iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ang-009798

Ensembl Protein ID

CAK48691

UniProt Accession

A2RAG5; ATG18_ASPNC

Genbank Protein ID

CAK48691.1

Protein Name

Autophagy-related protein 18

Genbank Nucleotide ID

AM270401

Gene Name

atg18; An18g03070

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
An18g03070	CAK48691	CAK48691

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.30e-08	31.7	186	223

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgt.ikvWDlrtgvll 36
           H ++  c+ + sd tl++++sd gt i+v+++ +g++l
   Q: 186  HRSPLACITLnSDgTLIATASDKGTiIRVFSVPDGRKL 223
           999********999***********9********9987 PP

Organism

Aspergillus niger

Functional Description
(View)

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Protein Sequence
(Fasta)

MSMNFVTFNQ DYSYLAVATS KGFRIFTTDP FAKSYETKEG NIAIIEMLFS TSLVALILSP 60
RRLQITNTKR QSTICELTFP TTVLAVKLNR KRLVIVLEDQ IYLYDIQTMK LLYTIETSPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGATGA ACTTCGTGAC GTTTAACCAG GACTATAGCT ACCTAGCTGT GGGTAAGGCT 60
CTTCCTGCTC CCGTCTCTTA CCTTCTATAC TCGTGAAATA TGTCTTGACA CCTGTCAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0926--Vacuole
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

SMART

SM00320--WD40

Gene Ontology

GO:0010008--C:endosome membrane
GO:0000329--C:fungal-type vacuole membrane
GO:0005794--C:Golgi apparatus
GO:0034045--C:pre-autophagosomal structure membrane
GO:0016236--P:macroautophagy
GO:0015031--P:protein transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000966	Aegilops tauschii	31.75	6.00e-49	186.00
IUUC-Aml-001842	Ailuropoda melanoleuca	36.27	4.00e-65	240.00
IUUC-Atr-002710	Amborella trichopoda	31.79	8.00e-44	169.00
IUUC-Apl-003390	Anas platyrhynchos	35.37	1.00e-65	241.00
IUUC-Aca-004975	Anolis carolinensis	35.89	1.00e-68	252.00
IUUC-Aly-006332	Arabidopsis lyrata	30.86	1.00e-47	182.00
IUUC-Ath-007660	Arabidopsis thaliana	30.62	9.00e-42	162.00
IUUC-Ago-007948	Ashbya gossypii	39.27	4.00e-77	280.00
IUUC-Acl-008148	Aspergillus clavatus	87.29	0.00e+00	686.00
IUUC-Afl-008562	Aspergillus flavus	88.19	0.00e+00	671.00
IUUC-Afu-008936	Aspergillus fumigatus	86.26	0.00e+00	685.00
IUUC-Ani-009254	Aspergillus nidulans	87.95	0.00e+00	696.00
IUUC-Aor-010066	Aspergillus oryzae	88.19	0.00e+00	671.00
IUUC-Ate-010266	Aspergillus terreus	90.12	0.00e+00	716.00
IUUC-Ame-010727	Astyanax mexicanus	37.32	1.00e-71	261.00
IUUC-Bta-012655	Bos taurus	35.95	2.00e-69	254.00
IUUC-Bci-013627	Botrytis cinerea	59.90	7.00e-133	465.00
IUUC-Bdi-014739	Brachypodium distachyon	31.28	4.00e-49	186.00
IUUC-Bol-015492	Brassica oleracea	34.80	1.00e-45	175.00
IUUC-Bra-017319	Brassica rapa	34.07	2.00e-37	147.00
IUUC-Cel-018503	Caenorhabditis elegans	31.79	7.00e-49	186.00
IUUC-Cja-018829	Callithrix jacchus	44.27	5.00e-55	206.00
IUUC-Cfa-020858	Canis familiaris	34.77	2.00e-65	241.00
IUUC-Cpo-022235	Cavia porcellus	44.11	1.00e-59	221.00
IUUC-Cre-022613	Chlamydomonas reinhardtii	33.09	1.00e-40	158.00
IUUC-Csa-023963	Chlorocebus sabaeus	43.48	3.00e-56	210.00
IUUC-Cho-024328	Choloepus hoffmanni	36.77	2.00e-63	234.00
IUUC-Cin-025343	Ciona intestinalis	34.91	2.00e-59	221.00
IUUC-Csv-025920	Ciona savignyi	35.55	2.00e-65	240.00
IUUC-Cgl-026425	Colletotrichum gloeosporioides	70.59	8.00e-56	209.00
IUUC-Cne-026947	Cryptococcus neoformans	50.47	3.00e-103	367.00
IUUC-Dre-027490	Danio rerio	37.08	3.00e-71	260.00
IUUC-Dno-030057	Dasypus novemcinctus	36.27	8.00e-66	242.00
IUUC-Dor-030472	Dipodomys ordii	44.12	2.00e-54	204.00
IUUC-Dse-031215	Dothistroma septosporum	51.17	4.00e-123	432.00
IUUC-Dme-031881	Drosophila melanogaster	34.44	4.00e-32	130.00
IUUC-Ete-032362	Echinops telfairi	33.42	1.00e-57	215.00
IUUC-Eca-034362	Equus caballus	36.03	5.00e-66	243.00
IUUC-Eeu-034479	Erinaceus europaeus	35.98	7.00e-25	105.00
IUUC-Fca-036230	Felis catus	36.12	1.00e-65	242.00
IUUC-Fal-036782	Ficedula albicollis	35.78	2.00e-65	241.00
IUUC-Fox-037797	Fusarium oxysporum	57.18	1.00e-125	441.00
IUUC-Fso-038174	Fusarium solani	57.21	9.00e-125	438.00
IUUC-Gmo-039706	Gadus morhua	33.41	4.00e-58	216.00
IUUC-Ggr-040113	Gaeumannomyces graminis	70.00	5.00e-104	369.00
IUUC-Gga-040690	Gallus gallus	35.71	5.00e-69	253.00
IUUC-Gac-041360	Gasterosteus aculeatus	36.19	1.00e-70	258.00
IUUC-Gma-043876	Glycine max	43.70	2.00e-57	214.00
IUUC-Ggo-045610	Gorilla gorilla	31.56	1.00e-33	135.00
IUUC-Hsa-046782	Homo sapiens	43.87	2.00e-56	211.00
IUUC-Hvu-047851	Hordeum vulgare	31.26	8.00e-49	186.00
IUUC-Itr-048693	Ictidomys tridecemlineatus	43.87	1.00e-56	212.00
IUUC-Kpa-049378	Komagataella pastoris	47.47	2.00e-75	275.00
IUUC-Lch-050413	Latimeria chalumnae	33.49	2.00e-63	234.00
IUUC-Lpe-051205	Leersia perrieri	30.86	9.00e-49	185.00
IUUC-Loc-052379	Lepisosteus oculatus	35.14	2.00e-39	154.00
IUUC-Lma-052948	Leptosphaeria maculans	62.56	3.00e-152	529.00
IUUC-Laf-054007	Loxodonta africana	36.12	6.00e-69	253.00
IUUC-Mcc-055304	Macaca mulatta	35.32	2.00e-38	150.00
IUUC-Meu-056020	Macropus eugenii	31.47	6.00e-32	129.00
IUUC-Mor-057125	Magnaporthe oryzae	55.90	6.00e-136	475.00
IUUC-Mpo-057416	Magnaporthe poae	28.78	6.00e-29	120.00
IUUC-Mtr-058536	Medicago truncatula	31.67	5.00e-46	176.00
IUUC-Mla-058885	Melampsora laricipopulina	22.22	3.00e-14	70.10
IUUC-Mga-059795	Meleagris gallopavo	35.37	1.00e-65	242.00
IUUC-Mvi-060219	Microbotryum violaceum	49.52	6.00e-103	365.00
IUUC-Mmr-061096	Microcebus murinus	34.25	2.00e-65	241.00
IUUC-Mdo-062881	Monodelphis domestica	36.04	9.00e-69	251.00
IUUC-Mmu-063787	Mus musculus	35.89	7.00e-68	249.00
IUUC-Mac-064838	Musa acuminata	37.45	5.00e-49	186.00
IUUC-Mpu-066019	Mustela putorius furo	41.64	5.00e-59	219.00
IUUC-Mlu-068016	Myotis lucifugus	36.60	4.00e-69	253.00
IUUC-Nfi-068424	Neosartorya fischeri	87.95	0.00e+00	691.00
IUUC-Ncr-068833	Neurospora crassa	55.42	1.00e-130	457.00
IUUC-Nle-069047	Nomascus leucogenys	34.97	3.00e-42	164.00
IUUC-Opr-070933	Ochotona princeps	47.06	2.00e-39	154.00
IUUC-Ont-072495	Oreochromis niloticus	36.43	6.00e-71	259.00
IUUC-Oan-073084	Ornithorhynchus anatinus	36.05	3.00e-63	234.00
IUUC-Ocu-074689	Oryctolagus cuniculus	44.49	2.00e-60	224.00
IUUC-Oba-075601	Oryza barthii	40.00	2.00e-40	157.00
IUUC-Obr-076476	Oryza brachyantha	30.62	9.00e-49	185.00
IUUC-Ogl-077630	Oryza glaberrima	31.10	3.00e-49	187.00
IUUC-Ogu-078089	Oryza glumaepatula	40.00	1.00e-40	158.00
IUUC-Oin-079071	Oryza indica	40.00	1.00e-40	158.00
IUUC-Olo-080657	Oryza longistaminata	32.06	9.00e-49	187.00
IUUC-Ome-081702	Oryza meridionalis	36.36	4.00e-46	177.00
IUUC-Oni-083063	Oryza nivara	40.00	1.00e-40	158.00
IUUC-Opu-083460	Oryza punctata	31.10	9.00e-48	183.00
IUUC-Oru-084845	Oryza rufipogon	40.00	1.00e-40	158.00
IUUC-Osa-086113	Oryza sativa	40.00	1.00e-40	158.00
IUUC-Ola-086628	Oryzias latipes	36.01	2.00e-44	171.00
IUUC-Olu-087808	Ostreococcus lucimarinus	31.60	9.00e-42	162.00
IUUC-Oga-088894	Otolemur garnettii	43.87	1.00e-56	211.00
IUUC-Oar-089850	Ovis aries	35.37	5.00e-66	243.00
IUUC-Ptr-090456	Pan troglodytes	43.87	1.00e-56	211.00
IUUC-Pan-092111	Papio anubis	44.11	5.00e-60	223.00
IUUC-Psi-094095	Pelodiscus sinensis	35.61	4.00e-66	243.00
IUUC-Pma-094403	Petromyzon marinus	29.60	2.00e-31	127.00
IUUC-Pno-095015	Phaeosphaeria nodorum	61.79	2.00e-146	509.00
IUUC-Ppa-095480	Physcomitrella patens	32.77	9.00e-46	176.00
IUUC-Pfo-096987	Poecilia formosa	36.02	2.00e-69	254.00
IUUC-Pab-097754	Pongo abelii	43.87	2.00e-56	211.00
IUUC-Pop-099157	Populus trichocarpa	34.28	5.00e-42	163.00
IUUC-Pca-100176	Procavia capensis	28.83	1.00e-26	112.00
IUUC-Ppe-101799	Prunus persica	31.59	8.00e-40	155.00
IUUC-Pva-103047	Pteropus vampyrus	34.86	7.00e-66	242.00
IUUC-Pgr-103258	Puccinia graminis	22.96	6.00e-12	63.90
IUUC-Ptt-103915	Puccinia triticina	24.38	5.00e-18	84.30
IUUC-Pte-104139	Pyrenophora teres	62.35	3.00e-143	499.00
IUUC-Pyt-104488	Pyrenophora triticirepentis	61.87	2.00e-143	499.00
IUUC-Rno-105990	Rattus norvegicus	35.89	6.00e-68	249.00
IUUC-Sce-106327	Saccharomyces cerevisiae	37.35	2.00e-81	294.00
IUUC-Sha-106581	Sarcophilus harrisii	35.54	4.00e-65	239.00
IUUC-Sja-107913	Schizosaccharomyces japonicus	39.71	4.00e-79	286.00
IUUC-Spo-108068	Schizosaccharomyces pombe	52.59	7.00e-70	255.00
IUUC-Ssl-108418	Sclerotinia sclerotiorum	59.62	2.00e-143	499.00
IUUC-Smo-109446	Selaginella moellendorffii	32.70	4.00e-53	200.00
IUUC-Sit-110095	Setaria italica	30.38	2.00e-46	178.00
IUUC-Sly-111030	Solanum lycopersicum	30.68	1.00e-46	178.00
IUUC-Stu-112534	Solanum tuberosum	35.11	2.00e-39	155.00
IUUC-Sar-113276	Sorex araneus	35.98	8.00e-25	105.00
IUUC-Sbi-114020	Sorghum bicolor	30.38	6.00e-47	179.00
IUUC-Sre-115219	Sporisorium reilianum	50.80	4.00e-106	376.00
IUUC-Ssc-116360	Sus scrofa	35.95	5.00e-69	253.00
IUUC-Tgu-116951	Taeniopygia guttata	35.37	9.00e-66	242.00
IUUC-Tru-117889	Takifugu rubripes	34.71	2.00e-67	248.00
IUUC-Tsy-119533	Tarsius syrichta	45.57	2.00e-18	83.60
IUUC-Tni-119729	Tetraodon nigroviridis	34.84	1.00e-38	151.00
IUUC-Tca-121732	Theobroma cacao	31.19	4.00e-38	150.00
IUUC-Tre-121895	Trichoderma reesei	57.66	6.00e-139	485.00
IUUC-Tvi-122311	Trichoderma virens	57.63	4.00e-138	483.00
IUUC-Tae-125776	Triticum aestivum	31.75	6.00e-49	186.00
IUUC-Tur-126757	Triticum urartu	31.28	1.00e-47	181.00
IUUC-Ttr-128940	Tursiops truncatus	35.20	2.00e-34	137.00
IUUC-Uma-129438	Ustilago maydis	49.65	3.00e-94	336.00
IUUC-Vda-129782	Verticillium dahliae	54.08	5.00e-95	339.00
IUUC-Vvi-131674	Vitis vinifera	30.79	5.00e-48	183.00
IUUC-Xtr-131806	Xenopus tropicalis	35.31	2.00e-42	164.00
IUUC-Xma-133370	Xiphophorus maculatus	36.02	2.00e-69	254.00
IUUC-Yli-134337	Yarrowia lipolytica	49.07	3.00e-99	353.00
IUUC-Zma-135654	Zea mays	31.58	6.00e-44	169.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence