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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045772
Ensembl Protein ID ENSP00000321203.7
UniProt Accession Q8NFZ5; B1AKS4; B3KTY8; D3DVQ9; Q7L5L2; Q9BQR6; Q9H682; TNIP2_HUMAN
Genbank Protein ID CAC34835.1; AAM21315.1; BAB15382.1; BAG53250.1; EAW82514.1; CAM28233.1; CAM28233.1; CAM28252.1; CAM28252.1; EAW82516.1; AAH02740.2
Protein Name TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2; Fetal liver LKB1-interacting protein
Genbank Nucleotide ID AJ304866; AF372839; AK026176; AK096296; CH471131; AL121750; AL110117; AL110117; AL121750; CH471131; BC002740
Gene Name TNIP2; ABIN2; FLIP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000168884.14 ENST00000315423.11 ENSP00000321203.7
ENSG00000168884.14 ENST00000503235.1 ENSP00000426314.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBAN UBAN 18212736
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBAN 3.60e-23 82.9 289 345
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBAN
   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           ++++le+v++L+qQ+ +Yk+DF++ERadREr++++++eL+e+v++l++qvs+++ds+
   Q: 289  RDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSR 345
           6899***************************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
 Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Protein Sequence
(Fasta)
MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA RLAALEGDAA 60
PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER LEEKEREMQQ LLSQPQHERE 120
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Protein Fasta Sequence


>IUUC-Hsa-045772|UBD,UBAN|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGAAAGTTCC GGGAAGGGCG GCAGCCGGCG GGGCCCGGGC GCGGAAGTTG CCGGCGGCCG 60
CGCGGCCTCC CGGGCGGGCC TACAGCCATG TCCCGGGACC CGGGGTCGGG CGGCTGGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045772|UBD,UBAN|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0395--Inflammatory response
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032419--CC2-LZ_dom
IPR022008--EABR
IPR034735--ZF_CCHC_NOA
PROSITE

PS51801--ZF_CCHC_NOA
Pfam

PF12180--EABR
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0019901--F:protein kinase binding
GO:0006915--P:apoptotic process
GO:0023035--P:CD40 signaling pathway
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0006954--P:inflammatory response
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:0050871--P:positive regulation of B cell activation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043032--P:positive regulation of macrophage activation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0051403--P:stress-activated MAPK cascade
GO:0034134--P:toll-like receptor 2 signaling pathway
GO:0034138--P:toll-like receptor 3 signaling pathway
GO:0034162--P:toll-like receptor 9 signaling pathway
GO:0006351--P:transcription, DNA-templated
KEGG hsa:79155
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001697 Ailuropoda melanoleuca 73.45 7.00e-137 479.00
IUUC-Apl-003896 Anas platyrhynchos 46.65 2.00e-95 342.00
IUUC-Ame-011223 Astyanax mexicanus 34.61 3.00e-44 172.00
IUUC-Bta-012996 Bos taurus 76.56 8.00e-135 473.00
IUUC-Cja-019376 Callithrix jacchus 86.30 6.00e-166 577.00
IUUC-Cfa-021027 Canis familiaris 71.03 6.00e-151 527.00
IUUC-Cpo-021372 Cavia porcellus 69.29 4.00e-116 411.00
IUUC-Csa-023221 Chlorocebus sabaeus 96.04 0.00e+00 703.00
IUUC-Dre-028604 Danio rerio 34.31 3.00e-50 192.00
IUUC-Dno-029976 Dasypus novemcinctus 64.55 2.00e-52 199.00
IUUC-Dor-030364 Dipodomys ordii 59.83 8.00e-60 224.00
IUUC-Eca-033582 Equus caballus 82.09 3.00e-160 557.00
IUUC-Eeu-034751 Erinaceus europaeus 67.62 5.00e-62 230.00
IUUC-Fca-036086 Felis catus 76.45 1.00e-133 469.00
IUUC-Fal-036828 Ficedula albicollis 46.68 2.00e-100 359.00
IUUC-Gmo-038838 Gadus morhua 36.69 2.00e-45 176.00
IUUC-Gga-041179 Gallus gallus 45.15 7.00e-98 351.00
IUUC-Gac-042266 Gasterosteus aculeatus 35.25 2.00e-40 160.00
IUUC-Ggo-044971 Gorilla gorilla 98.60 0.00e+00 723.00
IUUC-Itr-048993 Ictidomys tridecemlineatus 76.85 1.00e-135 475.00
IUUC-Lch-049851 Latimeria chalumnae 39.74 5.00e-64 238.00
IUUC-Loc-052551 Lepisosteus oculatus 37.12 3.00e-56 213.00
IUUC-Laf-053650 Loxodonta africana 57.85 4.00e-88 318.00
IUUC-Mcc-054744 Macaca mulatta 96.04 0.00e+00 718.00
IUUC-Meu-056799 Macropus eugenii 55.70 6.00e-37 147.00
IUUC-Mga-060124 Meleagris gallopavo 47.45 2.00e-91 329.00
IUUC-Mmr-061466 Microcebus murinus 86.62 1.00e-162 565.00
IUUC-Mdo-062389 Monodelphis domestica 56.18 3.00e-115 409.00
IUUC-Mmu-064000 Mus musculus 75.50 2.00e-159 555.00
IUUC-Mpu-066109 Mustela putorius furo 78.38 4.00e-167 580.00
IUUC-Mlu-067666 Myotis lucifugus 68.05 2.00e-74 271.00
IUUC-Nle-069689 Nomascus leucogenys 95.27 7.00e-177 612.00
IUUC-Opr-070774 Ochotona princeps 60.50 4.00e-75 274.00
IUUC-Ont-072439 Oreochromis niloticus 37.33 2.00e-56 213.00
IUUC-Oan-072817 Ornithorhynchus anatinus 55.19 2.00e-62 231.00
IUUC-Ocu-074621 Oryctolagus cuniculus 66.76 1.00e-85 310.00
IUUC-Ola-087305 Oryzias latipes 37.56 4.00e-52 198.00
IUUC-Oga-087920 Otolemur garnettii 77.83 4.00e-151 527.00
IUUC-Oar-090351 Ovis aries 65.62 1.00e-19 87.40
IUUC-Ptr-090879 Pan troglodytes 99.17 3.00e-128 451.00
IUUC-Pan-092022 Papio anubis 96.27 0.00e+00 705.00
IUUC-Psi-093302 Pelodiscus sinensis 45.77 9.00e-101 360.00
IUUC-Pno-095083 Phaeosphaeria nodorum 24.82 9.00e-04 40.00
IUUC-Pfo-097250 Poecilia formosa 35.73 2.00e-47 183.00
IUUC-Pab-097929 Pongo abelii 97.52 0.00e+00 638.00
IUUC-Pca-100271 Procavia capensis 69.74 8.00e-44 171.00
IUUC-Pva-102234 Pteropus vampyrus 70.98 2.00e-121 429.00
IUUC-Rno-105850 Rattus norvegicus 78.27 2.00e-175 608.00
IUUC-Sha-107375 Sarcophilus harrisii 54.73 3.00e-96 345.00
IUUC-Ssc-116269 Sus scrofa 79.81 8.00e-153 533.00
IUUC-Tgu-116960 Taeniopygia guttata 51.14 2.00e-98 352.00
IUUC-Tru-118002 Takifugu rubripes 33.48 3.00e-46 179.00
IUUC-Tni-120023 Tetraodon nigroviridis 35.59 1.00e-49 190.00
IUUC-Tre-121983 Trichoderma reesei 34.21 2.50e-02 33.10
IUUC-Tbe-127592 Tupaia belangeri 75.18 6.00e-149 520.00
IUUC-Ttr-128362 Tursiops truncatus 71.81 7.00e-123 433.00
IUUC-Vpa-130399 Vicugna pacos 75.07 3.00e-129 454.00
IUUC-Xtr-132677 Xenopus tropicalis 43.99 6.00e-79 288.00
Created Date 25-Jun-2017

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