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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064079
UUCD1 version UUC-MuM-01192
Ensembl Protein ID ENSMUSP00000099913.4
UniProt Accession Q8C6M1; Q69ZT5; Q8CJ72; UBP20_MOUSE
Genbank Protein ID AAN15803.1; BAD32361.1; BAC35715.1; BAE37447.1; CAM18433.1; EDL08500.1; AAH79674.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme 20; Ubiquitin thioesterase 20; Ubiquitin-specific-processing protease 20; VHL-interacting deubiquitinating enzyme 2
Genbank Nucleotide ID AF449715; AK173083; AK054279; AK163663; AL844546; CH466542; BC079674
Gene Name Usp20; Kiaa1003; Vdu2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026854.16 ENSMUST00000102849.10 ENSMUSP00000099913.4
ENSMUSG00000026854.16 ENSMUST00000061544.10 ENSMUSP00000060167.4
ENSMUSG00000026854.16 ENSMUST00000142232.1 ENSMUSP00000115347.1
ENSMUSG00000026854.16 ENSMUST00000136588.2 ENSMUSP00000119197.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.00e-108 363.7 145 686
Active Site
Position(s) Description Evidence
154 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
645 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLISEVWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk..............eknkpkeeeeeedkselsde.................................. 129
           qqD+qEfl++l+dql+eelk+              +++++++e ++ d+s ++de                                  
   Q: 229  QQDTQEFLRCLMDQLHEELKEpmvaavaaltdardSDSSDTDERRDGDRSPSEDEflscdsssdrgegdgqgrgggsskaemellisde 317
           *******************997776665555555444444445555554544444********************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 318  agraisekermkdrkfswgqqrtnseqvdedadvdtamasldeqsreaqppsprstspcqtpepdneahirsssrpcspvhhhheghsk 406
           ***************************************************************************************** PP
   S: 130  ............................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..... 185
                                        +++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+     
   Q: 407  lsssppraspvrmgpsyvlkkaqvpstgGRRRKEQSYRSVISDVFNGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiy 495
           ****************************99*************************************************99888***** PP
   S: 186  ............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                       +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+  lPe+L
   Q: 496  qnvpakpgacgdsyssqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLCLPEIL 584
           ***************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtev 317
           ++hLkRf  ++e + + k++++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev
   Q: 585  CVHLKRF--RHEVMYSFKVSSHVSFPLEgLDLRPFLAKECTSQ--VTTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEV 669
           *******..9999***************************999..9**************************78999************ PP
   S: 318  keeevleetgstaYvlfYkr 337
           +e+ v++    +aYvlfY++
   Q: 670  HETVVQN---VEAYVLFYRK 686
           *******...9*******98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MGDARDLCPH LDCIGEVTKE DLLLKSKGTC QSCGVAGPNL WACLQVTCPY VGCGESFADH 60
SSIHAQVKKH NLTVNLTTFR VWCYACEREV FLEQRLAVHL ASSSARLSEQ DSPPPSHPLK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064079|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCTCTCCCG ATTGGACGTC TGACGGTGAG GAGGCGGGGC GTGGCAGGCA GAGCCACAAG 60
ACTCTAGGCA GCGCCGCGGT GGGCTAGCTT GACTGACAGG CGGCGCGGTT GCGACGGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064079|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP
SMART

SM00695--DUSP
SM00290--ZnF_UBP
Gene Ontology

GO:0005813--C:centrosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0001664--F:G-protein coupled receptor binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:74270
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002209 Ailuropoda melanoleuca 91.16 0.00e+00 1654.00
IUUC-Apl-003351 Anas platyrhynchos 83.60 0.00e+00 1550.00
IUUC-Aca-005077 Anolis carolinensis 74.97 0.00e+00 1095.00
IUUC-Ame-011777 Astyanax mexicanus 74.59 0.00e+00 1334.00
IUUC-Bta-013063 Bos taurus 92.36 0.00e+00 1659.00
IUUC-Cja-019868 Callithrix jacchus 91.71 0.00e+00 1705.00
IUUC-Cfa-020761 Canis familiaris 90.72 0.00e+00 1657.00
IUUC-Cpo-022267 Cavia porcellus 85.19 0.00e+00 1536.00
IUUC-Csa-024251 Chlorocebus sabaeus 92.36 0.00e+00 1710.00
IUUC-Cho-024483 Choloepus hoffmanni 94.34 5.00e-122 432.00
IUUC-Csv-025889 Ciona savignyi 44.38 1.00e-35 142.00
IUUC-Dre-028061 Danio rerio 73.10 0.00e+00 1206.00
IUUC-Dno-029423 Dasypus novemcinctus 91.81 0.00e+00 1667.00
IUUC-Dor-030877 Dipodomys ordii 90.18 0.00e+00 1078.00
IUUC-Dme-031837 Drosophila melanogaster 48.70 1.00e-136 481.00
IUUC-Ete-032802 Echinops telfairi 78.35 4.00e-131 462.00
IUUC-Eca-034283 Equus caballus 90.83 0.00e+00 1649.00
IUUC-Eeu-034620 Erinaceus europaeus 88.61 0.00e+00 1178.00
IUUC-Fca-036357 Felis catus 91.27 0.00e+00 1640.00
IUUC-Fal-037411 Ficedula albicollis 84.13 0.00e+00 1550.00
IUUC-Gga-041101 Gallus gallus 83.84 0.00e+00 1535.00
IUUC-Gac-041315 Gasterosteus aculeatus 72.99 0.00e+00 1322.00
IUUC-Ggo-045600 Gorilla gorilla 91.75 0.00e+00 1650.00
IUUC-Hsa-045825 Homo sapiens 92.58 0.00e+00 1670.00
IUUC-Itr-048549 Ictidomys tridecemlineatus 79.96 0.00e+00 1382.00
IUUC-Lch-050002 Latimeria chalumnae 74.33 0.00e+00 1312.00
IUUC-Loc-052574 Lepisosteus oculatus 76.62 0.00e+00 1400.00
IUUC-Laf-054428 Loxodonta africana 90.85 0.00e+00 1649.00
IUUC-Mcc-055736 Macaca mulatta 92.14 0.00e+00 1706.00
IUUC-Mga-059781 Meleagris gallopavo 83.10 0.00e+00 1535.00
IUUC-Mdo-063048 Monodelphis domestica 84.22 0.00e+00 1501.00
IUUC-Mpu-066616 Mustela putorius furo 89.98 0.00e+00 1692.00
IUUC-Mlu-067294 Myotis lucifugus 90.28 0.00e+00 1610.00
IUUC-Nle-070015 Nomascus leucogenys 91.92 0.00e+00 1625.00
IUUC-Opr-070328 Ochotona princeps 90.09 0.00e+00 1660.00
IUUC-Ont-071464 Oreochromis niloticus 74.21 0.00e+00 1312.00
IUUC-Oan-073259 Ornithorhynchus anatinus 76.88 0.00e+00 1288.00
IUUC-Ocu-074630 Oryctolagus cuniculus 88.21 0.00e+00 1571.00
IUUC-Ola-087240 Oryzias latipes 74.62 0.00e+00 1292.00
IUUC-Oga-088761 Otolemur garnettii 90.83 0.00e+00 1673.00
IUUC-Oar-089490 Ovis aries 87.01 0.00e+00 1493.00
IUUC-Ptr-091662 Pan troglodytes 92.36 0.00e+00 1664.00
IUUC-Pan-092199 Papio anubis 91.94 0.00e+00 1699.00
IUUC-Psi-093726 Pelodiscus sinensis 84.75 0.00e+00 1554.00
IUUC-Pma-094389 Petromyzon marinus 62.25 2.00e-98 352.00
IUUC-Pfo-096522 Poecilia formosa 71.88 0.00e+00 959.00
IUUC-Pab-098632 Pongo abelii 92.03 0.00e+00 1654.00
IUUC-Pca-100614 Procavia capensis 84.65 0.00e+00 1296.00
IUUC-Pva-102922 Pteropus vampyrus 88.49 0.00e+00 957.00
IUUC-Rno-105215 Rattus norvegicus 98.36 0.00e+00 1753.00
IUUC-Sce-106176 Saccharomyces cerevisiae 31.14 3.00e-24 107.00
IUUC-Sha-106601 Sarcophilus harrisii 83.05 0.00e+00 1488.00
IUUC-Ssc-115533 Sus scrofa 90.29 0.00e+00 1631.00
IUUC-Tgu-117364 Taeniopygia guttata 83.97 0.00e+00 1523.00
IUUC-Tru-117770 Takifugu rubripes 71.70 0.00e+00 1294.00
IUUC-Tni-120001 Tetraodon nigroviridis 72.40 0.00e+00 1272.00
IUUC-Ttr-128732 Tursiops truncatus 91.70 0.00e+00 1657.00
IUUC-Xtr-132157 Xenopus tropicalis 75.63 0.00e+00 1352.00
Created Date 25-Jun-2017

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