iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-022499

Ensembl Protein ID

ENSCPOP00000011922.2

UniProt Accession

H0VNA6; H0VNA6_CAVPO

Genbank Protein ID

ENSCPOP00000011922

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02050290

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000013242.3	ENSCPOT00000013370.2	ENSCPOP00000011922.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	5.80e-13	48.1	347	375
ULD/UDP/UBQ/UBQ_Other	7.50e-11	41.8	233	289

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           +++W C++CTf+N+P++++CemCs++R+c
   Q: 347  QPGWPCPSCTFINAPNRPGCEMCSTQRPC 375
           689*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 8    ldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdg 64
           + +++ +lk +p++t+a L+e++++++g+pp+ q++i+ G++L  + ++La+yg++++
   Q: 233  ASSAHISLKAHPHCTIAALQEQVFSEFGFPPAVQHWII-GRYLcVPERSLASYGVHQD 289
           4455677889****************************.**************99754 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MAPPAGGEAA GGDSSSARIL LAVHAVVRPQ RAGPGAEAPL RRLQLSTDPE RPGRLRLQLQ 60
GSSPPQVNLE WPLESVSYTI CSPSQHELQP PPGGPGTLSL HFLNSEEAQR WAALVQGASA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCTC CGGCAGGTGG GGAGGCAGCA GGTGGGGACT CTAGCTCGGC CAGGATCCTC 60
CTGGCTGTGC ACGCTGTAGT GAGGCCGCAG AGGGCTGGAC CCGGTGCAGA GGCGCCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000111	Aegilops tauschii	32.56	1.30e-02	33.90
IUUC-Aml-001223	Ailuropoda melanoleuca	76.26	6.00e-124	437.00
IUUC-Apl-004151	Anas platyrhynchos	63.83	1.00e-15	74.30
IUUC-Acl-008308	Aspergillus clavatus	40.00	4.50e-02	32.30
IUUC-Bta-012948	Bos taurus	72.99	1.00e-130	459.00
IUUC-Cja-019031	Callithrix jacchus	76.04	5.00e-123	434.00
IUUC-Cfa-020863	Canis familiaris	69.69	2.00e-107	382.00
IUUC-Csa-023641	Chlorocebus sabaeus	74.32	5.00e-121	427.00
IUUC-Dre-027612	Danio rerio	35.26	3.00e-44	172.00
IUUC-Dno-029459	Dasypus novemcinctus	54.34	1.00e-56	213.00
IUUC-Dor-030914	Dipodomys ordii	62.30	8.00e-78	283.00
IUUC-Ete-032940	Echinops telfairi	65.02	2.00e-97	348.00
IUUC-Eca-033537	Equus caballus	72.80	2.00e-127	448.00
IUUC-Eeu-035176	Erinaceus europaeus	62.25	6.00e-58	218.00
IUUC-Fca-035971	Felis catus	76.56	2.00e-122	432.00
IUUC-Gmo-039219	Gadus morhua	36.06	2.00e-45	176.00
IUUC-Gac-041562	Gasterosteus aculeatus	49.30	5.00e-28	118.00
IUUC-Ggo-044678	Gorilla gorilla	76.10	1.00e-125	442.00
IUUC-Hsa-046578	Homo sapiens	77.44	2.00e-129	455.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	74.79	6.00e-138	483.00
IUUC-Mcc-055686	Macaca mulatta	68.11	7.00e-122	430.00
IUUC-Meu-055912	Macropus eugenii	51.46	2.00e-59	222.00
IUUC-Mmr-060584	Microcebus murinus	73.57	2.00e-134	471.00
IUUC-Mdo-062191	Monodelphis domestica	54.84	2.00e-83	302.00
IUUC-Mmu-063740	Mus musculus	69.06	9.00e-105	373.00
IUUC-Mpu-066878	Mustela putorius furo	71.73	2.00e-105	375.00
IUUC-Mlu-067878	Myotis lucifugus	74.86	2.00e-130	458.00
IUUC-Nle-069748	Nomascus leucogenys	75.40	7.00e-120	423.00
IUUC-Ont-072270	Oreochromis niloticus	36.62	5.00e-46	178.00
IUUC-Obr-076087	Oryza brachyantha	48.48	6.00e-04	37.70
IUUC-Ome-081262	Oryza meridionalis	40.00	3.40e-02	32.70
IUUC-Oga-088300	Otolemur garnettii	72.92	1.00e-140	492.00
IUUC-Oar-089549	Ovis aries	73.51	5.00e-135	473.00
IUUC-Ptr-090961	Pan troglodytes	78.26	1.00e-118	419.00
IUUC-Pan-092687	Papio anubis	75.89	6.00e-126	443.00
IUUC-Pab-097872	Pongo abelii	74.62	5.00e-119	421.00
IUUC-Pca-100363	Procavia capensis	65.32	1.00e-63	236.00
IUUC-Pva-102595	Pteropus vampyrus	73.49	2.00e-112	399.00
IUUC-Rno-105856	Rattus norvegicus	70.49	1.00e-105	375.00
IUUC-Sha-106838	Sarcophilus harrisii	52.12	3.00e-76	278.00
IUUC-Sar-113611	Sorex araneus	67.37	2.00e-27	115.00
IUUC-Ssc-116263	Sus scrofa	72.83	2.00e-133	469.00
IUUC-Tru-118089	Takifugu rubripes	39.67	3.00e-52	199.00
IUUC-Tni-120004	Tetraodon nigroviridis	40.73	9.00e-46	177.00
IUUC-Tbe-127471	Tupaia belangeri	65.99	2.00e-105	375.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence