaia belangeri	32.62	2.00e-28	119.00
IUUC-Ttr-128888	Tursiops truncatus	33.43	5.00e-101	361.00
IUUC-Uma-129361	Ustilago maydis	35.15	4.00e-66	245.00
IUUC-Xtr-132811	Xenopus tropicalis	28.87	3.00e-77	281.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence