iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062191

Ensembl Protein ID

ENSMODP00000013146.3

UniProt Accession

F7ES70; F7ES70_MONDO

Protein Name

Uncharacterized protein

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000010491.3	ENSMODT00000013388.3	ENSMODP00000013146.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	3.00e-12	46.0	340	366
ULD/UDP/UBQ/UBQ_Other	3.70e-13	49.3	216	280

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 3    aqWaCsaCTflNePeavkCemCsrpRg 29
            +W+C++CTf+N P +++CemCs+ R+
   Q: 340  VGWSCPSCTFINVPGRPGCEMCSTERP 366
           68***********************98 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk.dg 64
           qvtv+++ +s + +l+v+p++tVa L+e+++k+ g+pp+ qr+++ G++L  + ++La+yg++ dg
   Q: 216  QVTVEDAASSaHISLRVHPHCTVAALQEQVFKEYGFPPRVQRWVI-GRCLcVPERSLASYGVQrDG 280
           89*******************************************.**************885155 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MAPPAGGGEE PEGAALEEAV VFVEVRGLGP GSGPGPDGLW RLQLSAEAAR PGHFRLALQG 60
SGSPPGGLQW PLESVTCTSR GPCELELQPP KEGPGPGAVT LCFQDTQDAQ RWSTLLERAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCGC CTGCAGGCGG GGGCGAGGAG CCAGAGGGCG CGGCGCTGGA GGAGGCGGTA 60
GTGTTCGTGG AGGTGCGTGG CCTGGGACCC GGGTCGGGTC CAGGGCCCGA TGGGCTGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR001876--Znf_RanBP2

PROSITE

PS50053--UBIQUITIN_2
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	55.69	5.00e-79	288.00
IUUC-Apl-004151	Anas platyrhynchos	67.39	2.00e-17	79.70
IUUC-Acl-008308	Aspergillus clavatus	44.00	1.20e-01	31.20
IUUC-Afl-008658	Aspergillus flavus	34.09	3.10e-02	33.10
IUUC-Aor-009946	Aspergillus oryzae	34.09	3.10e-02	33.10
IUUC-Bta-012948	Bos taurus	56.27	3.00e-87	315.00
IUUC-Cja-019031	Callithrix jacchus	54.15	3.00e-67	248.00
IUUC-Cfa-020863	Canis familiaris	55.70	2.00e-75	276.00
IUUC-Cpo-022499	Cavia porcellus	51.56	7.00e-73	267.00
IUUC-Csa-023641	Chlorocebus sabaeus	55.13	4.00e-69	254.00
IUUC-Dno-029459	Dasypus novemcinctus	63.82	4.00e-42	165.00
IUUC-Dor-030914	Dipodomys ordii	67.69	2.00e-39	156.00
IUUC-Ete-032940	Echinops telfairi	59.06	2.00e-61	229.00
IUUC-Eca-033537	Equus caballus	53.78	2.00e-82	298.00
IUUC-Eeu-035176	Erinaceus europaeus	55.80	6.00e-44	171.00
IUUC-Fca-035971	Felis catus	53.76	6.00e-81	294.00
IUUC-Gmo-039219	Gadus morhua	37.20	5.00e-44	171.00
IUUC-Ggo-044678	Gorilla gorilla	53.69	4.00e-69	254.00
IUUC-Hsa-046578	Homo sapiens	55.26	1.00e-71	263.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	53.46	8.00e-78	283.00
IUUC-Mcc-055686	Macaca mulatta	54.28	5.00e-74	271.00
IUUC-Meu-055912	Macropus eugenii	74.73	4.00e-94	337.00
IUUC-Mor-057018	Magnaporthe oryzae	34.15	1.00e-05	44.30
IUUC-Mmr-060584	Microcebus murinus	52.62	2.00e-73	269.00
IUUC-Mmu-063740	Mus musculus	47.99	2.00e-64	239.00
IUUC-Mpu-066878	Mustela putorius furo	54.69	2.00e-75	275.00
IUUC-Mlu-067878	Myotis lucifugus	54.00	2.00e-76	278.00
IUUC-Nle-069748	Nomascus leucogenys	54.82	5.00e-66	244.00
IUUC-Ont-072270	Oreochromis niloticus	38.92	1.00e-41	164.00
IUUC-Oga-088300	Otolemur garnettii	53.16	9.00e-78	283.00
IUUC-Oar-089549	Ovis aries	55.15	8.00e-86	310.00
IUUC-Ptr-090961	Pan troglodytes	58.65	5.00e-66	244.00
IUUC-Pan-092687	Papio anubis	55.59	2.00e-71	262.00
IUUC-Pab-097872	Pongo abelii	53.87	4.00e-65	241.00
IUUC-Pca-100363	Procavia capensis	72.61	6.00e-53	201.00
IUUC-Pva-102595	Pteropus vampyrus	57.48	4.00e-71	261.00
IUUC-Rno-105856	Rattus norvegicus	47.81	2.00e-62	233.00
IUUC-Sha-106838	Sarcophilus harrisii	79.70	1.00e-137	483.00
IUUC-Sar-113611	Sorex araneus	83.02	3.00e-19	89.00
IUUC-Ssc-116263	Sus scrofa	53.81	4.00e-81	295.00
IUUC-Tru-118089	Takifugu rubripes	39.59	1.00e-45	177.00
IUUC-Tni-120004	Tetraodon nigroviridis	40.00	3.00e-42	165.00
IUUC-Tbe-127471	Tupaia belangeri	53.11	8.00e-63	234.00
IUUC-Ttr-128534	Tursiops truncatus	58.17	3.00e-64	238.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence