iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117679

UUCD1 version

UUC-TaR-00846

Ensembl Protein ID

ENSTRUP00000039377.1

UniProt Accession

H2UR04; H2UR04_TAKRU

Protein Name

Uncharacterized protein

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000015404.1	ENSTRUT00000039518.1	ENSTRUP00000039377.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-100	338.1	484	821

Active Site

Position(s)	Description	Evidence
789	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k+lev f++Ee+ld+gG+ re+++l++k l++++++lf ++s+n++  ++pn ++  +   +lk++ef Gr++gk+l+++     
   Q: 484  SDWSKNLEVVFQDEEALDWGGPRREWFELICKTLFDTSNQLFtRFSDNNQGLVHPNAERPAH--LRLKMYEFSGRIVGKCLFESalgga 570
           799***************************************778889999******99975..9******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ d+e+yk+ + +i++n   d++e++l ++ ++ +++ +  k++eL++gG++i VtneNk 
   Q: 571  ykQLVRARFTRSFLAQIIGLRMNYKYFETDDQEFYKTkVCFILNN---DVSEMDLVFAEEKYSKSGQLEKVVELISGGAQIAVTNENKM 656
           99***********************************99****99...9**************************************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++ +ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v+++f++e
   Q: 657  HYLNLLAQYRLATQVRDEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVQDFKAHAvIVGGSWHFREKVMKWFWAVVSSFTQE 745
           **************************************************************445778999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGf++l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+l++ L +Ai+e+ +gF++
   Q: 746  ELARLLQFTTGSSQLPPGGFNTLCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEELHKLLKLAISEGsEGFGM 821
           ************************99555555.******************************************97 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MFYVIGGITV SIIAFVFTIK FLCELAARVV SFLQNEDPGR RGDRSIYDYV RGNYLDPRSC 60
KVSWDWKEPQ EVGQTMSFRV QLFYKNGQPF PAHRPVGLRV NITHIELALD IPVTQEVLHD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTACG TGATTGGTAA GTGAGTTATG AAAGGAAAAA TAAATGTTAA AATGGAGGGA 60
TTTTAAAGTT GATTACCCTT AATTCTTCAG TGCAGATAAA CATCCATGAC AAATCACTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	80.90	0.00e+00	1358.00
IUUC-Apl-004071	Anas platyrhynchos	78.49	0.00e+00	1293.00
IUUC-Aca-005218	Anolis carolinensis	79.85	0.00e+00	1336.00
IUUC-Ame-011871	Astyanax mexicanus	93.67	0.00e+00	1581.00
IUUC-Bta-012978	Bos taurus	80.68	0.00e+00	1355.00
IUUC-Cja-019081	Callithrix jacchus	80.80	0.00e+00	1352.00
IUUC-Cfa-020736	Canis familiaris	78.61	0.00e+00	1280.00
IUUC-Cpo-021581	Cavia porcellus	80.68	0.00e+00	1356.00
IUUC-Csa-024189	Chlorocebus sabaeus	75.32	0.00e+00	695.00
IUUC-Cho-024751	Choloepus hoffmanni	80.44	0.00e+00	1313.00
IUUC-Cin-025773	Ciona intestinalis	42.11	2.00e-149	522.00
IUUC-Csv-026090	Ciona savignyi	40.79	9.00e-173	600.00
IUUC-Dre-027788	Danio rerio	91.61	0.00e+00	1553.00
IUUC-Dno-030022	Dasypus novemcinctus	80.68	0.00e+00	1356.00
IUUC-Dme-031577	Drosophila melanogaster	48.68	0.00e+00	714.00
IUUC-Ete-032402	Echinops telfairi	79.12	0.00e+00	1291.00
IUUC-Eca-033908	Equus caballus	81.29	0.00e+00	1363.00
IUUC-Eeu-034869	Erinaceus europaeus	86.18	0.00e+00	832.00
IUUC-Fca-036023	Felis catus	80.92	0.00e+00	1358.00
IUUC-Fal-037477	Ficedula albicollis	80.92	0.00e+00	1344.00
IUUC-Gmo-039197	Gadus morhua	94.28	0.00e+00	1560.00
IUUC-Gga-040704	Gallus gallus	78.86	0.00e+00	1337.00
IUUC-Gac-041511	Gasterosteus aculeatus	93.92	0.00e+00	1587.00
IUUC-Ggo-044527	Gorilla gorilla	77.67	0.00e+00	1280.00
IUUC-Hsa-046082	Homo sapiens	80.80	0.00e+00	1353.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	81.17	0.00e+00	1361.00
IUUC-Lch-049772	Latimeria chalumnae	74.24	0.00e+00	1186.00
IUUC-Loc-052541	Lepisosteus oculatus	89.68	0.00e+00	1506.00
IUUC-Laf-053852	Loxodonta africana	80.80	0.00e+00	1347.00
IUUC-Mcc-054759	Macaca mulatta	75.52	0.00e+00	627.00
IUUC-Meu-056247	Macropus eugenii	65.94	0.00e+00	705.00
IUUC-Mga-060161	Meleagris gallopavo	78.40	0.00e+00	1320.00
IUUC-Mmr-061447	Microcebus murinus	81.04	0.00e+00	1359.00
IUUC-Mdo-062110	Monodelphis domestica	78.74	0.00e+00	1317.00
IUUC-Mmu-064349	Mus musculus	80.68	0.00e+00	1355.00
IUUC-Mpu-065824	Mustela putorius furo	81.29	0.00e+00	1356.00
IUUC-Mlu-067729	Myotis lucifugus	80.92	0.00e+00	1334.00
IUUC-Nle-069721	Nomascus leucogenys	80.92	0.00e+00	1344.00
IUUC-Opr-070189	Ochotona princeps	80.66	0.00e+00	1345.00
IUUC-Ont-072122	Oreochromis niloticus	95.86	0.00e+00	1581.00
IUUC-Oan-072700	Ornithorhynchus anatinus	71.95	0.00e+00	1068.00
IUUC-Ocu-074057	Oryctolagus cuniculus	81.04	0.00e+00	1360.00
IUUC-Ola-087492	Oryzias latipes	93.80	0.00e+00	1573.00
IUUC-Oga-088084	Otolemur garnettii	81.04	0.00e+00	1352.00
IUUC-Oar-090354	Ovis aries	80.47	0.00e+00	1336.00
IUUC-Ptr-091456	Pan troglodytes	80.56	0.00e+00	1347.00
IUUC-Pan-092596	Papio anubis	79.73	0.00e+00	1327.00
IUUC-Psi-092942	Pelodiscus sinensis	80.68	0.00e+00	1339.00
IUUC-Pma-094662	Petromyzon marinus	62.13	0.00e+00	761.00
IUUC-Pfo-096838	Poecilia formosa	95.38	0.00e+00	1542.00
IUUC-Pab-097849	Pongo abelii	80.56	0.00e+00	1350.00
IUUC-Pca-100498	Procavia capensis	76.35	0.00e+00	729.00
IUUC-Pva-102599	Pteropus vampyrus	80.56	0.00e+00	1340.00
IUUC-Rno-105776	Rattus norvegicus	80.80	0.00e+00	1347.00
IUUC-Sha-106699	Sarcophilus harrisii	79.34	0.00e+00	1327.00
IUUC-Sar-113621	Sorex araneus	80.32	0.00e+00	1318.00
IUUC-Ssc-115742	Sus scrofa	80.80	0.00e+00	1358.00
IUUC-Tgu-116490	Taeniopygia guttata	80.32	0.00e+00	1339.00
IUUC-Tsy-119607	Tarsius syrichta	76.40	0.00e+00	924.00
IUUC-Tni-120376	Tetraodon nigroviridis	92.35	0.00e+00	1492.00
IUUC-Tbe-127348	Tupaia belangeri	56.33	2.00e-147	515.00
IUUC-Ttr-128786	Tursiops truncatus	77.64	0.00e+00	1291.00
IUUC-Vpa-130180	Vicugna pacos	78.95	0.00e+00	1047.00
IUUC-Xtr-132631	Xenopus tropicalis	66.99	0.00e+00	1110.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence