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Tag Content
UUCD2 ID IUUC-Gga-041153
UUCD1 version UUC-GaG-00759
Ensembl Protein ID ENSGALP00000015973.3
UniProt Accession Q5ZJW8; DTL_CHICK
Genbank Protein ID CAG31975.1
Protein Name Denticleless protein homolog
Genbank Nucleotide ID AJ720316
Gene Name DTL; CDT2; RCJMB04_15a2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000009837.4 ENSGALT00000015990.3 ENSGALP00000015973.3
ENSGALG00000009837.4 ENSGALT00000061437.1 ENSGALP00000057985.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-38 129.8 355 387
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDl 30
           gH+ +vt++a+  sd t ++++sdD+t+++W+l
   Q: 355  GHSQEVTSIAWcpSDfTKIATCSDDNTVRIWRL 387
           8***********999****************97 PP
   
Organism Gallus gallus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
 Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
Protein Sequence
(Fasta)
MLCRALLLRA AGHRQSSSLP LQHLLDGYRC SREDDHLSYG EIGMPVPPFG CSFSAAPNFE 60
HVLAVANEEG FVRLYDTEAQ NTTKLISKEW QAHSNAVFDL AWVPGEHRIV TASGDQTAKV 120
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Protein Fasta Sequence


>IUUC-Gga-041153|E3,WD_repeat|Gallus gallus
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Nucleotide Sequence
(Fasta)
GCGCTACGCC GGTCCGCGGA CTCTTGGCCA TGCTGTGCCG CGCGCTGCTC CTCCGCGCCG 60
CCGGACACCG TGAGTACCGC GAGTACTGCG CCCCGGGGGC TGCCGTGCAG GGAGCCCGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gga-041153|E3,WD_repeat|Gallus gallus
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Sequence Source Ensembl
Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0235--DNA replication
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0005694--C:chromosome
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006260--P:DNA replication
GO:0031572--P:G2 DNA damage checkpoint
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG gga:421373
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002111 Ailuropoda melanoleuca 62.46 0.00e+00 772.00
IUUC-Atr-003097 Amborella trichopoda 37.13 7.00e-67 248.00
IUUC-Apl-004088 Anas platyrhynchos 87.13 0.00e+00 1244.00
IUUC-Aca-004732 Anolis carolinensis 61.56 0.00e+00 805.00
IUUC-Aly-005686 Arabidopsis lyrata 34.24 5.00e-62 231.00
IUUC-Ath-006970 Arabidopsis thaliana 34.41 2.00e-61 229.00
IUUC-Acl-008219 Aspergillus clavatus 27.80 6.00e-20 92.40
IUUC-Afu-008784 Aspergillus fumigatus 23.69 4.00e-20 93.20
IUUC-Ani-009304 Aspergillus nidulans 23.73 5.00e-18 86.30
IUUC-Ang-009842 Aspergillus niger 23.29 1.00e-21 97.80
IUUC-Aor-009883 Aspergillus oryzae 28.09 3.00e-20 93.60
IUUC-Ate-010454 Aspergillus terreus 28.62 1.00e-20 94.00
IUUC-Ame-010949 Astyanax mexicanus 46.89 2.00e-170 592.00
IUUC-Bta-012333 Bos taurus 62.89 0.00e+00 784.00
IUUC-Bci-013733 Botrytis cinerea 26.44 1.00e-20 95.10
IUUC-Bdi-014494 Brachypodium distachyon 34.84 1.00e-57 217.00
IUUC-Bol-015301 Brassica oleracea 34.70 2.00e-59 223.00
IUUC-Bra-017384 Brassica rapa 35.23 1.00e-61 230.00
IUUC-Cel-018498 Caenorhabditis elegans 28.73 1.00e-33 137.00
IUUC-Cja-019534 Callithrix jacchus 61.65 0.00e+00 788.00
IUUC-Cfa-020847 Canis familiaris 61.85 0.00e+00 779.00
IUUC-Cpo-021695 Cavia porcellus 61.03 0.00e+00 785.00
IUUC-Cre-022762 Chlamydomonas reinhardtii 28.32 6.00e-43 170.00
IUUC-Csa-023748 Chlorocebus sabaeus 61.48 0.00e+00 791.00
IUUC-Cho-024445 Choloepus hoffmanni 68.42 2.00e-139 489.00
IUUC-Cgl-026664 Colletotrichum gloeosporioides 25.25 2.00e-20 94.40
IUUC-Cne-027008 Cryptococcus neoformans 23.81 8.00e-16 80.10
IUUC-Dre-027536 Danio rerio 48.74 5.00e-172 597.00
IUUC-Dno-030035 Dasypus novemcinctus 57.34 0.00e+00 754.00
IUUC-Dor-030814 Dipodomys ordii 63.96 1.00e-68 254.00
IUUC-Dse-031354 Dothistroma septosporum 25.64 1.00e-30 127.00
IUUC-Dme-031691 Drosophila melanogaster 44.00 1.00e-80 294.00
IUUC-Ete-032814 Echinops telfairi 58.33 6.00e-159 554.00
IUUC-Eca-033332 Equus caballus 62.32 0.00e+00 778.00
IUUC-Fca-035571 Felis catus 62.41 0.00e+00 775.00
IUUC-Fal-037421 Ficedula albicollis 81.56 0.00e+00 1169.00
IUUC-Fox-038069 Fusarium oxysporum 23.92 7.00e-18 85.10
IUUC-Fso-038192 Fusarium solani 23.73 3.00e-19 90.10
IUUC-Gmo-039365 Gadus morhua 66.34 8.00e-159 553.00
IUUC-Ggr-039904 Gaeumannomyces graminis 24.19 8.00e-17 82.40
IUUC-Gac-041984 Gasterosteus aculeatus 48.05 8.00e-176 610.00
IUUC-Gma-043734 Glycine max 36.02 1.00e-62 233.00
IUUC-Ggo-044419 Gorilla gorilla 61.57 0.00e+00 786.00
IUUC-Hsa-045862 Homo sapiens 61.38 0.00e+00 788.00
IUUC-Hvu-047728 Hordeum vulgare 35.49 2.00e-62 233.00
IUUC-Itr-048786 Ictidomys tridecemlineatus 61.82 0.00e+00 803.00
IUUC-Lch-050616 Latimeria chalumnae 54.79 0.00e+00 676.00
IUUC-Lpe-051222 Leersia perrieri 35.89 3.00e-61 229.00
IUUC-Loc-052564 Lepisosteus oculatus 53.17 0.00e+00 657.00
IUUC-Lma-053098 Leptosphaeria maculans 24.12 4.00e-26 112.00
IUUC-Laf-053892 Loxodonta africana 59.97 0.00e+00 761.00
IUUC-Mcc-055854 Macaca mulatta 61.48 0.00e+00 791.00
IUUC-Mor-057144 Magnaporthe oryzae 28.28 9.00e-18 85.50
IUUC-Mpo-057501 Magnaporthe poae 30.52 6.00e-15 75.90
IUUC-Mtr-058510 Medicago truncatula 36.31 8.00e-58 217.00
IUUC-Mla-058823 Melampsora laricipopulina 27.42 7.00e-23 102.00
IUUC-Mga-060128 Meleagris gallopavo 95.47 0.00e+00 1347.00
IUUC-Mvi-060475 Microbotryum violaceum 33.06 5.00e-43 169.00
IUUC-Mmr-061331 Microcebus murinus 61.57 0.00e+00 773.00
IUUC-Mdo-063020 Monodelphis domestica 60.88 0.00e+00 816.00
IUUC-Mmu-063713 Mus musculus 58.07 0.00e+00 738.00
IUUC-Mac-064653 Musa acuminata 36.91 3.00e-60 225.00
IUUC-Mpu-066490 Mustela putorius furo 62.27 0.00e+00 774.00
IUUC-Mlu-067900 Myotis lucifugus 60.64 0.00e+00 766.00
IUUC-Nfi-068433 Neosartorya fischeri 24.42 3.00e-20 93.60
IUUC-Ncr-068776 Neurospora crassa 28.17 8.00e-30 125.00
IUUC-Nle-069675 Nomascus leucogenys 59.24 0.00e+00 724.00
IUUC-Opr-070769 Ochotona princeps 48.18 3.00e-90 325.00
IUUC-Ont-071441 Oreochromis niloticus 47.54 1.00e-168 586.00
IUUC-Oan-072757 Ornithorhynchus anatinus 61.80 0.00e+00 787.00
IUUC-Ocu-074670 Oryctolagus cuniculus 61.43 0.00e+00 784.00
IUUC-Oba-075844 Oryza barthii 35.93 9.00e-59 221.00
IUUC-Obr-076625 Oryza brachyantha 37.85 7.00e-64 238.00
IUUC-Ogl-077771 Oryza glaberrima 35.93 1.00e-58 220.00
IUUC-Ogu-078475 Oryza glumaepatula 33.98 2.00e-50 192.00
IUUC-Oin-079958 Oryza indica 35.93 1.00e-58 220.00
IUUC-Olo-080311 Oryza longistaminata 35.10 6.00e-49 187.00
IUUC-Ome-081985 Oryza meridionalis 35.10 9.00e-58 217.00
IUUC-Oni-082921 Oryza nivara 35.93 1.00e-58 220.00
IUUC-Opu-083174 Oryza punctata 33.78 3.00e-57 216.00
IUUC-Oru-084338 Oryza rufipogon 34.99 2.00e-59 223.00
IUUC-Osa-085609 Oryza sativa 45.88 4.00e-21 94.70
IUUC-Olu-087907 Ostreococcus lucimarinus 27.63 5.00e-29 121.00
IUUC-Oga-088358 Otolemur garnettii 61.96 0.00e+00 796.00
IUUC-Oar-089994 Ovis aries 62.55 0.00e+00 788.00
IUUC-Ptr-091338 Pan troglodytes 61.76 0.00e+00 796.00
IUUC-Pan-091759 Papio anubis 61.40 0.00e+00 786.00
IUUC-Psi-093211 Pelodiscus sinensis 69.93 0.00e+00 880.00
IUUC-Pma-094588 Petromyzon marinus 59.25 4.00e-93 334.00
IUUC-Pno-094964 Phaeosphaeria nodorum 24.67 9.00e-28 118.00
IUUC-Ppa-095159 Physcomitrella patens 39.12 2.00e-65 243.00
IUUC-Pfo-096592 Poecilia formosa 44.73 7.00e-155 540.00
IUUC-Pab-098597 Pongo abelii 48.81 4.00e-154 538.00
IUUC-Pop-099255 Populus trichocarpa 38.97 5.00e-64 238.00
IUUC-Pca-100593 Procavia capensis 51.53 4.00e-171 594.00
IUUC-Ppe-101333 Prunus persica 36.80 5.00e-57 214.00
IUUC-Pva-102283 Pteropus vampyrus 58.96 0.00e+00 712.00
IUUC-Pgr-103383 Puccinia graminis 29.84 2.00e-23 103.00
IUUC-Ptt-103974 Puccinia triticina 32.00 2.00e-21 97.10
IUUC-Pte-104329 Pyrenophora teres 24.09 8.00e-27 115.00
IUUC-Pyt-104424 Pyrenophora triticirepentis 27.70 2.00e-26 113.00
IUUC-Rno-105720 Rattus norvegicus 58.43 0.00e+00 742.00
IUUC-Sha-106891 Sarcophilus harrisii 59.19 0.00e+00 771.00
IUUC-Sja-107723 Schizosaccharomyces japonicus 27.17 7.00e-26 111.00
IUUC-Spo-108060 Schizosaccharomyces pombe 26.28 1.00e-21 97.40
IUUC-Ssl-108481 Sclerotinia sclerotiorum 26.29 6.00e-19 89.00
IUUC-Sit-109862 Setaria italica 35.82 4.00e-59 222.00
IUUC-Sly-111468 Solanum lycopersicum 36.39 5.00e-61 228.00
IUUC-Stu-112346 Solanum tuberosum 34.76 2.00e-57 216.00
IUUC-Sar-113734 Sorex araneus 68.04 2.00e-85 310.00
IUUC-Sbi-114076 Sorghum bicolor 35.67 9.00e-60 224.00
IUUC-Sre-114918 Sporisorium reilianum 23.92 1.00e-16 81.60
IUUC-Ssc-115561 Sus scrofa 60.53 0.00e+00 764.00
IUUC-Tgu-117011 Taeniopygia guttata 82.20 0.00e+00 1128.00
IUUC-Tru-118411 Takifugu rubripes 46.70 8.00e-161 560.00
IUUC-Tsy-119367 Tarsius syrichta 52.25 0.00e+00 628.00
IUUC-Tni-120301 Tetraodon nigroviridis 61.15 2.00e-153 535.00
IUUC-Tca-121265 Theobroma cacao 37.85 2.00e-62 233.00
IUUC-Tre-121997 Trichoderma reesei 25.33 4.00e-20 93.20
IUUC-Tvi-122292 Trichoderma virens 25.00 6.00e-21 95.90
IUUC-Tae-123660 Triticum aestivum 34.18 7.00e-61 228.00
IUUC-Tur-126794 Triticum urartu 31.73 4.00e-47 181.00
IUUC-Tme-127090 Tuber melanosporum 26.75 2.00e-18 86.30
IUUC-Tbe-127646 Tupaia belangeri 68.41 4.00e-172 598.00
IUUC-Ttr-128171 Tursiops truncatus 62.89 0.00e+00 790.00
IUUC-Uma-129525 Ustilago maydis 25.12 1.00e-22 101.00
IUUC-Vda-129871 Verticillium dahliae 24.57 2.00e-23 103.00
IUUC-Vpa-130554 Vicugna pacos 75.90 1.00e-89 324.00
IUUC-Vvi-131698 Vitis vinifera 38.33 3.00e-63 235.00
IUUC-Xtr-131962 Xenopus tropicalis 57.69 0.00e+00 780.00
IUUC-Xma-133803 Xiphophorus maculatus 46.24 1.00e-165 576.00
IUUC-Zma-135693 Zea mays 32.67 5.00e-57 215.00
Created Date 25-Jun-2017

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