iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132432

UUCD1 version

UUC-XeT-00277

Ensembl Protein ID

ENSXETP00000048273.3

UniProt Accession

F6UA42; UHRF1_XENTR

Protein Name

E3 ubiquitin-protein ligase UHRF1; RING-type E3 ubiquitin transferase UHRF1; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 1

Genbank Nucleotide ID

AAMC01100082

Gene Name

uhrf1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000022306.3	ENSXETT00000048273.3	ENSXETP00000048273.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	1.20e-11	44.5	1	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 1    vqvtvksldgs.eltlk.vnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           ++++v+++dg+ +  +  +++ + V +L+ +i++ +g+  e+qrL y+Gk +e+++tL dy +  ++ + ll++
   Q: 1    MWIQVRTMDGRdTRRIDsLSKLTKVEDLRARIQQIFGVALESQRLFYRGKQMENGHTLFDYSVGLNDIVQLLVR 74
           789*******955555599******************************************9988888888776 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions (By similarity).

Protein Sequence
(Fasta)

MWIQVRTMDG RDTRRIDSLS KLTKVEDLRA RIQQIFGVAL ESQRLFYRGK QMENGHTLFD 60
YSVGLNDIVQ LLVRQIPDSV PTKDKECGIS DADSGCGSGQ GESDKNSSCG EGATDVDGQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGATTC AGGTGCGTAC AATGGATGGC CGAGACACTC GTCGTATTGA TTCTTTGTCA 60
AAATTAACTA AAGTGGAAGA TCTAAGGGCG AGGATTCAGC AAATATTTGG GGTGGCATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015947--PUA-like_domain
IPR014722--Rib_L2_dom2
IPR003105--SRA_YDG
IPR021991--TTD_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50053--UBIQUITIN_2
PS51015--YDG
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00628--PHD
PF02182--SAD_SRA
PF12148--TTD
PF00240--ubiquitin

SMART

SM00249--PHD
SM00184--RING
SM00466--SRA
SM00213--UBQ

Gene Ontology

GO:0000791--C:euchromatin
GO:0000792--C:heterochromatin
GO:0000790--C:nuclear chromatin
GO:0005720--C:nuclear heterochromatin
GO:0005657--C:replication fork
GO:0044729--F:hemi-methylated DNA-binding
GO:0042393--F:histone binding
GO:0035064--F:methylated histone binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0010390--P:histone monoubiquitination
GO:0016574--P:histone ubiquitination
GO:0010216--P:maintenance of DNA methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090308--P:regulation of methylation-dependent chromatin silencing
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000242	Aegilops tauschii	36.46	1.00e-48	187.00
IUUC-Aml-001285	Ailuropoda melanoleuca	67.00	0.00e+00	1048.00
IUUC-Atr-002603	Amborella trichopoda	34.79	1.00e-49	191.00
IUUC-Apl-003819	Anas platyrhynchos	74.06	0.00e+00	1093.00
IUUC-Aca-004970	Anolis carolinensis	60.61	0.00e+00	928.00
IUUC-Aly-006276	Arabidopsis lyrata	35.63	6.00e-52	198.00
IUUC-Ath-006667	Arabidopsis thaliana	33.91	1.00e-49	191.00
IUUC-Ame-011845	Astyanax mexicanus	71.07	0.00e+00	1076.00
IUUC-Bta-012600	Bos taurus	67.38	0.00e+00	1048.00
IUUC-Bci-013703	Botrytis cinerea	28.08	2.00e-10	60.50
IUUC-Bdi-014586	Brachypodium distachyon	33.67	1.00e-47	184.00
IUUC-Bol-015519	Brassica oleracea	35.14	6.00e-49	188.00
IUUC-Bra-017110	Brassica rapa	35.38	2.00e-49	190.00
IUUC-Cja-018864	Callithrix jacchus	67.33	0.00e+00	1059.00
IUUC-Cfa-020558	Canis familiaris	67.42	0.00e+00	1050.00
IUUC-Cpo-022125	Cavia porcellus	66.92	0.00e+00	1065.00
IUUC-Cre-022645	Chlamydomonas reinhardtii	35.61	8.00e-22	98.60
IUUC-Csa-023649	Chlorocebus sabaeus	64.88	0.00e+00	1018.00
IUUC-Cin-025454	Ciona intestinalis	52.54	0.00e+00	747.00
IUUC-Cne-026942	Cryptococcus neoformans	45.12	2.00e-29	121.00
IUUC-Dre-028200	Danio rerio	73.48	0.00e+00	1133.00
IUUC-Dno-029523	Dasypus novemcinctus	71.50	0.00e+00	847.00
IUUC-Dor-031084	Dipodomys ordii	66.67	0.00e+00	1057.00
IUUC-Eca-033266	Equus caballus	68.26	0.00e+00	1044.00
IUUC-Eeu-035077	Erinaceus europaeus	78.19	2.00e-139	488.00
IUUC-Fal-037550	Ficedula albicollis	71.10	0.00e+00	1003.00
IUUC-Gmo-039452	Gadus morhua	68.55	0.00e+00	1064.00
IUUC-Gga-040484	Gallus gallus	72.31	0.00e+00	1154.00
IUUC-Gac-042196	Gasterosteus aculeatus	68.92	0.00e+00	1076.00
IUUC-Gma-044194	Glycine max	36.10	5.00e-51	195.00
IUUC-Ggo-045414	Gorilla gorilla	68.13	0.00e+00	1080.00
IUUC-Hsa-046236	Homo sapiens	68.13	0.00e+00	1081.00
IUUC-Hvu-047471	Hordeum vulgare	37.17	3.00e-46	179.00
IUUC-Itr-047867	Ictidomys tridecemlineatus	66.58	0.00e+00	1024.00
IUUC-Lch-050162	Latimeria chalumnae	70.17	0.00e+00	1051.00
IUUC-Lpe-050756	Leersia perrieri	34.49	3.00e-44	173.00
IUUC-Loc-051806	Lepisosteus oculatus	72.53	0.00e+00	1132.00
IUUC-Lma-052953	Leptosphaeria maculans	30.33	7.00e-10	58.50
IUUC-Laf-053671	Loxodonta africana	67.58	0.00e+00	1079.00
IUUC-Mcc-055513	Macaca mulatta	67.96	0.00e+00	1081.00
IUUC-Mpo-057318	Magnaporthe poae	27.96	5.00e-08	52.40
IUUC-Mtr-057930	Medicago truncatula	33.82	5.00e-48	185.00
IUUC-Mla-058836	Melampsora laricipopulina	40.70	1.00e-33	137.00
IUUC-Mga-059759	Meleagris gallopavo	71.97	0.00e+00	1049.00
IUUC-Mvi-060378	Microbotryum violaceum	47.16	3.00e-32	132.00
IUUC-Mmr-060600	Microcebus murinus	63.60	0.00e+00	919.00
IUUC-Mdo-061911	Monodelphis domestica	73.17	0.00e+00	1141.00
IUUC-Mmu-063738	Mus musculus	62.09	0.00e+00	963.00
IUUC-Mac-064697	Musa acuminata	35.51	2.00e-50	193.00
IUUC-Mpu-065696	Mustela putorius furo	66.58	0.00e+00	1040.00
IUUC-Mlu-067538	Myotis lucifugus	64.20	0.00e+00	1002.00
IUUC-Opr-070813	Ochotona princeps	54.21	1.00e-134	473.00
IUUC-Ont-072292	Oreochromis niloticus	71.88	0.00e+00	1090.00
IUUC-Oba-075108	Oryza barthii	34.49	8.00e-45	175.00
IUUC-Obr-076572	Oryza brachyantha	33.67	7.00e-45	175.00
IUUC-Ogl-077177	Oryza glaberrima	34.49	8.00e-45	175.00
IUUC-Ogu-078298	Oryza glumaepatula	34.49	8.00e-45	175.00
IUUC-Oin-079911	Oryza indica	34.49	9.00e-45	175.00
IUUC-Olo-080527	Oryza longistaminata	44.50	1.00e-34	141.00
IUUC-Ome-081137	Oryza meridionalis	47.88	2.00e-34	140.00
IUUC-Oni-082510	Oryza nivara	33.58	1.00e-45	177.00
IUUC-Opu-083974	Oryza punctata	34.49	7.00e-45	175.00
IUUC-Oru-084985	Oryza rufipogon	33.74	1.00e-45	178.00
IUUC-Osa-085339	Oryza sativa	34.49	8.00e-45	175.00
IUUC-Ola-086416	Oryzias latipes	70.64	0.00e+00	1087.00
IUUC-Oga-088221	Otolemur garnettii	67.25	0.00e+00	1077.00
IUUC-Oar-089604	Ovis aries	63.61	0.00e+00	961.00
IUUC-Ptr-090559	Pan troglodytes	68.30	0.00e+00	1080.00
IUUC-Pan-092855	Papio anubis	67.96	0.00e+00	1082.00
IUUC-Psi-093763	Pelodiscus sinensis	77.48	0.00e+00	874.00
IUUC-Pma-094339	Petromyzon marinus	65.03	0.00e+00	947.00
IUUC-Ppa-095940	Physcomitrella patens	36.87	3.00e-53	203.00
IUUC-Pfo-096243	Poecilia formosa	67.45	0.00e+00	1060.00
IUUC-Pab-098243	Pongo abelii	68.01	0.00e+00	1063.00
IUUC-Pop-099561	Populus trichocarpa	35.70	2.00e-51	197.00
IUUC-Pca-100503	Procavia capensis	64.50	0.00e+00	1002.00
IUUC-Ppe-101961	Prunus persica	35.92	4.00e-49	189.00
IUUC-Pva-102240	Pteropus vampyrus	69.04	0.00e+00	895.00
IUUC-Pgr-103644	Puccinia graminis	47.56	2.00e-33	137.00
IUUC-Ptt-103867	Puccinia triticina	45.56	1.00e-33	137.00
IUUC-Pyt-104740	Pyrenophora triticirepentis	28.26	9.00e-11	62.00
IUUC-Rno-105345	Rattus norvegicus	62.68	0.00e+00	978.00
IUUC-Sha-106618	Sarcophilus harrisii	73.37	0.00e+00	1152.00
IUUC-Smo-109556	Selaginella moellendorffii	34.94	2.00e-42	167.00
IUUC-Sit-110588	Setaria italica	35.40	4.00e-48	186.00
IUUC-Sly-111415	Solanum lycopersicum	32.69	1.00e-45	177.00
IUUC-Stu-112842	Solanum tuberosum	33.91	1.00e-46	181.00
IUUC-Sar-113651	Sorex araneus	68.15	3.00e-83	302.00
IUUC-Sbi-114726	Sorghum bicolor	49.48	2.00e-41	163.00
IUUC-Sre-115182	Sporisorium reilianum	43.58	2.00e-32	133.00
IUUC-Ssc-116081	Sus scrofa	67.42	0.00e+00	1055.00
IUUC-Tgu-116538	Taeniopygia guttata	74.29	0.00e+00	941.00
IUUC-Tru-117599	Takifugu rubripes	69.74	0.00e+00	1053.00
IUUC-Tca-121781	Theobroma cacao	32.58	1.00e-46	181.00
IUUC-Tae-124962	Triticum aestivum	36.46	2.00e-48	187.00
IUUC-Tme-127149	Tuber melanosporum	47.40	5.00e-27	115.00
IUUC-Ttr-128522	Tursiops truncatus	66.58	0.00e+00	1049.00
IUUC-Vda-129727	Verticillium dahliae	26.54	4.00e-07	48.90
IUUC-Vvi-131413	Vitis vinifera	34.47	3.00e-49	189.00
IUUC-Xma-133516	Xiphophorus maculatus	68.12	0.00e+00	1071.00
IUUC-Zma-135894	Zea mays	35.56	2.00e-46	180.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence