iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-002360

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01112084

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000012585.1	ENSAMET00000013842.1	ENSAMEP00000013285.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.20e-144	482.0	963	1510

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++i+ed +++ll+l+++l+ a+R+++++++r+l++++++    
   Q: 963  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDIAED-RRSLLHLSSRLNGALRQEQNFADRFLPDDEAA---- 1027
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve+++++       ++
   Q: 1028 ----QALGKTCWEALVSPLVQNITSPDEDGISPLgWLLDQYLECREAAHNPQSRAAAFSSRVRRLTHLLVHVEPCEAP-------PP 1103
           ....**************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
            va++r k++++ +++++L++r+l+  ++++l+++++++++eq++++lt++++++d   +V+r++e+++ lqk++se+F+++a+Fl 
   Q: 1104 AVATPRPKGRNRSHDWSSLATRGLPssIVRNLTRCWRAVVEEQVNTFLTSHWRDED---FVPRYCEHFHNLQKSSSELFGPRAAFLL 1187
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++  ++k ++lkaa+++E++Ar+iDq++++s ++g++++e++aql+++l+    +s++d+   Fe+yY++++a+RLls    
   Q: 1188 ALHNGCAGGLLKLPFLKAAHVSEQFARHIDQRIQGSrIGGARGMEMLAQLQRCLETALLFSGLDMataFEHYYQHYMADRLLS--LG 1272
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+++L ++M+++l++Se+l+rqF+                                            
   Q: 1273 SSWLEGAVLEQI----GLCFPNRLpQQMLRSLSTSEELQRQFHvyqlqrldqellklddtekriqggheasdkehkgekaeeaegag 1355
           ************....*********************************************************************** PP
   S: 453  ................eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkL 511
                           e+++ ++e +++e+svlvLs+++Wp a   +t  ++++LP++l+ t++++++fY        le++ +R+L
   Q: 1356 aaaatdvagedeedeeEDEDLYYEGAMPEVSVLVLSPRCWPIAsiRHTlnPRTCLPSYLRGTLNRYTNFYsksqsyptLERGLQRRL 1442
           **************98889999*********************76333679************************************ PP
   S: 512  qWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqv 582
           qW++ lgrael++    g ++l+Vst+Qm++LL++n+ ++vsve+l + ++l++++L +++++L+ss+   ++
   Q: 1443 QWTW-LGRAELQF----GDQTLHVSTVQMWLLLYLNDLKAVSVESLLALSGLSPDMLDQAIGPLTSSRgpLDL 1510
           ****.********....*************************************************9944444 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDD GEGGSGQVDC 60
KAEHILLWMS DDEIYASCHK MLGEDGQVSG RPPETAGEAG ALDQSVLGEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGGGG AGCTCCGCTA CAGGGAATTC CGAGTGCCCC TGGGGCCGGG CTTGCACGCC 60
TATCCAGATG AGCTGATCCG CCAGCGTGTG GGCCACGATG GGCATCCTGA GTACCAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013285	Bos taurus	86.11	0.00e+00	2784.00
IUUC-Cja-019033	Callithrix jacchus	81.90	0.00e+00	2620.00
IUUC-Cfa-020695	Canis familiaris	90.72	0.00e+00	1834.00
IUUC-Cpo-021513	Cavia porcellus	78.28	0.00e+00	2483.00
IUUC-Csa-023798	Chlorocebus sabaeus	85.61	0.00e+00	2747.00
IUUC-Dno-029587	Dasypus novemcinctus	81.33	0.00e+00	1477.00
IUUC-Dor-030234	Dipodomys ordii	83.71	0.00e+00	2774.00
IUUC-Ete-032612	Echinops telfairi	75.90	0.00e+00	904.00
IUUC-Eca-033408	Equus caballus	91.21	0.00e+00	2844.00
IUUC-Fca-035483	Felis catus	91.86	0.00e+00	2903.00
IUUC-Gac-041628	Gasterosteus aculeatus	46.55	0.00e+00	1319.00
IUUC-Ggo-044721	Gorilla gorilla	86.44	0.00e+00	2711.00
IUUC-Hsa-046406	Homo sapiens	86.55	0.00e+00	2737.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	86.72	0.00e+00	2748.00
IUUC-Lch-049956	Latimeria chalumnae	47.30	0.00e+00	855.00
IUUC-Laf-054068	Loxodonta africana	86.25	0.00e+00	2787.00
IUUC-Mcc-055464	Macaca mulatta	85.84	0.00e+00	2721.00
IUUC-Meu-056198	Macropus eugenii	57.75	0.00e+00	1332.00
IUUC-Mmr-061464	Microcebus murinus	86.05	0.00e+00	2734.00
IUUC-Mdo-062018	Monodelphis domestica	60.03	0.00e+00	1412.00
IUUC-Mmu-063413	Mus musculus	76.79	0.00e+00	2385.00
IUUC-Mpu-066146	Mustela putorius furo	94.27	0.00e+00	2887.00
IUUC-Mlu-067036	Myotis lucifugus	86.88	0.00e+00	2793.00
IUUC-Opr-070670	Ochotona princeps	78.08	0.00e+00	2493.00
IUUC-Oan-073451	Ornithorhynchus anatinus	51.80	0.00e+00	1178.00
IUUC-Ocu-074155	Oryctolagus cuniculus	83.90	0.00e+00	2655.00
IUUC-Oga-089084	Otolemur garnettii	85.60	0.00e+00	2804.00
IUUC-Oar-090029	Ovis aries	88.12	0.00e+00	2803.00
IUUC-Ptr-091282	Pan troglodytes	85.07	0.00e+00	2719.00
IUUC-Pan-091883	Papio anubis	85.96	0.00e+00	2751.00
IUUC-Pab-098383	Pongo abelii	83.46	0.00e+00	2664.00
IUUC-Pca-100519	Procavia capensis	75.25	0.00e+00	825.00
IUUC-Pva-102417	Pteropus vampyrus	86.43	0.00e+00	2268.00
IUUC-Rno-105962	Rattus norvegicus	78.43	0.00e+00	2518.00
IUUC-Sar-113750	Sorex araneus	81.80	5.00e-175	608.00
IUUC-Ssc-115899	Sus scrofa	81.27	0.00e+00	2459.00
IUUC-Tsy-118860	Tarsius syrichta	82.87	0.00e+00	1105.00
IUUC-Tbe-127660	Tupaia belangeri	84.03	0.00e+00	1382.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence