iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045553

UUCD1 version

UUC-GoG-00441

Ensembl Protein ID

ENSGGOP00000010659.2

UniProt Accession

G3R5S6; G3R5S6_GORGO

Protein Name

Uncharacterized protein

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000010928.2	ENSGGOT00000010977.2	ENSGGOP00000010659.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.10e-91	306.3	657	976

Active Site

Position(s)	Description	Evidence
947	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
            d+ k+l vef +E + + gGv++ef++++++e+ +p++g+f+y e ++++++p++ +     e+ ++F  +G+l+g++l++ ++ +lp
   Q: 657  TDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKP----EKKRYFL-FGMLCGLSLFNLNVANLP 740
           688899*************************************************9885....7889995.5***************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           ++ ++yk+ll++k sledl+e+ p l ksl+e+++ + +di ++ l+++fs++     ++++++L+p+G  ipV ++Nk++Yv+++++y
   Q: 741  FPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDDADDIGDA-LCIRFSIH----WDQNDVDLIPNGIAIPVDQTNKRDYVSKYIDY 824
           ************************************99999997.*****855....5779999************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           +++ ++k  +e+f++Gf++v+++e+l+ F +eel + i G++++d+++++++ +y++gy++++p+iq Fw+++++++ +e+k+fL F+T
   Q: 825  IFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSEYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLT 913
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           g++rl ++G+++++  +f +++  s+++ P+s TC n L LP+Ys++e ++e L++Ai++++gF
   Q: 914  GRDRLHARGIQKME-IVFRCPETFSERDHPKSITCHNILYLPKYSTMERMEEALQVAINNNRGF 976
           **************.77888889****************************************9 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MYFCWGADSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRGA 60
QRGELPEPIQ ALETLIVDLV SCGKEHSLAV CHKGRVFAWG AGSEGQLGIG EFKEISFTPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACTTCT GTTGGGGCGC CGACTCCCGG GAGCTGCAGC GCCGGAGGAC GGCGGGCAGC 60
CCCGGGGCTG AGCTACTGCA GGCGGCCAGC GGGGAGCGCC ACTCTCTGCT GCTGCTGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	69.64	0.00e+00	1338.00
IUUC-Aca-004663	Anolis carolinensis	45.53	0.00e+00	840.00
IUUC-Bta-013080	Bos taurus	71.84	0.00e+00	1400.00
IUUC-Cja-018891	Callithrix jacchus	83.87	0.00e+00	1678.00
IUUC-Cfa-020763	Canis familiaris	70.26	0.00e+00	1291.00
IUUC-Cpo-022346	Cavia porcellus	68.29	0.00e+00	1390.00
IUUC-Csa-023049	Chlorocebus sabaeus	92.15	0.00e+00	1911.00
IUUC-Dno-029093	Dasypus novemcinctus	74.17	0.00e+00	1494.00
IUUC-Eca-034098	Equus caballus	74.61	0.00e+00	1412.00
IUUC-Eeu-035028	Erinaceus europaeus	59.73	6.00e-169	588.00
IUUC-Fca-036283	Felis catus	72.18	0.00e+00	1392.00
IUUC-Hsa-046396	Homo sapiens	94.41	0.00e+00	1937.00
IUUC-Loc-052700	Lepisosteus oculatus	40.93	0.00e+00	764.00
IUUC-Laf-054433	Loxodonta africana	69.16	0.00e+00	1429.00
IUUC-Mcc-055014	Macaca mulatta	87.71	0.00e+00	1834.00
IUUC-Mdo-061839	Monodelphis domestica	56.03	0.00e+00	1024.00
IUUC-Mmu-064378	Mus musculus	64.93	0.00e+00	1277.00
IUUC-Mpu-066293	Mustela putorius furo	69.06	0.00e+00	1308.00
IUUC-Mlu-067407	Myotis lucifugus	70.43	0.00e+00	1389.00
IUUC-Nle-069978	Nomascus leucogenys	92.05	0.00e+00	1912.00
IUUC-Opr-070190	Ochotona princeps	57.94	0.00e+00	674.00
IUUC-Oga-088780	Otolemur garnettii	67.37	0.00e+00	1350.00
IUUC-Oar-090307	Ovis aries	71.83	0.00e+00	1387.00
IUUC-Ptr-091567	Pan troglodytes	93.72	0.00e+00	1913.00
IUUC-Pan-091802	Papio anubis	86.61	0.00e+00	1778.00
IUUC-Pab-098024	Pongo abelii	75.27	0.00e+00	1463.00
IUUC-Pva-102382	Pteropus vampyrus	67.68	0.00e+00	1294.00
IUUC-Rno-105768	Rattus norvegicus	62.15	0.00e+00	1207.00
IUUC-Sha-106525	Sarcophilus harrisii	53.81	0.00e+00	1094.00
IUUC-Sar-113014	Sorex araneus	60.48	3.00e-160	558.00
IUUC-Tsy-119565	Tarsius syrichta	78.23	2.00e-176	613.00
IUUC-Vpa-130214	Vicugna pacos	69.54	0.00e+00	1246.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence