iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048977

Ensembl Protein ID

ENSSTOP00000020125.1

UniProt Accession

I3N6X9; I3N6X9_ICTTR

Genbank Protein ID

ENSSTOP00000020125

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01029953

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000023870.1	ENSSTOT00000021109.1	ENSSTOP00000020125.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.80e-11	42.7	297	349

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClkls.......veeelpnsekwiCpkC 51
           + C+vC++gge    l++C+ C ++fH aCl+++             +s +w C  C
   Q: 297  DECAVCRDGGE----LICCDGCPRAFHLACLSPPlreiprlLTGGHASSGTWRCACC 349
           57*********....*******************66655542223333334999988 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

AAGDSALRRL LRLHRTEIAV AVDSAFPLLH ALADHDVVPE DKFQETLRLK EKEGCSQAFH 60
ALLSWLLTQD TAAILDFWRV LFKDYNLERY GRLRPILDSF PKDVDLSQPR KGRKPPASPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCTGGGG ACTCGGCGCT GCGCCGCCTC CTGAGACTGC ACCGCACCGA GATCGCCGTG 60
GCCGTGGACA GCGCCTTTCC GCTGCTGCAT GCGCTGGCCG ACCATGACGT GGTCCCTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0003682--F:chromatin binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	71.89	5.00e-174	603.00
IUUC-Aca-004543	Anolis carolinensis	67.74	5.00e-24	101.00
IUUC-Bta-012988	Bos taurus	71.63	4.00e-177	613.00
IUUC-Cja-019486	Callithrix jacchus	69.21	4.00e-90	324.00
IUUC-Cfa-021069	Canis familiaris	72.71	7.00e-174	603.00
IUUC-Cpo-021649	Cavia porcellus	70.52	3.00e-162	565.00
IUUC-Csa-023960	Chlorocebus sabaeus	74.95	2.00e-167	582.00
IUUC-Dre-028583	Danio rerio	33.21	3.00e-67	249.00
IUUC-Dno-029869	Dasypus novemcinctus	64.46	3.00e-121	428.00
IUUC-Dor-030263	Dipodomys ordii	85.11	9.00e-45	173.00
IUUC-Ete-032778	Echinops telfairi	89.80	9.00e-48	184.00
IUUC-Eca-034328	Equus caballus	70.97	9.00e-167	579.00
IUUC-Fca-035400	Felis catus	68.28	1.00e-164	572.00
IUUC-Fal-036644	Ficedula albicollis	48.83	3.00e-70	259.00
IUUC-Ggo-045250	Gorilla gorilla	74.54	8.00e-173	599.00
IUUC-Hsa-046603	Homo sapiens	74.46	1.00e-171	595.00
IUUC-Lch-050310	Latimeria chalumnae	37.57	2.00e-89	322.00
IUUC-Loc-052508	Lepisosteus oculatus	44.70	4.00e-75	275.00
IUUC-Laf-054028	Loxodonta africana	76.69	1.00e-134	473.00
IUUC-Mcc-054935	Macaca mulatta	74.22	5.00e-180	623.00
IUUC-Mga-059318	Meleagris gallopavo	39.83	3.00e-52	198.00
IUUC-Mmr-061557	Microcebus murinus	61.43	2.00e-131	462.00
IUUC-Mdo-062475	Monodelphis domestica	51.94	3.00e-124	438.00
IUUC-Mmu-063994	Mus musculus	68.98	0.00e+00	671.00
IUUC-Mpu-066347	Mustela putorius furo	73.84	0.00e+00	679.00
IUUC-Mlu-068239	Myotis lucifugus	62.20	5.00e-86	310.00
IUUC-Nle-069544	Nomascus leucogenys	76.92	2.00e-23	101.00
IUUC-Opr-071199	Ochotona princeps	75.20	8.00e-72	264.00
IUUC-Ont-072571	Oreochromis niloticus	31.40	1.00e-49	190.00
IUUC-Oan-073739	Ornithorhynchus anatinus	53.69	5.00e-140	491.00
IUUC-Ola-086528	Oryzias latipes	34.02	2.00e-39	156.00
IUUC-Oga-088353	Otolemur garnettii	75.51	0.00e+00	686.00
IUUC-Oar-090065	Ovis aries	70.63	6.00e-138	483.00
IUUC-Ptr-091347	Pan troglodytes	74.35	2.00e-164	571.00
IUUC-Pan-092423	Papio anubis	74.42	1.00e-180	625.00
IUUC-Psi-093798	Pelodiscus sinensis	49.18	5.00e-121	427.00
IUUC-Pfo-096145	Poecilia formosa	64.52	6.00e-19	88.60
IUUC-Pab-098369	Pongo abelii	81.39	3.00e-124	437.00
IUUC-Pca-100537	Procavia capensis	66.79	6.00e-165	573.00
IUUC-Pva-102639	Pteropus vampyrus	72.50	7.00e-174	603.00
IUUC-Rno-105285	Rattus norvegicus	70.84	0.00e+00	676.00
IUUC-Sha-107159	Sarcophilus harrisii	50.64	1.00e-124	439.00
IUUC-Ssc-115773	Sus scrofa	73.46	0.00e+00	654.00
IUUC-Tgu-116922	Taeniopygia guttata	48.51	2.00e-70	258.00
IUUC-Tru-118263	Takifugu rubripes	30.86	1.00e-55	210.00
IUUC-Tsy-119270	Tarsius syrichta	70.08	5.00e-92	331.00
IUUC-Tni-120138	Tetraodon nigroviridis	29.76	3.00e-54	206.00
IUUC-Tbe-128077	Tupaia belangeri	67.98	1.00e-180	625.00
IUUC-Ttr-128781	Tursiops truncatus	76.76	8.00e-75	274.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence