iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037048

Ensembl Protein ID

ENSFALP00000003288.1

UniProt Accession

U3JKI4; U3JKI4_FICAL

Genbank Protein ID

ENSFALP00000003288

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Genbank Nucleotide ID

AGTO01011305

Gene Name

RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000003152.1	ENSFALT00000003301.1	ENSFALP00000003288.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/MIU	45.88	2.00e-78	291.00	IUUC-Hsa-046424
UBD/Alpha-Helix/UMI	45.88	2.00e-78	291.00	IUUC-Hsa-046424
E3 activity/RING/RING	45.88	2.00e-78	291.00	IUUC-Hsa-046424

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ficedula albicollis

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MSKKSKAPLS LSDCLCQICM EIFVEPVTLP CSHTLCNYCF QMTVEKASLC CPFCRRRVSS 60
WARYNTRRNT LVNWELWEKI QKNYPEECER RINGQDLDEE ICSPKPRHQL SKPGELRQEY 120

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Nucleotide Sequence
(Fasta)

GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG AGGGCCCGCC 60
GGCGCTGTCT CCCAGCAGGC CCGGCGGGGG AGGCGGAAGG GGAGAAGGAG GAGACAGAAG 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0031491--F:nucleosome binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0035518--P:histone H2A monoubiquitination
GO:0036351--P:histone H2A-K13 ubiquitination
GO:0036352--P:histone H2A-K15 ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	35.53	3.00e-10	59.30
IUUC-Aml-001573	Ailuropoda melanoleuca	42.74	2.00e-83	302.00
IUUC-Atr-002992	Amborella trichopoda	37.14	2.00e-09	56.20
IUUC-Apl-003963	Anas platyrhynchos	64.79	4.00e-161	561.00
IUUC-Aca-004420	Anolis carolinensis	44.66	4.00e-90	325.00
IUUC-Ame-011521	Astyanax mexicanus	43.96	6.00e-46	177.00
IUUC-Bta-013002	Bos taurus	43.22	3.00e-83	302.00
IUUC-Cja-019945	Callithrix jacchus	43.27	6.00e-84	304.00
IUUC-Cfa-020533	Canis familiaris	44.63	6.00e-86	311.00
IUUC-Cpo-021643	Cavia porcellus	38.85	1.00e-61	230.00
IUUC-Csa-023638	Chlorocebus sabaeus	45.08	4.00e-89	322.00
IUUC-Cho-024319	Choloepus hoffmanni	42.01	1.00e-75	276.00
IUUC-Cin-025679	Ciona intestinalis	32.74	1.00e-23	103.00
IUUC-Csv-026052	Ciona savignyi	34.97	3.00e-24	105.00
IUUC-Dre-028519	Danio rerio	58.33	3.00e-42	165.00
IUUC-Dno-029294	Dasypus novemcinctus	41.95	5.00e-85	308.00
IUUC-Ete-032714	Echinops telfairi	64.96	3.00e-41	162.00
IUUC-Eca-033343	Equus caballus	46.35	2.00e-89	322.00
IUUC-Fca-036251	Felis catus	44.61	8.00e-88	317.00
IUUC-Gmo-039400	Gadus morhua	51.26	1.00e-35	141.00
IUUC-Gga-040444	Gallus gallus	64.75	0.00e+00	671.00
IUUC-Gac-041735	Gasterosteus aculeatus	47.00	7.00e-43	166.00
IUUC-Gma-044332	Glycine max	37.35	6.00e-12	65.10
IUUC-Ggo-044940	Gorilla gorilla	35.80	5.00e-39	155.00
IUUC-Hsa-046424	Homo sapiens	43.35	7.00e-84	304.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	45.18	4.00e-77	281.00
IUUC-Lch-050649	Latimeria chalumnae	41.73	2.00e-60	226.00
IUUC-Loc-051847	Lepisosteus oculatus	36.51	1.00e-52	200.00
IUUC-Laf-053938	Loxodonta africana	43.47	6.00e-92	331.00
IUUC-Mcc-055360	Macaca mulatta	42.51	4.00e-83	301.00
IUUC-Meu-056684	Macropus eugenii	40.85	5.00e-77	281.00
IUUC-Mtr-058007	Medicago truncatula	39.47	1.00e-11	63.90
IUUC-Mga-059699	Meleagris gallopavo	66.55	0.00e+00	647.00
IUUC-Mmr-060779	Microcebus murinus	42.28	1.00e-89	323.00
IUUC-Mdo-062225	Monodelphis domestica	44.46	7.00e-84	304.00
IUUC-Mmu-064239	Mus musculus	39.22	2.00e-66	246.00
IUUC-Mpu-066141	Mustela putorius furo	45.25	8.00e-94	337.00
IUUC-Mlu-067945	Myotis lucifugus	47.15	5.00e-90	325.00
IUUC-Nle-069769	Nomascus leucogenys	44.73	7.00e-85	307.00
IUUC-Opr-070905	Ochotona princeps	40.38	3.00e-75	275.00
IUUC-Ont-071477	Oreochromis niloticus	46.55	8.00e-40	157.00
IUUC-Oan-073587	Ornithorhynchus anatinus	70.87	2.00e-51	193.00
IUUC-Ocu-073832	Oryctolagus cuniculus	44.37	1.00e-81	297.00
IUUC-Obr-076219	Oryza brachyantha	38.16	3.00e-10	59.30
IUUC-Ogl-077658	Oryza glaberrima	42.11	3.00e-10	59.30
IUUC-Oin-079383	Oryza indica	42.11	2.00e-10	59.70
IUUC-Ome-081482	Oryza meridionalis	42.11	2.00e-10	59.70
IUUC-Oni-083025	Oryza nivara	42.11	2.00e-10	59.70
IUUC-Opu-083547	Oryza punctata	41.67	1.00e-09	57.40
IUUC-Oru-084946	Oryza rufipogon	35.56	3.00e-07	49.70
IUUC-Osa-085978	Oryza sativa	42.11	2.00e-10	59.70
IUUC-Ola-086478	Oryzias latipes	54.40	2.00e-38	150.00
IUUC-Oga-088318	Otolemur garnettii	46.52	4.00e-86	311.00
IUUC-Oar-089647	Ovis aries	42.76	3.00e-84	305.00
IUUC-Ptr-090516	Pan troglodytes	43.52	1.00e-88	320.00
IUUC-Pan-092302	Papio anubis	42.76	7.00e-85	307.00
IUUC-Psi-093604	Pelodiscus sinensis	53.39	5.00e-147	514.00
IUUC-Pfo-096441	Poecilia formosa	57.04	2.00e-45	176.00
IUUC-Pab-097729	Pongo abelii	42.66	1.00e-84	307.00
IUUC-Pca-100552	Procavia capensis	73.33	4.00e-39	155.00
IUUC-Pva-102780	Pteropus vampyrus	43.00	2.00e-84	306.00
IUUC-Rno-105461	Rattus norvegicus	41.07	6.00e-79	288.00
IUUC-Sha-106809	Sarcophilus harrisii	45.64	3.00e-90	325.00
IUUC-Sly-111317	Solanum lycopersicum	42.11	6.00e-13	68.20
IUUC-Stu-112446	Solanum tuberosum	39.02	1.00e-12	67.00
IUUC-Sar-113579	Sorex araneus	41.03	2.00e-69	256.00
IUUC-Sbi-113834	Sorghum bicolor	38.16	6.00e-11	61.60
IUUC-Tgu-117187	Taeniopygia guttata	95.83	1.00e-106	378.00
IUUC-Tru-118182	Takifugu rubripes	54.35	6.00e-37	147.00
IUUC-Tni-120205	Tetraodon nigroviridis	56.74	6.00e-47	181.00
IUUC-Tca-121416	Theobroma cacao	39.47	1.00e-11	63.50
IUUC-Tvi-122557	Trichoderma virens	41.67	6.00e-05	42.00
IUUC-Tae-123092	Triticum aestivum	35.53	4.00e-10	59.30
IUUC-Tur-126688	Triticum urartu	34.21	3.00e-10	58.90
IUUC-Tbe-127622	Tupaia belangeri	43.86	3.00e-94	338.00
IUUC-Ttr-128988	Tursiops truncatus	43.39	9.00e-86	310.00
IUUC-Vpa-130302	Vicugna pacos	65.87	3.00e-46	179.00
IUUC-Vvi-131424	Vitis vinifera	38.16	1.00e-09	57.00
IUUC-Xtr-132196	Xenopus tropicalis	37.56	1.00e-69	257.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence