iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052664

Ensembl Protein ID

ENSLOCP00000012118.1

UniProt Accession

W5MUQ9; W5MUQ9_LEPOC

Genbank Protein ID

ENSLOCP00000012118

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01004706

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000009882.1	ENSLOCT00000012139.1	ENSLOCP00000012118.1
ENSLOCG00000009882.1	ENSLOCT00000012149.1	ENSLOCP00000012128.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-75	255.4	2542	2864

Active Site

Position(s)	Description	Evidence
2834	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G++r ++++ +++  + d  ++lf +  +++ ++ +p ++s      +l++F+ +Gr+lg++l +++l++++l+++++k l
   Q: 2542 ENRKRHGSSRSVVDMELDDPDDGDdnAPLFyQPGKRGFYSPRPGKSSE----TRLNCFRNIGRILGLCLLQNELCPITLNRHVIKVL 2624
           556666777777777777777766667788233333666666666554....79********************************* PP
   S: 101  lgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +dp +y+s  + i++++  +++   +++dl+f ++ ++ +   ++eL++gG nipVt  N +eYv++++e+r+  
   Q: 2625 LGRKVNWHDFAFFDPVMYESlRQLILASQsgDAEAVFAAMDLAFAIDLCKEEGGGQVELVSGGVNIPVTPLNVYEYVRKYAEHRMLV 2711
           ********************5556666665566888899************************************************ PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             +  ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F
   Q: 2712 VAEPSLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYF 2798
           ***************************************************9999999999989999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2799 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2864
           *********999******..799999.99**********************************9.99875 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNFSSHPPL NVLEQATIKQ CVVGPNHAAF 60
LLEDGRVCRI GFAVQPDRLE LGKPDGSDGS KLSSGSGTGR TSRPGRTSDP PWFLSGSDTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCCGATGT CCAATCAGCG TCGCGCTTGT ATTTCTGCTG ATCATCACAG AGCGAAGGAG 60
CTGGTAGAGT TAAGATGGCG GAGTGTGGAT GAGGGGGTAG CAAATCAAGG CTCTGCTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	89.16	0.00e+00	4208.00
IUUC-Apl-004165	Anas platyrhynchos	89.74	0.00e+00	4204.00
IUUC-Aca-004577	Anolis carolinensis	89.46	0.00e+00	3656.00
IUUC-Ame-010702	Astyanax mexicanus	86.60	0.00e+00	2524.00
IUUC-Bta-012313	Bos taurus	89.91	0.00e+00	4269.00
IUUC-Cel-018165	Caenorhabditis elegans	31.76	4.00e-81	298.00
IUUC-Cja-019858	Callithrix jacchus	89.80	0.00e+00	4254.00
IUUC-Cfa-020973	Canis familiaris	90.01	0.00e+00	4271.00
IUUC-Cpo-022108	Cavia porcellus	91.56	0.00e+00	1812.00
IUUC-Csa-023985	Chlorocebus sabaeus	89.77	0.00e+00	4304.00
IUUC-Cho-025034	Choloepus hoffmanni	80.38	0.00e+00	928.00
IUUC-Cin-025715	Ciona intestinalis	40.72	0.00e+00	875.00
IUUC-Csv-026131	Ciona savignyi	46.67	0.00e+00	663.00
IUUC-Dre-027730	Danio rerio	90.62	0.00e+00	4171.00
IUUC-Dno-029123	Dasypus novemcinctus	86.80	0.00e+00	4076.00
IUUC-Dor-030757	Dipodomys ordii	88.59	0.00e+00	1355.00
IUUC-Dme-032192	Drosophila melanogaster	52.56	8.00e-175	609.00
IUUC-Ete-032292	Echinops telfairi	86.33	0.00e+00	1955.00
IUUC-Eca-034347	Equus caballus	89.70	0.00e+00	4177.00
IUUC-Eeu-034873	Erinaceus europaeus	85.77	0.00e+00	4012.00
IUUC-Fca-036485	Felis catus	88.35	0.00e+00	4108.00
IUUC-Fal-037071	Ficedula albicollis	90.19	0.00e+00	4211.00
IUUC-Gmo-039589	Gadus morhua	89.41	0.00e+00	4063.00
IUUC-Gga-041195	Gallus gallus	89.00	0.00e+00	4151.00
IUUC-Gac-042538	Gasterosteus aculeatus	89.69	0.00e+00	4094.00
IUUC-Ggo-045351	Gorilla gorilla	89.43	0.00e+00	4285.00
IUUC-Hsa-045941	Homo sapiens	89.98	0.00e+00	4319.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	89.77	0.00e+00	4225.00
IUUC-Lch-050480	Latimeria chalumnae	90.03	0.00e+00	4143.00
IUUC-Laf-053960	Loxodonta africana	87.97	0.00e+00	1431.00
IUUC-Mcc-054703	Macaca mulatta	89.77	0.00e+00	4299.00
IUUC-Meu-056431	Macropus eugenii	83.44	0.00e+00	765.00
IUUC-Mga-059289	Meleagris gallopavo	89.83	0.00e+00	3366.00
IUUC-Mmr-061737	Microcebus murinus	89.43	0.00e+00	4161.00
IUUC-Mdo-062499	Monodelphis domestica	89.87	0.00e+00	4184.00
IUUC-Mmu-063273	Mus musculus	89.28	0.00e+00	4188.00
IUUC-Mpu-066907	Mustela putorius furo	90.11	0.00e+00	3891.00
IUUC-Mlu-067942	Myotis lucifugus	89.50	0.00e+00	4236.00
IUUC-Nle-069527	Nomascus leucogenys	89.84	0.00e+00	4277.00
IUUC-Opr-070626	Ochotona princeps	84.87	0.00e+00	1165.00
IUUC-Ont-071951	Oreochromis niloticus	90.28	0.00e+00	4113.00
IUUC-Oan-072958	Ornithorhynchus anatinus	90.34	0.00e+00	3870.00
IUUC-Ocu-074503	Oryctolagus cuniculus	88.39	0.00e+00	4182.00
IUUC-Ola-086757	Oryzias latipes	89.11	0.00e+00	4158.00
IUUC-Oga-088781	Otolemur garnettii	89.84	0.00e+00	4259.00
IUUC-Oar-089274	Ovis aries	89.56	0.00e+00	4199.00
IUUC-Ptr-090669	Pan troglodytes	90.07	0.00e+00	3720.00
IUUC-Pan-092226	Papio anubis	89.63	0.00e+00	4282.00
IUUC-Psi-093502	Pelodiscus sinensis	89.92	0.00e+00	4192.00
IUUC-Pma-094454	Petromyzon marinus	82.78	0.00e+00	732.00
IUUC-Pfo-096173	Poecilia formosa	89.85	0.00e+00	3826.00
IUUC-Pab-098355	Pongo abelii	90.79	0.00e+00	2943.00
IUUC-Pca-100570	Procavia capensis	90.54	0.00e+00	1059.00
IUUC-Pva-102572	Pteropus vampyrus	87.01	0.00e+00	1222.00
IUUC-Rno-104916	Rattus norvegicus	87.88	0.00e+00	3658.00
IUUC-Sha-106653	Sarcophilus harrisii	89.68	0.00e+00	4234.00
IUUC-Sar-113517	Sorex araneus	83.53	0.00e+00	1216.00
IUUC-Ssc-115470	Sus scrofa	90.91	0.00e+00	2368.00
IUUC-Tgu-116932	Taeniopygia guttata	89.92	0.00e+00	4190.00
IUUC-Tru-117682	Takifugu rubripes	90.23	0.00e+00	2652.00
IUUC-Tsy-119417	Tarsius syrichta	86.73	0.00e+00	2317.00
IUUC-Tni-120442	Tetraodon nigroviridis	85.73	0.00e+00	3729.00
IUUC-Tbe-127456	Tupaia belangeri	78.60	0.00e+00	1754.00
IUUC-Ttr-128606	Tursiops truncatus	89.74	0.00e+00	1261.00
IUUC-Vpa-130112	Vicugna pacos	87.26	0.00e+00	3441.00
IUUC-Xtr-131929	Xenopus tropicalis	88.14	0.00e+00	4213.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence