iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021649

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02049560

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000019868.1	ENSCPOT00000026960.1	ENSCPOP00000017458.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.70e-12	47.3	299	351

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClkls.......veeelpnsekwiCpkC 51
           + C+vC++gge    l++C+ C ++fH aCl+++       v  +  +s +w C+ C
   Q: 299  DECAVCRDGGE----LICCDGCPRAFHLACLSPPlhkiprlVTGDNGSSGTWRCSCC 351
           57*********....*******************88877774444444445***999 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

RAGGDAVLRR LLRLHRTEIA VAVDSAFPLL HSLADHDVVP EDKFQETLLL KEKEGCPQAF 60
HALLSWLLTQ DTAAITDFWR VLFKDYHLAR YGGLRPVLDG FPKDVDLSQP RKGRKPPSGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCTGGCG GGGACGCAGT GCTGCGCAGG CTGCTGAGGC TGCACCGCAC GGAGATCGCG 60
GTGGCCGTGG ACAGTGCCTT CCCGCTGCTG CACTCGCTGG CCGACCACGA CGTCGTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0003682--F:chromatin binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	68.35	1.00e-170	592.00
IUUC-Aca-004543	Anolis carolinensis	61.29	4.00e-21	92.00
IUUC-Bta-012988	Bos taurus	69.19	0.00e+00	631.00
IUUC-Cja-019486	Callithrix jacchus	60.82	2.00e-85	308.00
IUUC-Cfa-021069	Canis familiaris	67.08	4.00e-163	567.00
IUUC-Csa-023960	Chlorocebus sabaeus	70.70	4.00e-162	564.00
IUUC-Dre-028583	Danio rerio	39.88	4.00e-55	208.00
IUUC-Dno-029869	Dasypus novemcinctus	60.25	9.00e-123	433.00
IUUC-Dor-030263	Dipodomys ordii	77.66	5.00e-41	161.00
IUUC-Ete-032778	Echinops telfairi	85.45	1.00e-45	177.00
IUUC-Eca-034328	Equus caballus	66.84	2.00e-161	561.00
IUUC-Fca-035400	Felis catus	64.83	6.00e-164	570.00
IUUC-Fal-036644	Ficedula albicollis	46.78	5.00e-65	241.00
IUUC-Ggo-045250	Gorilla gorilla	70.46	5.00e-171	593.00
IUUC-Hsa-046603	Homo sapiens	70.92	4.00e-171	594.00
IUUC-Itr-048977	Ictidomys tridecemlineatus	68.26	4.00e-168	584.00
IUUC-Lch-050310	Latimeria chalumnae	40.54	1.00e-91	330.00
IUUC-Loc-052508	Lepisosteus oculatus	46.78	4.00e-75	275.00
IUUC-Laf-054028	Loxodonta africana	62.80	4.00e-149	521.00
IUUC-Mcc-054935	Macaca mulatta	69.43	1.00e-173	602.00
IUUC-Mga-059318	Meleagris gallopavo	37.54	4.00e-47	181.00
IUUC-Mmr-061557	Microcebus murinus	58.36	5.00e-124	437.00
IUUC-Mdo-062475	Monodelphis domestica	48.28	6.00e-114	404.00
IUUC-Mmu-063994	Mus musculus	66.19	0.00e+00	664.00
IUUC-Mpu-066347	Mustela putorius furo	69.63	0.00e+00	669.00
IUUC-Mlu-068239	Myotis lucifugus	58.85	5.00e-84	304.00
IUUC-Nle-069544	Nomascus leucogenys	70.59	1.00e-21	96.70
IUUC-Opr-071199	Ochotona princeps	73.28	1.00e-67	250.00
IUUC-Ont-072571	Oreochromis niloticus	31.12	3.00e-32	132.00
IUUC-Oan-073739	Ornithorhynchus anatinus	53.38	1.00e-136	480.00
IUUC-Ola-086528	Oryzias latipes	32.94	2.00e-37	149.00
IUUC-Oga-088353	Otolemur garnettii	70.33	0.00e+00	652.00
IUUC-Oar-090065	Ovis aries	66.75	1.00e-136	479.00
IUUC-Ptr-091347	Pan troglodytes	70.46	9.00e-163	566.00
IUUC-Pan-092423	Papio anubis	68.98	1.00e-174	606.00
IUUC-Psi-093798	Pelodiscus sinensis	50.37	7.00e-125	440.00
IUUC-Pfo-096145	Poecilia formosa	60.32	5.00e-18	85.90
IUUC-Pab-098369	Pongo abelii	77.65	2.00e-122	432.00
IUUC-Pca-100537	Procavia capensis	63.92	2.00e-158	552.00
IUUC-Pva-102639	Pteropus vampyrus	67.62	3.00e-158	551.00
IUUC-Rno-105285	Rattus norvegicus	67.08	0.00e+00	672.00
IUUC-Sha-107159	Sarcophilus harrisii	46.99	6.00e-118	417.00
IUUC-Ssc-115773	Sus scrofa	65.16	4.00e-172	597.00
IUUC-Tgu-116922	Taeniopygia guttata	44.94	1.00e-63	236.00
IUUC-Tru-118263	Takifugu rubripes	31.83	4.00e-54	205.00
IUUC-Tsy-119270	Tarsius syrichta	66.00	1.00e-88	320.00
IUUC-Tni-120138	Tetraodon nigroviridis	29.64	7.00e-55	208.00
IUUC-Tbe-128077	Tupaia belangeri	63.81	3.00e-176	611.00
IUUC-Ttr-128781	Tursiops truncatus	75.00	5.00e-72	265.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence