iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012379

Ensembl Protein ID

ENSBTAP00000003283.5

UniProt Accession

Q08DP6; RHG10_BOVIN

Genbank Protein ID

AAI23632.1

Protein Name

Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 10

Genbank Nucleotide ID

BC123631

Gene Name

ARHGAP10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000002531.5	ENSBTAT00000003283.5	ENSBTAP00000003283.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.40e-11	43.6	731	784

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           k ++ y+ ea+++ eL+++ G + + + +++ + gWl+g  +l+gkrGl+P+n+v+ 
   Q: 731  KARAVYPCEAEHSSELSFEIGAIFEDV-QTSREPGWLEG--TLNGKRGLIPQNYVKL 784
           7789***********************.***********..8*************85 PP

Organism

Bos taurus

Functional Description
(View)

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

Protein Sequence
(Fasta)

MGLQPLEFSD CYLDSPWFRE RIRAHEAELE RTNKFIKELI KDGKNLIAAT KTLSAAQRKF 60
AHSLRDFKFE FIGDAETDDE RCIDASLREF SNFLKNLEEQ REIMALSVTE TLIKPLEKFR 120

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Nucleotide Sequence
(Fasta)

CTTCGGCGGG GGCTGCCGGG ATCCCGGCGC CGCGCTCTCG CTCGCTGCCG CCGTGCTGTT 60
GCGTGCGGGC CGGCTCCCCT CCTCGGGGCA TGTCCGCGCT GCTCTCGCCG CACGCCCGGG 120

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Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-0472--Membrane
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001452--SH3_domain

PROSITE

PS50003--PH_DOMAIN
PS50238--RHOGAP
PS50002--SH3

Pfam

PF00169--PH
PF00620--RhoGAP
PF14604--SH3_9

SMART

SM00233--PH
SM00324--RhoGAP
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0007010--P:cytoskeleton organization
GO:0043066--P:negative regulation of apoptotic process
GO:0007165--P:signal transduction

KEGG

bta:510704

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001253	Ailuropoda melanoleuca	93.13	0.00e+00	1437.00
IUUC-Apl-003297	Anas platyrhynchos	78.30	0.00e+00	1198.00
IUUC-Aca-005285	Anolis carolinensis	77.99	0.00e+00	1219.00
IUUC-Cel-018542	Caenorhabditis elegans	40.10	1.00e-123	437.00
IUUC-Cja-019182	Callithrix jacchus	92.11	0.00e+00	1409.00
IUUC-Cfa-021141	Canis familiaris	93.77	0.00e+00	1428.00
IUUC-Csa-023847	Chlorocebus sabaeus	92.51	0.00e+00	1325.00
IUUC-Cin-025725	Ciona intestinalis	40.25	6.00e-147	514.00
IUUC-Dre-027525	Danio rerio	60.38	0.00e+00	877.00
IUUC-Dno-029215	Dasypus novemcinctus	86.56	0.00e+00	919.00
IUUC-Dor-030308	Dipodomys ordii	82.02	0.00e+00	1127.00
IUUC-Dme-032147	Drosophila melanogaster	42.62	5.00e-133	468.00
IUUC-Ete-032666	Echinops telfairi	79.33	0.00e+00	764.00
IUUC-Eca-033545	Equus caballus	94.41	0.00e+00	1327.00
IUUC-Fca-036457	Felis catus	93.89	0.00e+00	1444.00
IUUC-Fal-036703	Ficedula albicollis	79.92	0.00e+00	1233.00
IUUC-Gga-040830	Gallus gallus	78.27	0.00e+00	1238.00
IUUC-Gac-041728	Gasterosteus aculeatus	56.73	0.00e+00	840.00
IUUC-Ggo-044569	Gorilla gorilla	90.60	0.00e+00	1273.00
IUUC-Hsa-045658	Homo sapiens	93.13	0.00e+00	1398.00
IUUC-Loc-051740	Lepisosteus oculatus	64.52	0.00e+00	978.00
IUUC-Laf-053641	Loxodonta africana	92.24	0.00e+00	1384.00
IUUC-Mcc-055152	Macaca mulatta	92.62	0.00e+00	1436.00
IUUC-Mmr-061434	Microcebus murinus	92.64	0.00e+00	1322.00
IUUC-Mdo-062864	Monodelphis domestica	87.79	0.00e+00	1365.00
IUUC-Mmu-064061	Mus musculus	89.82	0.00e+00	1382.00
IUUC-Mlu-067375	Myotis lucifugus	91.54	0.00e+00	1291.00
IUUC-Nle-069319	Nomascus leucogenys	89.59	0.00e+00	722.00
IUUC-Ont-071443	Oreochromis niloticus	61.24	0.00e+00	902.00
IUUC-Oan-072978	Ornithorhynchus anatinus	82.39	0.00e+00	1092.00
IUUC-Ocu-074591	Oryctolagus cuniculus	86.45	0.00e+00	1243.00
IUUC-Ola-087508	Oryzias latipes	64.10	0.00e+00	771.00
IUUC-Oga-088922	Otolemur garnettii	87.53	1.00e-179	622.00
IUUC-Oar-089531	Ovis aries	97.58	0.00e+00	1471.00
IUUC-Ptr-091149	Pan troglodytes	92.11	0.00e+00	1399.00
IUUC-Pan-092591	Papio anubis	92.88	0.00e+00	1435.00
IUUC-Pfo-097265	Poecilia formosa	60.28	0.00e+00	892.00
IUUC-Pab-097780	Pongo abelii	92.88	0.00e+00	1397.00
IUUC-Rno-104991	Rattus norvegicus	89.69	0.00e+00	1381.00
IUUC-Sha-107629	Sarcophilus harrisii	84.71	0.00e+00	1114.00
IUUC-Ssc-115511	Sus scrofa	76.79	0.00e+00	721.00
IUUC-Tgu-117458	Taeniopygia guttata	79.54	0.00e+00	1227.00
IUUC-Tru-117724	Takifugu rubripes	63.68	0.00e+00	767.00
IUUC-Ttr-129045	Tursiops truncatus	92.78	0.00e+00	1300.00
IUUC-Xtr-132112	Xenopus tropicalis	71.11	0.00e+00	1102.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence