iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000016431.1	ENSONIT00000020710.1	ENSONIP00000020692.1
ENSONIG00000016431.1	ENSONIT00000020711.1	ENSONIP00000020693.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-75	255.2	2516	2839

Active Site

Position(s)	Description	Evidence
2809	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 16   EegldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykl 99
           +e+ + +G+tr ++++ +++  + d  ++lf +  +++ ++ +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k 
   Q: 2516 QENRKRHGSTRSVVDMELDDPDDGDdnAPLFyQPGKRGFYSPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKV 2598
           5667778999999888888888877777888233333666666666654....89******************************** PP
   S: 100  llgkklsledleevdpelykslkeikena...esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
           llg+k++++d++ +dp +y+sl ++ ++    e++   +++dl+f ++ ++ + + ++eL++gG n+pVt  N +eYv++++e+r+ 
   Q: 2599 LLGRKVNWHDFAFFDPVMYESLRQLIRHSqagEAEAVFAAMDLAFAIDLCKEEGAGQVELLSGGVNMPVTPLNVYEYVRRYAEHRML 2685
           *********************7776666546666999999*********************************************** PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLq 266
              ++ ++a+r+G+ +v+p++ l+ +t+e+++ll++G+ e++v++l ++t+++++  e+  ++    +wFw+++e++s++er++++ 
   Q: 2686 VVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENADKLlqfkRWFWSIVEKMSMTERQDLVY 2772
           ****************************************************9999999888888999******************* PP
   S: 267  FvTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2773 FWTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2839
           **********999******..799999.99**********************************9.99875 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYSYNSHPHL SLLEQATLKQ CVVGPNHAGF 60
LLEDGRVCRI SFAVQPDRLE LSKPDGSDGS KLSSGSGTGR SSRPGRTSDP PWFLSGSDTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATAACCTC GCAAAATTTA ACCCCTTCTT TGACCTTCAT AGTGCTTTAG TGAACATATG 60
AACACCTCGA CTGCCTAACA GACAAAACAG ACTAAGATGC AATAGGTGAA CTGGATTAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	89.02	0.00e+00	3916.00
IUUC-Apl-004165	Anas platyrhynchos	89.00	0.00e+00	3913.00
IUUC-Aca-004577	Anolis carolinensis	88.39	0.00e+00	3568.00
IUUC-Ame-010702	Astyanax mexicanus	89.86	0.00e+00	2620.00
IUUC-Bta-012313	Bos taurus	88.36	0.00e+00	3926.00
IUUC-Cel-018165	Caenorhabditis elegans	26.91	2.00e-85	312.00
IUUC-Cja-019858	Callithrix jacchus	88.47	0.00e+00	3952.00
IUUC-Cfa-020973	Canis familiaris	88.47	0.00e+00	3930.00
IUUC-Cpo-022108	Cavia porcellus	90.72	0.00e+00	1746.00
IUUC-Csa-023985	Chlorocebus sabaeus	89.42	0.00e+00	3966.00
IUUC-Cho-025034	Choloepus hoffmanni	79.15	0.00e+00	912.00
IUUC-Cin-025715	Ciona intestinalis	41.55	0.00e+00	880.00
IUUC-Csv-026131	Ciona savignyi	47.09	0.00e+00	672.00
IUUC-Dre-027730	Danio rerio	93.01	0.00e+00	4277.00
IUUC-Dno-029123	Dasypus novemcinctus	85.84	0.00e+00	3795.00
IUUC-Dor-030757	Dipodomys ordii	84.24	0.00e+00	2566.00
IUUC-Dme-032192	Drosophila melanogaster	52.13	2.00e-176	615.00
IUUC-Ete-032292	Echinops telfairi	85.78	0.00e+00	1887.00
IUUC-Eca-034347	Equus caballus	88.28	0.00e+00	3881.00
IUUC-Eeu-034873	Erinaceus europaeus	84.34	0.00e+00	3724.00
IUUC-Fca-036485	Felis catus	86.61	0.00e+00	3821.00
IUUC-Fal-037071	Ficedula albicollis	89.76	0.00e+00	3920.00
IUUC-Gmo-039589	Gadus morhua	94.33	0.00e+00	4290.00
IUUC-Gga-041195	Gallus gallus	87.38	0.00e+00	3820.00
IUUC-Gac-042538	Gasterosteus aculeatus	95.64	0.00e+00	4356.00
IUUC-Ggo-045351	Gorilla gorilla	88.11	0.00e+00	3986.00
IUUC-Hsa-045941	Homo sapiens	88.47	0.00e+00	3975.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	88.40	0.00e+00	3929.00
IUUC-Lch-050480	Latimeria chalumnae	88.73	0.00e+00	3904.00
IUUC-Loc-052664	Lepisosteus oculatus	89.52	0.00e+00	4161.00
IUUC-Laf-053960	Loxodonta africana	85.65	0.00e+00	1398.00
IUUC-Mcc-054703	Macaca mulatta	89.42	0.00e+00	3965.00
IUUC-Meu-056431	Macropus eugenii	81.70	0.00e+00	736.00
IUUC-Mga-059289	Meleagris gallopavo	88.33	0.00e+00	3251.00
IUUC-Mmr-061737	Microcebus murinus	88.06	0.00e+00	3863.00
IUUC-Mdo-062499	Monodelphis domestica	88.32	0.00e+00	3884.00
IUUC-Mmu-063273	Mus musculus	87.91	0.00e+00	3890.00
IUUC-Mpu-066907	Mustela putorius furo	88.89	0.00e+00	3792.00
IUUC-Mlu-067942	Myotis lucifugus	88.66	0.00e+00	3938.00
IUUC-Nle-069527	Nomascus leucogenys	88.40	0.00e+00	3976.00
IUUC-Opr-070626	Ochotona princeps	79.16	0.00e+00	1278.00
IUUC-Oan-072958	Ornithorhynchus anatinus	89.20	0.00e+00	3792.00
IUUC-Ocu-074503	Oryctolagus cuniculus	87.52	0.00e+00	3853.00
IUUC-Ola-086757	Oryzias latipes	94.45	0.00e+00	4405.00
IUUC-Oga-088781	Otolemur garnettii	88.25	0.00e+00	3923.00
IUUC-Oar-089274	Ovis aries	89.09	0.00e+00	3914.00
IUUC-Ptr-090669	Pan troglodytes	88.79	0.00e+00	3620.00
IUUC-Pan-092226	Papio anubis	88.29	0.00e+00	3942.00
IUUC-Psi-093502	Pelodiscus sinensis	88.08	0.00e+00	3895.00
IUUC-Pma-094454	Petromyzon marinus	81.68	0.00e+00	730.00
IUUC-Pfo-096173	Poecilia formosa	95.60	0.00e+00	4115.00
IUUC-Pab-098355	Pongo abelii	89.61	0.00e+00	2881.00
IUUC-Pca-100570	Procavia capensis	89.29	0.00e+00	1008.00
IUUC-Pva-102572	Pteropus vampyrus	86.24	0.00e+00	1183.00
IUUC-Rno-104916	Rattus norvegicus	86.75	0.00e+00	3554.00
IUUC-Sha-106653	Sarcophilus harrisii	88.15	0.00e+00	3891.00
IUUC-Sar-113517	Sorex araneus	80.47	0.00e+00	1009.00
IUUC-Ssc-115470	Sus scrofa	88.96	0.00e+00	2299.00
IUUC-Tgu-116932	Taeniopygia guttata	89.32	0.00e+00	3898.00
IUUC-Tru-117682	Takifugu rubripes	96.09	0.00e+00	2846.00
IUUC-Tsy-119417	Tarsius syrichta	84.91	0.00e+00	2241.00
IUUC-Tni-120442	Tetraodon nigroviridis	90.75	0.00e+00	3987.00
IUUC-Tbe-127456	Tupaia belangeri	78.28	0.00e+00	1713.00
IUUC-Ttr-128606	Tursiops truncatus	87.37	0.00e+00	1241.00
IUUC-Vpa-130112	Vicugna pacos	85.95	0.00e+00	3340.00
IUUC-Xtr-131929	Xenopus tropicalis	87.58	0.00e+00	3880.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence