iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064323

UUCD1 version

UUC-MuM-00990

Ensembl Protein ID

ENSMUSP00000037574.5

UniProt Accession

Q9JLV2; Q920J6; Q99L03; TP4AP_MOUSE

Genbank Protein ID

AAM46938.1; AAF36513.1; AAH03931.1; AAH33274.1; AAH57330.1; AAL08422.1

Protein Name

Short transient receptor potential channel 4-associated protein; Protein TAP1; Rabex-5/Rin2-interacting protein; TNF-receptor ubiquitous scaffolding/signaling protein

Genbank Nucleotide ID

AF509881; AF130458; BC003931; BC033274; BC057330; AF093589

Gene Name

Trpc4ap; Trrp4ap

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000038324.13	ENSMUST00000041059.11	ENSMUSP00000037574.5
ENSMUSG00000038324.13	ENSMUST00000103140.4	ENSMUSP00000099429.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	98.12	0.00e+00	1442.00	IUUC-Hsa-046967

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC (By similarity). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Protein Sequence
(Fasta)

MAAAPAAAGA GASRGRRLAA TAAAWGGWGG RPRPGNILLQ LRQGQLTGRG LVRAVQFTET 60
FLTERDKLSK WSGIPQLLLK LYATSHLHSD FVECQSILKE ISPLLSMEAM AFVTEDRKFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGAGAGTC CTCCGCCGCC CCGTAGAAAT CGACACGGCT CCGGGACCGC TTGCTTCCTG 60
TTTGTCGGAC GAGGAGACAT GGCGGCAGCG CCCGCAGCGG CTGGAGCTGG GGCCAGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR022162--DUF3689

Pfam

PF12463--DUF3689

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0019902--F:phosphatase binding
GO:0048820--P:hair follicle maturation
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:56407

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002271	Ailuropoda melanoleuca	95.82	0.00e+00	1434.00
IUUC-Apl-003296	Anas platyrhynchos	85.65	0.00e+00	1252.00
IUUC-Aca-004428	Anolis carolinensis	82.28	0.00e+00	1271.00
IUUC-Bta-013309	Bos taurus	97.72	0.00e+00	1431.00
IUUC-Cja-019857	Callithrix jacchus	97.98	0.00e+00	1440.00
IUUC-Cfa-020458	Canis familiaris	97.85	0.00e+00	1439.00
IUUC-Cpo-021530	Cavia porcellus	97.98	0.00e+00	1439.00
IUUC-Csa-024042	Chlorocebus sabaeus	97.98	0.00e+00	1439.00
IUUC-Dno-029698	Dasypus novemcinctus	90.55	0.00e+00	1326.00
IUUC-Dor-030424	Dipodomys ordii	88.36	9.00e-93	334.00
IUUC-Ete-032935	Echinops telfairi	77.43	0.00e+00	1087.00
IUUC-Eca-033775	Equus caballus	98.25	0.00e+00	1442.00
IUUC-Eeu-034570	Erinaceus europaeus	92.74	0.00e+00	1352.00
IUUC-Fca-035469	Felis catus	97.98	0.00e+00	1438.00
IUUC-Hsa-046967	Homo sapiens	98.12	0.00e+00	1415.00
IUUC-Itr-049049	Ictidomys tridecemlineatus	98.69	0.00e+00	876.00
IUUC-Lch-049503	Latimeria chalumnae	80.43	0.00e+00	1198.00
IUUC-Laf-054113	Loxodonta africana	97.85	0.00e+00	1445.00
IUUC-Mcc-054997	Macaca mulatta	98.12	0.00e+00	1441.00
IUUC-Mga-059837	Meleagris gallopavo	81.79	0.00e+00	1241.00
IUUC-Mmr-061617	Microcebus murinus	97.85	0.00e+00	1439.00
IUUC-Mpu-066520	Mustela putorius furo	97.98	0.00e+00	1439.00
IUUC-Mlu-067982	Myotis lucifugus	97.57	0.00e+00	1432.00
IUUC-Nle-069547	Nomascus leucogenys	93.82	0.00e+00	1364.00
IUUC-Opr-070688	Ochotona princeps	93.05	0.00e+00	1352.00
IUUC-Ocu-074062	Oryctolagus cuniculus	97.64	0.00e+00	1467.00
IUUC-Oga-088592	Otolemur garnettii	97.58	0.00e+00	1433.00
IUUC-Oar-090121	Ovis aries	96.80	0.00e+00	1421.00
IUUC-Ptr-090791	Pan troglodytes	97.98	0.00e+00	1414.00
IUUC-Pan-092043	Papio anubis	98.55	0.00e+00	1341.00
IUUC-Pab-097973	Pongo abelii	97.98	0.00e+00	1414.00
IUUC-Pca-100766	Procavia capensis	90.59	0.00e+00	1352.00
IUUC-Pva-102516	Pteropus vampyrus	96.19	0.00e+00	1207.00
IUUC-Rno-105758	Rattus norvegicus	99.06	0.00e+00	1456.00
IUUC-Sha-107329	Sarcophilus harrisii	84.76	0.00e+00	1304.00
IUUC-Sar-112997	Sorex araneus	85.34	4.00e-153	534.00
IUUC-Ssc-115491	Sus scrofa	97.98	0.00e+00	1437.00
IUUC-Tgu-116860	Taeniopygia guttata	84.65	0.00e+00	1322.00
IUUC-Tru-117727	Takifugu rubripes	73.92	0.00e+00	1142.00
IUUC-Tbe-127852	Tupaia belangeri	80.59	9.00e-112	397.00
IUUC-Ttr-129195	Tursiops truncatus	97.85	0.00e+00	1431.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence