iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089610

Ensembl Protein ID

ENSOARP00000006120.1

UniProt Accession

W5P6R6; W5P6R6_SHEEP

Genbank Protein ID

ENSOARP00000006120

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AMGL01115488

Gene Name

USP27X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000005706.1	ENSOART00000006214.1	ENSOARP00000006120.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-90	304.5	156	498

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 156  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 240
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g l+s+++c++c+ vs++ +p +d+sl++pg+
   Q: 241  DAHEFLIAALDVLHRHCKG----------------DDAGKAASNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS 313
           *****************22................22335678899999***************************************9 PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
            ++  +                   +l+dcL+ ft++e+l ++ k++c +c+++qe++k+l+++klP v ++h+kRf  +++ k+r+ki
   Q: 314  CTSFWPmspgressvngeshipgitTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF--EHSAKQRRKI 400
           98766699*********************************************************************..55667999** PP
   S: 250  nkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           +++++fpleLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl   
   Q: 401  TTYISFPLELDMTPFMASSKESRMNgqlqlptnsgndENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLD-- 487
           ******************5544444566666666666**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 488  -SEGYLLFYHKQ 498
           .********985 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

ELRVIYQCFV WCGTPETRKS KAKSCICHVC GTHLNRLHSC LSCVFFGCFT EKHIHEHAET 60
KQHNLAVDLY YGGIYCFMCK DYVYDRDIEQ IAKEEQGEAL KLQASTSTEV SHQQYSMPGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACTGCGGG TGATCTACCA GTGCTTCGTG TGGTGTGGAA CCCCAGAGAC CAGGAAAAGC 60
AAGGCAAAGT CGTGTATCTG CCATGTGTGC GGCACCCATT TGAACAGACT CCACTCTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002084	Ailuropoda melanoleuca	97.02	0.00e+00	1017.00
IUUC-Aly-006565	Arabidopsis lyrata	35.59	1.00e-73	270.00
IUUC-Ath-007536	Arabidopsis thaliana	35.81	7.00e-74	271.00
IUUC-Bta-012659	Bos taurus	99.77	0.00e+00	915.00
IUUC-Bol-016509	Brassica oleracea	37.11	2.00e-74	273.00
IUUC-Bra-016962	Brassica rapa	35.90	3.00e-73	269.00
IUUC-Cja-019954	Callithrix jacchus	89.69	0.00e+00	937.00
IUUC-Cfa-020956	Canis familiaris	98.25	0.00e+00	1060.00
IUUC-Cpo-022014	Cavia porcellus	96.42	0.00e+00	1015.00
IUUC-Csa-023350	Chlorocebus sabaeus	97.71	0.00e+00	898.00
IUUC-Dno-029905	Dasypus novemcinctus	96.80	0.00e+00	889.00
IUUC-Dor-030832	Dipodomys ordii	97.41	2.00e-112	399.00
IUUC-Eca-033957	Equus caballus	96.62	0.00e+00	1013.00
IUUC-Fca-035768	Felis catus	97.42	0.00e+00	1021.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.14	9.00e-58	217.00
IUUC-Gma-043933	Glycine max	37.25	9.00e-88	317.00
IUUC-Ggo-044925	Gorilla gorilla	96.42	0.00e+00	1013.00
IUUC-Hsa-045775	Homo sapiens	97.94	0.00e+00	900.00
IUUC-Itr-048775	Ictidomys tridecemlineatus	97.94	0.00e+00	901.00
IUUC-Laf-053947	Loxodonta africana	95.63	0.00e+00	1008.00
IUUC-Mmr-061013	Microcebus murinus	96.80	0.00e+00	892.00
IUUC-Mmu-064287	Mus musculus	95.88	0.00e+00	879.00
IUUC-Mac-065419	Musa acuminata	34.71	1.00e-75	277.00
IUUC-Mpu-066433	Mustela putorius furo	96.62	0.00e+00	1016.00
IUUC-Mlu-067330	Myotis lucifugus	95.62	0.00e+00	1001.00
IUUC-Nle-069084	Nomascus leucogenys	97.94	0.00e+00	900.00
IUUC-Ocu-074951	Oryctolagus cuniculus	94.63	0.00e+00	997.00
IUUC-Oga-088771	Otolemur garnettii	97.67	0.00e+00	1056.00
IUUC-Pan-092253	Papio anubis	98.25	0.00e+00	1063.00
IUUC-Ppa-095413	Physcomitrella patens	34.58	4.00e-83	302.00
IUUC-Pab-098324	Pongo abelii	96.42	0.00e+00	1013.00
IUUC-Pop-099558	Populus trichocarpa	36.25	2.00e-87	316.00
IUUC-Pca-100329	Procavia capensis	95.63	0.00e+00	1004.00
IUUC-Ppe-102020	Prunus persica	38.62	2.00e-93	336.00
IUUC-Pva-102721	Pteropus vampyrus	91.25	0.00e+00	938.00
IUUC-Pgr-103657	Puccinia graminis	29.31	4.00e-38	152.00
IUUC-Rno-105081	Rattus norvegicus	96.11	0.00e+00	884.00
IUUC-Spo-108226	Schizosaccharomyces pombe	32.52	4.00e-61	228.00
IUUC-Smo-109310	Selaginella moellendorffii	36.40	7.00e-87	314.00
IUUC-Sly-111077	Solanum lycopersicum	38.46	1.00e-79	290.00
IUUC-Stu-112203	Solanum tuberosum	39.01	2.00e-76	279.00
IUUC-Sar-113174	Sorex araneus	93.36	0.00e+00	922.00
IUUC-Sre-115195	Sporisorium reilianum	27.46	3.00e-52	200.00
IUUC-Ssc-115315	Sus scrofa	99.20	0.00e+00	1047.00
IUUC-Tsy-119413	Tarsius syrichta	73.16	0.00e+00	739.00
IUUC-Tca-121154	Theobroma cacao	39.14	6.00e-92	331.00
IUUC-Ttr-129006	Tursiops truncatus	96.75	0.00e+00	994.00
IUUC-Vvi-131477	Vitis vinifera	38.26	2.00e-77	283.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence