iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022346

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02040781

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000014376.3	ENSCPOT00000014521.2	ENSCPOP00000012950.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.50e-86	288.9	688	1006

Active Site

Position(s)	Description	Evidence
977	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           +dl+k l vef +E   + gGvt ef++++++e+ +p++g+f y e+++++++p + ++    e+ ++F  +G+l+g++l++ ++ +
   Q: 688  ADLSKTLVVEFIKEIRPESGGVTAEFFHCIFEEMTHPEYGMFIYPEEGSCMWFPVSPKY----EKKSYFL-FGMLCGLSLFNFNIAK 769
           79999*****************************************************9....6789995.5*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           +p++ ++yk+ll++k sledl+e+     ksl+e+++ + sd eel  d+ fs+      ++++++L+p+G ++pV+++Nk++Yv +
   Q: 770  IPFPLALYKKLLDQKPSLEDLKELSLFWEKSLQEVLSDEGSDFEEL--DMYFSI----HWNQNDVDLIPNGTSVPVNKANKKDYVAK 850
           ************************************9977777775..666653....35678888********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
            v+y+++++ik  +e+f +Gf++v++ + ++ F +eel + + G++++d+ed++k+ +y++gy+ ++p+iq+Fw+++++f+ +e+k+
   Q: 851  CVDYIFNTSIKAVYEEFCRGFYKVCDRKAIRCFYPEELMTAVIGSTNYDWEDFEKNSQYEEGYHISHPTIQMFWKAFHKFTLDEKKK 937
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           fL F+Tg++rl ++G+++    +f+++ d s++++P+s TC + L LP Ys++e ++e L +Ai++ +gF
   Q: 938  FLLFLTGRDRLHIRGIQNRG-IIFCCPADFSEKDYPRSLTCHSILYLPAYSTMERMEEALHTAINSHRGF 1006
           ******************99.99*******************************************9999 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

AYFGWSADAG RRRARRPAAA GTGLLQAASG ERHALLLLTN QVVHACGDNS GGQLGRRGAP 60
SGKQPVPKEP IQALVNLPVD LVSCGKEHSL AVCHKGKVFA WGVGSDGQLG TGKFEEICFI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTACTTCG GCTGGAGCGC GGACGCGGGA CGCCGGAGGG CGCGGCGCCC GGCAGCGGCG 60
GGCACGGGGC TGCTGCAGGC GGCCAGCGGG GAGCGGCACG CGCTGCTCCT GCTGACCAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	68.94	0.00e+00	1314.00
IUUC-Aca-004663	Anolis carolinensis	47.11	0.00e+00	827.00
IUUC-Bta-013080	Bos taurus	67.67	0.00e+00	1314.00
IUUC-Cja-018891	Callithrix jacchus	68.31	0.00e+00	1357.00
IUUC-Cfa-020763	Canis familiaris	68.10	0.00e+00	1275.00
IUUC-Csa-023049	Chlorocebus sabaeus	69.96	0.00e+00	1453.00
IUUC-Cho-025101	Choloepus hoffmanni	52.13	1.00e-137	484.00
IUUC-Dno-029093	Dasypus novemcinctus	67.48	0.00e+00	1359.00
IUUC-Dor-030862	Dipodomys ordii	42.77	0.00e+00	662.00
IUUC-Eca-034098	Equus caballus	70.26	0.00e+00	1343.00
IUUC-Eeu-035028	Erinaceus europaeus	64.25	1.00e-147	517.00
IUUC-Fca-036283	Felis catus	69.67	0.00e+00	1340.00
IUUC-Ggo-045553	Gorilla gorilla	68.29	0.00e+00	1368.00
IUUC-Hsa-046396	Homo sapiens	70.52	0.00e+00	1424.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	42.98	0.00e+00	745.00
IUUC-Loc-052736	Lepisosteus oculatus	41.27	0.00e+00	702.00
IUUC-Laf-054433	Loxodonta africana	65.23	0.00e+00	1387.00
IUUC-Mcc-055014	Macaca mulatta	66.63	0.00e+00	1388.00
IUUC-Mmr-060783	Microcebus murinus	42.21	0.00e+00	682.00
IUUC-Mdo-061839	Monodelphis domestica	53.03	0.00e+00	947.00
IUUC-Mmu-064378	Mus musculus	64.26	0.00e+00	1262.00
IUUC-Mpu-066293	Mustela putorius furo	66.16	0.00e+00	1230.00
IUUC-Mlu-067407	Myotis lucifugus	66.17	0.00e+00	1316.00
IUUC-Nle-069978	Nomascus leucogenys	70.06	0.00e+00	1449.00
IUUC-Opr-070190	Ochotona princeps	56.13	0.00e+00	650.00
IUUC-Ocu-074305	Oryctolagus cuniculus	47.48	0.00e+00	855.00
IUUC-Oga-088780	Otolemur garnettii	65.00	0.00e+00	1288.00
IUUC-Oar-090307	Ovis aries	68.41	0.00e+00	1373.00
IUUC-Ptr-091567	Pan troglodytes	70.55	0.00e+00	1429.00
IUUC-Pan-091802	Papio anubis	65.50	0.00e+00	1352.00
IUUC-Pab-098024	Pongo abelii	56.43	0.00e+00	1060.00
IUUC-Pca-100315	Procavia capensis	54.04	0.00e+00	750.00
IUUC-Pva-102382	Pteropus vampyrus	62.95	0.00e+00	1191.00
IUUC-Rno-105768	Rattus norvegicus	61.13	0.00e+00	1197.00
IUUC-Sha-106525	Sarcophilus harrisii	51.79	0.00e+00	1016.00
IUUC-Sar-113014	Sorex araneus	59.00	9.00e-156	544.00
IUUC-Tsy-119240	Tarsius syrichta	47.72	6.00e-157	548.00
IUUC-Tbe-127787	Tupaia belangeri	44.52	0.00e+00	748.00
IUUC-Ttr-128191	Tursiops truncatus	47.82	0.00e+00	815.00
IUUC-Vpa-130214	Vicugna pacos	65.09	0.00e+00	1180.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence