• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046506
Ensembl Protein ID ENSP00000202556.9
UniProt Accession Q96KQ4; B2RMX5; O94870; ASPP1_HUMAN
Genbank Protein ID CAC83011.2; EAW81847.1; AAI36528.1; BAA34491.1
Protein Name Apoptosis-stimulating of p53 protein 1; Protein phosphatase 1 regulatory subunit 13B
Genbank Nucleotide ID AJ318887; AL049840; BC136527; AB018314
Gene Name PPP1R13B; ASPP1; KIAA0771
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000088808.16 ENST00000557587.1 ENSP00000451433.1
ENSG00000088808.16 ENST00000202556.13 ENSP00000202556.9
ENSG00000088808.16 ENST00000556597.1 ENSP00000451739.1
ENSG00000088808.16 ENST00000557082.5 ENSP00000451396.1
ENSG00000088808.16 ENST00000553739.2 ENSP00000450734.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.80e-11 45.4 1023 1074
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPen 57
           +  +l+dyeaqn+deL++++Gd ++++  k+e + +W+ +   l  ++G +P+n
   Q: 1023 VAYALWDYEAQNSDELSFHEGDALTILrRKDESETEWWWA--RLGDREGYVPKN 1074
           5679***********************99*********99..8**********9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
 Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
Protein Sequence
(Fasta)
MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR GNERPIPFDH 60
MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ RTQRNVINVP GEKRTENGVG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046506|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCGGGCGG GCCGCAGGCT GTCGGGCTGG GGCTGAGGCT GAGGCTGAGG TTGAGGCGGC 60
GGCGGCGGCG GCCGGGTGCC CGGGACAGCG ACGCAGCGCG CCGGCGGCCG CGACAGGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046506|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR028319--ASPP_1
IPR001452--SH3_domain
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3
Pfam

PF12796--Ank_2
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00248--ANK
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0072332--P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0045786--P:negative regulation of cell cycle
GO:1901216--P:positive regulation of neuron death
GO:1900740--P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process
GO:1901796--P:regulation of signal transduction by p53 class mediator
KEGG hsa:23368
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001642 Ailuropoda melanoleuca 90.59 0.00e+00 1831.00
IUUC-Apl-004077 Anas platyrhynchos 79.98 0.00e+00 1577.00
IUUC-Aca-004550 Anolis carolinensis 69.80 0.00e+00 1447.00
IUUC-Ame-011289 Astyanax mexicanus 62.59 0.00e+00 646.00
IUUC-Bta-012477 Bos taurus 89.42 0.00e+00 1691.00
IUUC-Cel-018245 Caenorhabditis elegans 50.28 1.00e-52 201.00
IUUC-Cja-019672 Callithrix jacchus 97.52 0.00e+00 1873.00
IUUC-Cfa-020703 Canis familiaris 91.48 0.00e+00 1792.00
IUUC-Cpo-022364 Cavia porcellus 90.93 0.00e+00 1768.00
IUUC-Csa-023051 Chlorocebus sabaeus 98.35 0.00e+00 1906.00
IUUC-Dre-028211 Danio rerio 59.39 0.00e+00 1174.00
IUUC-Dor-030295 Dipodomys ordii 82.92 0.00e+00 1125.00
IUUC-Eca-033910 Equus caballus 92.67 0.00e+00 1771.00
IUUC-Eeu-035287 Erinaceus europaeus 80.82 0.00e+00 1360.00
IUUC-Fca-035913 Felis catus 91.20 0.00e+00 1778.00
IUUC-Fal-036698 Ficedula albicollis 80.42 0.00e+00 1574.00
IUUC-Gga-041256 Gallus gallus 76.00 0.00e+00 1556.00
IUUC-Gac-041539 Gasterosteus aculeatus 64.41 0.00e+00 645.00
IUUC-Ggo-045619 Gorilla gorilla 99.45 0.00e+00 1812.00
IUUC-Itr-048178 Ictidomys tridecemlineatus 83.32 0.00e+00 1634.00
IUUC-Lch-050122 Latimeria chalumnae 74.45 0.00e+00 1522.00
IUUC-Loc-052306 Lepisosteus oculatus 57.26 0.00e+00 743.00
IUUC-Laf-053834 Loxodonta africana 89.62 0.00e+00 1721.00
IUUC-Mcc-055785 Macaca mulatta 98.17 0.00e+00 1870.00
IUUC-Meu-056089 Macropus eugenii 71.76 5.00e-150 525.00
IUUC-Mga-059590 Meleagris gallopavo 79.23 0.00e+00 1436.00
IUUC-Mmr-060975 Microcebus murinus 94.50 0.00e+00 1790.00
IUUC-Mdo-062632 Monodelphis domestica 81.50 0.00e+00 1665.00
IUUC-Mmu-064285 Mus musculus 91.83 0.00e+00 1831.00
IUUC-Mpu-066414 Mustela putorius furo 90.10 0.00e+00 1758.00
IUUC-Mlu-068059 Myotis lucifugus 85.71 0.00e+00 1709.00
IUUC-Opr-070603 Ochotona princeps 84.78 0.00e+00 1461.00
IUUC-Ont-072410 Oreochromis niloticus 62.20 0.00e+00 651.00
IUUC-Ocu-074964 Oryctolagus cuniculus 88.32 0.00e+00 1691.00
IUUC-Ola-087385 Oryzias latipes 61.59 0.00e+00 1082.00
IUUC-Oga-088492 Otolemur garnettii 92.31 0.00e+00 1825.00
IUUC-Ptr-091354 Pan troglodytes 99.45 0.00e+00 1875.00
IUUC-Pan-092354 Papio anubis 98.17 0.00e+00 1870.00
IUUC-Psi-093223 Pelodiscus sinensis 80.18 0.00e+00 1607.00
IUUC-Pfo-097053 Poecilia formosa 70.71 9.00e-150 525.00
IUUC-Pab-097758 Pongo abelii 99.16 0.00e+00 1160.00
IUUC-Pca-100736 Procavia capensis 84.51 0.00e+00 748.00
IUUC-Pva-102307 Pteropus vampyrus 85.10 0.00e+00 1605.00
IUUC-Rno-105716 Rattus norvegicus 91.90 0.00e+00 1756.00
IUUC-Sha-107553 Sarcophilus harrisii 81.70 0.00e+00 1573.00
IUUC-Ssc-115833 Sus scrofa 80.97 0.00e+00 1398.00
IUUC-Tgu-116995 Taeniopygia guttata 80.70 0.00e+00 1578.00
IUUC-Tru-117861 Takifugu rubripes 60.09 0.00e+00 1158.00
IUUC-Tni-120130 Tetraodon nigroviridis 64.98 0.00e+00 666.00
IUUC-Tbe-127866 Tupaia belangeri 90.50 0.00e+00 1117.00
IUUC-Xtr-132886 Xenopus tropicalis 72.67 0.00e+00 1429.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved