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Tag Content
iUUCD ID IUUC-Lma-053259
Ensembl Protein ID CBX98560
UniProt Accession E5A4L2; E5A4L2_LEPMJ
Genbank Protein ID CBX98560.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID FP929134
Gene Name URM1; LEMA_P077990.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
LEMA_P077990.1 CBX98560 CBX98560
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 40.20 7.00e-19 86.70 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Leptosphaeria maculans
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MSDMQNDTIP ITIEFSGGLE MLFANQKRHT LAMPTQDEAG KPANIAFLVR HLCDKVMKDP 60
RKDLFVLDGT VRPGILVLIN EADWELEGED EYELGKNDHI MFVSTLHGG 109
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Protein Fasta Sequence


>IUUC-Lma-053259|ULD,UBQ_Other|Leptosphaeria maculans
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Nucleotide Sequence
(Fasta)
ATGTCAGACA TGCAGAATGA TACGATTCCG ATAACTATCG AATTCAGGTA ATGGTGTCTC 60
AGTCTGCGAA CCCAACGTCC ACCACTTACA CCACACATGT AGCGGCGGGC TGGAGATGCT 120
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Nucleotide Fasta Sequence


>IUUC-Lma-053259|ULD,UBQ_Other|Leptosphaeria maculans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 44.55 4.00e-21 90.90
IUUC-Atr-003089 Amborella trichopoda 46.46 4.00e-20 87.40
IUUC-Apl-003382 Anas platyrhynchos 47.37 2.00e-20 88.60
IUUC-Aca-004981 Anolis carolinensis 44.55 4.00e-21 91.30
IUUC-Aly-005517 Arabidopsis lyrata 40.62 1.00e-13 65.90
IUUC-Ath-006718 Arabidopsis thaliana 53.06 2.00e-11 58.90
IUUC-Ago-007917 Ashbya gossypii 38.24 5.00e-19 84.00
IUUC-Acl-008054 Aspergillus clavatus 71.70 3.00e-19 84.30
IUUC-Afl-008704 Aspergillus flavus 57.30 9.00e-28 112.00
IUUC-Aor-009890 Aspergillus oryzae 56.86 6.00e-33 130.00
IUUC-Bta-012448 Bos taurus 44.55 2.00e-21 91.70
IUUC-Bci-013865 Botrytis cinerea 62.26 6.00e-39 150.00
IUUC-Bdi-014980 Brachypodium distachyon 41.77 8.00e-12 60.10
IUUC-Bol-016055 Brassica oleracea 53.06 8.00e-12 60.10
IUUC-Bra-016845 Brassica rapa 53.06 8.00e-12 60.10
IUUC-Cel-018485 Caenorhabditis elegans 32.38 5.00e-08 47.40
IUUC-Cja-019587 Callithrix jacchus 45.54 2.00e-21 92.00
IUUC-Cfa-020653 Canis familiaris 45.54 1.00e-21 92.40
IUUC-Cpo-021622 Cavia porcellus 45.54 2.00e-21 92.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 49.50 4.00e-23 97.40
IUUC-Csa-023756 Chlorocebus sabaeus 44.74 2.00e-13 66.20
IUUC-Cgl-026518 Colletotrichum gloeosporioides 64.36 3.00e-38 148.00
IUUC-Cne-026953 Cryptococcus neoformans 44.86 6.00e-22 94.70
IUUC-Cme-027314 Cyanidioschyzon merolae 41.18 2.00e-15 72.00
IUUC-Dre-027884 Danio rerio 45.45 2.00e-19 85.10
IUUC-Dno-029262 Dasypus novemcinctus 43.21 6.00e-13 65.10
IUUC-Dor-030601 Dipodomys ordii 43.75 2.00e-07 45.40
IUUC-Dme-031893 Drosophila melanogaster 45.28 3.00e-20 88.20
IUUC-Ete-032773 Echinops telfairi 45.00 6.00e-21 90.10
IUUC-Eca-034187 Equus caballus 46.53 1.00e-21 92.40
IUUC-Eeu-034808 Erinaceus europaeus 43.56 1.00e-20 89.70
IUUC-Fca-036107 Felis catus 45.54 2.00e-21 92.00
IUUC-Fal-036607 Ficedula albicollis 48.42 9.00e-21 89.40
IUUC-Fox-037698 Fusarium oxysporum 65.66 1.00e-37 145.00
IUUC-Gmo-039492 Gadus morhua 48.04 1.00e-20 89.40
IUUC-Ggr-039965 Gaeumannomyces graminis 65.69 5.00e-37 144.00
IUUC-Gga-041268 Gallus gallus 45.54 7.00e-22 93.60
IUUC-Gac-042111 Gasterosteus aculeatus 46.53 3.00e-21 91.30
IUUC-Gma-043240 Glycine max 51.02 4.00e-11 57.80
IUUC-Ggo-045176 Gorilla gorilla 44.74 2.00e-11 60.10
IUUC-Hsa-046077 Homo sapiens 45.54 3.00e-19 84.70
IUUC-Itr-048111 Ictidomys tridecemlineatus 47.31 3.00e-17 77.80
IUUC-Kpa-049157 Komagataella pastoris 50.98 2.00e-23 99.00
IUUC-Lch-049889 Latimeria chalumnae 45.54 2.00e-21 91.70
IUUC-Lpe-050783 Leersia perrieri 52.08 3.00e-10 55.10
IUUC-Loc-052400 Lepisosteus oculatus 47.52 2.00e-21 92.00
IUUC-Laf-053596 Loxodonta africana 44.66 2.00e-20 89.00
IUUC-Mcc-054845 Macaca mulatta 46.88 5.00e-19 84.00
IUUC-Meu-055968 Macropus eugenii 45.54 6.00e-23 97.10
IUUC-Mor-057126 Magnaporthe oryzae 61.90 1.00e-35 139.00
IUUC-Mpo-057311 Magnaporthe poae 67.62 4.00e-40 154.00
IUUC-Mtr-058266 Medicago truncatula 51.02 2.00e-11 58.50
IUUC-Mla-058847 Melampsora laricipopulina 37.74 1.00e-11 59.70
IUUC-Mga-059468 Meleagris gallopavo 47.37 1.00e-20 89.00
IUUC-Mvi-060235 Microbotryum violaceum 31.79 3.00e-17 79.30
IUUC-Mdo-061948 Monodelphis domestica 46.53 2.00e-23 98.60
IUUC-Mmu-063946 Mus musculus 48.48 6.00e-22 93.60
IUUC-Mac-064812 Musa acuminata 53.06 1.00e-11 59.70
IUUC-Mpu-066763 Mustela putorius furo 46.53 5.00e-21 90.90
IUUC-Mlu-066970 Myotis lucifugus 43.59 1.00e-13 65.90
IUUC-Ncr-068824 Neurospora crassa 61.47 1.00e-38 149.00
IUUC-Nle-069849 Nomascus leucogenys 44.74 2.00e-13 66.20
IUUC-Opr-070227 Ochotona princeps 45.54 2.00e-21 92.00
IUUC-Ont-072530 Oreochromis niloticus 47.06 6.00e-22 94.00
IUUC-Oan-073191 Ornithorhynchus anatinus 48.39 5.00e-20 87.40
IUUC-Ocu-074460 Oryctolagus cuniculus 45.54 2.00e-21 92.00
IUUC-Oba-075499 Oryza barthii 53.06 1.00e-10 57.40
IUUC-Obr-076896 Oryza brachyantha 53.06 3.00e-11 60.10
IUUC-Ogl-077834 Oryza glaberrima 53.06 7.00e-11 57.00
IUUC-Ogu-078622 Oryza glumaepatula 53.06 7.00e-11 57.00
IUUC-Oin-079358 Oryza indica 53.06 1.00e-10 57.80
IUUC-Olo-081035 Oryza longistaminata 37.76 4.00e-12 62.40
IUUC-Oni-082425 Oryza nivara 53.06 7.00e-11 57.00
IUUC-Opu-083461 Oryza punctata 52.08 5.00e-10 55.10
IUUC-Oru-084875 Oryza rufipogon 53.19 3.00e-10 54.30
IUUC-Oga-089128 Otolemur garnettii 46.53 2.00e-21 92.00
IUUC-Oar-089896 Ovis aries 44.55 2.00e-21 91.70
IUUC-Ptr-091618 Pan troglodytes 44.74 2.00e-11 60.10
IUUC-Pan-092238 Papio anubis 44.74 2.00e-13 66.20
IUUC-Psi-093879 Pelodiscus sinensis 47.47 5.00e-22 94.00
IUUC-Pma-094484 Petromyzon marinus 43.37 3.00e-14 68.20
IUUC-Ppa-095801 Physcomitrella patens 42.35 3.00e-15 71.60
IUUC-Pfo-097192 Poecilia formosa 47.52 4.00e-21 90.90
IUUC-Pab-098203 Pongo abelii 45.54 4.00e-19 84.30
IUUC-Pop-099614 Populus trichocarpa 51.02 6.00e-12 60.50
IUUC-Pca-100507 Procavia capensis 42.31 2.00e-13 65.10
IUUC-Ppe-101174 Prunus persica 38.61 2.00e-15 72.00
IUUC-Pva-102735 Pteropus vampyrus 45.54 1.00e-18 82.40
IUUC-Pgr-103510 Puccinia graminis 42.20 6.00e-15 70.90
IUUC-Ptt-103918 Puccinia triticina 36.45 9.00e-12 60.50
IUUC-Pte-104173 Pyrenophora teres 77.98 1.00e-48 182.00
IUUC-Pyt-104806 Pyrenophora triticirepentis 77.06 4.00e-48 181.00
IUUC-Rno-105820 Rattus norvegicus 47.47 3.00e-21 91.70
IUUC-Sce-106366 Saccharomyces cerevisiae 40.20 8.00e-20 86.70
IUUC-Sja-107727 Schizosaccharomyces japonicus 39.39 3.00e-20 88.60
IUUC-Spo-108074 Schizosaccharomyces pombe 42.57 6.00e-16 73.60
IUUC-Smo-108944 Selaginella moellendorffii 37.63 1.00e-13 65.90
IUUC-Sit-110277 Setaria italica 42.35 1.00e-12 63.20
IUUC-Sly-111505 Solanum lycopersicum 39.76 2.00e-12 62.00
IUUC-Stu-112076 Solanum tuberosum 41.18 5.00e-12 60.50
IUUC-Sbi-114274 Sorghum bicolor 40.26 1.00e-11 59.70
IUUC-Sre-114953 Sporisorium reilianum 47.17 5.00e-26 107.00
IUUC-Ssc-115418 Sus scrofa 46.53 7.00e-22 93.60
IUUC-Tgu-117311 Taeniopygia guttata 48.42 8.00e-21 89.70
IUUC-Tru-118598 Takifugu rubripes 47.87 2.00e-19 84.70
IUUC-Tni-120109 Tetraodon nigroviridis 44.12 5.00e-18 80.90
IUUC-Tca-120942 Theobroma cacao 43.75 5.00e-11 57.40
IUUC-Tre-122099 Trichoderma reesei 68.09 2.00e-30 121.00
IUUC-Tvi-122285 Trichoderma virens 64.36 2.00e-31 125.00
IUUC-Tae-125193 Triticum aestivum 55.10 8.00e-12 60.10
IUUC-Tur-126677 Triticum urartu 44.26 4.00e-09 51.60
IUUC-Tme-127120 Tuber melanosporum 64.36 8.00e-37 143.00
IUUC-Tbe-128050 Tupaia belangeri 37.62 6.00e-15 70.50
IUUC-Ttr-129019 Tursiops truncatus 44.55 5.00e-20 87.40
IUUC-Uma-129483 Ustilago maydis 50.00 5.00e-27 110.00
IUUC-Vda-129690 Verticillium dahliae 50.89 6.00e-28 114.00
IUUC-Vvi-131174 Vitis vinifera 51.02 3.00e-11 58.20
IUUC-Xma-133862 Xiphophorus maculatus 47.52 4.00e-21 90.90
IUUC-Yli-134398 Yarrowia lipolytica 47.57 5.00e-23 97.10
IUUC-Zma-134964 Zea mays 37.65 1.00e-12 62.80
Created Date 25-Jun-2017

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